Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
2010 StandoutNobel
Tissue expression of PD-L1 mediates peripheral T cell tolerance
2006
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies
2009 StandoutNobel
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
2013 StandoutNobel
Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity
2013 StandoutScience
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
2005 StandoutNobel
Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8 + T cells in NOD mice
2008 StandoutNobel
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 + T lymphocytes are prognostic factors of human ovarian cancer
2007 StandoutNobel
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
2017 StandoutNature
The kinetic-segregation model: TCR triggering and beyond
2006
Re-establishing immunological self-tolerance in autoimmune disease
2012 StandoutNobel
Generalized Resistance to Thymic Deletion in the NOD Mouse
2004
The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
2006
Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
2015 Standout
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
2009 StandoutNobel
The microbiota in adaptive immune homeostasis and disease
2016 StandoutNature
Treg and CTLA-4: Two intertwining pathways to immune tolerance
2013
Genetic susceptibility to type 1 diabetes
2005
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Co‐stimulatory pathways in lymphocyte regulation: the immunoglobulin superfamily
2005 StandoutNobel
Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation
2010
Intrinsic and extrinsic control of peripheral T‐cell tolerance by costimulatory molecules of the CD28/ B7 family
2011
Cell-autonomous and -non-autonomous roles of CTLA-4 in immune regulation
2011 StandoutNobel
Genetics, pathogenesis and clinical interventions in type 1 diabetes
2010 Nature
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
2006 StandoutNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
2011
Association ofCTLA4 polymorphism with regulatory T cell frequency
2005
Balancing co-stimulation and inhibition with BTLA and HVEM
2006
CTLA4 gene polymorphism and autoimmunity
2005
The Stages of Type 1A Diabetes
2005
Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells
2007
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling
2007
CTLA-4 suppresses the pathogenicity of self antigen–specific T cells by cell-intrinsic and cell-extrinsic mechanisms
2009
Negative regulators of T‐cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections
2009 StandoutNobel
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
Control of peripheral T‐cell tolerance and autoimmunity via the CTLA‐4 and PD‐1 pathways
2008
Checkpoint Blockade in Cancer Immunotherapy
2006 StandoutNobel
CD28 and CTLA‐4 coreceptor expression and signal transduction
2009
B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse
2004 StandoutNobel
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
2011 StandoutNobel
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
A MOLECULAR PERSPECTIVE OF CTLA-4 FUNCTION
2005
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo
2006
THE B7 FAMILY REVISITED
2005 Standout
Cell intrinsic mechanisms of T‐cell inhibition and application to cancer therapy
2008 StandoutNobel
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
2008 StandoutNobel
Tyrosine 201 of the cytoplasmic tail of CTLA ‐4 critically affects T regulatory cell suppressive function
2014
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
2008 StandoutNobel
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Hierarchical Regulation of CTLA-4 Dimer-Based Lattice Formation and Its Biological Relevance for T Cell Inactivation
2005
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Regulation of the Small GTPase Rap1 and Extracellular Signal-Regulated Kinases by the Costimulatory Molecule CTLA-4
2005
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice
2011
CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism
2006 StandoutNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2band dose-dependent requirement of H-2g7for diabetes in NOD mice
2008 StandoutNobel
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
2007 StandoutNobel
THE NOD MOUSE: A Model of Immune Dysregulation
2004
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function
2011
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
2008 StandoutNobel
Single dose of anti–CTLA-4 enhances CD8 + T-cell memory formation, function, and maintenance
2010 StandoutNobel
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
2007 StandoutNobel
Sex-Specific Effect of Insulin-Dependent Diabetes 4 on Regulation of Diabetes Pathogenesis in the Nonobese Diabetic Mouse
2005
B7-Independent Inhibition of T Cells by CTLA-4
2005
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
2009 StandoutScience
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Dan Rainbow being referenced
An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells
2004
An Autoimmune Disease‐Associated CTLA4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells
2005
Type 1 diabetes genes and pathways shared by humans and NOD mice
2005
Chapter 6 Gene–Gene Interactions in the NOD Mouse Model of Type 1 Diabetes
2008
Fine Mapping, Gene Content, Comparative Sequencing, and Expression Analyses SupportCtla4andNramp1as Candidates forIdd5.1andIdd5.2in the Nonobese Diabetic Mouse
2004