Citation Impact
Citing Papers
Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
2015 StandoutNobel
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
2010 StandoutScience
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Transcriptomic portrait of human Mesenchymal Stromal/Stem cells isolated from bone marrow and placenta
2014
Nanog Is the Gateway to the Pluripotent Ground State
2009 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells
2003
Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis
2002
Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
1997 Nature
Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells
2002
Inflammation and cancer
2002 StandoutNature
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
2005 StandoutNobel
The Adaptor Protein Nck1 Mediates Endothelin A Receptor-regulated Cell Migration through the Cdc42-dependent c-Jun N-terminal Kinase Pathway
2004
STAT proteins: From normal control of cellular events to tumorigenesis
2003
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
2009 Standout
Control of the Embryonic Stem Cell State
2011
A RANK/TRAF6-dependent Signal Transduction Pathway Is Essential for Osteoclast Cytoskeletal Organization and Resorptive Function
2002
pp60v- Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways
1999
Oncogenic kinase signalling
2001 StandoutNature
Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains
2008
Synergistic Roles for Pim-1 and c-Myc in STAT3-Mediated Cell Cycle Progression and Antiapoptosis
1999
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
1999 Standout
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Stat3 as an Oncogene
1999 Standout
Feeder-independent culture of human embryonic stem cells
2006
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
Transcriptional regulation and transpositional selection of active SINE sequences
1992
Mapping and analysis of chromatin state dynamics in nine human cell types
2011 StandoutNature
Gene function in mouse embryogenesis: get set for gastrulation
2007
Rho GTPases in cell biology
2002 StandoutNature
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors
2000
Role of Src expression and activation in human cancer
2000
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
The role of STATs in transcriptional control and their impact on cellular function
2000
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
2001
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Phosphorylation of c-Crk II on the Negative Regulatory Tyr222 Mediates Nerve Growth Factor-induced Cell Spreading and Morphogenesis
2000
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
STATs in oncogenesis
2000 Standout
Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation
2001
Immunity, Inflammation, and Cancer
2010 Standout
Activation of STAT transcription factors in oncogenic tyrosine kinase signaling
1998
Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo
2006
Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling
2000
Osteoclast differentiation and activation
2003 StandoutNature
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
2002
Live or let die: the cell's response to p53
2002 Standout
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
2005 Standout
Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis
2001
Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
2000
Co-operative Effect of c-Src Tyrosine Kinase and Stat3 in Activation of Hepatocyte Growth Factor Expression in Mammary Carcinoma Cells
2001
Molecular Identity of Human Outer Radial Glia during Cortical Development
2015
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
The TNF-receptor-associated factor family
2001
STAT proteins: novel molecular targets for cancer drug discovery
2000
PI3K/Akt: getting it right matters
2008
New cell lines from mouse epiblast share defining features with human embryonic stem cells
2007 StandoutNature
STAT proteins as novel targets for cancer therapy
1999
Crosstalk in NF-κB signaling pathways
2011 Standout
Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells
1999
The STATs of cancer — new molecular targets come of age
2004 Standout
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth
2002
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
2006
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
Activation of STAT proteins and growth control
2001
αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells
2000
Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes
2005
Cancer-related inflammation
2008 StandoutNature
Human DNA methylomes at base resolution show widespread epigenomic differences
2009 StandoutNature
IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled
2000
STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies
2006
Fibrinolysis, inflammation, and regulation of the plasminogen activating system
2007
Glucocorticoids Inhibit the Transcriptional Activity of LEF/TCF in Differentiating Osteoblasts in a Glycogen Synthase Kinase-3β-dependent and -independent Manner
2004
Pro-angiogenic Activities of CYR61 (CCN1) Mediated through Integrins αvβ3 and α6β1 in Human Umbilical Vein Endothelial Cells
2002 Standout
Interleukin-4 Reversibly Inhibits Osteoclastogenesis via Inhibition of NF-κB and Mitogen-activated Protein Kinase Signaling
2002
Efficient differentiation of human embryonic stem cells to definitive endoderm
2005
Generation of a dual-labeled fluorescence biosensor for Crk-II phosphorylation using solid-phase expressed protein ligation
2000
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
2003
Microphthalmia Transcription Factor Is a Target of the p38 MAPK Pathway in Response to Receptor Activator of NF-κB Ligand Signaling
2002
Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice
2007 StandoutNobel
The role of protein kinase C δ activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation
2006
Apoptotic Regulation by the Crk Adapter Protein Mediated by Interactions with Wee1 and Crm1/Exportin
2002
Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells
2006
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1
2001
RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution
2002
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction
2002
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
2004
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
Integrin Signaling
1999 StandoutScience
Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma
2002
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesisin vivo
2000
Activation of STAT3 by the Hepatitis C Virus Core Protein Leads to Cellular Transformation
2002
Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation
1998
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
2012 StandoutNobel
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.
2002
CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity
2002
Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.
1999
Wee1-Regulated Apoptosis Mediated by the Crk Adaptor Protein in Xenopus Egg Extracts
2000
Receptor Activator of NF-κB Ligand (RANKL) Activates TAK1 Mitogen-Activated Protein Kinase Kinase Kinase through a Signaling Complex Containing RANK, TAB2, and TRAF6
2002
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation
1997
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules
2010
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Negative Regulation of Cytokine Signaling Pathways
2000 Standout
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
Inactivation of CMP- N -acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution
2002 StandoutNobel
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice
2009 StandoutNobel
Synthesis of Lipidated Green Fluorescent Protein and Its Incorporation in Supported Lipid Bilayers
2005 StandoutNobel
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
2001
Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.
2002
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
2001
U0126 and PD98059, Specific Inhibitors of MEK, Accelerate Differentiation of RAW264.7 Cells into Osteoclast-like Cells
2002
Works of Daniel Besser being referenced
Insulin regulates the activity of forkhead transcription factor Hnf-3β/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization
2003
Activation and Nuclear Translocation of Mitogen-activated Protein Kinases by Polyomavirus Middle-T or Serum Depend on Phosphatidylinositol 3-Kinase
1995
Mesenchymal stromal cells (MSCs): science and f(r)iction
2012
Expression of Nodal, Lefty-A, and Lefty-B in Undifferentiated Human Embryonic Stem Cells Requires Activation of Smad2/3
2004
Protein Kinase B β/Akt2 Plays a Specific Role in Muscle Differentiation
2001
SH2 and SH3‐containing adaptor proteins: redundant or independent mediators of intracellular signal transduction
1996
DNA methylation inhibits transcription by RNA polymerase III of a tRNA gene, but not of a 5S rRNA gene
1990
TRANCE, a TNF Family Member, Activates Akt/PKB through a Signaling Complex Involving TRAF6 and c-Src
1999
Cooperation of two PEA3/AP1 sites in uPA gene induction by TPA and FGF-2
1997
Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2
1997
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase
2002
Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblasts.
1995
Stat3 Activation Is Required for Cellular Transformation by v-src
1998
A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation
1999
TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
2005