Citation Impact
Citing Papers
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
2007 StandoutScienceNobel
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
1996 Standout
Molecular mediators of hepatic steatosis and liver injury
2004 Standout
Leptin inhibits norepinephrine and dopamine release from rat hypothalamic neuronal endings
1999
Combined Linkage and Association Sib-Pair Analysis for Quantitative Traits
1999
Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
2009
Glutamate and GABA receptor signalling in the developing brain
2004
Acute stimulation of glucose metabolism in mice by leptin treatment
1997 Nature
Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.
1998
Hyperleptinemia of Pregnancy Associated with the Appearance of a Circulating Form of the Leptin Receptor
1997
Inflammation and metabolic disorders
2006 StandoutNature
Recombinant Leptin for Weight Loss in Obese and Lean Adults
1999
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
1995 Standout
Identification of targets of leptin action in rat hypothalamus.
1996
Identification and expression cloning of a leptin receptor, OB-R
1995 Standout
Receptor-mediated regional sympathetic nerve activation by leptin.
1997
Absence of Soluble Leptin Receptor in Plasma fromdbPas/dbPas and Otherdb/db Mice
1998
Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area
1999
Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice
2011
Congenital leptin deficiency is associated with severe early-onset obesity in humans
1997 StandoutNature
A Longitudinal Assessment of Hormonal and Physical Alterations during Normal Puberty in Boys. V. Rising Leptin Levels May Signal the Onset of Puberty1
1997
Relatively low plasma leptin concentrations precede weight gain in Pima Indians
1997
Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.
1996
Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans
2002
The role of neuropeptide Y in the antiobesity action of the obese gene product
1995 Nature
Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition.
1997
Leptin-Replacement Therapy for Lipodystrophy
2002
Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice
1996
A General Test of Association for Quantitative Traits in Nuclear Families
2000
Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
1996
Association study designs for complex diseases
2001
Leptin Concentrations in Relation to Body Mass Index and the Tumor Necrosis Factor-α System in Humans1
1997
Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
1997
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
The Leptin Receptor
1997
Treatment of Obesity with Celastrol
2015 Standout
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
1995 Standout
Obesity, diabetes and the central nervous system
1998
Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene
1998
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
1996 Standout
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
1997 Standout
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
2000 StandoutNatureNobel
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
2007 Standout
A human leptin mutant induces weight gain in normal mice
1997
Pathophysiological Significance of theObeseGene Product, Leptin, in Ventromedial Hypothalamus (VMH)-Lesioned Rats: Evidence for Loss of Its Satiety Effect in VMH-Lesioned Rats1
1997
Diabetes epidemiology as a tool to trigger diabetes research and care
1999
Transient increase in obese gene expression after food intake or insulin administration
1995 Nature
Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.
1997
Perspective: Hexosamines and Nutrient Sensing
2000
Allele sharing and allelic association I: Sib pair tests with increased power
2002
Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation
2007 StandoutNobel
The arcuate nucleus as a primary site of satiety effect of leptin in rats
1997
Pedigree tests of transmission disequilibrium
2000
Searching for ways out of the autism maze: genetic, epigenetic and environmental clues
2006
Central nervous system control of food intake
2000 StandoutNature
Synergy Between Leptin and Cholecystokinin (CCK) to Control Daily Caloric Intake
1997
Imaging second messenger dynamics in developing neural circuits
2008
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
CTLA4 gene polymorphism and autoimmunity
2005
Global and societal implications of the diabetes epidemic
2001 StandoutNature
What’s in a Name? In Search of Leptin’s Physiologic Role1
1998
Serum Immunoreactive Leptin Concentrations in Patients with Anorexia Nervosa before and after Partial Weight Recovery
1997
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Transmission/disequilibrium tests for quantitative traits
2000
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
1998 StandoutNature
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Leptin accelerates the onset of puberty in normal female mice.
1997
Cerebrospinal Fluid Leptin in Anorexia Nervosa: Correlation with Nutritional Status and Potential Role in Resistance to Weight Gain1
1997
A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2
1997
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
1995
Abnormal splicing of the leptin receptor in diabetic mice
1996 StandoutNature
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
2002
Adipogenesis and Obesity: Rounding Out the Big Picture
1996
Modern science versus the stigma of obesity
2004
Leptin at 14 y of age: an ongoing story
2009
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
2000
The hormone resistin links obesity to diabetes
2001 StandoutNature
Mice lacking melanin-concentrating hormone are hypophagic and lean
1998 Nature
The biology of leptin: a review.
1998
Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
2009
Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding
1997
The stomach is a source of leptin
1998 Nature
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
1998 StandoutNature
From Lesions to Leptin
1999
Obesity and the Regulation of Energy Balance
2001 Standout
The Drosophila takeout Gene Is a Novel Molecular Link between Circadian Rhythms and Feeding Behavior
2000 StandoutNobel
Genome-wide association studies for common diseases and complex traits
2005 Standout
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Expression of ob Gene in Adipose Cells
1996
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Unraveling the central nervous system pathways underlying responses to leptin
1998
Confidence intervals for the effect of a prognostic factor after selection of an ‘optimal’ cutpoint
2004
Diet-induced obese mice develop peripheral, but not central, resistance to leptin.
