Citation Impact
Citing Papers
A Novel Functional Human Eukaryotic Translation Initiation Factor 4G
1998
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Translation Initiation Factor eIF4G-1 Binds to eIF3 through the eIF3e Subunit
2006
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F
1998
Defining the proteolytic landscape during enterovirus infection
2020 StandoutNobel
Formation of the ∼350-kDa Apg12-Apg5·Apg16 Multimeric Complex, Mediated by Apg16 Oligomerization, Is Essential for Autophagy in Yeast
2002 StandoutNobel
A new translational regulator with homology to eukaryotic translation initiation factor 4G
1997
Human protein synthesis initiation factor eIF-4γ is encoded by a single gene (EIF4G) that maps to chromosome 3q27—qter
1995
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3
2015 StandoutNobel
SSL2, a suppressor of a stem-loop mutation in the HIS4 leader encodes the yeast homolog of human ERCC-3
1992
Characterization of the roles of conserved cysteine and histidine residues in poliovirus 2A protease
1992
Substrate requirements of a human rhinoviral 2A proteinase
1991
eIF4E activity is regulated at multiple levels
1999
Lack of direct correlation between p220 cleavage and the shut-off of host translation after poliovirus infection
1992
4E-BP3, a New Member of the Eukaryotic Initiation Factor 4E-binding Protein Family
1998
Expression of poliovirus 2Apro in mammalian cells: effects on translation
1995
Internal Initiation of Translation Directed by the 5′-Untranslated Region of the mRNA for eIF4G, a Factor Involved in the Picornavirus-induced Switch from Cap-dependent to Internal Initiation
1996
Molecular virology of hepatitis C virus.
1997
A Consideration of Alternative Models for the Initiation of Translation in Eukaryotes
1992
Requirements for U2 snRNP addition to yeast pre-mRNA
1992 StandoutNobel
Cap-Independent Translation and Internal Initiation of Translation in Eukaryotic Cellular mRNA Molecules
1995
Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases
1995
Intact Eukaryotic Initiation Factor 4G Is Required for Hepatitis A Virus Internal Initiation of Translation
1997
A Novel Interaction between Adrenergic Receptors and the α-Subunit of Eukaryotic Initiation Factor 2B
1997 StandoutNobel
Transcription factor b (TFIIH) is required during nucleotide-excision repair in yeast
1994 StandoutNatureNobel
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway
2000 StandoutNobel
Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast
1998 StandoutNobel
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation
1998 Nature
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Protein synthesis initiation factor 4G
1999
Stimulation of translation in 3T3-L1 cells in response to insulin and phorbol ester is directly correlated with increased phosphate labelling of initiation factor (eIF-) 4F and ribosomal protein S6
1993
Translation Eukaryotic Initiation Factor 4G Recognizes a Specific Structural Element within the Internal Ribosome Entry Site of Encephalomyocarditis Virus RNA
1998
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA
1988 StandoutNature
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
The plant translational apparatus
1996
Phosphorylation of eIF-4E on Serine 209 by Protein Kinase C Is Inhibited by the Translational Repressors, 4E-binding Proteins
1996
Expansion of the eukaryotic proteome by alternative splicing
2010 StandoutNature
Modulation of Translation Initiation in Rat Skeletal Muscle and Liver in Response to Food Intake
1997
Translational regulation of the heat shock response
1994
Cap recap: The involvement of eIF-4F in regulating gene expression
1992
An Antibody Fragment from a Phage Display Library Competes for Ligand Binding to the Low Density Lipoprotein Receptor Family and Inhibits Rhinovirus Infection
1995 StandoutNobel
The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate
1997
Listening to silence and understanding nonsense: exonic mutations that affect splicing
2002 Standout
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Increased phosphorylation of eukaryotic initiation factor 4α during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation
1993
Participation of initiation factors in the recruitment of mRNA to ribosomes
1994
Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage
1997 StandoutNobel
Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair
1993 StandoutNobel
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting
1989 StandoutNatureNobel
Cryo-EM Visualization of a Viral Internal Ribosome Entry Site Bound to Human Ribosomes
2004 StandoutNobel
A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation
1998
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
A Fresh Look at iPS Cells
2009 StandoutNobel
Intracellular translation initiation factor levels in Saccharomyces cerevisiae and their role in cap‐complex function
2002
Signalling through either the p38 or ERK mitogen‐activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR‐CD3)‐stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells
1997
The human insulin-like growth factor II leader 1 contains an internal ribosomal entry site
1995
Initiation of Protein Synthesis in Eukaryotic Cells
1996
Ten Strategies of Interferon Evasion by Viruses
2017
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Hepatitis C virus 3′UTR regulates viral translation through direct interactions with the host translation machinery
2013 StandoutNobel
Characterization of eIF3k
2003
Functional Characterization of the Internal Ribosome Entry Site of eIF4G mRNA
