Citation Impact
Citing Papers
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
2011
Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
2005 StandoutNobel
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
2005 StandoutScience
TOR Signaling in Growth and Metabolism
2006 Standout
Signal integration in the endoplasmic reticulum unfolded protein response
2007 Standout
eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory
2007
AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
2009 Science
Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED
2015 StandoutNobel
Schizophrenia risk from complex variation of complement component 4
2016 StandoutNature
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis
2002
ER chaperones in mammalian development and human diseases
2007
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Dipeptidyl peptidase IV inhibitors: A promising new therapeutic approach for the management of type 2 diabetes
2005
GLP‐1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells
2003
A Novel Domain in AMP-Activated Protein Kinase Causes Glycogen Storage Bodies Similar to Those Seen in Hereditary Cardiac Arrhythmias
2003
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
2006
Fatty acid metabolism as a target for obesity treatment
2005
mTOR Signaling in Growth Control and Disease
2012 Standout
Inflammation and metabolic disorders
2006 StandoutNature
Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
2004
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
2004 StandoutNature
Characterization of the Carboxyl-terminal Domain of the Rat Glucose-dependent Insulinotropic Polypeptide (GIP) Receptor
1999
Minireview: Glucagon-Like Peptides Regulate Cell Proliferation and Apoptosis in the Pancreas, Gut, and Central Nervous System
2004
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
2005 Standout
From acute ER stress to physiological roles of the Unfolded Protein Response
2006
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Central nervous system control of food intake and body weight
2006 StandoutNature
β-Cell Adaptation to Insulin Resistance
2002
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
2004 Nature
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
2004 StandoutNobel
Effects of GLP-1-(7–36)NH2, GLP-1-(7–37), and GLP-1- (9–36)NH2on Intravenous Glucose Tolerance and Glucose-Induced Insulin Secretion in Healthy Humans
2003
ER stress and diseases
2007
New sources of pancreatic β-cells
2005
Exendin‐4 differentiation of a human pancreatic duct cell line into endocrine cells: Involvement of PDX‐1 and HNF3β transcription factors
2002
Liver Adenosine Monophosphate-Activated Kinase-α2 Catalytic Subunit Is a Key Target for the Control of Hepatic Glucose Production by Adiponectin and Leptin But Not Insulin
2006
Hallmarks of aging: An expanding universe
2023 Standout
Glucose-Dependent Insulinotropic Polypeptide Confers Early Phase Insulin Release to Oral Glucose in Rats: Demonstration by a Receptor Antagonist1
2000
Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans
2004
Critical Role of cAMP-GEFII·Rim2 Complex in Incretin-potentiated Insulin Secretion
2001
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
2009 Standout
The biology of incretin hormones
2006 Standout
Structural basis for AMP binding to mammalian AMP-activated protein kinase
2007 Nature
In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
2004
The Glucagon‐Like Peptides
2006
Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1
1998
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
2008 StandoutNature
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
2010 StandoutNobel
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Metazoan MicroRNAs
2018 Standout
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
2007
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
2014 StandoutNature
Biology of Incretins: GLP-1 and GIP
2007 Standout
Determinants of the Impaired Secretion of Glucagon-Like Peptide-1 in Type 2 Diabetic Patients
2001
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Crucial role for LKB1 to AMPKα2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes☆
2008
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
Glucagon-like peptide 1(GLP-1) in biology and pathology
2005
Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA‐B and HLA‐A
2009
Effects of short-term chemical ablation of the GIP receptor on insulin secretion, islet morphology and glucose homeostasis in mice
2004
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
International Union of Pharmacology. XXXV. The Glucagon Receptor Family
2003
Activation of mTORC2 by Association with the Ribosome
2011
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors
2004
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
2010
PTEN Deletion and Concomitant c-Myc Activation Do Not Lead to Tumor Formation in Pancreatic β Cells
2008 StandoutNobel
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
2005
Endoplasmic reticulum stress and pancreatic β-cell death
2011
The Physiology of Glucagon-like Peptide 1
2007 Standout
Effects of the novel (Pro3)GIP antagonist and exendin(9–39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin
2003
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
2008 Standout
AKT/PKB Signaling: Navigating the Network
2017 Standout
The LKB1 tumor suppressor negatively regulates mTOR signaling
2004
The role of autophagy during the early neonatal starvation period
2004 StandoutNatureNobel
Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle
2004
Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes
2008
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Small Nucleolar RNAs U32a, U33, and U35a Are Critical Mediators of Metabolic Stress
2011
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells
2005
The major glucagon-like peptide-1 metabolite, GLP-1-(9–36)-amide, does not affect glucose or insulin levels in mice
2004
Incretins, insulin secretion and Type 2 diabetes mellitus
2004
