Citation Impact
Citing Papers
Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
2009 StandoutScienceNobel
Essential role for KH domains in RNA binding: Impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome
1994
Advances in Molecular Analysis of Fragile X Syndrome
1994
Ionotropic Glutamate Receptors & CNS Disorders
2008
RNA polymerase II and the integration of nuclear events
2000
Structural Basis of Transcription
2004 StandoutNobel
Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage
2003
Stranded in an active gene
1993
TFIIH: a key component in multiple DNA transactions
1996
TFIIS binds to mouse RNA polymerase I and stimulates transcript elongation and hydrolytic cleavage of nascent rRNA
1996
Distinction and Relationship between Elongation Rate and Processivity of RNA Polymerase II In Vivo
2005
The RNA–DNA Hybrid Maintains the Register of Transcription by Preventing Backtracking of RNA Polymerase
1997
MUF1, A Novel Elongin BC-interacting Leucine-rich Repeat Protein That Can Assemble with Cul5 and Rbx1 to Reconstitute a Ubiquitin Ligase
2001
Coupling between transcription termination and RNA polymerase inchworming
1995
Elongator, a Multisubunit Component of a Novel RNA Polymerase II Holoenzyme for Transcriptional Elongation
1999
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
2001 StandoutNobel
A Posttranscriptional Role for the Yeast Paf1-RNA Polymerase II Complex Is Revealed by Identification of Primary Targets
2005
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
RNA Polymerase II Ternary Complexes May Become Arrested after Transcribing to within 10 Bases of the End of Linear Templates
1995
Recycling of the general transcription factors during RNA polymerase II transcription.
1995
Yeast RNA Polymerase II Subunit RPB9
2000
In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants
2006 StandoutNobel
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
1998 StandoutNatureNobel
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Yeast RNA Polymerase II at 5 Å Resolution
1999 StandoutNobel
RNA Polymerase II Elongation Control
1998
Lack of Transcription-coupled Repair of Acetylaminofluorene DNA Adducts in Human Fibroblasts Contrasts Their Efficient Inhibition of Transcription
1998
Contacts between mammalian RNA polymerase II and the template DNA in a ternary elongation complex
1993
RNA polymerase II stalled at a thymine dimer: footprint and effect on excision repair
1997
Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeast
1994 StandoutNatureNobel
Ubiquitin Ligase Activity of TFIIH and the Transcriptional Response to DNA Damage
2005 StandoutNobel
A mediator required for activation of RNA polymerase II transcription in vitro
1991 StandoutNatureNobel
Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase
2003
MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos
1996 StandoutNobel
Formation and Crystallization of Yeast RNA Polymerase II Elongation Complexes
1997 StandoutNobel
The 8-Nucleotide-long RNA:DNA Hybrid Is a Primary Stability Determinant of the RNA Polymerase II Elongation Complex
2000
Stimulation of transcript elongation requires both the zinc finger and RNA polymerase II binding domains of human TFIIS
1991
Model for XPC-independent Transcription-coupled Repair of Pyrimidine Dimers in Humans
1997 StandoutNobel
Human Transcription Release Factor 2 Dissociates RNA Polymerases I and II Stalled at a Cyclobutane Thymine Dimer
1999 StandoutNobel
Promoting elongation with transcript cleavage stimulatory factors
2002
Abortive Initiation by Saccharomyces cerevisiae RNA Polymerase III
1999
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
1998 StandoutNobel
Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene
2018
Protein complexes in nucleotide excision repair
1999
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae
2003
Promoter Proximal Sequences Modulate RNA Polymerase II Elongation by a Novel Mechanism
1996
Phosphorylation of Serine 2 within the RNA Polymerase II C-Terminal Domain Couples Transcription and 3′ End Processing
2004
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
RNA Polymerase Switches between Inactivated and Activated States By Translocating Back and Forth along the DNA and the RNA
1997
Crystal structure of the GreA transcript cleavage factor from Escherichia coli
1995 Nature
A Human RNA Polymerase II Transcription Termination Factor Is a SWI2/SNF2 Family Member
1998
Complexes of yeast RNA polymerase II and RNA are substrates for TFIIS-induced RNA cleavage
1994
General Transcription Factors for RNA Polymerase II1
1997
High-resolution structure of an archaeal zinc ribbon defines a general architectural motif in eukaryotic RNA polymerases
1998
The Paf1 Complex Has Functions Independent of Actively Transcribing RNA Polymerase II
2004
Yeast Transcript Elongation Factor (TFIIS), Structure and Function
1998
Clustered α-amanitin resistance mutations in mouse
1995
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
1994 StandoutNatureNobel
Lack of transcription-coupled repair in mammalian ribosomal RNA genes
1993
Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes
1998
Elongation by RNA polymerase II: the short and long of it
2004
Fractions to Functions: RNA Polymerase II Thirty Years Later
1998
Transcription elongation: structural basis and mechanisms
1999
Recovery from Ultraviolet Light-Induced Depression of Ribosomal RNA Synthesis in Normal Human, Xeroderma Pigmentosum and Cockayne Syndrome Cells.
