Standout Papers
Citation Impact
Citing Papers
Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis
2006
High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells
2005 StandoutScience
Apg13p and Vac8p Are Part of a Complex of Phosphoproteins That Are Required for Cytoplasm to Vacuole Targeting
2000 StandoutNobel
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
1998 StandoutScience
extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins
1990
The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes
1991
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.
1995
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons
1993
HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.
1992
A highly conserved enhancer downstream of the human MLC1/3 locus is a target for multiple myogenic determination factors
1990
The muscle regulatory gene, Myf-6, has a biphasic pattern of expression during early mouse development.
1991
FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains
1992
A family of muscle gene promoter element (CArG) binding activities in Xenopus embryos: CArG/SRE discrimination and distribution during myogenesis
1991
Molecular Titration and Ultrasensitivity in Regulatory Networks
2008
CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis
1990 StandoutNobel
A network of protein–protein interactions in yeast
2000
Toward a Comprehensive Atlas of the Physical Interactome of Saccharomyces cerevisiae
2007
Yeast Two-Hybrid Systems and Protein Interaction Mapping Projects for Yeast and Worm
2000
Transcriptional regulation by dimerization: Two sides to an incestuous relationship
1990
Specificity in Signal Transduction
2004
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo
1991 Nobel
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
1990
Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor α-subunit gene
1990 Nature
BIND--The Biomolecular Interaction Network Database
2001
Genome‐wide protein interaction maps using two‐hybrid systems
2000
Evidence for dynamically organized modularity in the yeast protein–protein interaction network
2004 Nature
Functional and topological characterization of protein interaction networks
2004
Ubiquitin-Proteasome-mediated Degradation of Id1 Is Modulated by MyoD
2004 StandoutNobel
Protein function in the post-genomic era
2000 Nature
Lethality and centrality in protein networks
2001 StandoutNature
New light on Myc and Myb. Part I. Myc.
1990
Prospects for drug screening using the reverse two-hybrid system
1999
Protein arrays and microarrays
2001
Microarrays of cells expressing defined cDNAs
2001 Nature
Systematic and large-scale two-hybrid screens
2000
Selective Transport of α-Mannosidase by Autophagic Pathways
2010 StandoutNobel
The Human Homolog of Saccharomyces cerevisiae Apg7p Is a Protein-activating Enzyme for Multiple Substrates Including Human Apg12p, GATE-16, GABARAP, and MAP-LC3
2001
Differential Interactions of Id Proteins with Basic-Helix-Loop-Helix Transcription Factors
1997
The Helix–Loop–Helix Protein Id-1 Delays Onset of Replicative Senescence in Human Endothelial Cells
2002
In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants
2006 StandoutNobel
Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system
1997
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
1998 StandoutNatureNobel
Predictome: a database of putative functional links between proteins
2002
The Id proteins and angiogenesis
2001
Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins
2000
Proteomics: new perspectives, new biomedical opportunities
2000
Composition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP
2002
Delta-induced Notch Signaling Mediated by RBP-J Inhibits MyoD Expression and Myogenesis
1999 StandoutNobel
Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data
2018
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation
1990 StandoutNatureNobel
Activation of muscle genes without myogenesis by ectopic expression of MyoD in frog embryo cells
1990 StandoutNatureNobel
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors
2005
Assigning Function to Yeast Proteins by Integration of Technologies
2003 StandoutNobel
Towards an understanding of complex protein networks
2001
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
1993 Standout
MyoD or Myf-5 is required for the formation of skeletal muscle
1993 Standout
Structure of Atg5·Atg16, a Complex Essential for Autophagy
2006 StandoutNobel
Genes required for specifying cell fates in Drosophila embryonic sensory nervous system
1990
A role for the Drosophila neurogenic genes in mesoderm differentiation
1991 StandoutNobel
The continued evolution of two-hybrid screening approaches in yeast: how to outwit different preys with different baits
2000
A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein
1998
MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model
1990
DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions
2002
Functional antagonism between c-Jun and MyoD proteins: A direct physical association
1992
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
The protein–protein interaction map of Helicobacter pylori
2001 Nature
PAS is a dimerization domain common to Drosophila Period and several transcription factors
1993 StandoutNatureNobel
Subcellular localization of the yeast proteome
2002
MyoD and the regulation of myogenesis by helix-loop-helix proteins.
