Dalai Yan

Protein interaction networks revealed by proteome coevolution

In different organisms, the mode of interaction between two signaling proteins is not necessarily conserved

Atomic-Level Characterization of the Structural Dynamics of Proteins

Origins of coevolution between residues distant in protein 3D structures

Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion

Simultaneous prediction of protein folding and docking at high resolution

Protein structure determination using metagenome sequence data

Assessing the utility of coevolution-based residue–residue contact predictions in a sequence- and structure-rich era

Protein–protein interactions mapped by artificial proteases: where σ factors bind to RNA polymerase

Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism

Metabolomics‐driven quantitative analysis of ammonia assimilation in E. coli

A pupal transcriptomic screen identifies Ral as a target of store-operated calcium entry in Drosophila neurons

Relative Unidirectional Translation in an Artificial Molecular Assembly Fueled by Light

Regulation of the Type I-F CRISPR-Cas system by CRP-cAMP and GalM controls spacer acquisition and interference

Reconciling the “old” and “new” views of protein allostery: A molecular simulation study of chemotaxis Y protein (CheY)

The Molecular Architecture of the Mammalian DNA Repair Enzyme, Polynucleotide Kinase

ATP Binding Modulates the Nucleic Acid Affinity of Hepatitis C Virus Helicase

Structure of the Constitutively Active Double Mutant CheYD13K Y106W Alone and in Complex with a FliM Peptide

A De Novo Protein Binding Pair By Computational Design and Directed Evolution

Quantifying Absolute Protein Synthesis Rates Reveals Principles Underlying Allocation of Cellular Resources

Influence of Metabolism on Epigenetics and Disease

Direct Evidence for the Modulation of the Activity of the Erwinia chrysanthemi Quorum-sensing Regulator ExpR by Acylhomoserine Lactone Pheromone

Signal integration by Ca2+ regulates intestinal stem-cell activity

Natural products: An evolving role in future drug discovery

TGFβ signalling in context

Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity

Structural and Functional Studies of the Response Regulator HupR

Activation and regulation of the inflammasomes

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution

Conformational Changes in Protein Loops and Helices Induced by Post-Translational Phosphorylation

Molecular Dynamics Simulation for All

Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor

The origin of protein interactions and allostery in colocalization

How sigma docks to RNA polymerase and what sigma does

Genetic analysis of response regulator activation in bacterial chemotaxis suggests an intermolecular mechanism

Polynucleotide Kinase as a Potential Target for Enhancing Cytotoxicity by Ionizing Radiation and Topoisomerase I Inhibitors

The transcription factor Eyes absent is a protein tyrosine phosphatase

Biofilms: an emergent form of bacterial life

P–O Bond Destabilization Accelerates Phosphoenzyme Hydrolysis of Sarcoplasmic Reticulum Ca2+-ATPase

The 1.9 Å Structure of a Proteasome-11S Activator Complex and Implications for Proteasome-PAN/PA700 Interactions

SNAREs — engines for membrane fusion

Bacterial flagellar motor

Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO

Newer antibacterial drugs for a new century

On the Dependency of Cellular Protein Levels on mRNA Abundance

Super-resolution biomolecular crystallography with low-resolution data

The complete sequence of the mucosal pathogen Ureaplasma urealyticum

The Structure of Fcp1, an Essential RNA Polymerase II CTD Phosphatase

Phase transitions in the assembly of multivalent signalling proteins

The primary transcriptome of the major human pathogen Helicobacter pylori

Improved protein structure prediction using potentials from deep learning

Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change

Making sense of it all: bacterial chemotaxis

A Brief History of the Antibiotic Era: Lessons Learned and Challenges for the Future

Allostery and cooperativity revisited

Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering

Protein Tyrosine Phosphatases in the Human Genome

Computation of Conformational Coupling in Allosteric Proteins

Adaptation in CRISPR-Cas Systems

Transient Non-native Hydrogen Bonds Promote Activation of a Signaling Protein

Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines

Metabolic co-dependence gives rise to collective oscillations within biofilms

Structure and function of the AAA+ nucleotide binding pocket

Antibacterial drug discovery in the resistance era

ATP Ground- and Transition States of Bacterial Enhancer Binding AAA+ ATPases Support Complex Formation with Their Target Protein, σ54

Homeostasis of Eye Growth and the Question of Myopia

The Biosynthetic Logic of Polyketide Diversity

The CtrA Response Regulator Essential for Caulobacter crescentus Cell-cycle Progression Requires a Bipartite Degradation Signal for Temporally Controlled Proteolysis

Direct-coupling analysis of residue coevolution captures native contacts across many protein families

Design and Synthesis of Nonequilibrium Systems

Experimental and Computational Assessment of Conditionally Essential Genes inEscherichia coli

Energetics and Dynamics of Enzymatic Reactions

Implications of Rewiring Bacterial Quorum Sensing

Structural basis of activity and allosteric control of diguanylate cyclase

EVOLUTIONARY RELATIONSHIPS AND STRUCTURAL MECHANISMS OF AAA+ PROTEINS

Occurrence, Classification, and Biological Function of Hydrogenases:  An Overview

An A257V Mutation in the Bacillus subtilis Response Regulator Spo0A Prevents Regulated Expression of Promoters with Low-Consensus Binding Sites

Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter

Accurate protein structure modeling using sparse NMR data and homologous structure information

Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

Evolutionary-scale prediction of atomic-level protein structure with a language model

A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation

Recent Developments in the Methods and Applications of the Bond Valence Model

CheZ-Mediated Dephosphorylation of the Escherichia coli Chemotaxis Response Regulator CheY: Role for CheY Glutamate 89

Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor

Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy

Crystal Structure of the Caenorhabditis elegans Apoptosome Reveals an Octameric Assembly of CED-4

Challenges of Antibacterial Discovery

Amplification of Signaling Events in Bacteria

Protein contact prediction using metagenome sequence data and residual neural networks

BeF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}\begin{equation*}{\mathrm{_{3}^{-}}}\end{equation*}\end{document} acts as a phosphate analog in proteins phosphorylated on aspartate: Structure of a BeF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}\begin{equation*}{\mathrm{_{3}^{-}}}\end{equation*}\end{document} complex with phosphoserine phosphatase

Need‐based activation of ammonium uptake in Escherichia coli

Crystal structure of an activated response regulator bound to its target.

Regulation of the transcriptional activator NtrC1: structural studies of the regulatory and AAA ⁺ ATPase domains

NMR structure of activated CheY

Crystal Structure of Activated CheY

Coordination of bacterial proteome with metabolism by cyclic AMP signalling

Beryllofluoride mimics phosphorylation of NtrC and other bacterial response regulators

Ammonia acquisition in enteric bacteria: Physiological role of the ammonium/methylammonium transport B (AmtB) protein

Protection of the glutamate pool concentration in enteric bacteria

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Studies of the Mode of Action in Staphylococcus aureus

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Microbiology Profiling Studies with Staphylococci and Streptococci

A dimeric two‐component receiver domain inhibits the σ54‐dependent ATPase in DctD

New Class of Competitive Inhibitor of Bacterial Histidine Kinases

Targeted Protein Footprinting:  Where Different Transcription Factors Bind to RNA Polymerase

High-Resolution Solution Structure of the Beryllofluoride-Activated NtrC Receiver Domain