Citation Impact
Citing Papers
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
2002 Standout
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
2004 Standout
Hematopoietic Prostaglandin D Synthase Suppresses Intestinal Adenomas in Apc Min/+ Mice
2007
Metastasis: from dissemination to organ-specific colonization
2009 Standout
Antitumor activity and mechanism of action of the novel marine natural products mycalamide-A and -B and onnamide.
1989
Biological Mechanism Profiling Using an Annotated Compound Library
2003
Phase I clinical study of didemnin B
1998
15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
1995 Standout
Ferroptosis: Death by Lipid Peroxidation
2015 Standout
Mechanism Targeted Discovery of Antitumor Marine Natural Products
2004
Marine-derived anticancer agents in clinical trials
2003
Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates
1996
Phase II Trial of Didemnin B in Previously Treated Non-Hodgkin’s Lymphoma
2000
Didemnin B in favourable histology non-Hodgkin's lymphoma
1995
A phase II study of Didemnin B (NSC 325319) in advanced malignant melanoma: an Eastern Cooperative Oncology Group study (PB687)
1998
Marine natural products
1990 Standout
Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads
2010
Drug development from marine natural products
2008 Standout
STRATEGIES FOR THE DISCOVERY OF SECONDARY METABOLITES FROM MARINE BACTERIA: Ecological Perspectives
1994
Clinical applications of quinone-containing alkylating agents
2000
Cytotoxicity and neurocytotoxicity of new marine anticancer agents evaluated using in vitro assays
1999
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
1997 Standout
The biology and pharmacology of PGD2
1988
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
The biochemistry and medical significance of the flavonoids
2002 Standout
Structure-activity relationships of VP-16 analogues
1994
Mitochondrial cytochrome c release is caspase-dependent and does not involve mitochondrial permeability transition in didemnin B-induced apoptosis
2001
Mechanism of Protein Synthesis Inhibition by Didemnin B in Vitro
1995
Brain Cell and Tissue Recovery in Rats Made Deficient in n-3 Fatty Acids by Alteration of Dietary Fat
1989 StandoutNobel
Chemical ecology of marine organisms: An overview
1986
Natural Product Hybrids as New Leads for Drug Discovery
2003 Standout
Phase II trial of Didemnin B in patients with advanced renal cell carcinoma
1990
Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells
1998 Standout
Interferons and viruses: an evolutionary arms race of molecular interactions
2015 StandoutNobel
Phase II clinical trial of didemnin B in previously treated small cell lung cancer
1994
Pharmaceutical development of anticancer agents derived from marine sources
2000
Eicosanoids and cancer
2010 Standout
Thymocyte apoptosis induced by p53-dependent and independent pathways
1993 StandoutNature
Inhibition of protein synthesis by didemnin B is not sufficient to induce apoptosis in human mammary carcinoma (MCF7) cells
1999
Didemnin B induces apoptosis in proliferating but not resting peripheral blood mononuclear cells
2002
Phase I clinical and pharmacokinetic investigation of didemnin B, a cyclic depsipeptide
1988
Selective Rearrangements of Quadruply Hydrogen‐Bonded Dimer Driven by Donor–Acceptor Interaction
2003
Modern Synthetic Methods for Fluorine‐Substituted Target Molecules
2004 Standout
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
1995 Standout
Immunotherapy of Diffuse Gliomas: Biological Background, Current Status and Future Developments
2009 Standout
Treatment of lethal pichinde virus infections in weanling LVG/Lak hamsters with ribavirin, ribamidine, selenazofurin, and ampligen
1993
ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome
2007 Standout
A phase i clinical trial of didemnin B
1991
Dynemicins, new antibiotics with the 1,5-diyn-3-ene and anthraquinone subunit. I. Productin, isolation and physico-chemical properties.
1991
Synthesis and Cytotoxicity of Novel Lignans
1995 StandoutNobel
Didemnins, tamandarins and related natural products
2012
Natural products as probes of cell biology: 20 years of didemnin research
2002
Plant cell cultures: Chemical factories of secondary metabolites
2002 Standout
Interleukin‐3 and Bcl‐2 cooperatively inhibit etoposide‐induced apoptosis in a murine pre‐B cell line
1994
Phase I/II clinical trial of didemnin B in non-small-cell lung cancer: neuromuscular toxicity is dose-limiting
1991
Diving for drugs: tunicate anticancer compounds
2012
Nmr in drug discovery
2002 StandoutNobel
Phase II clinical and pharmacological study of didemnin B in patients with metastatic breast cancer
1992
Breast cancer metastasis: markers and models
2005 Standout
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin
2013
Crystal and molecular structure of didemnin B, an antiviral and cytotoxic depsipeptide.
1988
Improved synthesis of 1,5-dinaphtho[38]crown-10
2009 StandoutNobel
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Supramolecular Polymerization
2009 Standout
Marine epibiosis. I. Fouling and antifouling: some basic aspects
1989 Standout
Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortui
2009 StandoutNobel
Prostaglandin D2, a potential antineoplastic agent
1982
Anti-cancer-prostaglandin-induced cell-cycle arrest and its modulation by an inhibitor of the ATP-dependent glutathione S-conjugate export pump (GS-X pump)
1998 StandoutNobel
Didemnolines A-D, new N9-substituted β-carbolines from the marine ascidian Didemnum sp.
1995
The dominant diseases of modernized societies as omega-3 essential fatty acid deficiency syndrome: Substrate beriberi
1982
Tamandarins A and B: New Cytotoxic Depsipeptides from a Brazilian Ascidian of the Family Didemnidae
1999
Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin
2005 Standout
Novel Inhibitors of Erm Methyltransferases from NMR and Parallel Synthesis
1999
GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha.
