Citation Impact
Citing Papers
S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction
2015 Science
Oxidative Stress
2017 Standout
Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
2014 Science
PKA phosphorylation couples hepatic inositol-requiring enzyme 1α to glucagon signaling in glucose metabolism
2011
Reciprocal Regulation of DUSP9 and DUSP16 Expression by HIF1 Controls ERK and p38 MAP Kinase Activity and Mediates Chemotherapy-Induced Breast Cancer Stem Cell Enrichment
2018 StandoutNobel
Endoplasmic Reticulum Stress Regulates Hepatic Bile Acid Metabolism in Mice
2016
2019
Unfolded Protein Response Signaling and Metabolic Diseases
2013
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
The Unfolded Protein Response and Cell Fate Control
2017
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Abiotic Stress Signaling and Responses in Plants
2016 Standout
Regulation of cytoplasmic mRNA decay
2012
Regulation of microRNA function in animals
2018 Standout
Targeting hypoxia in cancer therapy
2011 Standout
A microRNA family exerts maternal control on sex determination in C. elegans
2017 StandoutNobel
mTOR Signaling in Growth Control and Disease
2012 Standout
Gene expression regulation mediated through reversible m6A RNA methylation
2014
Inflammatory links between obesity and metabolic disease
2011 Standout
Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis
2009
Autophagy and the Integrated Stress Response
2010 Standout
Regulation of microRNA biogenesis
2014 Standout
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
2015 Standout
Post-transcriptional gene regulation by mRNA modifications
2016 Standout
Endocrine aspects of organelle stress — cell non-autonomous signaling of mitochondria and the ER
2015
Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease
2011
IRE1 signaling exacerbates Alzheimer’s disease pathogenesis
2017
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment
2011
Hallmarks of aging: An expanding universe
2023 Standout
Differences in endoplasmic reticulum stress signalling kinetics determine cell survival outcome through activation of MKP-1
2010
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
2012 Standout
Signalling Pathways in the Unfolded Protein Response: Development from Yeast to Mammals
2009
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells
2015
Treatment of Obesity with Celastrol
2015 Standout
Role of MicroRNAs in the Regulation of Redox-Dependent Processes
2019
Modulating stress responses by the UPRosome: A matter of life and death
2011
Integrating single-cell transcriptomic data across different conditions, technologies, and species
2018 Standout
Type 2 diabetes as an inflammatory disease
2011 Standout
Mitochondria: In Sickness and in Health
2012 Standout
Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1
2010
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Nonmuscle Myosin IIB Links Cytoskeleton to IRE1α Signaling during ER Stress
2012
IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
2012
Endoplasmic Reticulum Stress, Pancreatic -Cell Degeneration, and Diabetes
2012
Metazoan MicroRNAs
2018 Standout
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells
2010
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
NOD1 and NOD2 signalling links ER stress with inflammation
2016 StandoutNature
Dynamics and functions of lipid droplets
2018 Standout
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
2017 Standout
Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association
2014
Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis
2017
BCL-2 family: integrating stress responses at the ER to control cell demise
2017
Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival
2017
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Endoplasmic reticulum stress and pancreatic β-cell death
2011
BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α
2012
Redox controls UPR to control redox
2014
The unfolded protein response signals through high-order assembly of Ire1
2008 Nature
The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells
2014
What We Talk About When We Talk About Fat
2014 Standout
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Diverse Endonucleolytic Cleavage Sites in the Mammalian Transcriptome Depend upon MicroRNAs, Drosha, and Additional Nucleases
2010
Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes
2017
Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage
2015
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
2011 Standout
The role of ER stress in lipid metabolism and lipotoxicity
2016
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
2009
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells
2010
Proteostasis control by the unfolded protein response
2015
ER stress-induced cell death mechanisms
2013 Standout
Divergent Effects of PERK and IRE1 Signaling on Cell Viability
2009
The Oscillating miRNA 959-964 Cluster Impacts Drosophila Feeding Time and Other Circadian Outputs
2012 StandoutNobel
Targeting ER stress induced apoptosis and inflammation in cancer
2010
Immunogenic cell death and DAMPs in cancer therapy
2012 Standout
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease
2014
Amyotrophic Lateral Sclerosis Pathogenesis: A Journey Through the Secretory Pathway
2010
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
2010
The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
2018
A Fibrosis‐Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis
2020 StandoutNobel
Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity
2015
The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes
2008
ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells
2013
Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis
2014
The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α
2011
Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation
2016
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
A functional link between the co-translational protein translocation pathway and the UPR
2015
Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress
2018
Immunometabolism governs dendritic cell and macrophage function
2015 Standout
A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1α Activation in Pancreatic β Cells
2010
MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP
2009
Endoplasmic Reticulum Stress in Immunity
2014
Metabolic control of cell death
2014 Science
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans
2015 StandoutNobel
A CHOP-regulated microRNA controls rhodopsin expression
2011
IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs
2018
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering
2010
The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis
2010
Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion
2011
Regulation of basal cellular physiology by the homeostatic unfolded protein response
2010
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Regulation of the Nrf2 antioxidant pathway by microRNAs: New players in micromanaging redox homeostasis
2013
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
2009
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs
2016
Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress
2011
Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing
2012
Managing the protein folding demands in the endoplasmic reticulum of plants
2016
Works of Dan Han being referenced
IRE1α Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2
2012 Science
IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
2009
A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress
2007
Caspase-2 Cleavage of BID Is a Critical Apoptotic Signal Downstream of Endoplasmic Reticulum Stress
2008