Standout Papers
Citation Impact
Citing Papers
Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates
2016 Standout
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles
2005 StandoutScience
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Exercise training increases size of hippocampus and improves memory
2011 Standout
Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
2006 StandoutNobel
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Cerebrospinal fluid tau and ptau 181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease
2009
Negatively Charged Amino Acids Near and in Transient Receptor Potential (TRP) Domain of TRPM4 Channel Are One Determinant of Its Ca2+ Sensitivity
2014
MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia
1999 Standout
Stability of person-specific blood-based infrared molecular fingerprints opens up prospects for health monitoring
2021 StandoutNobel
A minK–HERG complex regulates the cardiac potassium current IKr
1997 Nature
MinK Residues Line a Potassium Channel Pore
1996
ATP release via anion channels
2005
Effect of apolipoprotein E4 on clinical, neuroimaging, and biomarker measures in noncarrier participants in the Dominantly Inherited Alzheimer Network
2018
Ventricular arrhythmogenesis: Insights from murine models
2008
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 StandoutNature
Connexin disorders of the skin
2005
TRPM4 Is a Ca2+-Activated Nonselective Cation Channel Mediating Cell Membrane Depolarization
2002
Acute downregulation of Cx43 alters P2Y receptor expression levels in mouse spinal cord astrocytes
2003
CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment
2009
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions
2013 StandoutNature
Changes in cellular membrane and paracellular conductances by amphotericin B in the epithelium of the bullfrog cornea
1991
Expanding The Phenotypic Spectrum of Cx26 Disorders: Bart–Pumphrey Syndrome is Caused by a Novel Missense Mutation in GJB2
2004
Claudins in occluding junctions of humans and flies
2006
P2Y receptors play a critical role in epithelial cell communication and migration
2004
Nucleotide signalling during inflammation
2014 StandoutNature
Newborn Hearing Screening — A Silent Revolution
2006 Standout
Longitudinal Change of Biomarkers in Cognitive Decline
2011
Connexin disorders of the ear, skin, and lens
2004
Membrane-specific expression of functional purinergic receptors in normal human nasal epithelial cells
2004
An Update on Connexin Genes and their Nomenclature in Mouse and Man
2003
Physiology of Cell Volume Regulation in Vertebrates
2009
Transient receptor potential channelopathies
2010
K+ secretion activated by luminal P2Y2 and P2Y4 receptors in mouse colon
2005
Transient expression of P2X1 receptor subunits of ATP-gated ion channels in the developing rat cochlea
2001
Functional Domain Mapping and Selective Trans-dominant Effects Exhibited by Cx26 Disease-causing Mutations
2004
Roles of Met-34, Cys-64, and Arg-75 in the Assembly of Human Connexin 26
2003
Balancing Acts
2004 Standout
Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease
2010
N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1
2004 StandoutNobel
Regulatory volume decrease in a renal distal tubular cell line (A6) I. Role of K+ and Cl−
1995
A genetic approach to understanding auditory function
2001
Molecular basis of ancestral vertebrate electroreception
2017 StandoutNatureNobel
Extracellular Proteins Organize the Mechanosensory Channel Complex in C. elegans Touch Receptor Neurons
2004 StandoutNobel
Mutations in the Gene Encoding Tight Junction Claudin-14 Cause Autosomal Recessive Deafness DFNB29
2001
Gap junctions in the inner ear: Comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals
2003
Coiled Coils Direct Assembly of a Cold-Activated TRP Channel
2006 StandoutNobel
Comparison of ion transport mechanisms between vestibular dark cells and strial marginal cells
1995
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Perspectives on tight junction research
2012
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
2002 StandoutNatureNobel
Extracellular ATP as a signaling molecule for epithelial cells
2003
Gap junctions and the connexin protein family
2003
Importance of congenital cytomegalovirus infections as a cause for pre-lingual hearing loss
2005
Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems
2004
TRP channels as cellular sensors
2003 StandoutNature
Ion selectivity of volume regulatory mechanisms present during a hypoosmotic challenge in vestibular dark cells
1995
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
2009 Standout
Deep learning in histopathology: the path to the clinic
2021 Standout
Claudins and Other Tight Junction Proteins
2012
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
APOE predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging
2009
Networks of task co-activations
2013
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
2010 StandoutNature
Expansion of the eukaryotic proteome by alternative splicing
2010 StandoutNature
Osmolality and potassium cause alterations in the volume of glomerulosa cells.
