Citation Impact
Citing Papers
Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity
2011
Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
2011
On the mechanism of sensing unfolded protein in the endoplasmic reticulum
2005
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
2009 StandoutNobel
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response
2006
Signal integration in the endoplasmic reticulum unfolded protein response
2007 Standout
IRE-1 and HSP-4 Contribute to Energy Homeostasis via Fasting-Induced Lipases in C. elegans
2009
Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
2011 Standout
The Unfolded Protein Response and Cell Fate Control
2017
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Abiotic Stress Signaling and Responses in Plants
2016 Standout
mTOR Signaling in Growth Control and Disease
2012 Standout
Cotranslational Targeting of XBP1 Protein to the Membrane Promotes Cytoplasmic Splicing of Its Own mRNA
2009
Messenger RNA targeting to endoplasmic reticulum stress signalling sites
2008 Nature
AIP1 Is Critical in Transducing IRE1-mediated Endoplasmic Reticulum Stress Response
2008
From acute ER stress to physiological roles of the Unfolded Protein Response
2006
A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response
2017
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress
2015
Understanding the transcriptome through RNA structure
2011
Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing
2008
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
2006
Hallmarks of aging: An expanding universe
2023 Standout
Intermolecular hydroamination of oxygen-substituted allenes. New routes for the synthesis of N,O-chelated zirconium and titanium amido complexes
2011
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
2012 Standout
Treatment of Obesity with Celastrol
2015 Standout
Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes?
2014
Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat
2011 StandoutNobel
C. elegans Major Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles
2009 StandoutNobel
Modulating stress responses by the UPRosome: A matter of life and death
2011
Activation of the Unfolded Protein Response by Lipid Bilayer Stress
2017
Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms
2010
Nonmuscle Myosin IIB Links Cytoskeleton to IRE1α Signaling during ER Stress
2012
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
The endoplasmic reticulum stress response in immunity and autoimmunity
2008
Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells
2010
One step at a time: endoplasmic reticulum-associated degradation
2008
Endoplasmic Reticulum Stress and the Hallmarks of Cancer
2016
The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum
2019
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
ALG-2 Attenuates COPII Budding In Vitro and Stabilizes the Sec23/Sec31A Complex
2013 StandoutNobel
NOD1 and NOD2 signalling links ER stress with inflammation
2016 StandoutNature
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate
2018
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
Insights into RNA structure and function from genome-wide studies
2014 StandoutNobel
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response
2010
Endoribonucleases – enzymes gaining spotlight in mRNA metabolism
2009
Analysis of the XBP1 splicing mechanism using endoplasmic reticulum stress-indicators
2006
The unfolded protein response signals through high-order assembly of Ire1
2008 Nature
Ubiquitination of Inositol-requiring Enzyme 1 (IRE1) by the E3 Ligase CHIP Mediates the IRE1/TRAF2/JNK Pathway
2014
What We Talk About When We Talk About Fat
2014 Standout
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism
2010
XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease
2008 Standout
The structure of the PERK kinase domain suggests the mechanism for its activation
2011
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
COPII and the regulation of protein sorting in mammals
2011 StandoutNobel
Molecular Chaperones and Protein Quality Control
2006
Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes
2019
Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death
2017
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
2009
Proteostasis control by the unfolded protein response
2015
ER stress-induced cell death mechanisms
2013 Standout
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Divergent Effects of PERK and IRE1 Signaling on Cell Viability
2009
Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress‐Induced Endothelial Dysfunction
2018
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease
2014
ERADicate ER Stress or Die Trying
2007
Amyotrophic Lateral Sclerosis Pathogenesis: A Journey Through the Secretory Pathway
2010
Transmembrane bZIP Transcription Factors in ER Stress Signaling and the Unfolded Protein Response
2007
How Transmembrane Proteins Sense Endoplasmic Reticulum Stress
2007