1994
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
2020 Standout
The synthesis and biological activity of enediyne minor groove binding hybrids
1995
Regulation of the immune response by prostaglandins
1980
A short way to prostacyclin
1983 StandoutNobel
Antiproliferative Bistramides from Trididemnum cyclops from Madagascar
2009
Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.
1991
New potent cytotoxic lamellarin alkaloids from Indian ascidian Didemnum obscurum
2005
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Regulation of cell proliferation and differentiation by interferons
1985
Prostaglandins in squamous cell carcinoma of the head and neck: A preliminary study
1985
Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues
2010
Synthesis, structural aspects and cytotoxicity of the natural cyclopeptides yunnanins A, C and phakellistatins 1, 10
2003
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
1992 Standout
Structure−Activity Relationships of the Didemnins
1996
Prostaglandin and thromboxane synthesis by human intracranial tumors.
1989
Bacterial Biosynthesis and Maturation of the Didemnin Anti-cancer Agents
2012
Regulation of the immune response by prostaglandins
1983
Prostacyclin: A Potent Antimetastatic Agent
1981 Science
Treatment of mice with polyinosinic-polycytidilic polyribonucleotide reduces T-cell involvement in a localized inflammatory response to vaccinia virus challenge
1985 StandoutNobel
Origin and Variation of Tunicate Secondary Metabolites
2012
The Effects of Dietary α-Linolenic Acid on the Composition of Nerve Membranes, Enzymatic Activity, Amplitude of Electrophysiological Parameters, Resistance to Poisons and Performance of Learning Tasks in Rats
1989 StandoutNobel
Synthetic studies of didemnins. II. Approaches to statine diastereomers
1987
Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro
1985 StandoutScience
Synthesis of prostaglandin D1 and D2 via the three-component coupling process
1984 StandoutNobel
Pharmacological Developments Obtained from Marine Natural Products and Current Pipeline Perspective
2011
Chemistry of Biologically Important Synthetic Organoselenium Compounds
2001 Standout
Distinct lung-colonizing and lung-metastasizing cell populations in B16 mouse melanoma
1981 Nature
Evaluation of interferon and interferon inducers as antiviral agents: Animal studies
1981
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Aplidine: A Paradigm of how to Handle the Activity and Toxicity of a Novel Marine Anticancer Poison
2007
Didemnin B
1986
Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro.
1983
Chemical Defense in Ascidians of the Didemnidae Family
2002
Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells
2006
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
1999 Standout
Rapamycin inhibits didemnin B‐induced apoptosis in human HL‐60 cells: Evidence for the possible involvement of FK506‐binding protein 25
1999
Role of Platelets in Tumor Cell Metastases
1981
The production of podophyllotoxin and its 5-methoxy derivative through bioconversion of cyclodextrin-complexed desoxypodophyllotoxin by plant cell cultures
1995
Organocatalytic α‐Addition of Isocyanides to Aldehydes
2014 StandoutNobel
Prostaglandins and Inflammation
2011 Standout
Prostaglandin A Compounds as Antiviral Agents
1980 Science
Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.
2003
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
2011 StandoutScience
Lamellarins and Related Pyrrole-Derived Alkaloids from Marine Organisms
2007 Standout
Recovery of Altered Fatty Acid Composition Induced by a Diet Devoid of n‐3 Fatty Acids in Myelin, Synaptosomes, Mitochondria, and Microsomes of Developing Rat Brain
1986 StandoutNobel
Mechanism of action of didemnin B, a depsipeptide from the sea
1984
Self-assembly of a new series of quadruply hydrogen bonded heterotrimers driven by the donor–acceptor interaction
2005
“From Large-Scale Collections to the Potential Use of Genomic Techniques for Supply of Drug Candidates”
2018
Methods for the synthesis of gem-difluoromethylene compounds
1996
Synthetic Studies of Tamandarin B Side Chain Analogues
2010
Aromatic and Azaaromatic Diselenides, Benzisoselenazolones and Related Compounds as Immunomodulators Active in Humans: Synthesis and Properties
1993
Synthesis of statine and its analogues by homogeneous asymmetric hydrogenation
1988 StandoutNobel
Chemical Implications for Antitumor and Antiviral Prostaglandins: Reaction of Δ7-Prostaglandin A1 and Prostaglandin A1 Methyl Esters with Thiols
1997 StandoutNobel
Works of Dale A. Stringfellow being referenced
Antiproliferative Action of Interferon on Murine LI210 Cells: Interrelationship with Prostaglandins
1983
Inhibitors of topoisomerase II: Structure-activity relationships and mechanism of action of podophyllin congeners
1988
The search for more active and less toxic mitomycin and etoposide analogs
1987
Hyporeactivity Due to Infection: Recognition of a Transferable Hyporeactive Factor in the Serum of Encephalomyocarditis Virus-Infected Mice
1974
Prostaglandin Restoration of the Interferon Response of Hyporeactive Animals
1978 Science
Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents
1985
Prostaglandin D2 controls pulmonary metastasis of malignant melanoma cells
1979 Nature
Experimental antitumor activity of BMY-28175 a new fermentation derived antitumor agent
1990
[38] Induction of interferon with low molecular weight compounds: Fluorenone esters, ethers (tilorone), and pyrimidinones
1981
Didemnins: Antiviral and Antitumor Depsipeptides from a Caribbean Tunicate
1981 Science
Comparation Interferon-Inducing and Antiviral Properties of 2-Amino-5-Bromo-6-Methyl-4-Pyrimidinol (U-25,166), Tilorone Hydrochloride, and Polyinosinic-Polycytidylic Acid
1977
Didemnins A and B. Effectiveness against cutaneous herpes simplex virus in mice
1983
5-Substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents
1980
Tilorone Hydrochloride: an Oral Interferon-Inducing Agent
1972