1993
Dynamic Analysis of Amyloid β-Protein in Behaving Mice Reveals Opposing Changes in ISF versus Parenchymal Aβ during Age-Related Plaque Formation
2011
Noise induces up-regulation of P2X2 receptor subunit of ATP-gated ion channels in the rat cochlea
2003
The cochlear F-box protein OCP1 associates with OCP2 and connexin 26
2004
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
2013 Standout
Extracellular ATP-induced inward current in isolated epithelial cells of the endolymphatic sac
1999
IsK and KvLQT1: Mutation in Either of the Two Subunits of the Slow Component of the Delayed Rectifier Potassium Channel Can Cause Jervell and Lange-Nielsen Syndrome
1997
Physiology and Pathophysiology of Purinergic Neurotransmission
2007 Standout
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Genomic Structure of Three Long QT Syndrome Genes:KVLQT1, HERG,andKCNE1
1998
Purinergic receptors in auditory neurotransmission
2003
Connexin gene pathology
2003
Biomarker Modeling of Alzheimer’s Disease
2013
A constitutively open potassium channel formed by KCNQ1 and KCNE3
2000 StandoutNature
Alzheimer's Disease
2010 Standout
Distribution of Ca2+-Activated K+ Channel Isoforms along the Tonotopic Gradient of the Chicken's Cochlea
1997
MinK Potassium Channels Are Heteromultimeric Complexes
1997
Transgenic expression of a dominant-negative connexin26 causes degeneration of the organ of Corti and non-syndromic deafness
2003
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Hepatitis C Virus Entry
2007 StandoutNobel
Shapes of the Trajectories of 5 Major Biomarkers of Alzheimer Disease
2012
A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
1997
Stable knockdown of CFTR establishes a role for the channel in P2Y receptor‐stimulated anion secretion
2005
Vibrational spectroscopic analysis of peripheral blood plasma of patients with Alzheimer’s disease
2015
Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration
2003
Purinergic regulation of epithelial transport
2003
Double gene deletion reveals lack of cooperation between claudin 11 and claudin 14 tight junction proteins
2008
P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFα and potential role in myocardial cell death
2005
International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy
2006
Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes
2014
Mutation of the Na-K-Cl Co-Transporter Gene Slc12a2 Results in Deafness in Mice
1999
Pittsburgh Compound B Imaging and Prediction of Progression From Cognitive Normality to Symptomatic Alzheimer Disease
2009
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4
2002 Nature
Mutations in the gene for connexin 26 (GJB2) that cause hearing loss have a dominant negative effect on connexin 30
2003
Evidence for Ordering of Alzheimer Disease Biomarkers
2011
Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28
2011
Hair Cells – Beyond the Transducer
2006
Claudin Function in the Thick Ascending Limb of Henle's Loop
2009
KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness
1999
The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel
2004 StandoutNobel
A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly
2000
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Pharmacology of Vanilloid Transient Receptor Potential Cation Channels
2009
Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice
2000
Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
2009 Nature
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
2008 Standout
The Dynamics of Cortical and Hippocampal Atrophy in Alzheimer Disease
2011
Anemia of Chronic Disease
2005 Standout
The Color Loci of Mice – A Genetic Century
2003
Data sharing in neuroimaging research
2012
Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias
1997
Targeted epidermal expression of mutant Connexin 26(D66H) mimics true Vohwinkel syndrome and provides a model for the pathogenesis of dominant connexin disorders
2003
Tight junctions potentiate the insulative properties of small CNS myelinated axons
2008
Lecanemab in Early Alzheimer’s Disease
2022 Standout
Mutation of the Gene for I sK Associated With Both Jervell and Lange-Nielsen and Romano-Ward Forms of Long-QT Syndrome
1998
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Effect of Fetal Hypoxia on Heart Susceptibility to Ischemia and Reperfusion Injury in the Adult Rat
