Citation Impact
Citing Papers
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
2003 Standout
Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia
2006
Autonomic Nerve Development Contributes to Prostate Cancer Progression
2013 StandoutScience
Inhibition of Growth and Metastasis of Human Pancreatic Cancer Growing in Nude Mice by PTK 787/ZK222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinases
2001
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
2002
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment
2002
Cell mechanics and the cytoskeleton
2010 StandoutNature
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
The Vascular Endothelial Growth Factor Receptor Kdr/Flk–1 Is A Major Regulator of Malignant Ascites Formation in the Mouse Hepatocellular Carcinoma Model
2001
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
2001 Standout
The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development
2006
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
2005 StandoutNobel
mTOR Signaling in Growth Control and Disease
2012 Standout
The hypoxic response of tumors is dependent on their microenvironment
2003
Blood vessels and nerves: common signals, pathways and diseases
2003
Common mechanisms of nerve and blood vessel wiring
2005 Nature
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling
2011
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
2005 Standout
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
2004 StandoutNature
Signaling by members of the TGF-β family in vascular morphogenesis and disease
2010
Animal models of chronic obstructive pulmonary disease
2008
Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells
2009
VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
2001
Imaging in the era of molecular oncology
2008 StandoutNature
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
2004 Standout
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Systems Biology of Vascular Endothelial Growth Factors
2008
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
VEGF162, A New Heparin-binding Vascular Endothelial Growth Factor Splice Form That Is Expressed in Transformed Human Cells
2003
Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis
2005
Soluble VEGF isoforms are essential for establishingepiphyseal vascularization and regulating chondrocyte development and survival
2004
The biology of VEGF and its receptors
2003 Standout
A New Weapon for Attacking Tumor Blood Vessels
2008 StandoutNobel
Angiopoietin 1 Promotes Tumor Angiogenesis and Tumor Vessel Plasticity of Human Cervical Cancer in Mice
2002
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Angiogenesis in health and disease
2003 Standout
Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration
2000
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells
2002 StandoutNobel
Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
2002
Lymphangiogenesis in development and human disease
2005 StandoutNature
VEGF receptor signalling ? in control of vascular function
2006 Standout
Recombinant adenovirus as a methodology for exploration of physiologic functions of growth factor pathways
2007
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis
2010 Nature
The Carboxyl-terminal Domain(111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency
1996
A mechanosensitive transcriptional mechanism that controls angiogenesis
2009 Nature
phospholipase C gamma-1is required downstream ofvascular endothelial growth factorduring arterial development
2003
Heparin Regulates Vascular Endothelial Growth Factor165-dependent Mitogenic Activity, Tube Formation, and Its Receptor Phosphorylation of Human Endothelial Cells
2005
Vascular endothelial growth factor and its receptors
1996
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Angiogenesis in life, disease and medicine
2005 StandoutNature
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
2002
VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis
2010
‘Accidental’ anti-angiogenic drugs
2000
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
2003
VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
2004 Standout
Molecular regulation of angiogenesis and lymphangiogenesis
2007 Standout
Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
1995 StandoutNature
Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders
2003
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
2014 StandoutNature
Sensory Nerves Determine the Pattern of Arterial Differentiation and Blood Vessel Branching in the Skin
2002
Cancer immunotherapy comes of age
2011 StandoutNature
Mechanisms of angiogenesis
1997 StandoutNature
VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix
1997
Significance of vascular endothelial growth factor (VEGF)/soluble VEGF receptor‐1 relationship in breast cancer
2001
The biology of vascular endothelial growth factors
2005
The Role of Neuropilin in Vascular and Tumor Biology
2002
Genetic dissection of tumor angiogenesis: are PlGF and VEGFR-1 novel anti-cancer targets?
2003
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
1996 StandoutNature
Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors
2008
Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
2000
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Pericytes regulate the blood–brain barrier
2010 StandoutNature
Effect of the vascular endothelial growth factor receptor‐2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice
2002
Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling
2003
Carboplatin selectively induces the VEGF stress response in endothelial cells: Potentiation of antitumor activity by combination treatment with antibody to VEGF
2004
Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
2004 Standout
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
1996 StandoutNature
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Ocular neovascularization: a valuable model system
2003
VEGF: an update on biological and therapeutic aspects
2000
Angiogenesis as a therapeutic target
2005 StandoutNature
Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors
2001
Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors
2015 StandoutNobel
What do oncogenic mutations have to do with angiogenesis/vascular dependence of tumors?
2002
Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer
2010
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Abnormal lymphatic vessel development in neuropilin 2 mutant mice
2002
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy
2012
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
2004 Standout
Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice
1997 StandoutScience
Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel.
2000
Arterial–Venous Specification During Development
2009
VEGF-Trap: A VEGF blocker with potent antitumor effects
2002
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.
1994
Regression of established tumors and metastases by potent vascular endothelial growth factor blockade
2003
The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
2005 Standout
Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias
2001
Molecular distinction between arteries and veins
2003
Elevated Flk1 (Vascular Endothelial Growth Factor Receptor 2) Signaling Mediates Enhanced Angiogenesis in β3-Integrin–Deficient Mice
2004
Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback
2005
A Vascular Endothelial Growth Factor Receptor-2 Inhibitor Enhances Antitumor Immunity through an Immune-Based Mechanism
2007
Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells
2009
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
2012 StandoutNobel
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
2005 StandoutScience
Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion.
2002
A monoclonal antibody to vascular endothelial–cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
2002
T cell exclusion, immune privilege, and the tumor microenvironment
2015 StandoutScience
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization.
1995
Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production.
2002
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
2009 StandoutScience
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.
2001
The splice variants of vascular endothelial growth factor (VEGF) and their receptors
2001
Vascular Remodeling Marks Tumors That Recur During Chronic Suppression of Angiogenesis
2004
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
2004 Standout
Soluble VEGF isoforms are essential for establishingepiphyseal vascularization and regulating chondrocyte development and survival
2004
Works of Dan Hicklin being referenced
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
2002
A Novel Antiapoptotic Role for α 1 -Antitrypsin in the Prevention of Pulmonary Emphysema
2006
Heparin modulates the interaction of VEGF165 with soluble and cell associated flk-1 receptors.
1994
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
2002
Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms
2002
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.
1999
70 Therapeutic human monoclonal antibody targeting VEGFR-1 suppresses growth of human breast cancers
2004