Standout Papers
Citation Impact
Citing Papers
Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor
2008
Disruption of T helper 2-immune responses in Epstein–Barr virus-induced gene 3-deficient mice
2002
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
2004 StandoutScience
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
2007 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Progressive CD4+ central–memory T cell decline results in CD4+ effector–memory insufficiency and overt disease in chronic SIV infection
2007
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Modulation of CD1d-restricted NKT cell responses by using N- acyl variants of α-galactosylceramides
2005
Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins
2003 Science
Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse
2001
Glycolipid antigen induces long-term natural killer T cell anergy in mice
2005
Mechanisms for Glycolipid Antigen-Driven Cytokine Polarization by Vα14 i NKT Cells
2009
Tumor Cells Loaded with α-Galactosylceramide Induce Innate NKT and NK Cell-Dependent Resistance to Tumor Implantation in Mice
2007
α-Galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis
2003
The Paradox of Immune Molecular Recognition of α-Galactosylceramide: Low Affinity, Low Specificity for CD1d, High Affinity for αβ TCRs
2003
CD1d-restricted mouse Vα14 and human Vα24 T cells: lymphocytes of innate immunity
2000
Oxidative stress and diabetic cardiovascular complications
2005
Detection and activation of human Vα24+ natural killer T cells using α-galactosyl ceramide-pulsed dendritic cells
2003 StandoutNobel
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
2005 StandoutNatureNobel
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Inhibition of antitumor immunity by invariant natural killer T cells in a T‐cell lymphoma model in vivo
2006
Intravascular Immune Surveillance by CXCR6+ NKT Cells Patrolling Liver Sinusoids
2005
Regulation of antitumour immunity by CD1d-restricted NKT cells
2004
The unique role of natural killer T cells in the response to microorganisms
2007
Thymocyte expression of cathepsin L is essential for NKT cell development
2002
Presentation of self and microbial lipids by CD1 molecules
2001
Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
2003
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease
2000 Standout
Clinical Implications of Thiopurine Methyltransferase-Optimization of Drug Dosage and Potential Drug Interactions
1998
CD1 tetramers: a powerful tool for the analysis of glycolipid-reactive T cells
2002
The biology of RAGE and its ligands: Uncovering mechanisms at the heart of diabetes and its complications
2007
Localization and Suppression of a Kinetic Defect in Cystic Fibrosis Transmembrane Conductance Regulator Folding
1997
Natural killer T (NKT) cells and their role in antitumor immunity
2002
Clinical applications of natural killer T cell–based immunotherapy for cancer
2008
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
2006
NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma
2001
Dietary Advanced Glycation End Products and Their Potential Role in Cardiometabolic Disease in Children
2016 Standout
Prolonged IFN-γ–producing NKT response induced with α-galactosylceramide–loaded DCs
2002 StandoutNobel
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery
2007
Saposins facilitate CD1d-restricted presentation of an exogenous lipid antigen to T cells
2004
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
2007 StandoutNature
The Role of Advanced Glycation End Products in Progression and Complications of Diabetes
2008
CD1-Restricted T Cells and Tumor Immunity
2007
Murine CD1d-Restricted T Cell Recognition of Cellular Lipids
2000
NKT cells: what's in a name?
