Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
Low Surface Expression of B7-1 (CD80) Is an Immunoescape Mechanism of Colon Carcinoma
2006
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 + T lymphocytes are prognostic factors of human ovarian cancer
2007 StandoutNobel
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology
2006
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
1994
Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule
1995
Regulatory T Cells
2000 StandoutNobel
Enhanced Expression of CD80 (B7-1), CD86 (B7-2), and CD40 and Their Ligands CD28 and CD154 in Fulminant Hepatic Failure
1999
A negative regulatory function of B7 revealed in B7-1 transgenic mice
1994
Long-term inhibition of murine experimental autoimmune encephalomyelitis using CTLA-4-Fc supports a key role for CD28 costimulation.
1995
CD28-B7 interactions in T-cell activation
1994 StandoutNobel
Absence of B7-dependent responses in CD28-deficient mice
1994
Enhanced expression of B7-1, B7-2, and intercellular adhesion molecule 1 in sinusoidal endothelial cells by warm ischemia/reperfusion injury in rat liver
2001 StandoutNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Electrical manipulation of glycan-phosphatidyl inositol-tethered proteins in planar supported bilayers
1996
PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
2016 Standout
T Cell–Mediated Elimination of B7.2 Transgenic B Cells
1997 StandoutNobel
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
1999 Standout
Taking dendritic cells into medicine
2007 StandoutNatureNobel
CTLA-4 can function as a negative regulator of T cell activation
1994 Standout
Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells
1997
Restoring function in exhausted CD8 T cells during chronic viral infection
2005 StandoutNatureNobel
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
1995 Standout
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance
1994
Treatment of Murine Lupus with CTLA4Ig
1994 Science
Immunoglobulin fold characteristics of B7–1 (CD80) and B7–2 (CD86)
1994
The Role of CTLA‐4 in the Regulation and Initiation of T‐Cell Responses
1996 StandoutNobel
Both Extracellular Immunoglobin-like Domains of CD80 Contain Residues Critical for Binding T Cell Surface Receptors CTLA-4 and CD28
1995
The role of CD40 and CD80 accessory cell molecules in dendritic cell-dependent HIV-1 infection
1994
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors
1994
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Immunotherapy for pancreatic cancer — science driving clinical progress
2005
The Role of CD28 Costimulation in the Generation of Cytotoxic T Lymphocytes
1995
The Complexities of T‐Cell Co‐stimulation: CD28 and Beyond
1996
Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity
1995
The B7 and CD28 receptor families
1994
The B7–CD28 superfamily
2002
New perspectives of C1328-137-mediated T cell costimulation
1995
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo
1996 StandoutNobel
Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells
2004 StandoutNobel
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
1997 StandoutNobel
The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3′-Kinase
1994
The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.
1994
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
2009 Standout
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific
2000
Dendritic cells with TGF-β1 differentiate naïve CD4+CD25−T cells into islet-protective Foxp3+regulatory T cells
2007 StandoutNobel
Extending the B7 (CD80) gene family
1994
CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
1998 StandoutNobel
CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics
1997
B7x: A widely expressed B7 family member that inhibits T cell activation
2003 StandoutNobel
Manipulation of costimulatory signals to enhance antitumor T-cell responses
1995 StandoutNobel
Integrated NY-ESO-1 antibody and CD8+T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
2011 StandoutNobel
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
1995 StandoutNobel
The B7 Family and Cancer Therapy: Costimulation and Coinhibition
2007 StandoutNobel
CD28/B7 SYSTEM OF T CELL COSTIMULATION
1996 Standout
CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line.
1994
Blockade of CTLA-4 Signals Inhibits Th2-Mediated Murine Chronic Graft-Versus-Host Disease by an Enhanced Expansion of Regulatory CD8+ T Cells
2000
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
2018 StandoutNobel
The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
2008 StandoutNobel
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
2008 StandoutNobel
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
2003 StandoutNobel
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4.
1995
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
2007 StandoutNobel
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
1995
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
2008 StandoutNobel
B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells
2001
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.
1995
Distinct roles for CD28 and cytotoxic T lymphocyte-associated molecule-4 receptors during T cell activation?
1995
Suppressing Brownian motion of individual biomolecules in solution
2006 StandoutNobel
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells.
1994
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.
1994
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
1999 StandoutNobel
Works of Daisuke Ito being referenced
Chronic exposure of transforming growth factor beta 1 confers a more aggressive tumor phenotype through downregulation of p21WAF1/CIP1 in conditionally immortalized pancreatic epithelial cells
2004
B70 antigen is a second ligand for CTLA-4 and CD28
1993 Nature
CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL.
1995