Standout Papers
Citation Impact
Citing Papers
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ
2013 StandoutNobel
Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
2012 StandoutScienceNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry
2009 StandoutNobel
Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA
2012 StandoutNobel
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment
2013 StandoutNobel
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
Organization and Assembly of the TRAPPII Complex
2011
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
2013 Standout
TRAPP complexes in membrane traffic: convergence through a common Rab
2010
Cutting it close: CRISPR-associated endoribonuclease structure and function
2014 StandoutNobel
Computational Design of a Protein-Based Enzyme Inhibitor
2013 StandoutNobel
The Architecture of the Multisubunit TRAPP I Complex Suggests a Model for Vesicle Tethering
2006
Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases
2013 StandoutNobel
Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains
2020 StandoutNobel
Three-dimensional structure of human γ-secretase
2014 Nature
The exocyst complex
2018
Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release
2013 StandoutNobel
The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes
2016 StandoutNobel
Phosphatidylinositol 4-Phosphate Controls Both Membrane Recruitment and a Regulatory Switch of the Rab GEF Sec2p
2010
SNARE Requirements En Route to Exocytosis: from Many to Few
2012
Structural and Functional Characterization of an Archaeal Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Complex for Antiviral Defense (CASCADE)
2011
Remote Homology between Munc13 MUN Domain and Vesicle Tethering Complexes
2009
A Structure-Based Mechanism for Vesicle Capture by the Multisubunit Tethering Complex Dsl1
2009
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
2013 StandoutNobel
DNA Targeting by a Minimal CRISPR RNA-Guided Cascade
2016 StandoutNobel
Palmitoylation: policing protein stability and traffic
2006
Global Analysis of Protein Palmitoylation in Yeast
2006
The impact of bacterial infection on mast cell degranulation
2011
Rab GTPases as coordinators of vesicle traffic
2009 Standout
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Structural determinants of protein partitioning into ordered membrane domains and lipid rafts
2015
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Rapid online buffer exchange for screening of proteins, protein complexes and cell lysates by native mass spectrometry
2020 StandoutNobel
Complexin Controls Spontaneous and Evoked Neurotransmitter Release by Regulating the Timing and Properties of Synaptotagmin Activity
2012
The coming of age of de novo protein design
2016 StandoutNatureNobel
Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release
2013 StandoutNobel
Coordination of COPII vesicle trafficking by Sec23
2008 StandoutNobel
Syntaxin‐1 N‐peptide and Habc‐domain perform distinct essential functions in synaptic vesicle fusion
2012 StandoutNobel
Synaptic Vesicles Position Complexin to Block Spontaneous Fusion
2013
Protein production and purification
2008
Conservation of Helical Bundle Structure between the Exocyst Subunits
2009
Molecular machines governing exocytosis of synaptic vesicles
2012 Nature
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Coordination of Autophagosome–Lysosome Fusion by Atg8 Family Members
2018
Myosin V Transports Secretory Vesicles via a Rab GTPase Cascade and Interaction with the Exocyst Complex
2011 StandoutNobel
Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex
2009
Substrate-specific structural rearrangements of human Dicer
2013 StandoutNobel
The mystery of membrane organization: composition, regulation and roles of lipid rafts
2017 Standout
Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System
2012 StandoutNobel
The Lin28 cold-shock domain remodels pre-let-7 microRNA
2012
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Transcriptome analysis of Sulfolobus solfataricus infected with two related fuselloviruses reveals novel insights into the regulation of CRISPR-Cas system
2015
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state
2011 StandoutNobel
Structure and Activity of the RNA-Targeting Type III-B CRISPR-Cas Complex of Thermus thermophilus
2013 StandoutNobel
The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
2018
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Molecular interactions of theSaccharomyces cerevisiaeAtg1 complex provide insights into assembly and regulatory mechanisms
2015
De Novo Designed Proteins from a Library of Artificial Sequences Function in Escherichia Coli and Enable Cell Growth
2011
Complexin Activates Exocytosis of Distinct Secretory Vesicles Controlled by Different Synaptotagmins
2013 StandoutNobel
The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes
2008
De novo protein structure determination from near-atomic-resolution cryo-EM maps
2015 StandoutNobel
RNA processing enables predictable programming of gene expression
2012 StandoutNobel
Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site
2012 StandoutNobel
Rab35 GTPase : A Central Regulator of Phosphoinositides and F‐actin in Endocytic Recycling and Beyond
2016
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion
2012 Nobel
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
2016 Standout
Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins
2013
Exosomes
2019 Standout
Crystal structure of a bacterial homologue of glucose transporters GLUT1–4
2012 Nature
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
2-Bromopalmitate Analogues as Activity-Based Probes To Explore Palmitoyl Acyltransferases
2013
Palmitoylation of Ligands, Receptors, and Intracellular Signaling Molecules
2006
C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking
2011
Maintaining order: COG complex controls Golgi trafficking, processing, and sorting
2019
Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation
2017 StandoutNobel
Identification of palmitoylated mitochondrial proteins using a bio‐orthogonal azido‐palmitate analogue
2007 StandoutNobel
Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
2013
Artificial Molecular Machines
2015 Standout
Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies
2018
ORF157 from the Archaeal VirusAcidianusFilamentous Virus 1 Defines a New Class of Nuclease
2010
Rapid detection, discovery, and identification of post‐translationally myristoylated proteins during apoptosis using a bio‐orthogonal azidomyristate analog
2007 StandoutNobel
The Exocyst at a Glance
2015
The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?
2012 StandoutNobel
Deconstructing complexin function in activating and clamping Ca 2+ -triggered exocytosis by comparing knockout and knockdown phenotypes
2013 StandoutNobel
Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components
2009
Transcriptomic Landscape of von Economo Neurons in Human Anterior Cingulate Cortex Revealed by Microdissected-Cell RNA Sequencing
2018
Works of Daniel Kümmel being referenced
A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion
2011 StandoutNobel
Structures and mechanisms of vesicle coat components and multisubunit tethering complexes
2012
Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization
2005
Diversity in Structure and Function of Tethering Complexes: Evidence for Different Mechanisms in Vesicular Transport Regulation
2008
Complexin cross-links prefusion SNAREs into a zigzag array
2011 StandoutNobel
Distinct isocomplexes of the TRAPP trafficking factor coexist inside human cells
2008
Vectors for co-expression of an unrestricted number of proteins
2007
Structure of the Bet3–Tpc6B Core of TRAPP: Two Tpc6 Paralogs Form Trimeric Complexes with Bet3 and Mum2
2006
Characterization of the self-palmitoylation activity of the transport protein particle component Bet3
2010
Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate
2011
Crystal Structure of F-93 from Sulfolobus Spindle-Shaped Virus 1, a Winged-Helix DNA Binding Protein
2004
Unique self-palmitoylation activity of the transport protein particle component Bet3: A mechanism required for protein stability
2006
Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure
2018
The structure of the TRAPP subunit TPC6 suggests a model for a TRAPP subcomplex
2005
The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p
2013
Structure of D-63 from Sulfolobus Spindle-Shaped Virus 1: Surface Properties of the Dimeric Four-Helix Bundle Suggest an Adaptor Protein Function
2004
Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex
2011