Standout Papers
- Epitope mapping of the Syrian hamster prion protein utilizing chimeric and mutant genes in a vaccinia virus expression system (1991)
- Synthesis and trafficking of prion proteins in cultured cells. (1992)
- Regional mapping of prion proteins in brain. (1992)
- Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58. (1991)
- Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred. (1992)
- Immunologic and Molecular Biologic Studies of Prion Proteins in Bovine Spongiform Encephalopathy (1993)
- TRANSGENIC MICE EXPRESSING HAMSTER PRION PROTEIN PRODUCE SPECIES -SPECIFIC SCRAPIE INFECTIVITY AND AMYLOID PLAQUES (1990)
- Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells. (1990)
Citation Impact
Citing Papers
The Neuropathology and Epidemiology of Bovine Spongiform Encephalopathy
1995
Heparin‐like molecules bind differentially to prion‐proteins and change their intracellular metabolic fate
1993
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein
1996 StandoutNobel
Purification and properties of the cellular prion protein from Syrian hamster brain
1992 StandoutNobel
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Identification of Intermediate Steps in the Conversion of a Mutant Prion Protein to a Scrapie-like Form in Cultured Cells
1997
Chapter 37: PrPSc causes nerve cell death and stimulates astrocyte proliferation: a paradox
1992
Chemistry and biology of prions
1992
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing
1993
Linkage of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease to the prion protein gene
1992 StandoutNobel
Cell-free formation of protease-resistant prion protein
1994 Nature
Characterisation of antisera raised against species-specific peptide sequences from scrapie-associated fibril protein and their application for post-mortem immunodiagnosis of spongiform encephalopathies
1994
Identification of the residues in human CD4 critical for the binding of HIV
1989 StandoutNobel
Decreased receptor-mediated calcium response in prion-infected cells correlates with decreased membrane fluidity and IP sub 3 release
1996
Expression of Polyubiquitin and Heat‐Shock Protein 70 Genes Increases in the Later Stages of Disease Progression in Scrapie‐Infected Mouse Brain
1994
Glycosylinositol Phospholipid Anchors of the Scrapie and Cellular Prion Proteins Contain Sialic Acid
1992 StandoutNobel
Neurotoxicity of a prion protein fragment
1993 Nature
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
1990 StandoutNobel
BIOLOGY AND GENETICS OF PRION DISEASES
1994
A 'unified theory' of prion propagation
1991 Nature
Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins
1994 StandoutNobel
Molecular properties of complexes formed between the prion protein and synthetic peptides
1997 StandoutNobel
The Neurochemistry of Prion Diseases
1993
Properties of the Scrapie Prion Protein: Quantitative Analysis of Protease Resistance
1994
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Genetic and Infectious Prion Diseases
1993
Developmental expression of the prion protein gene in glial cells
1995
Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an α-helix
1997
Mutant prion proteins in Gerstmann-Sträussler-Scheinker disease with neurofibrillary tangles
1992 StandoutNobel
Scrapie strains retain their distinctive characteristics following passages of homogenates from different brain regions and spleen.
1997
Amyloid fibrils in Gerstmann-Sträussler-Scheinker disease (Indiana and Swedish Kindreds) express only PrP peptides encoded by the mutant allele
1994
Selective Neuronal Targeting in Prion Disease
1997 StandoutNobel
Human prion diseases
1994 StandoutNobel
Mutant and Infectious Prion Proteins Display Common Biochemical Properties in Cultured Cells
1996
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
Lysosomes as key organelles in the pathogenesis of prion encephalopathies
1992
The abnormal isoform of the prion protein accumulates in late‐endosome‐like organelles in scrapie‐infected mouse brain
1995
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform 1 1Edited by M. Yaniv
1997 StandoutNobel
Eight prion strains have PrPSc molecules with different conformations
1998 Nobel
Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice
1991 StandoutNobel
Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes
1993
Insoluble wild–type and protease–resistant mutant prion protein in brains of patients with inherited prion disease
1996 StandoutNobel
Prion Protein Biology
1998 Nobel
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
Chimeric prion protein expression in cultured cells and transgenic mice
1992 StandoutNobel
Deadly Conformations—Protein Misfolding in Prion Disease
1997
Prion (PrPSc)-specific epitope defined by a monoclonal antibody
1997 StandoutNatureNobel
Molecular biology and pathogenesis of prion diseases
1996
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
Circumventing tolerance to generate autologous monoclonal antibodies to the prion protein.
