Citation Impact
Citing Papers
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Structural, Functional, and Spectroscopic Characterization of the Substrate Scope of the Novel Nitrating Cytochrome P450 TxtE
2014 StandoutNobel
Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics
2016
Targeted glycan degradation potentiates the anticancer immune response in vivo
2020 StandoutNobel
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
2007 StandoutNobel
Cyclopropylamine inactivation of cytochromes P450: Role of metabolic intermediate complexes
2005
Function of alternative splicing
2004
“Allosterism” in the Elementary Steps of the Cytochrome P450 Reaction Cycle
2004
Biotransformations using prokaryotic P450 monooxygenases
2002
Protein engineering of oxygenases for biocatalysis
2002 StandoutNobel
Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme
2017 StandoutNobel
Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo
2013 StandoutNobel
QM/MM Methods for Biomolecular Systems
2009 Standout
Methods for Predicting Human Drug Metabolism
2006
Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries
2009
Pharmacokinetics of metronomic chemotherapy: a neglected but crucial aspect
2016
Cytochrome P450: taming a wild type enzyme
2011 StandoutNobel
Human Cytochrome P450 Family 4 Enzymes: Function, Genetic Variation and Regulation
2007
Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models
2016 StandoutNobel
Profiling gene expression of whole cytochrome P450 superfamily in human bronchial and peripheral lung tissues: Differential expression in non-small cell lung cancers
2009
Carbon–heteroatom bond formation catalysed by organometallic complexes
2008 StandoutNature
Crystal Structure of the F87W/Y96F/V247L Mutant of Cytochrome P-450cam with 1,3,5-Trichlorobenzene Bound and Further Protein Engineering for the Oxidation of Pentachlorobenzene and Hexachlorobenzene
2002
Laboratory evolution of cytochrome P450 BM‐3 monooxygenase for organic cosolvents
2003 StandoutNobel
Biotransformation of the sesquiterpene (+)-valencene by cytochrome P450cam and P450BM-3
2004
Cutting-edge capillary electrophoresis characterization of monoclonal antibodies and related products
2016
Nasopharyngeal carcinoma
2019 Standout
Chemo-enzymatic fluorination of unactivated organic compounds
2008 StandoutNobel
CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity
2019 StandoutNobel
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
DrugBank: a knowledgebase for drugs, drug actions and drug targets
2007 Standout
A Self‐Sufficient Peroxide‐Driven Hydroxylation Biocatalyst
2003 StandoutNobel
Quantum chemical studies of methane monooxygenase: comparision with P450
2002
Decreased Susceptibility of the Cytochrome P450 2B6 Variant K262R to Inhibition by Several Clinically Important Drugs
2008
P450BM3(CYP102A1): connecting the dots
2011
Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3
2006
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction
2021 StandoutNobel
Enantioselective Epoxidation of Terminal Alkenes to (R)‐ and (S)‐Epoxides by Engineered Cytochromes P450 BM‐3
2005 StandoutNobel
Zirconium‐Metalloporphyrin PCN‐222: Mesoporous Metal–Organic Frameworks with Ultrahigh Stability as Biomimetic Catalysts
2012 Standout
Engineering and assaying of cytochrome P450 biocatalysts
2008
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
2011
Strategies and challenges for the next generation of antibody–drug conjugates
2017 Standout
Selectivity enhancement in functionalization of C–H bonds: A review
2010
The ChEMBL database in 2017
2016 Standout
THE USE OF DEUTERIUM ISOTOPE EFFECTS TO PROBE THE ACTIVE SITE PROPERTIES, MECHANISM OF CYTOCHROME P450-CATALYZED REACTIONS, AND MECHANISMS OF METABOLICALLY DEPENDENT TOXICITY
2003
Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac
2015
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran
2014 StandoutNobel
Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
2015 StandoutNobel
Purification and Mechanism of Human Aldehyde Oxidase Expressed in Escherichia coli
2009
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
Microbial P450 enzymes in biotechnology
2004
Cytochromes P450 as versatile biocatalysts
2006
Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects onin vitroandin vivodrug–drug interactions
2010
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
2008 Standout
High-valent iron in chemical and biological oxidations
2006
Beyond Directing Groups: Transition‐Metal‐Catalyzed CH Activation of Simple Arenes
2012 Standout
Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants
2005
Engineered Alkane‐Hydroxylating Cytochrome P450BM3 Exhibiting Nativelike Catalytic Properties
2007 StandoutNobel
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Engineering Cytochrome P450 Enzymes
2007
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
New Features in the Catalytic Cycle of Cytochrome P450 during the Formation of Compound I from Compound 0
