Standout Papers
- The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1 (1994)
- Individual assignments of the heme resonances in the 360 MHz 1H NMR spectra of cytochrome c-557 from Crithidia oncopelti (1979)
- Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins (2010)
Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Structural Mechanisms for Domain Movements in Proteins
1994
Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2
1996
Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger
1999 StandoutNobel
Fatty Acid Substrate Specificities of Human Prostaglandin-endoperoxide H Synthase-1 and −2
1995
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
1995 StandoutNobel
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system
1994
Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
1999 StandoutNatureNobel
Pyridoxal phosphate-dependent enzymes
1995
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Molecular mechanism of vectorial proton translocation by bacteriorhodopsin
2000 StandoutNatureNobel
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors
1996
Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2
1995
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Detergents for the stabilization and crystallization of membrane proteins
2007
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Redesigning an integral membrane K+ channel into a soluble protein
2005
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution
2001 StandoutNatureNobel
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Reactions of Prostaglandin Endoperoxide Synthase and Its Compound I with Hydroperoxides
1996
Simple screening method for improving membrane protein thermostability
2011
A lipid’s eye view of membrane protein crystallization in mesophases
2000
Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2
1999
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
Screening and large-scale expression of membrane proteins in mammalian cells for structural studies
2014
Artificial membrane-like environments for in vitro studies of purified G-protein coupled receptors
2011
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Structure and Function of the Membrane Anchor Domain of Hepatitis C Virus Nonstructural Protein 5A
2004
An Amino-terminal Amphipathic α-Helix Mediates Membrane Association of the Hepatitis C Virus Nonstructural Protein 5A
2002
Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor
2012 StandoutNobel
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
1993 StandoutNatureNobel
UCSF Chimera—A visualization system for exploratory research and analysis
2004 Standout
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Searching protein structure databases has come of age
1994
Crystallization and preliminary X-ray analysis of membrane-bound pyrophosphatases
2012
Structure of the full-length TRPV2 channel by cryo-EM
2016
New amphiphiles for membrane protein structural biology
2011
A hydrogen-atom abstraction model for the function of YZ in photosynthetic oxygen evolution
1995
Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study
2012 StandoutNobel
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Fv fragment-mediated crystallization of the membrane protein bacterial cytochrome c oxidase
1995 Nobel
How coenzyme B12 radicals are generated: the crystal structure of methylmalonyl-coenzyme A mutase at 2 å resolution
1996
Comparison of Peroxidase Reaction Mechanisms of Prostaglandin H Synthase-1 Containing Heme and Mangano Protoporphyrin IX
1997
Structure and function of tetanus and botulinum neurotoxins
1995
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Prostaglandin endoperoxide synthases-1 and -2
1995
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
1996 Standout
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Hemifluorinated surfactants: a non‐dissociating environment for handling membrane proteins in aqueous solutions?
2004
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
1995 StandoutNobel
Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form
2002 StandoutNobel
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
1996 StandoutNature
Towards complete cofactor arrangement in the 3.0 Å resolution structure of photosystem II
2005 StandoutNature
A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins
2012 StandoutNobel
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
Structural Characterization of Arachidonyl Radicals Formed by Prostaglandin H Synthase-2 and Prostaglandin H Synthase-1 Reconstituted with Mangano Protoporphyrin IX
1998
Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin
2001 Standout
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
Spectroscopic Evidence for Reaction of Prostaglandin H Synthase-1 Tyrosyl Radical with Arachidonic Acid
1995
Role of Val509 in Time-dependent Inhibition of Human Prostaglandin H Synthase-2 Cyclooxygenase Activity by Isoform-selective Agents
1996
Membranes are more mosaic than fluid
2005 Nature
Involvement of Arginine 120, Glutamate 524, and Tyrosine 355 in the Binding of Arachidonate and 2-Phenylpropionic Acid Inhibitors to the Cyclooxygenase Active Site of Ovine Prostaglandin Endoperoxide H Synthase-1
1996
A genetic algorithm for the identification of conformationally invariant regions in protein molecules
2002
Determining membrane protein structures: still a challenge!
2007
COX-2 inhibitors
1999 Standout
Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-[125I]iodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site
1996
Copper amine oxidase: a novel use for a tyrosine
1995
Redesigning the Substrate Specificity of an Enzyme by Cumulative Effects of the Mutations of Non-active Site Residues
1999
Comparison of branched-chain and tightly coupled reaction mechanisms for prostaglandin H synthase
1995
Arginine 120 of Prostaglandin G/H Synthase-1 Is Required for the Inhibition by Nonsteroidal Anti-inflammatory Drugs Containing a Carboxylic Acid Moiety
1995
PROTEIN FOLDING: The Endgame
1997 StandoutNobel
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Rigid Amphiphiles for Membrane Protein Manipulation
2000
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Enzyme Mechanisms for Polycyclic Triterpene Formation
2000 Nobel
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
MEMBRANE PROTEIN FOLDING AND STABILITY: Physical Principles
1999
Electron diffraction analysis of structural changes in the photocycle of bacteriorhodopsin.
1993 StandoutNobel
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
1997 StandoutScienceNobel
The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum.
1994
Structure and Function of a Squalene Cyclase
1997 Science
Heme Enzyme Structure and Function
2014
The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 Å
1996 StandoutScience
NAMD2: Greater Scalability for Parallel Molecular Dynamics
1999 Standout
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
1995
Active-site zinc ligands and activated H2O of zinc enzymes.
1990
Detergents as Tools in Membrane Biochemistry
2001
The Kinetic Factors That Determine the Affinity and Selectivity for Slow Binding Inhibition of Human Prostaglandin H Synthase 1 and 2 by Indomethacin and Flurbiprofen
1996
Protein Radicals in Enzyme Catalysis
1998 Standout
Activation of olefins via asymmetric Brønsted acid catalysis
2018 StandoutScienceNobel
Heme-Containing Oxygenases
1996 Standout
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Works of Daniel Picot being referenced
The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1
1994 StandoutNature
Prostaglandin H synthase: Implications for membrane structure
1994
The open/closed conformational equilibrium of aspartate aminotransferase
1991
A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization
2011
Crystal structure of neutral protease from Bacillus cereus refined at 3.0A˚resolution and comparison with the homologous but more thermostable enzyme thermolysin
1988
The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase
1995
An atypical haem in the cytochrome b6f complex
2003 Nature
Domain closure in mitochondrial aspartate aminotransferase
1992
Maltose–neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins
2010 StandoutNobel
The art of crystallizing membrane proteins
1990
Strategies for crystallizing membrane proteins
1996
Synthesis and Use of Iodinated Nonsteroidal Antiinflammatory Drug Analogs as Crystallographic Probes of the Prostaglandin H2 Synthase Cyclooxygenase Active Site,
1996
Prostaglandin H synthase
1994
The 3.1 A X-ray crystal structure of the integral membrane enzyme prostaglandin H2 synthase-1.
1995