1991
Cotranscriptional Spliceosome Assembly Occurs in a Stepwise Fashion and Requires the Cap Binding Complex
2005
The GRID: The General Repository for Interaction Datasets
2003
Cell biology and the genome projects a concerted strategy for characterizing multiprotein complexes by using mass spectrometry
1997
The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development
1992 StandoutNobel
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Cotranscriptional Spliceosome Assembly Dynamics and the Role of U1 snRNA:5′ss Base Pairing in Yeast
2005 StandoutNobel
Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy
1990
Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination
2004 StandoutNobel
Is There a Bias in Proteome Research?
2001
Analysis of yeast protein kinases using protein chips
2000
I-POU: a POU-domain protein that inhibits neuron-specific gene activation
1991 Nature
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Global analysis of protein localization in budding yeast
2003 StandoutNature
Revealing the world of RNA interference
2004 StandoutNatureNobel
Id proteins in cell cycle control and cellular senescence
2001
Analysis of membrane protein interactions using yeast-based technologies
2002
Comparative assessment of large-scale data sets of protein–protein interactions
2002 StandoutNature
Cell proliferation inhibited by MyoD1 independently of myogenic differentiation
1990 Nature
Promoter-Specific Regulation of MyoD Binding and Signal Transduction Cooperate to Pattern Gene Expression
2002
Kinetochore Recruitment of Two Nucleolar Proteins Is Required for Homolog Segregation in Meiosis I
2003
Possible cross-regulation of phosphate and sulfate metabolism in Saccharomyces cerevisiae.
1992
Proteomics to study genes and genomes
2000 StandoutNature
The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development
1991
Correlation between transcriptome and interactome mapping data from Saccharomyces cerevisiae
2001
The C-terminal Region of an Apg7p/Cvt2p Is Required for Homodimerization and Is Essential for Its E1 Activity and E1-E2 Complex Formation
2001 StandoutNobel
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Regulation of Id1 Protein Expression in Mouse Embryo Fibroblasts by the Type 1 Insulin-like Growth Factor Receptor
2002
Biochemical analysis of TREX complex recruitment to intronless and intron‐containing yeast genes
2004 StandoutNobel
The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F
1991
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
MyoD family: a paradigm for development?
1990
Herculin, a fourth member of the MyoD family of myogenic regulatory genes.
1990
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
Helix-loop-helix proteins as regulators of muscle-specific transcription.
1993
B-Cell- and Myocyte-Specific E2-Box-Binding Factors Contain E12/E47-Like Subunits
1991 Nobel
Specificity and Stability in Topology of Protein Networks
2002 StandoutScience
A Biochemical Genomics Approach for Identifying Genes by the Activity of Their Products
1999 Science
The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage
1991 Science
Transformation-defective v-ski induces MyoD and myogenin expression but not myotube formation.
1991
Degradation of Myogenic Transcription Factor MyoD by the Ubiquitin Pathway In Vivo and In Vitro: Regulation by Specific DNA Binding
1998 StandoutNobel
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection
1990 Science
Topoisomerase I mutants: the gene on pBR322 that encodes resistance to tetracycline affects plasmid DNA supercoiling.
1986
Circadian oscillations in period gene mRNA levels are transcriptionally regulated.
1992 StandoutNobel
Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation.
1993
Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc
1991 StandoutScience
Domains outside of the DNA-binding domain impart target gene specificity to myogenin and MRF4.
1991
Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4.
1990
Paired MyoD-binding sites regulate myosin light chain gene expression.
1991
Muscle-specific expression of the troponin I gene requires interactions between helix-loop-helix muscle regulatory factors and ubiquitous transcription factors.
1991
Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.
1990
Domains Outside of the DNA-Binding Domain Impart Target Gene Specificity to Myogenin and MRF4
1991
Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins
2000
Aberrant regulation of MyoD1 contributes to the partially defective myogenic phenotype of BC3H1 cells [published erratum appears in J Cell Biol 1990 Jun;110(6):2231]
1990
Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization.
1990
Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.
1990
A guided tour in protein interaction space: Coiled coils from the yeast proteome
2000
The SCL Gene Is Formed from a Transcriptionally Complex Locus
1990
A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum
2010 StandoutNobel
Expression of a MyoD family member prefigures muscle pattern in Drosophila embryos.
