Citation Impact
Citing Papers
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells
2005 StandoutScience
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Ubiquitin-binding domains
2006
Targeting multiple Her-2 epitopes with monoclonal antibodies results in improved antigrowth activity of a human breast cancer cell line in vitro and in vivo.
2002
Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control
2002
Extracellular domains drive homo- but not hetero-dimerization of erbB receptors
2000
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
2001
The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors
1999
The Crystal Structure of a Truncated ErbB2 Ectodomain Reveals an Active Conformation, Poised to Interact with Other ErbB Receptors
2003
Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
2003 Nature
Biologic and therapeutic role of HER2 in cancer
2003
Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding
2004
Evolutionary Analysis of the ErbB Receptor and Ligand Families
2000
Systems Biology of Growth Factor‐Induced Receptor Endocytosis
2008
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
Regulation of V2 Vasopressin Receptor Degradation by Agonist-promoted Ubiquitination
2003 StandoutNobel
Oncogenic kinase signalling
2001 StandoutNature
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Tumor Necrosis Factor-α-converting Enzyme Is Required for Cleavage of erbB4/HER4
2000
Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases
2004
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Wound repair and regeneration
2008 StandoutNature
Shared Principles in NF-κB Signaling
2008 Standout
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
Regulation of Neuregulin Signaling by PSD-95 Interacting with ErbB4 at CNS Synapses
2000
Epidermal growth factor receptor: mechanisms of activation and signalling
2003
Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation
2005
The molecular basis for functional plasticity in type I interferon signaling
2015
Antitumour actions of interferons: implications for cancer therapy
2016
EGF–ERBB signalling: towards the systems level
2006 Standout
Autocrine Signalling Through erbB Receptors Promotes Constitutive Activation of Protein Kinase B/Akt in Breast Cancer Cell Lines
2003
Distinct monoubiquitin signals in receptor endocytosis
2003
Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling
2011
Mitochondria: In Sickness and in Health
2012 Standout
Signal Responsiveness of IκB Kinases Is Determined by Cdc37-assisted Transient Interaction with Hsp90
2007
When ubiquitin meets ubiquitin receptors: a signalling connection
2003
Erlotinib in Previously Treated Non–Small-Cell Lung Cancer
2005 Standout
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
2008 StandoutNature
Network organization of the human autophagy system
2010 StandoutNature
STAM and Hrs Are Subunits of a Multivalent Ubiquitin-binding Complex on Early Endosomes
2003
Negative receptor signalling
2003
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Trastuzumab — Mechanism of Action and Use in Clinical Practice
2007 Standout
Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation
2003
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
On the Dependency of Cellular Protein Levels on mRNA Abundance
2016 Standout
Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons
2011
G Protein-coupled Receptor Kinase 5 Regulates β1-Adrenergic Receptor Association with PSD-95
2002 StandoutNobel
Interferons and viruses: an evolutionary arms race of molecular interactions
2015 StandoutNobel
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
2013 StandoutNobel
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity
2017 StandoutNobel
TGFβ in Cancer
2008 Standout
NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer
2000 Standout
EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
2017
Developing Inhibitors of the Epidermal Growth Factor Receptor for Cancer Treatment
2003
USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response
2011
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
AKT/PKB Signaling: Navigating the Network
2017 Standout
β-Arrestin and Mdm2 Mediate IGF-1 Receptor-stimulated ERK Activation and Cell Cycle Progression
2007 StandoutNobel
Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks
2006 Standout
Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis
2003
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
2010
The Age of Crosstalk: Phosphorylation, Ubiquitination, and Beyond
2007
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Characterization of PINK1 processing, stability, and subcellular localization
2008
Synthesis of Heterobifunctional Protein Fusions Using Copper‐Free Click Chemistry and the Aldehyde Tag
2012 StandoutNobel
Interplay between gene expression noise and regulatory network architecture
2012
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
2004 Standout
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Multifaceted Activities of Type I Interferon Are Revealed by a Receptor Antagonist
2014 StandoutNobel
Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.
2002
Phase I Clinical Study of Pertuzumab, a Novel HER Dimerization Inhibitor, in Patients With Advanced Cancer
2005
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
2008 StandoutScience
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
2009 Standout
2012
Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes
2003 Standout
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
2014
Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation
2012
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane
2014
THE ESCRT COMPLEXES: Structure and Mechanism of a Membrane-Trafficking Network
2006
Cdc37 Regulation of the Kinome: When to Hold ‘Em and When to Fold ‘Em
2007
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Cooperation of the ErbB2 receptor and transforming growth factor β in induction of migration and invasion in mammary epithelial cells
2004
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
2005 StandoutScience
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis
2006 StandoutNobel
Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling
2015
The Phosphoinositide 3-Kinase Pathway
2002 StandoutScience
Vps27 recruits ESCRT machinery to endosomes during MVB sorting
2003
EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib
2004 Standout
Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells
2005
Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing
2005
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Daniel Harari being referenced
Receptor Density Is Key to the Alpha2/Beta Interferon Differential Activities
2009
Molecular mechanisms underlying ErbB2/HER2 action in breast cancer
2000
Hsp90 Recognizes a Common Surface on Client Kinases
2006
Epigen, the Last Ligand of ErbB Receptors, Reveals Intricate Relationships between Affinity and Mitogenicity
2004
Bridging the Species Divide: Transgenic Mice Humanized for Type-I Interferon Response
2014
ErbB Signaling Regulates Lineage Determination of Developing Pancreatic Islet Cells in Embryonic Organ Culture
2002
Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4
2002
Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase
1999
Type I Interferons Induce Apoptosis by Balancing cFLIP and Caspase-8 Independent of Death Ligands
2012
Hsp90 increases LIM kinase activity by promoting its homo‐dimerization
2006
Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment
2011