2005
P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations
2009
C−H Activation for the Construction of C−B Bonds
2009 Standout
Mechanisms of Resistance to Antibody–Drug Conjugates
2016
Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs
2013
Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates
2016
Selective C–H oxidation catalyzed by metalloporphyrins
2011
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Novel developments and trends of analytical methods for drug analysis in biological and environmental samples by molecularly imprinted polymers
2017
Protein−Surfactant Film Voltammetry of Wild-Type and Mutant Cytochrome P450 BM3
2005 StandoutNobel
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
Pharmaceuticals of Emerging Concern in Aquatic Systems: Chemistry, Occurrence, Effects, and Removal Methods
2019 Standout
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Engineering cytochrome P450cam into an alkane hydroxylase
2003
The Mononuclear Molybdenum Enzymes
2014 Standout
Theoretical Perspective on the Structure and Mechanism of Cytochrome P450 Enzymes
2005
Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3
2003 StandoutNobel
Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications
2017 Standout
Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications
2007
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
CLINICAL AND TOXICOLOGICAL RELEVANCE OF CYP2C9: Drug-Drug Interactions and Pharmacogenetics
2005
A Versatile Tripodal Cu(I) Reagent for C–N Bond Construction via Nitrene-Transfer Chemistry: Catalytic Perspectives and Mechanistic Insights on C–H Aminations/Amidinations and Olefin Aziridinations
2014
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Evidence for Two Different Active Oxygen Species in Cytochrome P450 BM3 Mediated Sulfoxidation and N-Dealkylation Reactions
2002
Structure and Chemistry of Cytochrome P450
2005 Standout
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Dan A. Rock being referenced
SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm
2015
Inexpensive Purification of P450 Reductase and Other Proteins Using 2′,5′-Adenosine Diphosphate Agarose Affinity Columns
2001
A method for determining two substrates binding in the same active site of cytochrome P450BM3: an explanation of high energy ω product formation
2003
Evaluation of Near Infrared Fluorescent Labeling of Monoclonal Antibodies as a Tool for Tissue Distribution
2014
Small Molecule Quantification by Liquid Chromatography-Mass Spectrometry for Metabolites of Drugs and Drug Candidates
2011
Effects of Interleukin-6 (IL-6) and an Anti-IL-6 Monoclonal Antibody on Drug-Metabolizing Enzymes in Human Hepatocyte Culture
2011
The effects of type II binding on metabolic stability and binding affinity in cytochrome P450 CYP3A4
2010
Active Site Mutations of Cytochrome P450cam Alter the Binding, Coupling, and Oxidation of the Foreign Substrates (R)- and (S)-2-Ethylhexanol
2002
Use of Kinetic Isotope Effects to Delineate the Role of Phenylalanine 87 in P450BM-3
2002
“Target-Site” Drug Metabolism and Transport
2015
Enzyme Source Effects on CYP2C9 Kinetics and Inhibition
2006
CYP2C9 Genotype-Dependent Effects on in Vitro Drug-Drug Interactions: Switching of Benzbromarone Effect from Inhibition to Activation in the CYP2C9.3 Variant
2005
Characterization of Ritonavir-Mediated Inactivation of Cytochrome P450 3A4
2014
Selection of Alternative CYP3A4 Probe Substrates for Clinical Drug Interaction Studies Using In Vitro Data and In Vivo Simulation
2010
Predicting the Drug Interaction Potential of AMG 853, a Dual Antagonist of the D-Prostanoid and Chemoattractant Receptor-Homologous Molecule Expressed on T Helper 2 Cells Receptors
2012
Characterization of the Active Site Properties of CYP4F12
2014
AN ANALYSIS OF THE REGIOSELECTIVITY OF AROMATIC HYDROXYLATION AND N-OXYGENATION BY CYTOCHROME P450 ENZYMES
2004
A NEW CLASS OF CYP2C9 INHIBITORS: PROBING 2C9 SPECIFICITY WITH HIGH-AFFINITY BENZBROMARONE DERIVATIVES
2003
CYP2C9 Inhibition: Impact of Probe Selection and Pharmacogenetics on in Vitro Inhibition Profiles
2006
Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper
2015
Alternative Splicing Determines the Function of CYP4F3 by Switching Substrate Specificity
2001
Formation of the Active Species of Cytochrome P450 by Using Iodosylbenzene: A Case for Spin‐Selective Reactivity
2007
Intact mass analysis of monoclonal antibodies by capillary electrophoresis—Mass spectrometry
2015
Time-Dependent Inactivation of P450 3A4 by Raloxifene: Identification of Cys239 as the Site of Apoprotein Alkylation1
2007
Benign Synthesis of 2-Ethylhexanoic Acid by Cytochrome P450cam: Enzymatic, Crystallographic, and Theoretical Studies
2001
Absolute Quantification of Aldehyde Oxidase Protein in Human Liver Using Liquid Chromatography–Tandem Mass Spectrometry
2013
Kinetic Isotope Effects Implicate the Iron−Oxene as the Sole Oxidant in P450-Catalyzed N-Dealkylation
2004