2003
Claudin Family Proteins in Caenorhabditis elegans
2011
Minimal Effects of VEGF and Anti-VEGF Drugs on the Permeability or Selectivity of RPE Tight Junctions
2010
INHERITED HEARING DEFECTS IN MICE
1995
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance
2011
Why Urea Eliminates Ammonia Rather than Hydrolyzes in Aqueous Solution
2007
Connexin interaction patterns in keratinocytes revealed morphologically and by FRET analysis
2005
Positive endocochlear potential: Mechanism of production by marginal cells of stria vascularis
1987
Cell volume control in vestibular dark cells during and after a hyposmotic challenge
1994
Structural and Functional Brain Networks: From Connections to Cognition
2013 StandoutScience
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
2013
Molecular Structure and Physiological Function of Chloride Channels
2002
Recent Stem Cell Advances: Induced Pluripotent Stem Cells for Disease Modeling and Stem Cell–Based Regeneration
2010 StandoutNobel
Control of epithelial transport via luminal P2 receptors
2003
Signaling at Purinergic P2X Receptors
2008
CONNEXINS AND CELL SIGNALING IN DEVELOPMENT AND DISEASE
2004
Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions
2003
UTP binding and phosphoinositidase C activation in ampulla from frog semicircular canal
2000
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
2011 Standout
Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears ofFoxi1null mutant mice
2003
Spectrum of Mutations in Long-QT Syndrome Genes
2000
MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults
2011
Molecular Genetics of Hearing Loss
2001
19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-
1991 StandoutNobel
Life cycle of connexins in health and disease
2006 Standout
Mechanisms of Action of Vanadium
1984
Catalytic Mechanism and Performance of Computationally Designed Enzymes for Kemp Elimination
2008 StandoutNobel
Distinct subdomain organization and molecular composition of a tight junction with adherens junction features
2006
Single-Channel Properties of IKs Potassium Channels
1998
Single-Channel Characteristics of Wild-Type IKs Channels and Channels formed with Two MinK Mutants that Cause Long QT Syndrome
1998
Receptors for Purines and Pyrimidines
2012 Standout
Claudins and the Modulation of Tight Junction Permeability
2013 Standout
Genetic and Molecular Basis of Cardiac Arrhythmias: Impact on Clinical Management Part III
1999
Brain β-amyloid load approaches a plateau
2013
Functional Significance of Cell Volume Regulatory Mechanisms
1998 Standout
Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
1999 StandoutScience
Block of an ether-a-go-go-Like K+Channel by Imipramine Rescuesegl-2Excitation Defects inCaenorhabditis elegans
1999
Overexpression of claudin-7 decreases the paracellular Cl– conductance and increases the paracellular Na+ conductance in LLC-PK1 cells
2005
Vesicular Storage of Adenosine Triphosphate in the Guinea-pig Cochlear Lateral Wall and Concentrations of ATP in the Endolymph during Sound Exposure and Hypoxia
2001
Apical sorting of a voltage- and Ca 2+ -activated K + channel α-subunit in Madin-Darby canine kidney cells is independent of N-glycosylation
2000
Effect of hepcidin on intestinal iron absorption in mice
2004
Vestibular dark cells contain the exchanger NHE-1 in the basolateral membrane
1996
Pharmacological characterization of ATP receptors in ampulla from frog semicircular canal
1998
Genetics of Sensory Mechanotransduction
2002 StandoutNobel
Works of Daniel C. Marcus being referenced
KCNJ10(Kir4.1)カリウムチャンネルノックアウトはか牛内直流電位を消失させる
2002
Adenosine Stimulates Anion Secretion Across Cultured and Native Adult Human Vas Deferens Epithelia1
2003
Decreased cerebrospinal fluid Aβ 42 correlates with brain atrophy in cognitively normal elderly
2009
Hypo-osmotic challenge stimulates transepithelial k+ secretion and activates apical i sK channel in vestibular dark cells
1995
Ion transport mechanisms responsible for K+ secretion and the transepithelial voltage across marginal cells of stria vascularis in vitro
1995
Deafness inClaudin 11-Null Mice Reveals the Critical Contribution of Basal Cell Tight Junctions to Stria Vascularis Function
2004
Transepithelial electrical responses to Cl− of nonsensory region of gerbil utricle