2004
NK cells and NKT cells in innate defense against viral infections
2001
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
CD1-restricted T-cell responses and microbial infection
2000 Nature
The unconventional lifestyle of NKT cells
2002
Selective induction of NK cell proliferation and cytotoxicity by activated NKT cells
2000
Neurodegeneration and Inflammation
2008
Regulation of NKT cell development by SAP, the protein defective in XLP
2005
Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy
2000
Immunity, Inflammation, and Cancer
2010 Standout
10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes
2008 Standout
Role of lipid trimming and CD1 groove size in cellular antigen presentation
2006
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Taking dendritic cells into medicine
2007 StandoutNatureNobel
NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway
2000
Genetic adjuvants for DNA vaccines
2001
Inhibition of tumor metastasis by adoptive transfer of IL-12-activated V?14 NKT cells
2001
Granulocyte-Macrophage Colony-Stimulating Factor Regulates Effector Differentiation of Invariant Natural Killer T Cells during Thymic Ontogeny
2006
Natural killer cells and viral infections
2003
Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus
2003
Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection
2004
Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes
2004
Origin and physiological roles of inflammation
2008 StandoutNature
Unaltered phenotype, tissue distribution and function of Vα14+ NKT cells in germ-free mice
2000
The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
2004
NKT cells: facts, functions and fallacies
2000
CD1d Endosomal Trafficking Is Independently Regulated by an Intrinsic CD1d-Encoded Tyrosine Motif and by the Invariant Chain
2001
Potentiation of antitumor effect of NKT cell ligand, α-galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells1
2000
Pharmacogenetics of Cancer Therapy: Getting Personal
1998
CD1d expression level in tumor cells is an important determinant for anti-tumor immunity by natural killer T cells
2006
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Glycolipids and phospholipids as natural CD1d-binding NKT cell ligands
2006
Molecular pathogenesis of inflammatory bowel disease: Genotypes, phenotypes and personalized medicine
2007
Autoreactivity by design: innate B and T lymphocytes
2001
IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
2001 StandoutNature
Going both ways: Immune regulation via CD1d-dependent NKT cells
2004
Critical role of Vα14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection
2003
NKT cells — conductors of tumor immunity?
2002
Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail–truncated CD1d
2001
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
The roles of IFNγ in protection against tumor development and cancer immunoediting
2002
Regulation of CD1d expression and function by a herpesvirus infection
2005
Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
2003
NKT Cells Enhance CD4+ and CD8+ T Cell Responses to Soluble Antigen In Vivo through Direct Interaction with Dendritic Cells
2003
Biological Activity of Lenalidomide and Its Underlying Therapeutic Effects in Multiple Myeloma
2012
Interferon-γ: an overview of signals, mechanisms and functions
2003 Standout
The Regulatory Role of Vα14 NKT Cells in Innate and Acquired Immune Response
2003
NK Cells, but Not NKT Cells, Are Involved in Pseudomonas aeruginosa Exotoxin A-Induced Hepatotoxicity in Mice
2004
Defective presentation of the CD1d1-restricted natural Va14Ja18 NKT lymphocyte antigen caused by β-d -glucosylceramide synthase deficiency
2003
CD1d Mediates T-Cell-Dependent Resistance to Secondary Infection with Encephalomyocarditis Virus (EMCV) In Vitro and Immune Response to EMCV Infection In Vivo
2006
Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
2005
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Expansion and Hyperactivity of CD1d-Restricted NKT Cells during the Progression of Systemic Lupus Erythematosus in (New Zealand Black × New Zealand White)F1 Mice
2005
Conserved and Heterogeneous Lipid Antigen Specificities of CD1d-Restricted NKT Cell Receptors
2006
CD1d Ligands: The Good, the Bad, and the Ugly
2006
Cutting Edge: The IgG Response to the Circumsporozoite Protein Is MHC Class II-Dependent and CD1d-Independent: Exploring the Role of GPIs in NK T Cell Activation and Antimalarial Responses
2000
Advanced Glycation End Products
2006 Standout
Selective Bystander Proliferation of Memory CD4+ and CD8+ T Cells Upon NK T or T Cell Activation
2000
The Biology of NKT Cells
2006 Standout
Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus
2003
The Vα14 NKT Cell TCR Exhibits High-Affinity Binding to a Glycolipid/CD1d Complex
2002
Expression of CD1d Under the Control of a MHC Class Ia Promoter Skews the Development of NKT Cells, But Not CD8+ T Cells
2003
Hepatic CD1d Expression in Hepatitis C Virus Infection and Recognition by Resident Proinflammatory CD1d-Reactive T Cells
2004
Stat6 Regulation of In Vivo IL-4 Responses
2000
Sequential production of interferon-γ by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide
2002
Innate Vα14+ natural killer T cells mature dendritic cells, leading to strong adaptive immunity
2007 StandoutNobel
Advanced Glycation End Product Interventions Reduce Diabetes-Accelerated Atherosclerosis
2004
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
2010 StandoutNobel
Dendritic Cell Maturation Overrules H-2d–Mediated Natural Killer T (Nkt) Cell Inhibition
2001
Glycation, Inflammation, and RAGE
2003
STIMULATION OF LUTEINISING HORMONE (L.H.) RELEASE AFTER ORAL ADMINISTRATION OF AN ANALOGUE OF L.H. RELEASING HORMONE
1975 StandoutNobel
Cutting Edge: Signaling Lymphocytic Activation Molecule-Associated Protein Controls NKT Cell Functions
2005
Natural Killer T Cell Ligand α-Galactosylceramide Enhances Protective Immunity Induced by Malaria Vaccines
2002
Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome
2012 Standout
Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications
2006
Activation of Natural Killer T Cells by α-Galactosylceramide Rapidly Induces the Full Maturation of Dendritic Cells In Vivo and Thereby Acts as an Adjuvant for Combined CD4 and CD8 T Cell Immunity to a Coadministered Protein
2003 StandoutNobel
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
Another View of T Cell Antigen Recognition: Cooperative Engagement of Glycolipid Antigens by Va14Ja18 Natural TCR
2003
A Phase I Study of α-Galactosylceramide (KRN7000)–Pulsed Dendritic Cells in Patients with Advanced and Recurrent Non–Small Cell Lung Cancer
2005
α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria
2000
Activation of Natural Killer T Cells Potentiates or Prevents Experimental Autoimmune Encephalomyelitis
2001
IFN-gamma-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, alpha-galactosylceramide.
