Citation Impact
Citing Papers
Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells
2013
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
A Pilot Trial Using Lymphocytes Genetically Engineered with an NY-ESO-1–Reactive T-cell Receptor: Long-term Follow-up and Correlates with Response
2014
MYC regulates the antitumor immune response through CD47 and PD-L1
2016 Science
BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma
2015
CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets
2013
A Phase I Pharmacokinetic and Biological Correlative Study of IMP321, a Novel MHC Class II Agonist, in Patients with Advanced Renal Cell Carcinoma
2009
Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8 + T Lymphocytes
2008 StandoutScienceNobel
SA-4-1BBL and Monophosphoryl Lipid A Constitute an Efficacious Combination Adjuvant for Cancer Vaccines
2014
Homeostatic Proliferation Plus Regulatory T-Cell Depletion Promotes Potent Rejection of B16 Melanoma
2008
Equilibrium between Host and Cancer Caused by Effector T Cells Killing Tumor Stroma
2008
Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients
2010
The Basic Principles of Chimeric Antigen Receptor Design
2013
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
2005 StandoutNobel
Spontaneous tumor rejection by cbl-b –deficient CD8+ T cells
2007
Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
2011 Standout
The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature
2012
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
The emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy
2023
A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments
2009
Single and Dual Amino Acid Substitutions in TCR CDRs Can Enhance Antigen-Specific T Cell Functions
2008
Oncoprotein Signaling Mediates Tumor-Specific Inflammation and Enhances Tumor Progression
2009
Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma
2019
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2
2010 Standout
Retargeting CD19 Chimeric Antigen Receptor T Cells via Engineered CD19-Fusion Proteins
2019
Local IL-21 Promotes the Therapeutic Activity of Effector T cells by Decreasing Regulatory T Cells Within the Tumor Microenvironment
2008
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Regulatory T-cell directed therapies in liver diseases
2013 StandoutNobel
How chemokines organize the tumour microenvironment
2023
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
GSK's antigen-specific cancer immunotherapy programme: Pilot results leading to Phase III clinical development
2007
Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment
2013
Therapeutic cancer vaccines: are we there yet?
2010
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity
2020
FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents
2011 StandoutNobel
Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues
2007
The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells
2013
Combination cancer immunotherapy and new immunomodulatory targets
2015
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
CAR-T cells: the long and winding road to solid tumors
2018
Innate and adaptive immune cells in the tumor microenvironment
2013 Standout
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
2015
Regulatory T Cells
2010
Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology
2013
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling
2007
The Human T Cell Response to Melanoma Antigens
2006
The Principles of Engineering Immune Cells to Treat Cancer
2017
Cancer immunotherapy via dendritic cells
2012 Standout
CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs
2018
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates
2008
Interferons Induce CXCR3-cognate Chemokine Production by Human Metastatic Melanoma
2010
Trial watch
2013
Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909
2005
Tyrosine kinase oncoprotein, RET/PTC3, induces the secretion of myeloid growth and chemotactic factors
2003
Adoptive immunotherapy for cancer: harnessing the T cell response
2012
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
2018
Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1
2008
A human memory T cell subset with stem cell–like properties
2011
Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy
2014
Rewiring T-cell responses to soluble factors with chimeric antigen receptors
2018
The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
2023
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
CD8+ T cell efficacy in vaccination and disease
2008
Adoptive cell transfer: a clinical path to effective cancer immunotherapy
2008
Taming cancer by inducing immunity via dendritic cells
2007
Tumor-infiltrating lymphocytes: apparently good for melanoma patients. But why?
2011
T cell immune reconstitution following lymphodepletion
2007
Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors
2013
Immunity, Inflammation, and Cancer
2010 Standout
Programmable synthetic receptors: the next-generation of cell and gene therapies
2024
Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation
2017
Chemopreventive agents induce programmed death-1-ligand 1 (PD-L1) surface expression in breast cancer cells and promote PD-L1-mediated T cell apoptosis
2007
T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-β1 Cytokine
2011 StandoutNobel
Cancer immunotherapy comes of age
2011 StandoutNature
Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity
2013
Therapeutic vaccines for cancer: an overview of clinical trials
2014
Split T Cell Tolerance against a Self/Tumor Antigen: Spontaneous CD4+ but Not CD8+ T Cell Responses against p53 in Cancer Patients and Healthy Donors
2011
Cancer Immunology
2008
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
2005
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis
2010
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
2007
Cancer-related inflammation
2008 StandoutNature
Microenvironmental regulation of tumor progression and metastasis
2013 Standout
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Clinical relevance of tumour-associated macrophages
2022
Skin-Resident T Cells: The Ups and Downs of On Site Immunity
2009
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication
2011 StandoutNobel
Adoptive cell therapy for the treatment of patients with metastatic melanoma
2009
Relapse or Eradication of Cancer Is Predicted by Peptide-Major Histocompatibility Complex Affinity
2013
Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma
2012
Adoptive Immunotherapy for Cancer or Viruses
2014
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Clinical Outcome of Lymphoma Patients After Idiotype Vaccination Is Correlated With Humoral Immune Response and Immunoglobulin G Fc Receptor Genotype
2004
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Roles of regulatory T cells in cancer immunity
2016
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3 high regulatory T cells in humans
2015 StandoutNobel
Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity
2014
Characterization of T-cell memory phenotype after in vitro expansion of tumor-infiltrating lymphocytes from melanoma patients.
