Standout Papers
- Identification of cellular proteins binding to the scrapie prion protein (1990)
- Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication (1990)
- Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques (1989)
- Rapid detection of Creutzfeldt‐Jakob disease and scrapie prion proteins (1990)
Citation Impact
Citing Papers
Heparin‐like molecules bind differentially to prion‐proteins and change their intracellular metabolic fate
1993
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Nucleic acids in prion preparations: unspecific background or essential component?
1994
Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier
1994
Prion protein is necessary for normal synaptic function
1994 Nature
Different Forms of the Bovine PrP Gene have Five or Six Copies of a Short, G-C-rich Element within the Protein-coding Exon
1991
Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein
1996 StandoutNobel
Unaltered susceptibility to BSE in transgenic mice expressing human prion protein
1995 Nature
Purification and properties of the cellular prion protein from Syrian hamster brain
1992 StandoutNobel
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Identification of Intermediate Steps in the Conversion of a Mutant Prion Protein to a Scrapie-like Form in Cultured Cells
1997
Prions and molecular chaperones
1993
Chapter 37: PrPSc causes nerve cell death and stimulates astrocyte proliferation: a paradox
1992
Chemistry and biology of prions
1992
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing
1993
Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease
1991 Nature
Regional distribution of protease‐resistant prion protein in fatal familial insomnia
1995
Linkage of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease to the prion protein gene
1992 StandoutNobel
Characterisation of antisera raised against species-specific peptide sequences from scrapie-associated fibril protein and their application for post-mortem immunodiagnosis of spongiform encephalopathies
1994
Mutation of the Prion Protein in Libyan Jews with Creutzfeldt–Jakob Disease
1991 StandoutNobel
Decreased receptor-mediated calcium response in prion-infected cells correlates with decreased membrane fluidity and IP sub 3 release
1996
Glycosylinositol Phospholipid Anchors of the Scrapie and Cellular Prion Proteins Contain Sialic Acid
1992 StandoutNobel
Scrapie Strain Variation and Its Implications
1991
Nuclease-resistant polyadenylated RNAs of significant size are detected by PCR in highly purified Creutzfeldt-Jakob disease preparations
1990
Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
1996 Nature
BIOLOGY AND GENETICS OF PRION DISEASES
1994
Scrapie prions: a three-dimensional model of an infectious fragment
1996
A 'unified theory' of prion propagation
1991 Nature
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins
1994 StandoutNobel
Fatal Familial Insomnia, a Prion Disease with a Mutation at Codon 178 of the Prion Protein Gene
1992
Sensitive enzyme-linked immunosorbent assay for detection of PrPSc in crude tissue extracts from scrapie-affected mice
1997
Molecular basis of phenotypic variability in sporadc creudeldt‐jakob disease
1996
To what Extent is Strain Variation Evidence for an Independent Genome in the Agent of the Transmissible Spongiform Encephalopathies?
1996
Prion Protein Peptides Induce .alpha.-Helix to .beta.-Sheet Conformational Transitions
1995
Molecular properties of complexes formed between the prion protein and synthetic peptides
1997 StandoutNobel
Prion Protein Isoforms, a Convergence of Biological and Structural Investigations
1995 StandoutNobel
The Neurochemistry of Prion Diseases
1993
Properties of the Scrapie Prion Protein: Quantitative Analysis of Protease Resistance
1994
The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis
1991
Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein
1995
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal
1994
Mice with gene targetted prion protein alterations show that Prnp, Sine and Prni are congruent
1998
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Genetic and Infectious Prion Diseases
1993
Developmental expression of the prion protein gene in glial cells
1995
Mutations and polymorphisms in the prion protein gene
1993
Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an α-helix
1997
Self-Seeded Fibers Formed by Sup35, the Protein Determinant of [PSI+], a Heritable Prion-like Factor of S. cerevisiae
1997
Immunologic and Molecular Biologic Studies of Prion Proteins in Bovine Spongiform Encephalopathy
1993 StandoutNobel
Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse.
1993 StandoutNobel
Comparative sequence analysis and expression of bovine PrP gene in mouse L-929 cells
1992
The transmissible amyloidoses: Genetical control of spontaneous generation of infectious amyloid proteins by nucleation of configurational change in host precursors: Kuru-CJD-GSS-Scrapie-BSE
1991 Nobel
Amyloid fibrils in Gerstmann-Sträussler-Scheinker disease (Indiana and Swedish Kindreds) express only PrP peptides encoded by the mutant allele
1994
Prion Protein Genes: Evolutionary and Functional Aspects
1991
Selective Neuronal Targeting in Prion Disease
1997 StandoutNobel
Human prion diseases
1994 StandoutNobel
Complete Genomic Sequence and Analysis of the Prion Protein Gene Region from Three Mammalian Species
1998 Nobel
Mutant and Infectious Prion Proteins Display Common Biochemical Properties in Cultured Cells
1996
Restriction fragment length polymorphisms of the scrapie-associated fibril protein (PrP) gene and their association with susceptibility to natural scrapie in British sheep
1991
The abnormal isoform of the prion protein accumulates in late‐endosome‐like organelles in scrapie‐infected mouse brain
1995
Eight prion strains have PrPSc molecules with different conformations
1998 Nobel
Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions
1995
Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice
1991 StandoutNobel
Search for a Putative Scrapie Genome in Purified Prion Fractions Reveals a Paucity of Nucleic Acids
1991
Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes
1993
Insoluble wild–type and protease–resistant mutant prion protein in brains of patients with inherited prion disease
1996 StandoutNobel
Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein 1 1Edited by A. R. Fersht
1999
Different scrapie-associated fibril proteins (PrP) are encoded by lines of sheep selected for different alleles of the Sip gene
1991
Prion Protein Biology
1998 Nobel
Molecular biology of prion diseases
1994
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
Chimeric prion protein expression in cultured cells and transgenic mice
1992 StandoutNobel
Prion (PrPSc)-specific epitope defined by a monoclonal antibody
1997 StandoutNatureNobel
A novel hamster prion protein mRNA contains an extra exon: increased expression in scrapie
1997
Transmissible Mink Encephalopathy Species Barrier Effect Between Ferret and Mink: PrP Gene and Protein Analysis
1994
Molecular biology and pathogenesis of prion diseases
1996
Mice devoid of PrP are resistant to scrapie
1993 Standout
Prion dementia without characteristic pathology
1990
GENETICS OF RESPONSE TO SLOW VIRUS (PRION) INFECTION
1990
Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice
1997 StandoutNobel
Transmissible spongiform encephalopathies: The threat of BSE to man
1990
Mutation and polymorphism of the prion protein gene in Libyan Jews with Creutzfeldt-Jakob disease (CJD).