1989
Immunolocalization of ClC-K chloride channel in strial marginal cells and vestibular dark cells
2001
Federated learning in medicine: facilitating multi-institutional collaborations without sharing patient data
2020 Standout
The Na+/H+ exchanger in transitional cells of the inner ear
1993
The membrane potential of vestibular dark cells is controlled by a large Cl− conductance
1992
Sidedness of action of loop diuretics and ouabain on nonsensory cells of utricle: A micro-Ussing chamber for inner ear tissues
1987
Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal
2005
Transepithelial voltage and resistance of vestibular dark cell epithelium from the gerbil ampulla
1994
K+ and Na+ absorption by outer sulcus epithelial cells
1999
Nonselective Cation and BK Channels in Apical Membrane of Outer Sulcus Epithelial Cells
2000
K+-induced swelling of vestibular dark cells is dependent on Na+ and Cl? and inhibited by piretanide
1990
Protein kinase C mediates P2U purinergic receptor inhibition of K+ channel in apical membrane of strial marginal cells
1998
A National Human Neuroimaging Collaboratory Enabled by the Biomedical Informatics Research Network (BIRN)
2008
Targeted Ablation of Connexin26 in the Inner Ear Epithelial Gap Junction Network Causes Hearing Impairment and Cell Death
2002
Inner Ear Defects Induced by Null Mutationof the isk Gene
1996
A Claudin-9–Based Ion Permeability Barrier Is Essential for Hearing
2009
Lack of pendrin HCO3−transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels
2007
Membrane potential measurements of transitional cells from the crista ampullaris of the Gerbil
1989
Potassium secretion by vestibular dark cell epithelium demonstrated by vibrating probe
1994
Loss of cochlear HCO3−secretion causes deafness via endolymphatic acidification and inhibition of Ca2+reabsorption in a Pendred syndrome mouse model
2007
Immunolocalization of P2Y4 and P2Y2 Purinergic Receptors in Strial Marginal Cells and Vestibular Dark Cells
2002
Divalent cations inhibit IsK/KvLQT1 channels in excised membrane patches of strial marginal cells
1998
Ca2+-activated nonselective cation, maxi K+ and Cl− channels in apical membrane of marginal cells of stria vascularis
1992
KCNJ10 (Kir4.1) potassium channel knockout abolishes endocochlear potential
2002
Maxi K+ channel in apical membrane of vestibular dark cells
1992
Specificity of action of vanadate to the organ of corti
1981
Direct measurement of longitudinal endolymph flow rate in the guinea pig cochlea
1986
P2X2Receptor Mediates Stimulation of Parasensory Cation Absorption by Cochlear Outer Sulcus Cells and Vestibular Transitional Cells
2001
Response of cochlear potentials to presumed alterations of ionic conductance: Endolymphatic perfusion of barium, valinomycin and nystatin
1983
Transepithelial cation movements in gerbil utricles
1985
Support of cochlear metabolic and ion transport processes solely by perilymphatic perfusion
1984
Two types of chloride channel in the basolateral membrane of vestibular dark cells
1993
Potassium secretion by nonsensory region of gerbil utricle in vitro
1987
Ca(2+)-activated nonselective cation channel in apical membrane of vestibular dark cells
1992
Evidence for Purinergic Receptors in Vestibular Dark Cell and Strial Marginal Cell Epithelia of Gerbil.
1995
Slowly activating voltage-dependent K+ conductance is apical pathway for K+ secretion in vestibular dark cells
1994
P2Upurinergic receptor inhibits apical IsK/KvLQT1 channel via protein kinase C in vestibular dark cells
1997
Evidence for the involvement of a K+ channel in isosmotic cell shrinking in vestibular dark cells
1992
Membrane transport parameters in frog corneal epithelium measured using impedance analysis techniques
1986
Apical P2Y4purinergic receptor controls K+secretion by vestibular dark cell epithelium
2001
Photometric determination of picomole quantities of calcium
1972
Vascular perfusion of the cochlea: Effect of potassium-free and rubidium-substituted media
1979
Comparison of the non-adrenergic action of phentolamine with that of vanadate on cochlear function
1982
Comments concerning a possible independent potassium pump in the cochlear duct
1980
Effects of barium and ion substitutions in artificial blood on endocochlear potential
1985