Citation Impact
Citing Papers
Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water
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Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
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A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C
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Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
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AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
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Accurate computational design of multipass transmembrane proteins
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2004
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
2003 Nature
MDC1: The art of keeping things in focus
2010
Collapse Precedes Folding in Denaturant-Dependent Assembly of Ubiquitin
2017
Reconstitution of Rad53 Activation by Mec1 through Adaptor Protein Mrc1
2009
Calcium-dependent Regulation of Protein Kinase D Revealed by a Genetically Encoded Kinase Activity Reporter
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Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
2017
De novo design of modular and tunable protein biosensors
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Hallmarks of Cancer: The Next Generation
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The promise and challenge of therapeutic genome editing
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A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart
2000
The Tandem BRCT Domain of 53BP1 Is Not Required for Its Repair Function
2006
Structure of a mammalian ryanodine receptor
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Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
Structural and functional insights into the B30.2/SPRY domain
2006
Structure and function of a new phosphopeptide-binding domain containing the FHA2 of rad53
1999
Spatio-temporal Dynamics of Protein Kinase B/Akt Signaling Revealed by a Genetically Encoded Fluorescent Reporter
2004 StandoutNobel
Stability of Checkpoint Kinase 2 Is Regulated via Phosphorylation at Serine 456
2007
ATR Regulates Fragile Site Stability
2002
A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease
2001
Cell cycle checkpoint signaling through the ATM and ATR kinases
2001 Standout
Chromatin dynamics and the preservation of genetic information
2007 Nature
Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies
2003
Bone marrow cells regenerate infarcted myocardium
2001 StandoutNature
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Chk1 and Chk2 kinases in checkpoint control and cancer
2003
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins
2005
Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase
2009 StandoutNobel
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals
2006
Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
2015
p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
2018
Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA
2003
The Zinc Finger-containing Transcription Factors GATA-4, -5, and -6
2000
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors
2016
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Lcd1p Recruits Mec1p to DNA Lesions In Vitro and In Vivo
2002
Phosphothreonine recognition comes into focus.
2000
ATM and related protein kinases: safeguarding genome integrity
2003 Standout
The hCds1 (Chk2)-FHA Domain Is Essential for a Chain of Phosphorylation Events on hCds1 That Is Induced by Ionizing Radiation
2001
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
A CRISPR toolbox to study virus–host interactions
2017
DNA repair pathways as targets for cancer therapy
2008
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
2016
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
2000
The Human Transcription Factors
2018 Standout
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
2011 Nature
Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase
2008
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Global Genetic Networks and the Genotype-to-Phenotype Relationship
2019
MDC1 interacts with Rad51 and facilitates homologous recombination
2005
The cellular response to DNA damage: A focus on MDC1 and its interacting proteins
2010
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Direct Activation of a GATA6 Cardiac Enhancer by Nkx2.5: Evidence for a Reinforcing Regulatory Network of Nkx2.5 and GATA Transcription Factors in the Developing Heart
2000
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR
2016
The rat ortholog of the presumptive flounder antifreeze enhancer‐binding protein is a helicase domain‐containing protein
2000
Checkpoint Kinase 2 (Chk2) Monomers or Dimers Phosphorylate Cdc25C after DNA Damage Regardless of Threonine 68 Phosphorylation
2002
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Maintenance of the DNA-Damage Checkpoint Requires DNA-Damage-Induced Mediator Protein Oligomerization
2009
The Chk2 protein kinase
2004
Sensing of intermediates in V(D)J recombination by ATM
2002
Repair of Strand Breaks by Homologous Recombination
2013
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae
2000
Trans‐activation of the DNA‐damage signalling protein kinase Chk2 by T‐loop exchange
2006
A genetic blueprint for cardiac development
2000 Nature
Structure and Activation Mechanism of the CHK2 DNA Damage Checkpoint Kinase
2009
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
2003
ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks
2001 Standout
Chemical-genomic profiling: Systematic analysis of the cellular targets of bioactive molecules
2011
Sensitivity to Poly(ADP-ribose) Polymerase (PARP) Inhibition Identifies Ubiquitin-specific Peptidase 11 (USP11) as a Regulator of DNA Double-strand Break Repair
2010
Suppressor mutations in Mecp2 -null mice implicate the DNA damage response in Rett syndrome pathology
2020
FoXS, FoXSDock and MultiFoXS: Single-state and multi-state structural modeling of proteins and their complexes based on SAXS profiles
2016
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
The DNA Damage Response: Ten Years After
2007
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome
2003
Budding Yeast Rad9 Is an ATP-Dependent Rad53 Activating Machine
2001
MDC1 is required for the intra-S-phase DNA damage checkpoint
2003 Nature
Sensing and responding to DNA damage
2000
CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
2018
Chk2 Oligomerization Studied by Phosphopeptide Ligation
2008 StandoutNobel
Modular peptide binding: From a comparison of natural binders to designed armadillo repeat proteins
2013
γH2AX and cancer
2008
Identification of the Mouse Neuromuscular Degeneration Gene and Mapping of a Second Site Suppressor Allele
1998
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1
2003
The Conformational Plasticity of Protein Kinases
2002
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
2009
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Gata5 is required for the development of the heart and endoderm in zebrafish
1999
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?