AMPK: a nutrient and energy sensor that maintains energy homeostasis
2012 Standout
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Endoplasmic Reticulum Stress Signaling in Disease
2006
The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor
2007
GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress
2006
XBP‐1 is required for biogenesis of cellular secretory machinery of exocrine glands
2005
Adenosine Monophosphate-Activated Protein Kinase: A Central Regulator of Metabolism with Roles in Diabetes, Cancer, and Viral Infection
2011
The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity
2015
Persistent Improvement of Type 2 Diabetes in the Goto-Kakizaki Rat Model by Expansion of the β-Cell Mass During the Prediabetic Period With Glucagon-Like Peptide-1 or Exendin-4
2002
Nutrients Suppress Phosphatidylinositol 3-Kinase/Akt Signaling via Raptor-Dependent mTOR-Mediated Insulin Receptor Substrate 1 Phosphorylation
2005
Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver
2005
The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading
2004
β-Cell Pdx1 Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-Like Peptide-1
2005
Autocrine Tumor Necrosis Factor Alpha Links Endoplasmic Reticulum Stress to the Membrane Death Receptor Pathway through IRE1α-Mediated NF-κB Activation and Down-Regulation of TRAF2 Expression
2006
Defective Glucose-Dependent Insulinotropic Polypeptide Receptor Expression in Diabetic Fatty Zucker Rats
2001
Double Incretin Receptor Knockout (DIRKO) Mice Reveal an Essential Role for the Enteroinsular Axis in Transducing the Glucoregulatory Actions of DPP-IV Inhibitors
2004
Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo
2001 StandoutNobel
Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet
2002
The AMP-activated protein kinase cascade – a unifying system for energy control
2003
Increased Uncoupling Protein-2 Levels in β-cells Are Associated With Impaired Glucose-Stimulated Insulin Secretion
2001
Incretin hormones - an update
2001
Gastrin Stimulates β-Cell Neogenesis and Increases Islet Mass From Transdifferentiated but Not From Normal Exocrine Pancreas Tissue
2002
Regulation of basal cellular physiology by the homeostatic unfolded protein response
2010
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation
2004 StandoutNobel
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Chemical Ablation of Gastric Inhibitory Polypeptide Receptor Action by Daily (Pro3)GIP Administration Improves Glucose Tolerance and Ameliorates Insulin Resistance and Abnormalities of Islet Structure in Obesity-Related Diabetes
2005
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Cardiac Function in Mice Lacking the Glucagon-Like Peptide-1 Receptor
2003
Adapting Proteostasis for Disease Intervention
2008 StandoutScience
Mitochondrial Dysfunction and Type 2 Diabetes
2005 StandoutScience
Glucose-Dependent Insulinotropic Polypeptide Is a Growth Factor for β (INS-1) Cells by Pleiotropic Signaling
2001
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
Resveratrol stimulates AMP kinase activity in neurons
2007
Neuroendocrine Function and Response to Stress in Mice with Complete Disruption of Glucagon-Like Peptide-1 Receptor Signaling1
2000
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors
2004
The Glucagon-Like Peptides
1999
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1)
2006
Tolerogenic Dendritic Cells
2003 StandoutNobel
Development and Characterization of a Glucagon-Like Peptide 1-Albumin Conjugate
2003
Induced Adiposity and Adipocyte Hypertrophy in Mice Lacking the AMP-Activated Protein Kinase-α2 Subunit
2004
Glucagon-Like Peptides: Regulators of Cell Proliferation, Differentiation, and Apoptosis
2003
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
NFAT Regulates Insulin Gene Promoter Activity in Response to Synergistic Pathways Induced by Glucose and Glucagon-Like Peptide-1
2002
Glucagon-Like Peptide-1, But Not Glucose-Dependent Insulinotropic Peptide, Regulates Fasting Glycemia and Nonenteral Glucose Clearance in Mice*
2000
Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
2000
Oscillations of cyclic AMP in hormone-stimulated insulin-secreting β-cells
2006 Nature
Cross-Presentation, Dendritic Cells, Tolerance and Immunity
2001
Proglucagon-Derived Peptides: Mechanisms of Action and Therapeutic Potential
2005
Works of Daisy Flamez being referenced
Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice
2001
T1DBase: integration and presentation of complex data for type 1 diabetes research
2006
The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity
2003
Selective Inhibition of Eukaryotic Translation Initiation Factor 2α Dephosphorylation Potentiates Fatty Acid-induced Endoplasmic Reticulum Stress and Causes Pancreatic β-Cell Dysfunction and Apoptosis
2006
Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene1 1The authors thank Emmy De Blay and Luc Bouwens for generous assistance with islet immunohistochemistry.
2003
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
2005
Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1
2003
Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype.
1999
Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.
1998
Mitogenic effect of gastrin and expression of gastrin receptors in duct-like cells of rat pancreas
2001
Glucose-Regulated Gene Expression Maintaining the Glucose-Responsive State of β-Cells
2002
Critical Role for Cataplerosis via Citrate in Glucose-Regulated Insulin Release
2002
Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice.
1998
Disruption of the γ-Interferon Signaling Pathway at the Level of Signal Transducer and Activator of Transcription-1 Prevents Immune Destruction of β-cells
2005
Dual Glucagon Recognition by Pancreatic β-Cells via Glucagon and Glucagon-Like Peptide 1 Receptors
1998
The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity
2003
Expression and Functional Activity of Glucagon, Glucagon-Like Peptide I, and Glucose-Dependent Insulinotropic Peptide Receptors in Rat Pancreatic Islet Cells
1996