2011
Acute Myeloid Leukemia
2015 Standout
Adoptive cell transfer as personalized immunotherapy for human cancer
2015 StandoutScience
Integrated NY-ESO-1 antibody and CD8+T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
2011 StandoutNobel
Cellular and molecular mechanisms in cancer immune escape: a comprehensive review
2013
Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human melanoma.
2009
Treg functional stability and its responsiveness to the microenvironment
2014
Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer.
2012
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma
2008 StandoutNobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
CD8+tumor-infiltrating lymphocytes at primary sites as a possible prognostic factor of cutaneous angiosarcoma
2013 StandoutNobel
Levels of peripheral CD4+FoxP3+ regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer
2012
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal
2014
Induced sensitization of tumor stroma leads to eradication of established cancer by T cells
2007
Going viral: chimeric antigen receptor T‐cell therapy for hematological malignancies
2014
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
Anti-CTLA-4 therapy results in higher CD4 + ICOS hi T cell frequency and IFN-γ levels in both nonmalignant and malignant prostate tissues
2009
Neoantigens in cancer immunotherapy
2015 StandoutScience
New Generation Vaccine Induces Effective Melanoma-Specific CD8+ T Cells in the Circulation but Not in the Tumor Site
2006
Redirecting αβT cells against cancer cells by transfer of a broadly tumor-reactive γδT-cell receptor
2011
Therapeutic cancer vaccines
2015
IL-2: The First Effective Immunotherapy for Human Cancer
2014
PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
2014
Epstein Barr virus–specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease
2007
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Exploiting the curative potential of adoptive T‐cell therapy for cancer
2013
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Biological Role and Potential Therapeutic Targeting of the Chemokine Receptor CXCR4 in Undifferentiated Thyroid Cancer
2007
Detailed Analysis of Intrahepatic CD8 T Cells in the Normal and Hepatitis C-Infected Liver Reveals Differences in Specific Populations of Memory Cells with Distinct Homing Phenotypes
2006
Central memory self/tumor-reactive CD8 + T cells confer superior antitumor immunity compared with effector memory T cells
2005
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Daniel J. Powell being referenced
Chimeric Antigen Receptor T Cells with Dissociated Signaling Domains Exhibit Focused Antitumor Activity with Reduced Potential for Toxicity In Vivo
2013
CD137 Accurately Identifies and Enriches for Naturally Occurring Tumor-Reactive T Cells in Tumor
2013
A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor
2012
Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
2013
Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor
2011
In Vivo Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)
2011
A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside
2013
Systematic analysis of CD39, CD103, CD137, and PD‐1 as biomarkers for naturally occurring tumor antigen‐specific TILs
2021
Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo
2007
A phase I clinical trial of adoptive transfer of folate receptor-alpha redirected autologous T cells for recurrent ovarian cancer
2012
Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes
2011
Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer
2013
Tumor Regression and Delayed Onset Toxicity Following B7-H4 CAR T Cell Therapy
2016
Redirected Antitumor Activity of Primary Human Lymphocytes Transduced With a Fully Human Anti-mesothelin Chimeric Receptor
2011
Partial Reduction of Human FOXP3+ CD4 T Cells In Vivo After CD25-directed Recombinant Immunotoxin Administration
2008
Adoptive immunotherapy for cancer: building on success
2006
Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy
2011
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy
2021
Persistence of Tumor Infiltrating Lymphocytes in Adoptive Immunotherapy Correlates With Telomere Length
2006
Engineering-enhanced CAR T cells for improved cancer therapy
2021
Phenotypic and Functional Maturation of Tumor Antigen-Reactive CD8+ T Lymphocytes in Patients Undergoing Multiple Course Peptide Vaccination
2003
The TRK-T1 fusion protein induces neoplastic transformation of thyroid epithelium
2000
Structures of MART-126/27–35 Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition
2007
Inability to Mediate Prolonged Reduction of Regulatory T Cells After Transfer of Autologous CD25-depleted PBMC and Interleukin-2 After Lymphodepleting Chemotherapy
2007
Relationship of p53 Overexpression on Cancers and Recognition by Anti-p53 T Cell Receptor-Transduced T Cells
2008
Adoptive Transfer of Vaccine-Induced Peripheral Blood Mononuclear Cells to Patients with Metastatic Melanoma following Lymphodepletion
2006
Autologous whole-tumor antigen vaccination in combination with adoptive T cell therapy for patients with recurrent ovarian cancer
2013
Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy
2004
Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes
2006
CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients
2012
Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor–expressing T cells
2015
Cutting Edge: Persistence of Transferred Lymphocyte Clonotypes Correlates with Cancer Regression in Patients Receiving Cell Transfer Therapy
2004
CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo
2011
Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity
2008
FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions
2008
Abstract LB-335: Autologous whole-tumor antigen vaccination in combination with adoptive T cell therapy for patients with recurrent ovarian cancer.
2013
A Thyroid Tumor-Specific Antigen Formed by the Fusion of Two Self Proteins
2003