2002
Lipid Protein Interactions: The Assembly of CD1d1 with Cellular Phospholipids Occurs in the Endoplasmic Reticulum
2002
The Contribution of NKT Cells, NK Cells, and Other γ-Chain-Dependent Non-T Non-B Cells to IL-12-Mediated Rejection of Tumors
2003
The Anti-Tumor Activity of IL-12: Mechanisms of Innate Immunity That Are Model and Dose Dependent
2000
Loss of IFN-γ Production by Invariant NK T Cells in Advanced Cancer
2001
Superior Protection against Malaria and Melanoma Metastases by a C-glycoside Analogue of the Natural Killer T Cell Ligand α-Galactosylceramide
2003
Critical contribution of IFN-γ and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of α-galactosylceramide
2001
Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo
2000
Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using Cd1d Tetramers
2000
Going both ways: Immune regulation via CD1d-dependent NKT cells
2004
Restoration of NK T Cell Development infyn-Mutant Mice by a TCR Reveals a Requirement for Fyn During Early NK T Cell Ontogeny
2004
Recycling CD1d1 Molecules Present Endogenous Antigens Processed in an Endocytic Compartment to NKT Cells
2002
Cutting Edge: Impaired Glycosphingolipid Trafficking and NKT Cell Development in Mice Lacking Niemann-Pick Type C1 Protein
2006
Progenitor and Terminal Subsets of CD8 + T Cells Cooperate to Contain Chronic Viral Infection
2012 Science
The Mouse Cd1d-Restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families
2001
Regulation of antitumour immunity by CD1d-restricted NKT cells
2004
Mechanisms of the Antimetastatic Effect in the Liver and of the Hepatocyte Injury Induced by α-Galactosylceramide in Mice
2001
A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors.
2002
Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
2006 StandoutNobel
Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis
2001
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
2001 StandoutNobel
Role of CD1d in Coxsackievirus B3-Induced Myocarditis
2003
Adapting Proteostasis for Disease Intervention
2008 StandoutScience
TOWARD AN UNDERSTANDING OF NKT CELL BIOLOGY: Progress and Paradoxes
2005
Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide.
