Citation Impact
Citing Papers
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Distinct prion proteins in short and long scrapie incubation period mice
1987 StandoutNobel
Nucleic acids in prion preparations: unspecific background or essential component?
1994
Molecular biology and genetics of prion diseases
1994 StandoutNobel
Scrapie prion liposomes and rods exhibit target sizes of 55,000 Da
1988 StandoutNobel
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Chemistry and biology of prions
1992
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing
1993
Prions and Neurodegenerative Diseases
1987 StandoutNobel
Glycosylinositol Phospholipid Anchors of the Scrapie and Cellular Prion Proteins Contain Sialic Acid
1992 StandoutNobel
A 60-kDa Prion Protein (PrP) with Properties of Both the Normal and Scrapie-associated Forms of PrP
1995
Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C
1990
Scrapie prions: a three-dimensional model of an infectious fragment
1996
A 'unified theory' of prion propagation
1991 Nature
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
1989 StandoutNatureNobel
Recombinant full‐length murine prion protein, mPrP(23–231): purification and spectroscopic characterization
1997 StandoutNobel
Prion Protein Isoforms, a Convergence of Biological and Structural Investigations
1995 StandoutNobel
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Genetic and Infectious Prion Diseases
1993
Molecular biology of transmissible spongiform encephalopathies
1996
Scrapie prion protein contains a phosphatidylinositol glycolipid
1987
Human prion diseases
1994 StandoutNobel
NMR characterization of the full‐length recombinant murine prion protein, mPrP(23–231)
1997 StandoutNobel
Human prion proteins expressed in Escherichia coli and purified by high‐affinity column refolding
1997 StandoutNobel
Transmissible and non-transmissible amyloidoses: autocatalytic post-translational conversion of host precursor proteins to β-pleated sheet configurations
1988 Nobel
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform 1 1Edited by M. Yaniv
1997 StandoutNobel
Analysis of linkage between scrapie incubation period and the prion protein gene in mice
1990
Search for a Scrapie‐Specific Nucleic Acid: A Progress Report
2007 Nobel
Search for a Putative Scrapie Genome in Purified Prion Fractions Reveals a Paucity of Nucleic Acids
1991
Purification and properties of the cellular and scrapie hamster prion proteins
1988
Prion Protein Biology
1998 Nobel
Molecular biology of prion diseases
1994
Deadly Conformations—Protein Misfolding in Prion Disease
1997
Prion (PrPSc)-specific epitope defined by a monoclonal antibody
1997 StandoutNatureNobel
A novel hamster prion protein mRNA contains an extra exon: increased expression in scrapie
1997
Molecular biology and pathogenesis of prion diseases
1996
Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein
1990 StandoutNatureNobel
Scrapie prions aggregate to form amyloid-like birefringent rods
1983 StandoutNobel
NMR structures of three single-residue variants of the human prion protein
2000 StandoutNobel
Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein.
1996 StandoutNobel
Replication of the Factor in Scrapie Material That Causes a Decrease in Polymorphonuclear Neutrophils
1973
Nature of the Scrapie Agent
1967 Nature
Aggregations of 35-Nanometer Particles Associated with Neuronal Cytopathic Changes in Natural Scrapie
1971 Science
Sedimentation properties of the scrapie agent.
1977
No Mouse PMN Leukocyte Depression after Inoculation with Brain Tissue from Multiple Sclerosis or Spongiform Encephalopathies
1974 StandoutNatureNobel
Properties of scrapie prion protein liposomes.
1988 StandoutNobel
Linkage of prion protein and scrapie incubation time genes
1986 StandoutNobel
Involvement of protein in scrapie agent infectivity
1983
Prion protein PrPc interacts with molecular chaperones of the Hsp60 family
1996
Analyses of frequency of infection, specific infectivity, and prion protein biosynthesis in scrapie-infected neuroblastoma cell clones
1988
Scrapie : A modified membrane hypothesis
1968
Search for Infectious Etiology in Chronic and Subacute Degenerative Diseases of the Central Nervous System
1967
Prion protein NMR structure and familial human spongiform encephalopathies
1998 StandoutNobel
Molecular characteristics of the major scrapie prion protein
1984 StandoutNobel
Sheep disease in human clothing
1989 Nature
Molecular Characteristics of Prion Rods Purified from Scrapie-Infected Hamster Brains
1986 StandoutNobel
Transmission experiments with multiple sclerosis: an interim report.
