Citation Impact
Citing Papers
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
2004 StandoutScience
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin
2003
The Bearded box, a novel 3′ UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression
1997
The K box, a conserved 3′ UTR sequence motif, negatively regulates accumulation of Enhancer of split Complex transcripts
1998
Therapeutic strategies for Alzheimer's disease
2002
Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger
1999 StandoutNobel
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
MicroRNAs
2004 Standout
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
2003 Nature
RNA recognition and translational regulation by a homeodomain protein
1996 Nature
A putative cell signal encoded by the folded gastrulation gene coordinates cell shape changes during Drosophila gastrulation
1994 StandoutNobel
An alternative pathway for yeast telomere maintenance rescues est1− senescence
1993 StandoutNobel
TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity
2006 Nature
The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA
1997 StandoutNobel
Pathological activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different γ-secretase complexes
2007
Quality control of mRNA 3′-end processing is linked to the nuclear exosome
2001 StandoutNatureNobel
Genes Expressed in Neurons of Adult Male Drosophila
1997 StandoutNobel
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
Staufen protein associates with the 3′UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner
1994 StandoutNobel
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Two Genetic Circuits Repress the Caenorhabditis elegans Heterochronic Gene lin-28 after Translation Initiation
2002
Spatial and Temporal Controls Target pal-1 Blastomere-Specification Activity to a Single Blastomere Lineage in C. elegans Embryos
1996
A synaptic model of memory: long-term potentiation in the hippocampus
1993 StandoutNature
MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos
1996 StandoutNobel
Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities
2003
Mutations inSTS1 suppress the defect in 3′ mRNA processing caused by therna15-2 mutation inSaccharomyces cerevisiae
1996
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
2002
Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing
2001 StandoutNobel
TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites
2009 StandoutNobel
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Viable deletions of a telomere from a Drosophila chromosome
1989
The plant translational apparatus
1996
Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-β Precursor Protein and Notch
2002
γ-Secretase Complex Assembly within the Early Secretory Pathway
2005
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Structure and function of tetanus and botulinum neurotoxins
1995
Neuronal RNA Granules
2001
Studies on the rate and site-specificity of P element transposition.
1991
PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1
2003
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
2002
Switching and Signaling at the Telomere
2001 StandoutNobel
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
1992
staufen, a gene required to localize maternal RNAs in the Drosophila egg
1991 StandoutNobel
Familial Alzheimer's Disease Presenilin 1 Mutations Cause Alterations in the Conformation of Presenilin and Interactions with Amyloid Precursor Protein
2005
Initiation of Protein Synthesis in Eukaryotic Cells
1996
Immature nicastrin stabilizes APH‐1 independent of PEN‐2 and presenilin: identification of nicastrin mutants that selectively interact with APH‐1
2004
Localization of presenilin–nicastrin complexes and γ‐secretase activity to the trans‐Golgi network
2003
A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the γ-Secretase Complex
2004
A pdf Neuropeptide Gene Mutation and Ablation of PDF Neurons Each Cause Severe Abnormalities of Behavioral Circadian Rhythms in Drosophila
1999 StandoutNobel
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
γ-Secretase Activity Is Associated with a Conformational Change of Nicastrin
2003
fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development
1994 StandoutNobel
Evidence That Assembly of an Active γ-Secretase Complex Occurs in the Early Compartments of the Secretory Pathway
2004
The functions of animal microRNAs
2004 StandoutNatureNobel
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain
2003
Structure and function of γ-secretase
2008
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
2006
The role of presenilin cofactors in the γ-secretase complex
2003 Nature
Telomere length predicts replicative capacity of human fibroblasts.
1992 StandoutNobel
The initial substrate-binding site of γ-secretase is located on presenilin near the active site
2005
γ-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation
2003
Crystal Structure of the Xanthine Oxidase-Related Aldehyde Oxido-Reductase from D. gigas
1995 ScienceNobel
Dual‐component amino‐acid‐mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos.
1985
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
1999 Standout
Epidermal induction and inhibition of neural fate by translation initiation factor 4AIII
1997
The msl-2 dosage compensation gene of Drosophila encodes a putative DNA-binding protein whose expression is sex specifically regulated by Sex-lethal
1995
Role of MicroRNAs in Plant and Animal Development
2003 StandoutScienceNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
CD147 is a regulatory subunit of the γ-secretase complex in Alzheimer's disease amyloid β-peptide production
2005
A conserved tripeptide sorts proteins to peroxisomes.
1989
A Nuclear 3′-5′ Exonuclease Involved in mRNA Degradation Interacts with Poly(A) Polymerase and the hnRNA Protein Npl3p
2000
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
2003
Spatial regulation of zerknüllt: a dorsal-ventral patterning gene in Drosophila.