1990
Analysis of MADS box protein–protein interactions in living plant cells
2002
Muscle-Specific Expression of the Troponin I Gene Requires Interactions between Helix-Loop-Helix Muscle Regulatory Factors and Ubiquitous Transcription Factors
1991
Differentiation requires continuous regulation.
1991 Nobel
A comprehensive two-hybrid analysis to explore the yeast protein interactome
2001 Standout
Use of site-specific recombination as a probe of DNA structure and metabolism in vivo
1987
Supercoiling of the DNA template during transcription.
1987 Standout
The DNA-binding protein E12 co-operates with XMyoD in the activation of muscle-specific gene expression in Xenopus embryos.
1992 StandoutNobel
A General Mechanism for Network-Dosage Compensation in Gene Circuits
2010 StandoutScienceNobel
Early expression of the myogenic regulatory gene, myf-5, in precursor cells of skeletal muscle in the mouse embryo
1991
MyoD and myogenin act on the chicken myosin light-chain 1 gene as distinct transcriptional factors.
1993
The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.
1990
MyoD induces growth arrest independent of differentiation in normal and transformed cells.
1990
Protein localization studies in the age of ‘Omics’
2005
Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.
1992
Inefficient Homooligomerization Contributes to the Dependence of Myogenin on E2A Products for Efficient DNA Binding
1991
Toward a protein–protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins
2000
Xenopus embryos contain a somite-specific, MyoD-like protein that binds to a promoter site required for muscle actin expression.
1991 StandoutNobel
A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae
2000
Sequence-Specific DNA Binding by the c-Myc Protein
1990 Science
Bacterial DNA topoisomerase I can relax positively supercoiled DNA containing a single-stranded loop
1985
In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR
1989 Science
Protein Interaction Mapping in C. elegans Using Proteins Involved in Vulval Development
2000 Science
Printing Proteins as Microarrays for High-Throughput Function Determination
2000 StandoutScience
B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits.
1991 Nobel
The adenovirus major late transcription factor USF is a member of the helix-loop-helix group of regulatory proteins and binds to DNA as a dimer.
1990
Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor
1991 Science
c-myc inhibition of MyoD and myogenin-initiated myogenic differentiation.
1991
Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms
2000
Noninvasive imaging of protein–protein interactions in living subjects by using reporter protein complementation and reconstitution strategies
2002
The Murine Sim-2 Gene Product Inhibits Transcription by Active Repression and Functional Interference
1997
Cyclic amplification and selection of targets (CASTing) for the myogenin consensus binding site.
1991
DNA Topoisomerases: Enzymes That Control DNA Conformation
1985
Identification of MRF4: a new member of the muscle regulatory factor gene family.
1989
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
2004 StandoutScienceNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
The Xenopus MyoD gene: an unlocalised maternal mRNA predates lineage- restricted expression in the early embryo
1990
Xenopus Myf-5 marks early muscle cells and can activate muscle genes ectopically in early embryos
1991 StandoutNobel
Global Analysis of Protein Activities Using Proteome Chips
2001 StandoutScience
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Yeast Two-Hybrid Systems and Protein Interaction Mapping Projects for Yeast and Worm
2000
Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation
2004 StandoutNobel
Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins.
1992
Inefficient homooligomerization contributes to the dependence of myogenin on E2A products for efficient DNA binding.
1991
Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.
1995
Integrative analysis of protein interaction data.
2000
Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.
1990
Works of Daniel Lockshon being referenced
The yeast two-hybrid system: prospects for protein linkage maps
1996
The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
1990 Standout
MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer
1989
The Complete Set of Predicted Genes from Saccharomyces cerevisiae in a Readily Usable Form
1997
Id: A Negative Regulator of Helix‐Loop‐Helix DNA Binding Proteins
1990
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
2000 StandoutNature
Positively supercoiled plasmid DNA is produced by treatment ofEscherichia coliwith DNA gyrase inhibitors
1983
Sites of reaction of Escherichia coli DNA gyrase on pBR322 in vivo as revealed by oxolinic acid-induced plasmid linearization
1985
Cotranscriptional Recruitment of the U1 snRNP to Intron-Containing Genes in Yeast
2003
MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.
1990
Escherichia coli DNA topoisomerase III: purification and characterization of a new type I enzyme
1984
The Sensitivity of Yeast Mutants to Oleic Acid Implicates the Peroxisome and Other Processes in Membrane Function
2006