Standout Papers
Citation Impact
Citing Papers
Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia
2013 StandoutNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
2010
Genetic origins and clinical phenotype of familial and acquired erythrocytosis and thrombocytosis
2008
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis
2009 StandoutNobel
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Cardiopulmonary function in two human disorders of the hypoxia‐inducible factor (HIF) pathway: von Hippel‐Lindau disease and HIF‐2α gain‐of‐function mutation
2011 StandoutNobel
A Knock-in Mouse Model of Human PHD2 Gene-associated Erythrocytosis Establishes a Haploinsufficiency Mechanism
2013
Understanding Human Glycosylation Disorders: Biochemistry Leads the Charge
2013
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α
2013
Induction of HIF‐1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR
2008 StandoutNobel
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
The von Hippel‐Lindau Tumor Suppressor Protein: An Update
2007 StandoutNobel
Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia
2010
Myelodysplasia with fibrosis: a distinct entity?
2001
Erythrocytosis and Pulmonary Hypertension in a Mouse Model of Human HIF2A Gain of Function Mutation
2013
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Mimicking Hypoxia to Treat Anemia: HIF-Stabilizer BAY 85-3934 (Molidustat) Stimulates Erythropoietin Production without Hypertensive Effects
2014
Myelodysplastic syndrome with increased marrow fibrosis: a distinct clinico‐pathological entity
1991
Glycosylation in health and disease
2019
Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension
2009 StandoutNobel
A rapid and non‐invasive selection of transgenic embryos before implantation using green fluorescent protein (GFP)
1995
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
2008 Standout
Variations within oxygen-regulated gene expression in humans
2008
Disorders of red cell volume regulation
2013
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude
2007
Pulmonary vascular response to air-breathing exercise in humans following an 8-h exposure to hypoxia
2009
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
2008 StandoutNobel
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
2013 StandoutNobel
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
The human side of hypoxia‐inducible factor
2008 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Oxygen homeostasis
2009 StandoutNobel
Cytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: Study of nine cases
1996
Therapeutic Manipulation of the HIF Hydroxylases
2009
Iron Homeostasis and Its Interaction with Prolyl Hydroxylases
2009
HIF-1–Dependent Respiratory, Cardiovascular, and Redox Responses to Chronic Intermittent Hypoxia
2007 StandoutNobel
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Clinical iron deficiency disturbs normal human responses to hypoxia
2016 StandoutNobel
THE GREEN FLUORESCENT PROTEIN
1998 StandoutNobel
The von Hippel-Lindau Chuvash mutation in mice causes carotid-body hyperplasia and enhanced ventilatory sensitivity to hypoxia
2013
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
2009 Standout
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
The HIF Pathway and Erythrocytosis
2011
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Determinants of ventilation and pulmonary artery pressure during early acclimatization to hypoxia in humans
2015
Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
2013 StandoutNobel
The von Hippel-Lindau Tumor Suppressor Gene
2020
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
2010 StandoutScienceNobel
Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans
2014
Iron, oxygen, and the pulmonary circulation
2015
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
Disorders of erythrocyte volume homeostasis
2015
Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF‐2 pathway
2015 StandoutNobel
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
HIF and pulmonary vascular responses to hypoxia
2013
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
2009 StandoutNobel
Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1
2013
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice
2009 StandoutNobel
Neurological Aspects of Human Glycosylation Disorders
2015
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
2013 StandoutNobel
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
2012 StandoutNobel
Works of D. Mark Layton being referenced
Myelofibrosis in primary myelodysplastic syndromes: a clinico‐morphological study of 10 cases
1989
Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1
2005
Hypomorphic promoter mutation in PIGM causes inherited glycosylphosphatidylinositol deficiency
2006
Clinicopathological features of acute undifferentiated leukaemia with a stem cell phenotype
1990
Targeted Therapy for Inherited GPI Deficiency
2007
Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology
2006 StandoutNobel
Mutation of the von Hippel-Lindau Gene Alters Human Cardiopulmonary Physiology
2007 StandoutNobel
Preimplantation diagnosis of a human β-globin transgene in biopsied trophectoderm cells and blastomeres of the mouse embryo
1992