1997
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
1996
Role of leptin in the neuroendocrine response to fasting
1996 StandoutNature
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
1996
Obesity and leptin resistance: distinguishing cause from effect
2010
A role for glucagon-like peptide-1 in the central regulation of feeding
1996 StandoutNature
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
1998 Nature
Obesity and insulin resistance
2000 Standout
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
1999
Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord
1998
Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice
1996 Standout
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
1996
Linkage Disequilibrium and the Search for Complex Disease Genes
2000
Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor
1996 Science
BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY
1997
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006 StandoutScience
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight*
1999
Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin
1998
Extreme Obesity May Be Linked to Markers Flanking the Human OB Gene
1996
The adipoinsular axis: effects of leptin on pancreatic β-cells
2000
Absence of Mutations in the Human OB Gene in Obese/Diabetic Subjects
1996
βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance
2002 StandoutScienceNobel
Liporegulation in Diet-induced Obesity
2001
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
1997
The Molecular Basis of the Obese Mutation in ob2JMice
1997
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
1998
Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
1997
The Role of SOCS-3 in Leptin Signaling and Leptin Resistance
1999
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Mode of action of OB protein (leptin) on feeding
1998
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Localization of Leptin Receptor (Ob-R) Messenger Ribonucleic Acid in the Rodent Hindbrain*
1998
Defective STAT signaling by the leptin receptor in diabetic mice.
1996
Changes in Plasma Leptin during the Treatment of Diabetic Ketoacidosis
1999
Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling*
1999
Leptin Signaling in the Central Nervous System and the Periphery
2004
Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus
1997
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
1997
Genetics of obesity
2006
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
A chemical approach for identifying O -GlcNAc-modified proteins in cells
2003 StandoutNobel
Reversal of the Sex Difference in Serum Leptin Levels upon Cross-Sex Hormone Administration in Transsexuals*
1997
The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
1996
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor
1998
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function
2011 StandoutNobel
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
Effects of Leptin on Insulin Sensitivity in Normal Rats*
1997
Uncoupling of Obesity from Insulin Resistance Through a Targeted Mutation in aP2 , the Adipocyte Fatty Acid Binding Protein
1996 Science
Leptin
2000
Evidence for Leptin Binding to Proteins in Serum of Rodents and Humans: Modulation With Obesity
1996
Characterization and adaptive optical correction of aberrations during in vivo imaging in the mouse cortex
2011 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin*
2000
Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome
2000 Standout
Mitochondrial Uncoupling Proteins in Energy Expenditure
2000
Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin
1997
Abnormal regulation of the leptin gene in the pathogenesis of obesity
1998
Regulation of fatty acid homeostasis in cells: Novel role of leptin
1999
Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y
1996 Science
Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy
1996
Imaging the glycome
2008 StandoutNobel
The Function of Leptin in Nutrition, Weight, and Physiology
2002
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development
2012 StandoutNobel
Leptin affects food intake via CRF-receptor-mediated pathways
1998
Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
2000 Science
Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage
1997
Physiological insulinemia acutely modulates plasma leptin.
1998
Molecular mediators of hepatic steatosis and liver injury
2004 Standout
Obese gene expression: reduction by fasting and stimulation by insulin and glucose in lean mice, and persistent elevation in acquired (diet-induced) and genetic (yellow agouti) obesity.
1996
Effect of fasting on serum leptin in normal human subjects.
1996
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
1998
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
2002
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
1997
The Structure of Haplotype Blocks in the Human Genome
2002 StandoutScience
Indication for Linkage of the Human OB Gene Region With Extreme Obesity
1996
Response of leptin to short-term and prolonged overfeeding in humans.
1996
Expression and Characterization of a Putative High Affinity Human Soluble Leptin Receptor
1997
Expression of Leptin Receptor Isoforms in Rat Brain Microvessels
1998
Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation
1997
Evidence That Plasma Leptin and Insulin Levels are Associated With Body Adiposity Via Different Mechanisms
1997
Leptin actions on food intake and body temperature are mediated by IL-1
1999
Works of Daniel Rabinowitz being referenced
A Unified Approach to Adjusting Association Tests for Population Admixture with Arbitrary Pedigree Structure and Arbitrary Missing Marker Information
2000
A Transmission Disequilibrium Test for Quantitative Trait Loci
1997
Systematic regulation of spine sizes and densities in pyramidal neurons
2003
Maximally Selected x2 Statistics for k× 2 Tables
1999
Approximating the Distribution of Maximally Selected McNemar's Statistics
2000
Networks of Coactive Neurons in Developing Layer 1
1998
Serotonin transporter gene promoter variants do not explain the hyperserotoninemia in autistic children
2002
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
1995 StandoutScience
The Effect of Marker Heterozygosity on the Power to Detect Linkage Disequilibrium
1997