1989
Differential contribution of the three Aph1 genes to γ-secretase activity in vivo
2005
In Vitro Characterization of the Presenilin-Dependent γ-Secretase Complex Using a Novel Affinity Ligand
2003
Mechanisms underlying epileptiform burst discharge
1980
Epileptogenic Agents Enhance Transmission at an Identified Weak Electrical Synapse in Aplysia
1981 StandoutScienceNobel
GABA and its receptors in the spinal cord
1996
Recording Inhibition and Excitation in the Cat's Retinal Ganglion Cells with Intracellular Electrodes
1959 StandoutNatureNobel
A new class of GABA agonist
1977 StandoutNature
Molecular Structure and Physiological Function of Chloride Channels
2002
Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat
1971
Presenilin-Dependent γ-Secretase on Plasma Membrane and Endosomes Is Functionally Distinct
2006
Investigating the Genetic Circuitry of Mastermind in Drosophila, a Notch Signal Effector
2007
Moonlighting activity of presenilin in plants is independent of γ-secretase and evolutionarily conserved
2007
Neural Science
2000 StandoutNobel
Effects of enkephalin and morphine on Renshaw cells in feline spinal cord
1976 Nature
Genesis of epileptic interictal spikes. New knowledge of cortical feedback systems suggests a neurophysiological explanation of brief paroxysms
1973
Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae
1996
Opposite Synaptic Actions Mediated by Different Branches of an Identifiable Interneuron in Aplysia
1967 StandoutScienceNobel
Intramembrane Proteolysis: Theme and Variations
2004 Science
Mapping the Drosophila Genome with Yeast Artificial Chromosomes
1989 Science
A Neuropeptide Gene Defined by the Drosophila Memory Mutant amnesiac
1995 Science
Molecular analysis of the swallow gene of Drosophila melanogaster.
1988
STRUCTURE AND BIOLOGICAL ACTIVITY OF A SERIES OF CONFORMATIONALLY RESTRICTED ANALOGUES OF GABA
1975
Protein Control of Redox Potentials of Iron−Sulfur Proteins
1996 StandoutNobel
Molecular and Behavioral Analysis of Four period Mutants in Drosophila melanogaster Encompassing Extreme Short, Novel Long, and Unorthodox Arrhythmic Types
1998 StandoutNobel
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses
1997 StandoutNobel
Excitatory Amino Acid Transmitters
1981 Standout
Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation
1997
Slow Membrane Potential Changes Accompanying Excitaltion and Inhibition in Spinal Noto‐ and Interneurons in the Cat during Natural Acti‐vation.
1958
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation.
1996 StandoutNobel
Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
2011 StandoutNobel
Biogenesis of γ-secretase early in the secretory pathway
2007 StandoutNobel
Toward a molecular definition of long-term memory storage
1996 StandoutNobel
The action of antidromic impulses on the cerebellar Purkinje cells
1966
Masking of mRNA by Y‐box proteins
1996
aubergine enhances oskar translation in the Drosophila ovary
1996
A common function for mRNA 5' and 3' ends in translation initiation in yeast.
1995
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
2003 StandoutNobel
Structure and function of telomeres
1991 StandoutNatureNobel
Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.
1977 StandoutNobel
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Genetic and developmental analysis of the sex-determining gene ‘double sex’ (dsx) ofDrosophila melanogaster
1987
Mutations in a newly identified Drosophila melanogaster gene, mago nashi, disrupt germ cell formation and result in the formation of mirror-image symmetrical double abdomen embryos
1991
Works of Daniel Curtis being referenced
Presenilin-Based Genetic Screens in Drosophila melanogaster Identify Novel Notch Pathway Modifiers
2006
Translational regulation in development
1995
aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation
2002
Presenilin diversifies its portfolio
2007
Identification ofcis-Acting Sequences That ControlnanosRNA Localization
1996
Selective effects of (?)-baclofen on spinal synaptic transmission in the cat
1981
The depression of spinal inhibition by morphine
1969
The interpretation of spike potentials of motoneurones
1957
nanos is an evolutionarily conserved organizer of anterior-posterior polarity
1995
Sequence of the Structural Gene for Xanthine Dehydrogenase (rosy Locus) in Drosophila melanogaster
1987
The time courses of excitatory and inhibitory synaptic actions
1959
Noradrenaline and Inhibition of Renshaw Cells
1966 Science
The differential effects of baclofen on segmental and descending excitation of spinal interneurones in the cat
1985
Mode of Action of Tetanus Toxin
1955 Nature
A pharmacological study of group I muscle afferent terminals and synaptic excitation in the intermediate nucleus and Clarke's column of the cat spinal cord
1986
Mutations Affecting Expression of the rosy Locus in Drosophila melanogaster
1987
Convulsive action of penicillin
1972
CIS‐ AND TRANS‐4‐AMINOCROTONIC ACID AS GABA ANALOGUES OF RESTRICTED CONFORMATION
1975
MOLECULAR MAPPING OF THE ROSY LOCUS IN DROSOPHILA MELANOGASTER
1986
Selective antagonist activity of 5-aminohex-2-enedioic acid on amino acid excitation of cat spinal neurones
1980
Tetanus toxin and spinal inhibition
1968