Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants
2002
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 StandoutScience
The F-box protein TIR1 is an auxin receptor
2005 StandoutNature
Computed Tomography — An Increasing Source of Radiation Exposure
2007 Standout
p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53
1999
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Functional regulation of p73 and p63: development and cancer
2003
p53, the Cellular Gatekeeper for Growth and Division
1997 Standout
Molecular mechanisms of drug resistance
2005
E2F-1 induced apoptosis
2001
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Activation of the p53 tumor suppressor protein
2002
Hypoxia-responsive transcription factors
2005
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
The ARF/p53 pathway
2000
Regulation of E2F1 activity by acetylation
2000
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
The p53 pathway
1999
Regulation and function of the p53 tumor suppressor protein
2001
MDM2 — master regulator of the p53 tumor suppressor protein
2000
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation
1996
The regulation of E2F by pRB-family proteins
1998 Standout
p21 in cancer: intricate networks and multiple activities
2009 Standout
β-Arrestin 2 Functions as a G-Protein-coupled Receptor-activated Regulator of Oncoprotein Mdm2
2003
The p53–Mdm2 module and the ubiquitin system
2002
Routinely Repeated Computed Tomography after Blunt Head Trauma: Does it Benefit Patients?
2004
Selective Ablation of Retinoblastoma Protein Function by the RET Finger Protein
2005
Live or let die: the cell's response to p53
2002 Standout
The Rb/E2F pathway: expanding roles and emerging paradigms
2000 Standout
Death and anti-death: tumour resistance to apoptosis
2002 Standout
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Finding function in novel targets: C. elegans as a model organism
2006
Growth Regulation by the E2F and DP Transcription Factor Families
1998
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53
2000
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
1999 StandoutNature
Mdm2 Inhibits the Apoptotic Function of p53 Mainly by Targeting It for Degradation
2000
The role of senescent cells in ageing
2014 StandoutNature
Mutations in Human ARF Exon 2 Disrupt Its Nucleolar Localization and Impair Its Ability to Block Nuclear Export of MDM2 and p53
1999
The PTEN, Mdm2, p53 tumor suppressor–oncoprotein network
2002
Seven-transmembrane receptors
2002 StandoutNobel
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
DNA Repair
2006
Modes of p53 Regulation
2009
Of flies and men; p53, a tumour suppressor
2004
p53; from inductive signal to cellular effect
1997
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
2004 StandoutNature
The cellular response to p53: the decision between life and death
1999
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Regulation of p53 Function
2001
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
Functional Interaction between DP-1 and p53
1996
Benzodiazepinedione inhibitors of the Hdm2:p53 complex suppress human tumor cell proliferation in vitro and sensitize tumors to doxorubicin in vivo
2006
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Cancer Cell Cycles
1996 StandoutScience
Activation and activities of the p53 tumour suppressor protein
2001
Regulation of p53 Function and Stability by Phosphorylation
1999
Apoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2
2004
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
1998 StandoutScience
Mechanisms Underlying Ubiquitination
2001 Standout
Cells Degrade a Novel Inhibitor of Differentiation with E1A-Like Properties upon Exiting the Cell Cycle
2000 StandoutNobel
Photophysical Properties of ZnS Nanoclusters with Spatially Localized Mn2+
1996
MDMX: a novel p53-binding protein with some functional properties of MDM2.
1996
MdmX Protects p53 from Mdm2-Mediated Degradation
2000
Kinetics of p53 Binding to Promoter Sites In Vivo
2001
Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
2001
The Pezcoller lecture: cancer cell cycles revisited.
2000
Surfing the p53 network
2000 StandoutNature
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
2000 StandoutScience
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Regulation of p53 stability
1999
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.
1997
The Corepressor mSin3a Interacts with the Proline-Rich Domain of p53 and Protects p53 from Proteasome-Mediated Degradation
2001
WormBook
2008
Arabidopsis Transcription Factors: Genome-Wide Comparative Analysis Among Eukaryotes
2000 StandoutScience
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
2009 StandoutScience
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
2009 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Organometallic Synthesis and Spectroscopic Characterization of Manganese-Doped CdSe Nanocrystals
2000 StandoutNobel
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53.
1997
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2
2010
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Distinct roles for E2F proteins in cell growth control and apoptosis
1997
Works of Daniel O’Connor being referenced
RB Regulates the Stability and the Apoptotic Function of p53 via MDM2
1999
Reimaging in pediatric neurotrauma: Factors associated with progression of intracranial injury
2002
To die or not to die: how does p53 decide?
2004
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
2003
ASPP Proteins Specifically Stimulate the Apoptotic Function of p53
2001
p53 phosphorylation mutants retain transcription activity.
1995
Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.
1995
Novel Function of the Cyclin A Binding Site of E2F in Regulating p53-Induced Apoptosis in Response to DNA Damage
2002
Applications of fast Fourier transform to deconvolution in single photon counting
1979
Proapoptotic p53-Interacting Protein 53BP2 Is Induced by UV Irradiation but Suppressed by p53
2000
Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb
2000