2007
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
2013
Early events in the mammalian response to DNA double-strand breaks
2008
The next generation of CRISPR–Cas technologies and applications
2019
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation
2001
Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain
2002
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication
2003
End-joining, translocations and cancer
2013
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
2003 StandoutNature
MDC1 is a mediator of the mammalian DNA damage checkpoint
2003 Nature
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Human Mus81-Associated Endonuclease Cleaves Holliday Junctions In Vitro
2001
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling
2002
Alternative end-joining mechanisms: a historical perspective
2013
The Checkpoint Clamp Activates Mec1 Kinase during Initiation of the DNA Damage Checkpoint
2006
Drug combinations: a strategy to extend the life of antibiotics in the 21st century
2019
Autophosphorylated Residues Involved in the Regulation of Human Chk2 In Vitro
2008
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
2001 Nature
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly
2007
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Mammalian G1- and S-phase checkpoints in response to DNA damage
2001
Regulation of Immunoglobulin Class-Switch Recombination
2014
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain
2003
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
2005 StandoutNatureNobel
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
GATA-dependent recruitment of MEF2 proteins to target promoters
2000
Sμbp-2 Represses the Epstein–Barr Virus Lytic Switch Promoter
1999
ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
2006 Nature
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
2008
Far-Field Optical Nanoscopy
2007 StandoutScienceNobel
The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila
1999
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
NMR structure of the forkhead-associated domain from the Arabidopsis receptor kinase-associated protein phosphatase
2003
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Quaternary Structure of ATR and Effects of ATRIP and Replication Protein A on Its DNA Binding and Kinase Activities
2004 StandoutNobel
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
2002 StandoutNobel
An Intramolecular Switch Regulates Phosphoindependent FHA Domain Interactions in Mycobacterium tuberculosis
2009
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
2009
Robust G1 checkpoint arrest in budding yeast: dependence on DNA damage signaling and repair
2002
Chk2 Activation and Phosphorylation-Dependent Oligomerization
2002
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
Phospho‐dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
2008
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways
2000
Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
2008
Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.
2003
The cellular response to DNA damage: A focus on MDC1 and its interacting proteins
2010
Accurate Mass-Driven Analysis for the Characterization of Protein Phosphorylation. Study of the Human Chk2 Protein Kinase
2006
Phosphorylation and Rapid Relocalization of 53BP1 to Nuclear Foci upon DNA Damage
2001
An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks
2008
DNA Double-Strand Breaks
2002 StandoutNobel
Improving Gene Editing Outcomes in Human Hematopoietic Stem and Progenitor Cells by Temporal Control of DNA Repair
2018
Structure and Function of the Phosphothreonine-Specific FHA Domain
2008
Interfaces Between the Detection, Signaling, and Repair of DNA Damage
2002 Science
ATR and ATRIP: Partners in Checkpoint Signaling
2001 Science
Human DNA Repair Genes
2001 StandoutScienceNobel
The Use of In Vitro Peptide-Library Screens in the Analysis of Phosphoserine/Threonine-Binding Domain Structure and Function
2004
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy
2006
Oligomerization of MDC1 Protein Is Important for Proper DNA Damage Response
2011
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Genome-wide CRISPR screen for Zika virus resistance in human neural cells
2019
GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease
1999
Histone marks: repairing DNA breaks within the context of chromatin
2012
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
2016
Non-homologous end-joining, a sticky affair
2007
Works of Daniel Durocher being referenced
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
2007 Science
PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint
2008
High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
2015
The Molecular Architecture of the Mammalian DNA Repair Enzyme, Polynucleotide Kinase
2005
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
2005 Nature
The FHA Domain in DNA Repair and Checkpoint Signaling
2000
Regulation of DNA Damage Responses by Ubiquitin and SUMO
2013
Saccharomyces cerevisiae Rad9 Acts as a Mec1 Adaptor to Allow Rad53 Activation
2005
Push back to respond better: regulatory inhibition of the DNA double-strand break response
2013
The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage
2009
The Molecular Basis of FHA Domain:Phosphopeptide Binding Specificity and Implications for Phospho-Dependent Signaling Mechanisms
2000
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
2001
The FHA domain
2001
A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice
2013
The control of DNA repair by the cell cycle
2016
Localization of the Catf1 transcription factor gene to mouse Chromosome 19
1995
The FHA Domain Is a Modular Phosphopeptide Recognition Motif
1999
Structural and Functional Versatility of the FHA Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2
2002
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
2004
Elg1 Forms an Alternative PCNA-Interacting RFC Complex Required to Maintain Genome Stability
2003
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation
2008
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
1997
RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins
2009
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
2010 Nature
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark
2013 Nature
Combinatorial interactions regulating cardiac transcription
1998
Systematic identification of fragile sites via genome-wide location analysis of γ-H2AX
2010
Regulatory ubiquitylation in response to DNA double-strand breaks
2009
The Atrial Natriuretic Factor Promoter Is a Downstream Target for Nkx-2.5 in the Myocardium
1996
Regulation of gene expression in the endocrine heart.
1998
The F-Box Protein Dia2 Overcomes Replication Impedance to Promote Genome Stability in Saccharomyces cerevisiae
2006
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes
2008