1996
Transcript cleavage factors from E. coli
1993
Transcriptional Pausing at +62 of the HIV-1 Nascent RNA Modulates Formation of the TAR RNA Structure
1998
Nuclease Cleavage of the Upstream Half of the Nontemplate Strand DNA in an Escherichia coli Transcription Elongation Complex Causes Upstream Translocation and Transcriptional Arrest
1997
Electron Crystal Structure of an RNA Polymerase II Transcription Elongation Complex
1999 StandoutNobel
Structure and Function of the Transcription Elongation Factor GreB Bound to Bacterial RNA Polymerase
2003
A novel mediator between activator proteins and the RNA polymerase II transcription apparatus
1990 StandoutNobel
Excision Repair in Mammalian Cells
1995 StandoutNobel
Molecular mechanism of nucleotide excision repair
1999
The Paf1 Complex Is Required for Histone H3 Methylation by COMPASS and Dot1p: Linking Transcriptional Elongation to Histone Methylation
2003
Analysis of the signals for transcription termination by purified RNA polymerase II
1990
Repair and Transcription: Collision or collusion?
1994
Double Mutants of Saccharomyces cerevisiae with Alterations in Global Genome and Transcription-Coupled Repair
1996
Discontinuous Mechanism of Transcription Elongation
1994 Science
Protein-RNA interactions in the active center of transcription elongation complex.
1996
RNA polymerase II transcription factor SIII. II. Functional properties and role in RNA chain elongation.
1993
Purification and characterization of yeast RNA polymerase II transcription factor b.
1991 StandoutNobel
Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution
2002 StandoutNobel
Transcription Elongation and Human Disease
1999
Control of formation of two distinct classes of RNA polymerase II elongation complexes.
1992
Initiation of eukaryotic messenger RNA synthesis.
1991
An RNA Polymerase II Transcription Factor Shares Functional Properties with Escherichia coli σ 70
1990 Science
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Quality Control by DNA Repair
1999 StandoutScienceNobel
Elongin (SIII): A Multisubunit Regulator of Elongation by RNA Polymerase II
1995 Science
Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II
2004 StandoutScienceNobel
Elongation by Drosophila RNA polymerase II. Transcription of 3′-extended DNA templates.
1988
Transcription initiated by RNA polymerase II and transcription factors from liver. Structure and action of transcription factors epsilon and tau.
1991
Footprinting analysis of mammalian RNA polymerase II along its transcript: an alternative view of transcription elongation.
1991
Cloning of the 62-Kilodalton Component of Basic Transcription Factor BTF2
1992 Science
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
1997 Standout
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution
2001 StandoutScienceNobel
RNA Polymerase Marching Backward
1993 Science
BASIC MECHANISMS OF TRANSCRIPT ELONGATION AND ITS REGULATION
1997
The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex.
1996
Nascent RNA cleavage by purified ternary complexes of vaccinia RNA polymerase.
1993
GreA-induced transcript cleavage is accompanied by reverse translocation to a different transcription complex conformation.
1994
Transcription-Coupled Repair and Human Disease
1994 Science
Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1
1997
Molecular Matchmakers
1993 StandoutScienceNobel
The connection between transcription and genomic instability
2002
The transcription factor TFIIS zinc ribbon dipeptide Asp-Glu is critical for stimulation of elongation and RNA cleavage by RNA polymerase II.
1994
RNA Polymerase II Elongation Complexes Paused after the Synthesis of 15- or 35-Base Transcripts Have Different Structures
1991
Evidence for a mediator cycle at the initiation of transcription
1997 StandoutNobel
Two dissociable subunits of yeast RNA polymerase II stimulate the initiation of transcription at a promoter in vitro.
1991 StandoutNobel
Fmr1 knockout mice: A model to study fragile X mental retardation
1994
The RNA polymerase II ternary complex cleaves the nascent transcript in a 3'----5' direction in the presence of elongation factor SII.
1992
Processing of Nontelomeric 3′ Ends by Telomerase: Default Template Alignment and Endonucleolytic Cleavage
1996
Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts.
1995
In vitro characterization of mutant yeast RNA polymerase II with reduced binding for elongation factor TFIIS.
1996
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Conserved Structures of Mediator and RNA Polymerase II Holoenzyme
1999 StandoutScienceNobel
Elongation factor TFIIS contains three structural domains: solution structure of domain II.
1996
Genetic Interaction between Transcription Elongation Factor TFIIS and RNA Polymerase II
1992
Mutations in gld-1, a female germ cell-specific tumor suppressor gene in Caenorhabditis elegans, affect a conserved domain also found in Src-associated protein Sam68.
1995
Telomerase in Yeast
1995 StandoutScienceNobel
Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair
1999
UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells.
1996
Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog.
1995
Yeast Transcript Elongation Factor (TFIIS), Structure and Function
1998
Identification of a 3'-->5' exonuclease activity associated with human RNA polymerase II.
