Standout Papers
- Thermodynamically Stable Aggregation-Resistant Antibody Domains through Directed Evolution (2008)
- Identification of Protein Domains by Shotgun Proteolysis (2006)
- Tapping diversity lost in transformations—in vitro amplification of ligation reactions (2006)
- Repertoires of aggregation-resistant human antibody domains (2007)
- Identification of functional similarities between proteins using directed evolution (2003)
Citation Impact
Citing Papers
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
2021 StandoutNobel
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
A Novel Promiscuous Class of Camelid Single-Domain Antibody Contributes to the Antigen-Binding Repertoire
2010
dsRNA with 5′ overhangs contributes to endogenous and antiviral RNA silencing pathways in plants
2009 StandoutNobel
The challenges and molecular approaches surrounding interleukin-2-based therapeutics in cancer
2018
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
2022 StandoutNobel
De novo design of immunoglobulin-like domains
2022 StandoutNobel
Soluble expression of proteins correlates with a lack of positively-charged surface
2013
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects
2020
Engineering precision nanoparticles for drug delivery
2020 Standout
Dendritic cells in cancer immunology and immunotherapy
2019 Standout
Determining cell type abundance and expression from bulk tissues with digital cytometry
2019 Standout
The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells
2019
A De Novo Protein Binding Pair By Computational Design and Directed Evolution
2011 StandoutNobel
Rheumatoid arthritis
2016 Standout
Engineering and characterization of a superfolder green fluorescent protein
2005 Standout
Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes
2017 StandoutNobel
Genetic analysis of resistance to viral infection
2007 StandoutNobel
Cancer immunotherapy via dendritic cells
2012 Standout
Trial watch
2013
The Chemokine System in Innate Immunity
2015
Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis
2015
T Follicular Helper Cell Biology: A Decade of Discovery and Diseases
2019
Dual modes of RNA-silencing suppression by Flock House virus protein B2
2005
Engineering interferons and interleukins for cancer immunotherapy
2022
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Development and Function of Dendritic Cell Subsets
2014
Local Triggering of the ICOS Coreceptor by CD11c+ Myeloid Cells Drives Organ Inflammation in Lupus
2015
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Design, Production and Molecular Structure of a New Family of Artificial Alpha-helicoidal Repeat Proteins (αRep) Based on Thermostable HEAT-like Repeats
2010
Stability of Protein Pharmaceuticals: An Update
2010
The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila
2008 StandoutNobel
Regulation and Function of the PD-L1 Checkpoint
2018 Standout
Engineered protein scaffolds as leads for synthetic inhibitors of protein–protein interactions
2018
Rational designs of in vivo CRISPR-Cas delivery systems
2019
Combinatorial approaches to protein stability and structure
2004
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
2020 StandoutNatureNobel
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
2020 Standout
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
2016 Standout
Survey of the year 2003 commercial optical biosensor literature
2004
Optimizing Protein Stability In Vivo
2009
Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition
2016 StandoutNobel
Emerging Strategies for Developing Next-Generation Protein Therapeutics for Cancer Treatment
2016
Targeting ferroptosis as a vulnerability in cancer
2022 Standout
Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer
2013 Standout
Dendritic cell metabolism
2014
Cell-Intrinsic IL-27 and gp130 Cytokine Receptor Signaling Regulates Virus-Specific CD4+ T Cell Responses and Viral Control during Chronic Infection
2013
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2
2017
Molecular and cellular insights into T cell exhaustion
2015 Standout
Bispecific antibodies: a mechanistic review of the pipeline
2019
Controlling protein assembly on inorganic crystals through designed protein interfaces
2019 StandoutNatureNobel
Macrophage and T Cell Produced IL-10 Promotes Viral Chronicity
2013
B Cell Responses: Cell Interaction Dynamics and Decisions
2019
A guide to cancer immunotherapy: from T cell basic science to clinical practice
2020 Standout
A General Computational Approach for Repeat Protein Design
2014 StandoutNobel
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
2018 Standout
Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability
2011
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
2020 Standout
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
2023 StandoutNobel
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection
2014
A segment of cold shock protein directs the folding of a combinatorial protein
2005 StandoutNobel
Design of a binding scaffold based on variable lymphocyte receptors of jawless vertebrates by module engineering
2012
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy
2018
Immunometabolism governs dendritic cell and macrophage function
2015 Standout
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
2019
Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation
2019 StandoutNobel
Genetic disruption of CD8 + Treg activity enhances the immune response to viral infection
2013
Preparation of Porous Polysaccharides Templated by Coordination Polymer with Three-Dimensional Nanochannels
2017 StandoutNobel
Computational Evolution of Threonine-Rich β-Hairpin Peptides Mimicking Specificity and Affinity of Antibodies
2019 StandoutNobel
RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila
2010 StandoutNobel
Contributions of Amino Acid Side Chains to the Kinetics and Thermodynamics of the Bivalent Binding of Protein L to Ig κ Light Chain
2004 StandoutNobel
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+ T Cells
2015
Monobodies and other synthetic binding proteins for expanding protein science
2017
Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors
2020
Viral persistence, liver disease, and host response in a hepatitis C–like virus rat model
2017 StandoutNobel
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Regulatory roles of IL-10–producing human follicular T cells
2019 StandoutNobel
Effects of interleukin-2 in immunostimulation and immunosuppression
2019
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Nanobodies: Natural Single-Domain Antibodies
2013 Standout
De novo design of protein logic gates
2020 StandoutScienceNobel
IL-21 Promotes CD8+ CTL Activity via the Transcription Factor T-bet
2013
Works of Daniel Christ being referenced
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
2014
Identification of functional similarities between proteins using directed evolution
2003 StandoutNobel
Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination
2018 Science
Expression, purification and characterization of recombinant interleukin-21
2010
Aggregation, stability, and formulation of human antibody therapeutics
2011
Repertoires of aggregation-resistant human antibody domains
2007 StandoutNobel
Sequence determinants of protein aggregation in human VH domains
2008
Challenges and opportunities for non-antibody scaffold drugs
2015
Selection of human antibody fragments by phage display
2007
Tapping diversity lost in transformations—in vitro amplification of ligation reactions
2006 StandoutNobel
Thermodynamically Stable Aggregation-Resistant Antibody Domains through Directed Evolution
2008 StandoutNobel
Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells
2017
I-motif DNA structures are formed in the nuclei of human cells
2018
FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production
2015
The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells
2013
A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity
2011
IL-21 Restricts Virus-driven Treg Cell Expansion in Chronic LCMV Infection
2013
Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization
2016
Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells
2017
Efficient Intracellular Delivery of CRISPR-Cas Ribonucleoproteins through Receptor Mediated Endocytosis
2019
Molecular Engineering of Therapeutic Cytokines
2013
General strategy for the generation of human antibody variable domains with increased aggregation resistance
2012
Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models
2011