The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1
2018
Coping with Protein Quality Control Failure
2017
A Fibrosis‐Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis
2020 StandoutNobel
3d Transition Metals for C–H Activation
2018 Standout
Autonomous translational pausing is required for XBP1u mRNA recruitment to the ER via the SRP pathway
2016
Heat induces the splicing by IRE1 of a mRNA encoding a transcription factor involved in the unfolded protein response in Arabidopsis
2011
Intracellular Signaling by the Unfolded Protein Response
2006
The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α
2011
Soft template induced phase selective synthesis of Fe2O3nanomagnets: one step towards peroxidase-mimic activity allowing colorimetric sensing of thioglycolic acid
2016
BiP Availability Distinguishes States of Homeostasis and Stress in the Endoplasmic Reticulum of Living Cells
2010
Dynamic changes in complexes of IRE1α, PERK, and ATF6α during endoplasmic reticulum stress
2018
Intrinsic Capacities of Molecular Sensors of the Unfolded Protein Response to Sense Alternate Forms of Endoplasmic Reticulum Stress
2006
Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response
2011 Science
Endoplasmic Reticulum Stress in Immunity
2014
Structural and mutational analysis of the ribosome-arresting human XBP1u
2019
Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR
2019
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering
2010
Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase
2011
Regulation of basal cellular physiology by the homeostatic unfolded protein response
2010
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis
2015
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles
2013
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)
2018 Standout
Formaldehyde in the Indoor Environment
2010 Standout
Adapting Proteostasis for Disease Intervention
2008 StandoutScience
Quantitative microscopy reveals dynamics and fate of clustered IRE1α
2019
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
2013 StandoutNobel
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
2009
Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling
2015
An unfolded protein-induced conformational switch activates mammalian IRE1
2017
Manganese Coordination Micelles That Activate Stimulator of Interferon Genes and Capture In Situ Tumor Antigens for Cancer Metalloimmunotherapy
2022
F-actin and a Type-II Myosin Are Required for Efficient Clustering of the ER Stress Sensor Ire1
2013
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
2013
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
Gold-catalyzed intramolecular hydroamination of α-amino allenamides as a route to enantiopure 2-vinylimidazolidinones
2009
Gold-Catalyzed Carbon−Heteroatom Bond-Forming Reactions
2011 Standout
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
2011
Role of Disulfide Bridges Formed in the Luminal Domain of ATF6 in Sensing Endoplasmic Reticulum Stress
2006
Photothermal Nanomaterials: A Powerful Light-to-Heat Converter
2023 Standout
A Passive Sampler for the Determination of Carbonyl Compounds in Indoor Air Employing O-(4-cyano-2-ethoxybenzyl)hydroxylamine as Reactive Adsorbent
2007
Gold(I)-Catalyzed Cyclization of β-Allenylhydrazones: An Efficient Synthesis of MultisubstitutedN-Aminopyrroles
2010
Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity
2015 Standout
Managing the protein folding demands in the endoplasmic reticulum of plants
2016
Works of Daisuke Oikawa being referenced
Direct Association of Unfolded Proteins with Mammalian ER Stress Sensor, IRE1β
2012
Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
2018
Experimental Approaches for Elucidation of Stress-Sensing Mechanisms of the IRE1 Family Proteins
2011
Identification of a consensus element recognized and cleaved by IRE1α
2010
Positive contribution of the IRE1α–XBP1 pathway to placental expression of CEA family genes
2010
Site-specific cleavage of CD59 mRNA by endoplasmic reticulum-localized ribonuclease, IRE1
2007
Copper-catalyzed intramolecular hydroamination of allenylamines to 3-pyrrolines or 2-alkenylpyrrolidines
2008
A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1
2004
Membrane lipid saturation activates IRE 1α without inducing clustering
2013
Synthesis of N-substituted 2-arylpyrroles by the reaction of (η2-imine)titanium complexes with 3,3-diethoxypropyne
2006
Measurement of Concentrations of Thioglycolic Acid, Dithiodiglycolic Acid and Ammonia in Indoor Air of a Beauty Salon
2012
Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing
2012
Evaluation of Passive Sampler for Measurement of Glutaraldehyde in Occupational Indoor Air
2005
Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins
2007
Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1
2007
An essential dimer-forming subregion of the endoplasmic reticulum stress sensor Ire1
2005
Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins
2009