1993 StandoutNobel
Are prions misfolded molecular chaperones?
1991
Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.
1994 StandoutNobel
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
1993 StandoutNobel
Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.
1995
Regional mapping of prion proteins in brain.
1992 StandoutNobel
Chemical chaperones interfere with the formation of scrapie prion protein.
1996 StandoutNobel
Viral particles are required for infection in neurodegenerative Creutzfeldt-Jakob disease.
1995
Scrapie prions selectively modify the stress response in neuroblastoma cells.
1995
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation
1997 StandoutNobel
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
1993 Standout
GENETICS OF PRIONS
1997 StandoutNobel
Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent
1992
Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity
1996 StandoutNobel
The future of cloning
1999 StandoutNatureNobel
Transmission of the BSE Agent to Mice in the Absence of Detectable Abnormal Prion Protein
1997 Science
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.
1996
Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform [published erratum appears in J Cell Biol 1995 Jul;130(2):501]
1995
Heterologous PrP molecules interfere with accumulation of protease-resistant PrP in scrapie-infected murine neuroblastoma cells
1994
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.
1995 StandoutNobel
Detection of Prion Protein in Formalin-Fixed Brain by Hydrated Autoclaving Immunohistochemistry for the Diagnosis of Scrapie in Sheep
1994
Prions and prion proteins 1
1991 StandoutNobel
Attempts to restore scrapie prion infectivity after exposure to protein denaturants.
1993
The Scrapie Agent: “A Virus by Any Other Name”
1991
Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity
1996 StandoutScienceNobel
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.
1991 StandoutNobel
Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation.
1990
A Transmembrane Form of the Prion Protein in Neurodegenerative Disease
1998 ScienceNobel
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Propagation of prion strains through specific conformers of the prion protein
1997 StandoutNobel
A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits.
1994
Brain Regional Distribution of Prion Protein PrP27-30 in Mice Stereotaxically Microinjected with Different Strains of Scrapie
1993
Assessment of Western Immunoblotting for the Confirmatory Diagnosis of Ovine Scrapie and Bovine Spongiform Encephalopathy (BSE)
1992
Prions
1998 StandoutNobel
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
1992 StandoutNobel
Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.
1990
Unusual Topogenic Sequence Directs Prion Protein Biogenesis
1990 StandoutScienceNobel
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform
1997 StandoutNobel
Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses.
1993
Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems
1992 StandoutNobel
Synthesis and trafficking of prion proteins in cultured cells.
1992 StandoutNobel
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
1996 StandoutNobel
High Prion and PrPSc Levels but Delayed Onset of Disease in Scrapie-Inoculated Mice Heterozygous for a Disrupted PrP Gene
1994
The prion's progress
1991 Nature
Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice.
1996
Evidence for synthesis of scrapie prion proteins in the endocytic pathway.
1992 StandoutNobel
Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform.
1993
A kinetic model for amyloid formation in the prion diseases: importance of seeding.
1993
Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy
1994
Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie.
1994 StandoutNobel
NMR structure of the bovine prion protein
2000 StandoutNobel
Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis
1991 StandoutNobel
The prion protein gene: a role in mouse embryogenesis?
1992
Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein.
1994 StandoutNobel
Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform
1997
Prion protein and the transmissible spongiform encephalopathies
1997
Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.
1992 StandoutNobel
Three hamster species with different scrapie incubation times and neuropathological features encode distinct prion proteins.
1990 StandoutNobel
Etiology and pathogenesis of prion diseases.
1995 StandoutNobel
The search for scrapie agent nucleic acid
1990
French autochthonous scrapied sheep without the 136Val PrP polymorphism
1993
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells.
1990 StandoutNobel
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.
1991
COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform
1997 StandoutNobel
Prion diseases of humans and animals
1996 StandoutNobel
Inherited prion diseases.
1994 StandoutNobel
Recombinant scrapie-like prion protein of 106 amino acids is soluble
1996 StandoutNobel
Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells.
1993 StandoutNobel
Prion liposomes
1990 StandoutNobel
Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein.
1994
Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity.
1993
Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred.
1992 StandoutNobel
Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans
1999 Nobel
Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein
1990 StandoutScienceNobel
Determinants of carboxyl-terminal domain translocation during prion protein biogenesis
1994 StandoutNobel
A new prion controls fungal cell fusion incompatibility
1997
Works of Dan Serban being referenced
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
1990 StandoutNobel
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques
1989 StandoutNobel
Identification of cellular proteins binding to the scrapie prion protein
1990 StandoutNobel
Rapid detection of Creutzfeldt‐Jakob disease and scrapie prion proteins
1990 StandoutNobel