1966
Precautions in Medical Care of, and in Handling Materials from, Patients with Transmissible Virus Dementia (Creutzfeldt-Jakob Disease)
1977 Nobel
Unusual resistance to ionizing radiation of the viruses of kuru, Creutzfeldt-Jakob disease, and scrapie.
1978 Nobel
Purification and structural studies of a major scrapie prion protein
1984 StandoutNobel
Evidence for an essential DNA component in the Scrapie agent
1978 Nature
Evidence for the low molecular weight nature of scrapie agent
1979 Nature
Viroids and prions.
1982
Toward Development of Assays for Scrapie-Specific Antibodies
1981 StandoutNobel
Biohazards of Investigations on the Transmissible Spongiform Encephalopathies
1980 StandoutNobel
Ruthenium red and lanthanum nitrate a possible tracer and negative stain for scrapie ?particles??
1974
Characterization of nucleic acids in membrane vesicles from scrapie-infected hamster brain
1985
Prions are novel infectious pathogens causing scrapie and creutzfeldt—Jakob disease
1986 StandoutNobel
Viremia in Experimental Creutzfeldt-Jakob Disease
1978 Science
Properties of the scrapie agent-endomembrane complex from hamster brain
1976
Developmental expression of prion protein gene in brain
1987 StandoutNobel
Inoculation of Voles, Chinese Hamsters, Gerbils and Guinea-pigs with Scrapie Brain Material
1972
Disruption of prion rods generates 10-nm spherical particles having high alpha-helical content and lacking scrapie infectivity
1996 StandoutNobel
Characteristics of a Short Incubation Model of Scrapie in the Golden Hamster
1977
Primary structure of prion protein may modify scrapie isolate properties.
1989 StandoutNobel
Partial purification and evidence for multiple molecular forms of the scrapie agent
1978 StandoutNobel
Characterization of Scrapie Infection in Mouse Neuroblastoma Cells
1987
Attempts to release the scrapie agent from tissue debris
1967
Prions and prion proteins 1
1991 StandoutNobel
Scrapie in Immunologically Deficient Mice
1971 Nature
Normal and scrapie-associated forms of prion protein differ in their sensitivities to phospholipase and proteases in intact neuroblastoma cells
1990
Orientated tubules in axoplasm of cerebellar myelinated nerve fibres in the rat
1967
Susceptibility of Scrapie Agent to Ionizing Radiation
1969 Nature
An experimental examination of the scrapie agent in cell membrane mixtures
1971
Novel Proteinaceous Infectious Particles Cause Scrapie
1982 StandoutScienceNobel
DNA Synthesis in Scrapie-Affected Mouse Brain
1967
Nature of the Scrapie Agent: Self-replication and Scrapie
1967 Nature
Identification of a Protein That Purifies with the Scrapie Prion
1982 StandoutScienceNobel
Course of Experimental Scrapie Virus Infection in the Goat
1974
Structure and conformation of low molecular weight pathogenic RNA from exocortis disease
1973
Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity
1996 StandoutScienceNobel
An experimental examination of the scrapie agent in cell membrane mixtures
1971
An electron-microscopic study of scrapie in the rat: Further observations on “inclusion bodies” and virus-like particles
1972
RESISTANCE OF THE SCRAPIE AGENT TO INACTIVATION BY PSORALENS
1983
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Prion protein biosynthesis in scrapie-infected and uninfected neuroblastoma cells
1989
Unconventional Viruses and the Origin and Disappearance of Kuru
1977 ScienceNobel
An electron microscopic study of natural scrapie sheep brain: Further observations on virus-like particles and paramyxovirus-like tubules
1974
Prions
1998 StandoutNobel
Reversible Chemical Modification of the Scrapie Agent
1981 StandoutScienceNobel
NMR solution structure of the human prion protein
2000 StandoutNobel
Scrapie: A Prototype Slow Infection
1972
Biology and Structure of Scrapie Prions
1986 StandoutNobel
Genetical control of the concentration of ME7 scrapie agent in the brain of mice
1969
Gel electrophoresis and glass permeation chromatography of the hamster scrapie agent after enzymatic digestion and detergent extraction
1980 StandoutNobel
Unusual Topogenic Sequence Directs Prion Protein Biogenesis
1990 StandoutScienceNobel
Purified scrapie prions resist inactivation by UV irradiation
1987
Detection of the Scrapie Agent in Tissues of Normal Mice with Special Reference to the Possibility of Accidental Laboratory Contamination
1971
Thiocyanate and hydroxyl ions inactivate the scrapie agent.