1996 StandoutNobel
Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice
1997 StandoutNobel
Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.
1994 StandoutNobel
Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.
1993 StandoutNobel
A prion protein cycles between the cell surface and an endocytic compartment in cultured neuroblastoma cells
1993
Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells
1993
Chemical chaperones interfere with the formation of scrapie prion protein.
1996 StandoutNobel
Scrapie prions selectively modify the stress response in neuroblastoma cells.
1995
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
1993 Standout
GENETICS OF PRIONS
1997 StandoutNobel
Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform [published erratum appears in J Cell Biol 1995 Jul;130(2):501]
1995
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.
1995 StandoutNobel
Prions and prion proteins 1
1991 StandoutNobel
Attempts to restore scrapie prion infectivity after exposure to protein denaturants.
1993
Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity
1996 StandoutScienceNobel
A Transmembrane Form of the Prion Protein in Neurodegenerative Disease
1998 ScienceNobel
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis
1997 StandoutNobel
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Propagation of prion strains through specific conformers of the prion protein
1997 StandoutNobel
Prions
1998 StandoutNobel
Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.
1992 StandoutNobel
Regional Expression and Cellular Localization of the α1and β Subunit of High Voltage-Activated Calcium Channels in Rat Brain
1997
Attempts to convert the cellular prion protein into the scrapie isoform in cell-free systems
1992 StandoutNobel
Abnormal isoform of prion proteins accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt-Jakob disease.
1992
Structure of the recombinant full-length hamster prion protein PrP(29–231): The N terminus is highly flexible
1997 StandoutNobel
Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains
1996 StandoutNobel
High Prion and PrPSc Levels but Delayed Onset of Disease in Scrapie-Inoculated Mice Heterozygous for a Disrupted PrP Gene
1994
Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice.
1996
Evidence for synthesis of scrapie prion proteins in the endocytic pathway.
1992 StandoutNobel
Quantitative Western blot assay for measurement of the murine acute phase reactant, serum amyloid P component
1986
Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease
1991
Three scrapie prion isolates exhibit different accumulation patterns of the prion protein scrapie isoform.
1993
A kinetic model for amyloid formation in the prion diseases: importance of seeding.
1993
Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis
1991 StandoutNobel
Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein.
1994 StandoutNobel
The Biology and Detection of Immune Complexes
1980
N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state
1991
Characterization of Detergent-insoluble Complexes Containing the Cellular Prion Protein and Its Scrapie Isoform
1997
Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.
1992 StandoutNobel
Three hamster species with different scrapie incubation times and neuropathological features encode distinct prion proteins.
1990 StandoutNobel
Etiology and pathogenesis of prion diseases.
1995 StandoutNobel
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.
1991
COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform
1997 StandoutNobel
Recombinant scrapie-like prion protein of 106 amino acids is soluble
1996 StandoutNobel
Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells.
1993 StandoutNobel
Serial transmission in rodents of neurodegeneration from transgenic mice expressing mutant prion protein.
1994
Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity.
1993
Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein
1990 StandoutScienceNobel
Works of D. Serban being referenced
Immunologic and Molecular Biologic Studies of Prion Proteins in Bovine Spongiform Encephalopathy
1993 StandoutNobel
Epitope mapping of the Syrian hamster prion protein utilizing chimeric and mutant genes in a vaccinia virus expression system
1991 StandoutNobel
Regional mapping of prion proteins in brain.
1992 StandoutNobel
TRANSGENIC MICE EXPRESSING HAMSTER PRION PROTEIN PRODUCE SPECIES -SPECIFIC SCRAPIE INFECTIVITY AND AMYLOID PLAQUES
1990 StandoutNobel
Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells.
1991
Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58.
1991 StandoutNobel
Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation.
1990
Serum amyloid P component and autoimmune parameters in the assessment of arthritis activity in MRL/lpr/lpr mice.
1985
Synthesis and trafficking of prion proteins in cultured cells.
1992 StandoutNobel
Receptors for immune complexes on cells within a polyoma virus‐induced murine sarcoma
1976
Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells.
1990 StandoutNobel
Prion protein preamyloid and amyloid deposits in Gerstmann-Sträussler-Scheinker disease, Indiana kindred.
1992 StandoutNobel