Standout Papers
Citation Impact
Citing Papers
Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment
2009
Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia
2006
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis
2012 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
Therapeutic implications of intrinsic or induced angiogenic growth factor redundancy in tumors revealed
2005
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Base-excision repair of oxidative DNA damage
2007 StandoutNature
An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia
2009
Inflammation and Cancer: Triggers, Mechanisms, and Consequences
2019 Standout
HIF-1: upstream and downstream of cancer metabolism
2009 StandoutNobel
RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1α during Hypoxia
2007
Mining the Human Gut Microbiota for Immunomodulatory Organisms
2017
Association Between Bacteremia From Specific Microbes and Subsequent Diagnosis of Colorectal Cancer
2018
NF-κB in cancer: from innocent bystander to major culprit
2002 Standout
Nutrients, Foods, and Colorectal Cancer Prevention
2015
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
2019 Standout
rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
1997
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Involvement of endothelial progenitor cells in tumor vascularization
2010
QGP-1 cells release 5-HT via TRPA1 activation; a model of human enterochromaffin cells
2009
Otto Warburg's contributions to current concepts of cancer metabolism
2011 Standout
Regulation of immunity and inflammation by hypoxia in immunological niches
2017
Inflammation and colorectal cancer: colitis-associated neoplasia
2012
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Colorectal cancer
2019 Standout
Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers
2008 StandoutNobel
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
2003 Standout
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
Predictive role of BRAF mutations in patients with advanced colorectal cancer receiving cetuximab and panitumumab: A meta-analysis
2015
Current understanding of the human microbiome
2018 Standout
The genetics of pancreatic cancer
2003
Towards large-cohort comparative studies to define the factors influencing the gut microbial community structure of ASD patients
2015
Hypoxia: A key regulator of angiogenesis in cancer
2007
Hypoxia-driven selection of the metastatic phenotype
2007
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin
2013 Standout
Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium
2007
The Exocyst Complex in Health and Disease
2016
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
2013 Standout
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
Modes of resistance to anti-angiogenic therapy
2008 Standout
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
2011
DNA mismatch repair: Molecular mechanism, cancer, and ageing
2008
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
2009 StandoutNobel
Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways
2009 StandoutNobel
The role of hypoxia in recurrence following resection of Dukes’ B colorectal cancer
2008
Insensitivity to anti–Müllerian hormone due to a mutation in the human anti–Müllerian hormone receptor
1995
ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes
2015
Cancer of the Ovary
2004 Standout
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells
2019
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Life with Oxygen
2007 StandoutScienceNobel
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Proteasomal Inhibition Attenuates Transcriptional Activity of Hypoxia-Inducible Factor 1 (HIF-1) via Specific Effect on the HIF-1α C-Terminal Activation Domain
2006
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum
2017
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway.
2003
Microsatellite instability in colorectal cancer
2006
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
2012 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment
2016
PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells
2009
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Increased Susceptibility to Colitis-Associated Cancer of Mice Lacking TIR8, an Inhibitory Member of the Interleukin-1 Receptor Family
2007
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
2012 StandoutNobel
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
Works of Daniel C. Chung being referenced
Oncogenic KRAS and BRAF Differentially Regulate Hypoxia-Inducible Factor-1α and -2α in Colon Cancer
2009
HIF‐1α and HIF‐2α have divergent roles in colon cancer
2008
Gastroenteropancreatic neuroendocrine tumours
2008
Genetics of hereditary colorectal cancer
2005
Oncogenic K-ras Stimulates Wnt Signaling in Colon Cancer Through Inhibition of GSK-3β
2005
Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
2010
Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells
2008
Mutually Exclusive Interactions between Factors Binding to Adjacent Sp1 and AT-rich Elements Regulate Gastrin Gene Transcription in Insulinoma Cells
1995
The Chromosomal Instability Pathway in Colon Cancer
2010
Analysis of the retinoblastoma tumour suppressor gene in pancreatic endocrine tumours
1997
Prevalence of Thyroid Cancer in Familial Adenomatous Polyposis Syndrome and the Role of Screening Ultrasound Examinations
2007
Hypoxic Regulation of Vascular Endothelial Growth Factor through the Induction of Phosphatidylinositol 3-Kinase/Rho/ROCK and c-Myc
2006
Induction of interleukin-8 preserves the angiogenic response in HIF-1α–deficient colon cancer cells
2005
Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment
2013 Standout
DNA mismatch repair and cancer
1995
The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis
2000
LKB1 — A master tumour suppressor of the small intestine and beyond
2002
Overexpression of Cyclin D1 Occurs Frequently in Human Pancreatic Endocrine Tumors1
2000
Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study
2009
Overexpression of Cyclin D1 Occurs Frequently in Human Pancreatic Endocrine Tumors
2000
Hypoxia-Inducible Factor-1-Independent Regulation of Vascular Endothelial Growth Factor by Hypoxia in Colon Cancer
2004
Exocyst Sec10 protects epithelial barrier integrity and enhances recovery following oxidative stress, by activation of the MAPK pathway
2010
Germline Mutations in Oncogene-Induced Senescence Pathways Are Associated With Multiple Sessile Serrated Adenomas
2013
The Hereditary Nonpolyposis Colorectal Cancer Syndrome: Genetics and Clinical Implications
2003