2001
Regulation of CD1d expression and function by a herpesvirus infection
2005
Quantitative and Qualitative Differences in the In Vivo Response of NKT Cells to Distinct α- and β-Anomeric Glycolipids
2004
Anatomy of CD1–lipid antigen complexes
2005
In Vivo Identification of Glycolipid Antigen–Specific T Cells Using Fluorescent Cd1d Tetramers
1999
The Danger Model: A Renewed Sense of Self
2002 StandoutScience
NKT Cells Provide Help for Dendritic Cell-Dependent Priming of MHC Class I-Restricted CD8+ T Cells In Vivo
2003
Human NKT Cells Mediate Antitumor Cytotoxicity Directly by Recognizing Target Cell CD1d with Bound Ligand or Indirectly by Producing IL-2 to Activate NK Cells
2001
Activation of Invariant NKT Cells by the Helminth Parasite Schistosoma mansoni
2006
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Effects of Intensive Glucose Lowering in Type 2 Diabetes
2008 Standout
Human CD1d–glycolipid tetramers generated byin vitrooxidative refolding chromatography
2001 Nobel
The Src Family Tyrosine Kinase Fyn Regulates Natural Killer T Cell Development
1999
A nonclassical non-Vα14Jα18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance
2005
The clinical implication and molecular mechanism of preferential IL-4 production by modified glycolipid-stimulated NKT cells
2004
Therapeutic activation of Vα24+Vβ11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity
2003
Lysosomal Localization of Murine CD1d Mediated by AP-3 Is Necessary for NK T Cell Development
2003
Impaired Clearance of Herpes Simplex Virus Type 1 From Mice Lacking CD1d or NKT Cells Expressing the Semivariant Vα14-Jα281 TCR
2003
The practical implementation of artificial intelligence technologies in medicine
2018 Standout
Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8 + T cells
2010 StandoutNobel
Antigen-Specific Cytotoxicity by Invariant NKT Cells In Vivo Is CD95/CD178-Dependent and Is Correlated with Antigenic Potency
2010 StandoutNobel
CD1d on Myeloid Dendritic Cells Stimulates Cytokine Secretion from and Cytolytic Activity of Vα24JαQ T Cells: A Feedback Mechanism for Immune Regulation
2000
PapA1 and PapA2 are acyltransferases essential for the biosynthesis of theMycobacterium tuberculosisvirulence factor Sulfolipid-1
2007 StandoutNobel
CD1: Antigen Presentation and T Cell Function
2004
Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
1999 StandoutScience
The role of cytokine DNAs as vaccine adjuvants for optimizing cellular immune responses
2004
Antigen Presentation and T Cell Stimulation by Dendritic Cells
2002
Critical Role of NK Cells Rather Than Vα14+NKT Cells in Lipopolysaccharide-Induced Lethal Shock in Mice
2002
A Critical Role for Natural Killer T Cells in Immunosurveillance of Methylcholanthrene-induced Sarcomas
2002
Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients
2005 StandoutNobel
A Cell-Type Specific CD1d Expression Program Modulates Invariant NKT Cell Development and Function
2006
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells
2000
The Mouse CD1d Cytoplasmic Tail Mediates CD1d Trafficking and Antigen Presentation by Adaptor Protein 3-Dependent and -Independent Mechanisms
2005
NKT Cell Stimulation with Glycolipid Antigen In Vivo: Costimulation-Dependent Expansion, Bim-Dependent Contraction, and Hyporesponsiveness to Further Antigenic Challenge
2005
Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining
2002
Cd1-Restricted Nk T Cells Protect Nonobese Diabetic Mice from Developing Diabetes
2001
CD4−CD8αα Subset of CD1d-Restricted NKT Cells Controls T Cell Expansion
2004
Distinct Roles of Dendritic Cells and B Cells in Va14Ja18 Natural T Cell Activation In Vivo
2005
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin
2002 Standout
Prolonged Elevation of Luteinizing Hormone (Lh) after Intranasal Administration of an Analog of Lh-Releasing Hormone
1976 StandoutNobel
Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome
2012 Standout
Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci
2003
RAGE Axis
2004
Works of Daniel Lee being referenced
The Cardiac Atlas Project—an imaging database for computational modeling and statistical atlases of the heart
2011
Cytokine Molecular Adjuvants Modulate Immune Responses Induced by DNA Vaccine Constructs for HIV-1 and SIV
1999
Hypopnea in pediatric patients with obesity hypertension
2004
Thiopurine Methyltransferase Pharmacogenetics: Human Gene Cloning and Characterization of a Common Polymorphism
1996
ATPase Activity of the Cystic Fibrosis Transmembrane Conductance Regulator
1996
Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection
2003
Synthetic LH-Releasing Hormone (LH-RH) Administered to Normal Men by Different Routes*
1973 StandoutNobel
Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection
2003
Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells
1999
RAGE Blockade Stabilizes Established Atherosclerosis in Diabetic Apolipoprotein E–Null Mice
2002
Distinct Subsets of CD1d-restricted T Cells Recognize Self-antigens Loaded in Different Cellular Compartments
1999
Unaltered phenotype, tissue distribution and function of Vα14+ NKT cells in germ-free mice
2000