1993
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
Functional topography of nascent RNA in elongation intermediates of RNA polymerase
1998
Factors regulating the transcriptional elongation activity of RNA polymerase II
1998
Multiple RNA Polymerase Conformations and GreA: Control of the Fidelity of Transcription
1993 Science
Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
2002 StandoutScienceNobel
Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2
1998 StandoutNobel
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
2004 StandoutScienceNobel
Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation.
1993 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Mechanistic studies of transcription arrest at the adenovirus major late attenuation site. Comparison of purified RNA polymerase II and washed elongation complexes.
1992
Conserved Structures and Diversity of Functions of RNA-Binding Proteins
1994 StandoutScience
GreA protein: a transcription elongation factor from Escherichia coli.
1992
Topology of Yeast RNA Polymerase II Subunits in Transcription Elongation Complexes Studied by Photoaffinity Cross-Linking
2000
RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6.
1994
RNA polymerase II transcription factor SIII. I. Identification, purification, and properties.
1993
A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains
1997 StandoutNobel
GreA-induced transcript cleavage in transcription complexes containing Escherichia coli RNA polymerase is controlled by multiple factors, including nascent transcript location and structure.
1994
Cockayne syndrome group B protein enhances elongation by RNA polymerase II
1997 StandoutNobel
Works of Daniel Reines being referenced
Identification of a Decay in Transcription Potential That Results in Elongation Factor Dependence of RNA Polymerase II
1995
FMR1 Protein: Conserved RNP Family Domains and Selective RNA Binding
1993 Science
Nucleotide Sequence Context Effect of a Cyclobutane Pyrimidine Dimer upon RNA Polymerase II Transcription
1997
Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells
1999
Mechanism and regulation of transcriptional elongation by RNA polymerase II
1999
Large‐scale screening of yeast mutants for sensitivity to the IMP dehydrogenase inhibitor 6‐azauracil
2004
Variation in the Size of Nascent RNA Cleavage Products as a Function of Transcript Length and Elongation Competence
1995
A DNA Minor Groove-binding Ligan Both Potentiates and Arrests Transcription by RNA Polymerase II
1994
Transcription elongation factor SII
2000
Histone Modifications Depict an Aberrantly Heterochromatinized FMR1 Gene in Fragile X Syndrome
2002
Effects of Aminofluorene and Acetylaminofluorene DNA Adducts on Transcriptional Elongation by RNA Polymerase II
1996
T7 RNA polymerase bypass of large gaps on the template strand reveals a critical role of the nontemplate strand in elongation
1995
Identification of intrinsic termination sites in vitro for RNA polymerase II within eukaryotic gene sequences
1987
[18] Purification of RNA polymerase II general transcription factors from rat liver
1996
Recognition of a Human Arrest Site Is Conserved between RNA Polymerase II and Prokaryotic RNA Polymerases
1998
Elongation Factor SII Contacts the 3′-End of RNA in the RNA Polymerase II Elongation Complex
1996
Mutations in RNA Polymerase II and Elongation Factor SII Severely Reduce mRNA Levels in Saccharomyces cerevisiae
1998
Use of an in Vivo Reporter Assay to Test for Transcriptional and Translational Fidelity in Yeast
2002
Purification of RNA using an anti-RNA monoclonal antibody
1991
The RNA polymerase II elongation complex. Factor-dependent transcription elongation involves nascent RNA cleavage.
1992
The RNA polymerase II general elongation factors
1996
Increased accommodation of nascent RNA in a product site on RNA polymerase II during arrest.
1996
RNA polymerase II elongation complex. Elongation complexes purified using an anti-RNA antibody do not contain initiation factor alpha
1991
Transcription initiated by RNA polymerase II and purified transcription factors from liver. Cooperative action of transcription factors tau and epsilon in initial complex formation.
1990
Transcript cleavage by RNA polymerase II arrested by a cyclobutane pyrimidine dimer in the DNA template.
1994
Saccharomyces cerevisiae Transcription Elongation Mutants Are Defective in PUR5 Induction in Response to Nucleotide Depletion
2000
Mutations in the Second Largest Subunit of RNA Polymerase II Cause 6-Azauracil Sensitivity in Yeast and Increased Transcriptional Arrest in Vitro
1996
Transcription elongation by RNA polymerase II: mechanism of SII activation.
1993
Transcription Elongation Factor SII (TFIIS) Enables RNA Polymerase II to Elongate through a Block to Transcription in a Human Gene in Vitro
1989
Elongation factor SII-dependent transcription by RNA polymerase II through a sequence-specific DNA-binding protein.
1993
Nascent RNA cleavage by arrested RNA polymerase II does not require upstream translocation of the elongation complex on DNA.
1993
Purified elongation factor SII is sufficient to promote read-through by purified RNA polymerase II at specific termination sites in the human histone H3.3 gene.
1990
Elongation factor-dependent transcript shortening by template-engaged RNA polymerase II.
1992
The RNA polymerase II general elongation factors
1996