Citation Impact
Citing Papers
Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
2013 Science
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
2010 StandoutScience
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
2010 StandoutScience
Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
2013 Science
Actin polymerization as a key innate immune effector mechanism to control Salmonella infection
2014
An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells
2016 Science
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
2018
Microfluidics-based systems biology
2006
The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge
2014
The role of chromatin accessibility in directing the widespread, overlapping patterns of Drosophila transcription factor binding
2011
Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance
2015
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance
2014 Standout
Dissecting Interferon-Induced Transcriptional Programs in Human Peripheral Blood Cells
2010
Necroptosis and its role in inflammation
2015 StandoutNature
Inflammatory links between obesity and metabolic disease
2011 Standout
Mechanisms of NOD-like Receptor-Associated Inflammasome Activation
2013
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
2010 Standout
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection in patients with spontaneous viral clearance
2018 StandoutNobel
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Bacterial Exotoxins and the Inflammasome
2015
COPs and POPs Patrol Inflammasome Activation
2017
Converging roles of caspases in inflammasome activation, cell death and innate immunity
2015
Selective Transcription in Response to an Inflammatory Stimulus
2010
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Predicting cell-type–specific gene expression from regions of open chromatin
2012
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes
2014
Activation and regulation of the inflammasomes
2013 Standout
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let‐7 family
2011
Pattern Recognition Receptors and Inflammation
2010 Standout
The Human Transcription Factors
2018 Standout
Reciprocal intronic and exonic histone modification regions in humans
2010
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases
2014 Nature
Reactive Oxygen Species Regulate Caspase-11 Expression and Activation of the Non-canonical NLRP3 Inflammasome during Enteric Pathogen Infection
2014
Cells on chips
2006 StandoutNature
Transcriptomic profiling facilitates classification of response to influenza challenge
2014
Severe Sepsis and Septic Shock
2013 Standout
Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium
2015
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events
2009
Homeostasis and Inflammation in the Intestine
2010
Type I Interferon Contributes to Noncanonical Inflammasome Activation, Mediates Immunopathology, and Impairs Protective Immunity during Fatal Infection with Lipopolysaccharide-Negative Ehrlichiae
2014
A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells
2011
C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity
2012
Molecular signatures of antibody responses derived from a systems biology study of five human vaccines
2013
Transcriptional Control of Inflammatory Responses
2014
Mechanisms of inflammasome activation: recent advances and novel insights
2015
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
Membrane Fusion
2003 StandoutNobel
On the Dependency of Cellular Protein Levels on mRNA Abundance
2016 Standout
Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa
2014
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death
2016
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium
2015
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Endotoxin tolerance: new mechanisms, molecules and clinical significance
2009 Standout
Transcriptional control of the inflammatory response
2009
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
2010
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
Revisiting Caspase-11 Function in Host Defense
2013
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
2014
Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity
2015
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
2009 Nature
The NAIP/NLRC4 inflammasomes
2015
Mechanisms and Functions of Inflammasomes
2014 Standout
Quantitative Models of the Mechanisms That Control Genome-Wide Patterns of Transcription Factor Binding during Early Drosophila Development
2011
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
2016 Standout
The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
2018
Structure and signalling in the IL-17 receptor family
2009 Standout
Navigating the network: signaling cross-talk in hematopoietic cells
2009
Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol
2013
Diverse mechanisms for inflammasome sensing of cytosolic bacteria and bacterial virulence
2015
Rapid Temporal Dynamics of Transcription, Protein Synthesis, and Secretion during Macrophage Activation
2014
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Applied bioinformatics for the identification of regulatory elements
2004
Innate Immune Receptors
2016
The origins and the future of microfluidics
2006 StandoutNature
Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens
2014
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Modeling and Simulation of Genetic Regulatory Systems: A Literature Review
2002 Standout
Microglial Physiology: Unique Stimuli, Specialized Responses
2009
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
MicroRNA let-7c Regulates Macrophage Polarization
2013
Complement pathway amplifies caspase-11–dependent cell death and endotoxin-induced sepsis severity
2016
Vaccinology in the era of high-throughput biology
2015
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
2017 Standout
Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages
2015
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain
2012
Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation
2016
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
2017
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
2015
Resolvins and Protectins in Inflammation Resolution
2011
NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx
2016
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex
2014
Pyroptotic cell death defends against intracellular pathogens
2015
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
2011 StandoutNobel
Vaccine innovations for emerging infectious diseases—a symposium report
2019 StandoutNobel
Mechanism of NLRP3 inflammasome activation
2014
Cytokine Storm
2020 Standout
Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis
2016
A noncanonical function of cGAMP in inflammasome priming and activation
2017
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin
2015
Caspase‐11: arming the guards against bacterial infection
2015
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
2011 StandoutScience
Guanylate binding proteins promote caspase-11–dependent pyroptosis in response to cytoplasmic LPS
2014
The NAIP –NLRC 4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus
2015
Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens
2015
Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation
2018
Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation
2016
Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps
2018
The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
2014
Regulation of inflammasome activation
2015
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation
2016
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by Flagellated Legionella Species in Mouse Macrophages and In Vivo
2015
Protective Role for Caspase-11 during Acute Experimental Murine Colitis
2014
Works of Daniel E. Zak being referenced
The Innate Immune Database (IIDB)
2008
Memory T Cell RNA Rearrangement Programmed by Heterogeneous Nuclear Ribonucleoprotein hnRNPLL
2008
Systems biology of innate immunity
2008
Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics
2008
Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals
2009
Importance of Input Perturbations and Stochastic Gene Expression in the Reverse Engineering of Genetic Regulatory Networks: Insights From an Identifiability Analysis of an In Silico Network
2003
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Genome-wide histone acetylation data improve prediction of mammalian transcription factor binding sites
2010
Continuous-Time Identification of Gene Expression Models
2003
Caspase-11 Protects Against Bacteria That Escape the Vacuole
2013 Science
Cutting Edge: Mouse NAIP1 Detects the Type III Secretion System Needle Protein
2013
Merck Ad5/HIV induces broad innate immune activation that predicts CD8 + T-cell responses but is attenuated by preexisting Ad5 immunity
2012
Systems analysis of protective immune responses to RTS,S malaria vaccination in humans
2017
PAINT: A Promoter Analysis and Interaction Network Generation Tool for Gene Regulatory Network Identification
2003