1981 StandoutNobel
Further purification and characterization of scrapie prions
1982 StandoutNobel
Scrapie infectious agent is virus-like in size and susceptibility to inactivation
1984 Nature
Scrapie and Creutzfeldt-Jakob disease prion proteins share physical properties and antigenic determinants.
1985 StandoutNobel
Is the scrapie agent a virus?
1976 Nature
Inability to Transmit Scrapie by Transfection of Mouse Embryo Cells in vitro
1982
Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy
1994
THE INFECTIVE PROCESS IN SCRAPIE
1968
NMR structure of the bovine prion protein
2000 StandoutNobel
A cellular gene encodes scrapie PrP 27-30 protein
1985 StandoutNobel
Experimental Scrapie in the Mouse: Electrophoretic and Sedimentation Properties of the Partially Purified Agent
1980 StandoutNobel
A comparison of the biochemical changes induced in mouse brain by cuprizone toxicity and by scrapie infection
1974
Further studies of the infectivity and stability of extracts and homogenates derived from scrapie affected mouse brains
1969
Failure to demonstrate a Relationship between Scrapie and Production of Interferon in Mice
1968 Nature
Prions: Novel Infectious Pathogens
1984 StandoutNobel
Transmission of Scrapie in Hamsters
1985 StandoutNobel
Scrapie agent contains a hydrophobic protein.
1981
Conservation of infectivity in purified fibrillary extracts of scrapie-infected hamster brain after sequential enzymatic digestion or polyacrylamide gel electrophoresis.
1990 Nobel
Cloning of a Gene Whose Expression Is Increased in Scrapie and in Senile Plaques in Human Brain
1985 Science
Identification of prion amyloid filaments in scrapie-infected brain
1985
Physical and Chemical Properties of the Transmissible Mink Encephalopathy Agent
1969
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
1986 StandoutNobel
The search for scrapie agent nucleic acid
1990
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells.
1990 StandoutNobel
In vitro Replication of Scrapie Agent in a Neuronal Model: Infection of PC12 Cells
1984
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.
1991
Is the Scrapie Agent a Viroid?
1972
Evidence suggesting that PrP is not the infectious agent in Creutzfeldt-Jakob disease.
1987
Infection of a cell line of mouse L fibroblasts with scrapie agent
1976 Nature
Host-genotype and agent effects in scrapie incubation: Change in allelic interaction with different strains of agent
1971
STUDIES ON DNA FROM NORMAL AND SCRAPIE‐AFFECTED MOUSE BRAIN
1972
Prion liposomes
1990 StandoutNobel
Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein.
1994
Antibodies to a scrapie prion protein
1984 StandoutNatureNobel
Purified prion proteins and scrapie infectivity copartition into liposomes.
1987 StandoutNobel
Purified scrapie prions resist inactivation by procedures that hydrolyze, modify, or shear nucleic acids
1987 StandoutNobel
Pathogenesis of mouse scrapie: Dynamics of agent replication in spleen, spinal cord and brain after infection by different routes
1979
Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein
1990 StandoutScienceNobel
Experimental Subacute Spongiform Virus Encephalopathies in Primates and Other Laboratory Animals
1973 StandoutScienceNobel
Works of D.A. Haig being referenced
The exceptionally small size of the scrapie agent
1966
The effect of homogenisation on the level of scrapie activity detected in cells from spleens of scrapie affected mice
1976
Inactivation of the Scrapie Agent by Near Monochromatic Ultraviolet Light
1970 Nature
Brain Cell Cultures from Mice Affected with Scrapie or Fed with Cuprizone
1971
Attempts to demonstrate neutralising antibodies in the sera of scrapie-affected animals
1966
Multiplication of Scrapie Agent in Cell Culture
1970
Further Studies on the Inactivation of the Scrapie Agent by Ultraviolet Light
1969
Protection by Anoxia of the Scrapie Agent and some DNA and RNA Viruses Irradiated as Dry Preparations
1968
The Effect of beta-Propiolactone on the Scrapie Agent
1968
Presence of the transmissible agent of scrapie in the serum of affected mice and rats
1967
Evidence for the Multiplication of Scrapie Agent in Cell Culture
1970 Nature
Does the Agent of Scrapie Replicate without Nucleic Acid ?
1967 Nature
Multiplication of Scrapie Agent in Mouse Spleen
1971
In‐vitro growth of pieces of brain from scrapie‐affected mice
1967
The Scrapie Agent: Evidence Against its Dependence for Replication on Intrinsic Nucleic Acid
1978