Standout Papers
Citation Impact
Citing Papers
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ
2013 StandoutNobel
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green
2018 StandoutNobel
A fluorophore ligase for site-specific protein labeling inside living cells
2010
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
Incorporation of sensing modalities into de novo designed fluorescence-activating proteins
2021 StandoutNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
A general method to improve fluorophores for live-cell and single-molecule microscopy
2015
Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo
2015 StandoutNobel
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins
2009
Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors
2013
In the right place at the right time: visualizing and understanding mRNA localization
2014
Genetically Encoded Copper‐Free Click Chemistry
2011
Quantum dots versus organic dyes as fluorescent labels
2008 Standout
A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins
2013
Fluorescent probes for super-resolution imaging in living cells
2008 Standout
Genetically Encodable Fluorescent Biosensors for Tracking Signaling Dynamics in Living Cells
2011
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
Molecules and Methods for Super-Resolution Imaging
2010 StandoutNobel
Stimulated Emission Depletion Nanoscopy of Living Cells Using SNAP-Tag Fusion Proteins
2010 StandoutNobel
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
Single-molecule imaging of transcription factor binding to DNA in live mammalian cells
2013
STED Microscopy and its Applications: New Insights into Cellular Processes on the Nanoscale
2012
Chemoenzymatic methods for site-specific protein modification
2010
Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction
2012
Development of SNAP‐Tag Fluorogenic Probes for Wash‐Free Fluorescence Imaging
2011
A colloidal quantum dot spectrometer
2015 StandoutNatureNobel
Choosing an effective protein bioconjugation strategy
2011
Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells
2009
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Strain-promoted double-click reaction for chemical modification of azido-biomolecules
2010
Quantitative measurement of cytosolic penetration using the chloroalkane penetration assay
2020
Reactivity of Biarylazacyclooctynones in Copper-Free Click Chemistry
2012 StandoutNobel
A biosensor for measuring NAD+ levels at the point of care
2019
Multiplex single-molecule interaction profiling of DNA-barcoded proteins
2014 Nature
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
“Turn-On” Protein Fluorescence: In Situ Formation of Cyanine Dyes
2014
A simple DNA handle attachment method for single molecule mechanical manipulation experiments
2016
Chemical tags: Applications in live cell fluorescence imaging
2011
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters
2014 StandoutNobel
Emerging Methods and Design Principles for Cell‐Penetrant Peptides
2018
RadicalS-Adenosylmethionine Enzymes
2014
Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins
2015
Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins
2014
Superresolution Imaging of Targeted Proteins in Fixed and Living Cells Using Photoactivatable Organic Fluorophores
2010 StandoutNobel
Diels–Alder Cycloaddition for Fluorophore Targeting to Specific Proteins inside Living Cells
2011
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors
2019
Rational Design of a Colorimetric pH Sensor from a Soluble Retinoic Acid Chaperone
2013
Understanding Cell Penetration of Cyclic Peptides
2019
Quantum Dot Targeting with Lipoic Acid Ligase and HaloTag for Single-Molecule Imaging on Living Cells
2012
Fluorophore Targeting to Cellular Proteins via Enzyme-Mediated Azide Ligation and Strain-Promoted Cycloaddition
2012 StandoutNobel
Minimalist Approaches to Protein Labelling: Getting the Most Fluorescent Bang for Your Steric Buck
2014
Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances
2019
Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes
2014 StandoutNobel
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Cell Penetration Profiling Using the Chloroalkane Penetration Assay
2018
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Cy3-Cy5 Covalent Heterodimers for Single-Molecule Photoswitching
2008 StandoutNobel
Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane
2014
Small-Molecule Labeling of Live Cell Surfaces for Three-Dimensional Super-Resolution Microscopy
2014 StandoutNobel
Organelle-Targetable Fluorescent Probes for Imaging Hydrogen Peroxide in Living Cells via SNAP-Tag Protein Labeling
2010
A Bioorthogonal Quadricyclane Ligation
2011 StandoutNobel
Chemically tunable mucin chimeras assembled on living cells
2015 StandoutNobel
Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy
2017
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
A Stilbene That Binds Selectively to Transthyretin in Cells and Remains Dark until It Undergoes a Chemoselective Reaction To Create a Bright Blue Fluorescent Conjugate
2010
Chemical Tags for Labeling Proteins Inside Living Cells
2011
Finding the Right (Bioorthogonal) Chemistry
2014
Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag
2011 StandoutNobel
Yeast Display Evolution of a Kinetically Efficient 13-Amino Acid Substrate for Lipoic Acid Ligase
2009
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
2015 StandoutNobel
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Stapled β-Hairpins Featuring 4-Mercaptoproline
2021 StandoutNobel
CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum
2015 StandoutNobel
Small-Molecule-Based Protein-Labeling Technology in Live Cell Studies: Probe-Design Concepts and Applications
2013
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Bright Building Blocks for Chemical Biology
2014
An In Vivo Covalent TMP-Tag Based on Proximity-Induced Reactivity
2009
Computational design of a red fluorophore ligase for site-specific protein labeling in living cells
2014 StandoutNobel
Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins
2017 StandoutNobel
Works of Dan Simpson being referenced
HaloTag7: A genetically engineered tag that enhances bacterial expression of soluble proteins and improves protein purification
2009
HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis
2008 Standout
Large-Scale Production of Coenzyme F 420 -5,6 by Using Mycobacterium smegmatis
2002