Standout Papers

N6-methyladenosine-dependent regulation of messenger RNA stability 2013 2026 2017 2021 3.2k
  1. N6-methyladenosine-dependent regulation of messenger RNA stability (2013)
    Xiao Wang, Zhike Lu et al. Nature
  2. A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation (2013)
    Jianzhao Liu, Yanan Yue et al. Nature Chemical Biology
  3. N6-methyladenosine Modulates Messenger RNA Translation Efficiency (2015)
    Xiao Wang, Boxuan Zhao et al. Cell

Citation Impact

Citing Papers

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2015
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
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2017
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
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2017
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2018
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2014
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2017
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2017
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2019
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation
2017
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2016
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2019
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2015
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2017
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2018
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2016
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2016
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m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition
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2014
N6-methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells
2018
METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner
2019
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2017
The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
2016
Dynamics of Human and Viral RNA Methylation during Zika Virus Infection
2016
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2016
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2018
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2019
METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
2019
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2019
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2012
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2019
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
2017
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2017
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2017
m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program
2017
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Transcriptome-wide high-throughput deep m6A-seq reveals unique differential m6A methylation patterns between three organs in Arabidopsis thaliana
2015
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2018
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2019
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2014
N6-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding
2015
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2018
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2017
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2019
WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
2019
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2019
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2018
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response
2018
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2018
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2014
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2019
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2012
Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans
2011
Widespread occurrence ofN6-methyladenosine in bacterial mRNA
2015
Role of N6-methyladenosine modification in cancer
2017
HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g
2017
Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs
2017
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
2014
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
2018
An N-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells
2018
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells
2017
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d
2018
ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1
2019
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome
2015 Standout
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2015
mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis
2018 Nature
N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
2017
RNA m6A methylation regulates the ultraviolet-induced DNA damage response
2017 Nature
A common class of transcripts with 5′-intron depletion, distinct early coding sequence features, and N 1 -methyladenosine modification
2016
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
2020 Standout
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers
2019 Standout
Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy
2018 StandoutNobel
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
2018
Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer
2019
Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions
2021
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2019
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2019 Standout
5′ UTR m6A Promotes Cap-Independent Translation
2015 Standout
Dynamic m6A mRNA methylation directs translational control of heat shock response
2015 Nature
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2019
Dynamic m6A modification regulates local translation of mRNA in axons
2017
RNA N6-methyladenosine modification in cancers: current status and perspectives
2018
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
2017
N6-Methyladenosine Modification Controls Circular RNA Immunity
2019
Amazing Diversity in Biochemical Roles of Fe(II)/2-Oxoglutarate Oxygenases
2018
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
2017 Nature
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2016
A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation
2015
m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer
2020 Standout
Nucleotide modifications within bacterial messenger RNAs regulate their translation and are able to rewire the genetic code
2015
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
2019
The dynamic epitranscriptome: N6-methyladenosine and gene expression control
2014
Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor
2018
Reversible methylation of m6Am in the 5′ cap controls mRNA stability
2016 Nature
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
2017
The role of senescent cells in ageing
2014 StandoutNature
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β
2018
Geroscience: Linking Aging to Chronic Disease
2014 Standout
Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome
2015
Regulation of m6A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline
2017
2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process
2015
YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma
2018
The Hallmarks of Aging
2013 Standout
Reading, writing and erasing mRNA methylation
2019 Standout
Unique features of the m6A methylome in Arabidopsis thaliana
2014
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
2019
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma
2019
DART-seq: an antibody-free method for global m6A detection
2019
The epigenetics of aging and neurodegeneration
2015
RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis
2019
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
2017
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency
2018 Nature
tRNA base methylation identification and quantification via high-throughput sequencing
2016
Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome
2016
N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
2015
Probing RNA Modification Status at Single-Nucleotide Resolution in Total RNA
2015
Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
2016 Nature
m6A RNA methylation promotes XIST-mediated transcriptional repression
2016 Nature
Comprehensive Integration of Single-Cell Data
2019 Standout
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
2019
The Biogenesis and Precise Control of RNA m6A Methylation
2019
The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention
2017
Reading m6A in the Transcriptome: m6A-Binding Proteins
2017
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
2014
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
2017
METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition
2018
Transient N-6-Methyladenosine Transcriptome Sequencing Reveals a Regulatory Role of m6A in Splicing Efficiency
2018
Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells
2016
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density
2017
N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
2015 StandoutNature
N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein
2017
Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA
2014
m1A and m1G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs
2016
Human METTL16 is a N 6 ‐methyladenosine (m 6 A) methyltransferase that targets pre‐mRNAs and various non‐coding RNAs
2017
METTL3 promotes the proliferation and mobility of gastric cancer cells
2019
HAMR: high-throughput annotation of modified ribonucleotides
2013
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
2023 StandoutNobel
Identification of a selective DNA ligase for accurate recognition and ultrasensitive quantification of N6-methyladenosine in RNA at one-nucleotide resolution
2018
An Elongation‐ and Ligation‐Based qPCR Amplification Method for the Radiolabeling‐Free Detection of Locus‐Specific N6‐Methyladenosine Modification
2018
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication
2018
N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
2018
N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression
2016
Rethinking m6A Readers, Writers, and Erasers
2017
Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer
2017
Cell Biology of theCaenorhabditis elegansNucleus
2017
Detection ofN6-methyladenosine based on the methyl-sensitivity of MazF RNA endonuclease
2017
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
N 6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential
2018
The dynamics of FTO binding and demethylation from the m6A motifs
2019
Engineering of a DNA Polymerase for Direct m6A Sequencing
2017
The Epitranscriptome of Noncoding RNAs in Cancer
2017
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Oncogenic Role of an Epigenetic Reader of m6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma
2020
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
2019 Standout
Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain
2014
The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells
2017
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
2018
Long noncoding RNA GAS5-AS1 suppresses growth and metastasis of cervical cancer by increasing GAS5 stability.
2019
FTO regulates the chemo‐radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β‐catenin through mRNA demethylation
2018
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
The role of the fat mass and obesity‑associated protein in the proliferation of pancreatic cancer cells
2018
Spermidine in health and disease
2018 StandoutScience
Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K‐Akt signaling in gastric cancer
2019
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation
2019
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2
2017
Downregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N6-methyladenosine levels
2017
Emerging Roles of RNA Modification: m6A and U-Tail
2014
N6‐Methyladenosine‐Sensitive RNA‐Cleaving Deoxyribozymes
2018
Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression?
2017
ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2
2018
Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification
2015
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA
2022 StandoutNobel
m6ASNP: a tool for annotating genetic variants by m6A function
2018
m6A modulates neuronal functions and sex determination in Drosophila
2016 Nature
YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
2017
YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells
2017
RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2
2019
Xio is a component of the Drosophila sex determination pathway and RNA N 6 -methyladenosine methyltransferase complex
2018
METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N 6‐methyladenosine‐dependent primary MicroRNA processing
2016
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor Resistance
2019
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function
2018
Structural insights into the molecular mechanism of the m6A writer complex
2016
Precise Antibody-Independent m6A Identification via 4SedTTP-Involved and FTO-Assisted Strategy at Single-Nucleotide Resolution
2018
Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma
2018
Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs
2018
Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification
2015
Next‐Generation Sequencing‐Based RiboMethSeq Protocol for Analysis of tRNA 2′‐O‐Methylation
2017
The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline
2017
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Cross-talk among writers, readers, and erasers of m 6 A regulates cancer growth and progression
2018
Detecting RNA modifications in the epitranscriptome: predict and validate
2017

Works of Dali Han being referenced

N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
2020 Science
ALKBH1-Mediated tRNA Demethylation Regulates Translation
2016
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
2015 Standout
High‐Resolution N6‐Methyladenosine (m6A) Map Using Photo‐Crosslinking‐Assisted m6A Sequencing
2014
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
2013 Standout
Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells
2019 Nature
Nm-seq maps 2′-O-methylation sites in human mRNA with base precision
2017
N6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas
2015
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling
2017
N6-methyladenosine-dependent regulation of messenger RNA stability
2013 StandoutNature
The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA
2016 Nature
Evolution of Alu Elements toward Enhancers
2014
Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway
2011
High‐Resolution N6‐Methyladenosine (m6A) Map Using Photo‐Crosslinking‐Assisted m6A Sequencing
2014
Highly efficient base editing in Staphylococcus aureus using an engineered CRISPR RNA-guided cytidine deaminase
2018
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