1998
The Predominant eIF4G-Specific Cleavage Activity in Poliovirus-Infected HeLa Cells Is Distinct from 2A Protease
1998
A new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translation
2009
Global Brain Ischemia and Reperfusion: Modifications in Eukaryotic Initiation Factors Associated with Inhibition of Translation Initiation
1996
Plasmid cDNA-directed protein synthesis in a coupled eukaryoticin vitrotranscription-translation system
1992 StandoutNobel
A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate
1996
Direct Cleavage of eIF4G by Poliovirus 2A Protease Is Inefficientin Vitro
1998
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Internal initiation of translation mediated by the 5′ leader of a cellular mRNA
1991 Nature
The j-Subunit of Human Translation Initiation Factor eIF3 Is Required for the Stable Binding of eIF3 and Its Subcomplexes to 40 S Ribosomal Subunits in Vitro
2004 StandoutNobel
Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation
1988
Eukaryotic Translation Initiation Factor 4G Is Targeted for Proteolytic Cleavage by Caspase 3 during Inhibition of Translation in Apoptotic Cells
1998
The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins
1995
Isolation and structural characterization of cap-binding proteins from poliovirus-infected HeLa cells
1985
cis- and trans-cleavage activities of poliovirus 2A protease expressed in Escherichia coli
1991
Structural and functional analysis of the ribosome landing pad of poliovirus type 2: in vivo translation studies
1991
Regulation of eukaryotic protein synthesis by initiation factors.
1993
Isolation and sequence of the cDNAs encoding the subunits of the isozyme form of wheat protein synthesis initiation factor 4F
1992
Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection
1987
Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
1985 StandoutScienceNobel
Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line
1999 StandoutScience
A Conserved HEAT Domain within eIF4G Directs Assembly of the Translation Initiation Machinery
2001
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
1999 Standout
Human Eukaryotic Translation Initiation Factor 4G (eIF4G) Possesses Two Separate and Independent Binding Sites for eIF4A
1997
Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex
1988
TOR controls translation initiation and early G1 progression in yeast.
1996
Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.
1987
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Mechanism and regulation of eukaryotic protein synthesis
1992
Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.
1993
Cleavage of p220 by Purified Poliovirus 2Apro in Cell-Free Systems: Effects on Translation of Capped and Uncapped mRNAs
1997
The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay.
1995 StandoutNobel
ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors.
1985
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.
1995
Hormone-induced meiotic maturation in Xenopus oocytes occurs independently of p70s6k activation and is associated with enhanced initiation factor (eIF)-4F phosphorylation and complex formation
1995
Pairing the cholinergic agonist carbachol with patterned Schaffer collateral stimulation initiates protein synthesis in hippocampal CA1 pyramidal cell dendrites via a muscarinic, NMDA-dependent mechanism
1993
DAP-5, a Novel Homolog of Eukaryotic Translation Initiation Factor 4G Isolated as a Putative Modulator of Gamma Interferon-Induced Programmed Cell Death
1997
RNA-stimulated ATPase activity of eukaryotic initiation factors.
1984
Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs
1994 StandoutNobel
Epidermal growth factor or okadaic acid stimulates phosphorylation of eukaryotic initiation factor 4F.
1991
Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis.
1987
Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection
1998
Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis
2019
Capped mRNAs with Reduced Secondary Structure Can Function in Extracts from Poliovirus-Infected Cells
1982
A cytoplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosomal entry is identical to the nuclear pyrimidine tract-binding protein.
1993
Human immunodeficiency virus tat-activated expression of poliovirus protein 2A inhibits mRNA translation.
1989 Nobel
Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA
1993
Identification and characterization of cap-binding proteins from yeast
1989
Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: Implications for U1 RNA and metazoan mRNA splicing
1983 StandoutNobel
Canonical Eukaryotic Initiation Factors Determine Initiation of Translation by Internal Ribosomal Entry
1996
Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.
1994
Bidirectional RNA Helicase Activity of Eucaryotic Translation Initiation Factors 4A and 4F
1990
Cell Cycle Status Affects Coxsackievirus Replication, Persistence, and Reactivation In Vitro
2002
Differential Regulation of Translation and eIF4E Phosphorylation During Human Thymocyte Maturation
1998
Eukaryotic Initiation Factor 4GII (eIF4GII), but Not eIF4GI, Cleavage Correlates with Inhibition of Host Cell Protein Synthesis after Human Rhinovirus Infection
1999
pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
1998 StandoutNobel
Inhibition of translation in cells infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 2
1989
A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme.
1997 StandoutNobel
Evidence that the SKI antiviral system of Saccharomyces cerevisiae acts by blocking expression of viral mRNA.
1993
Replication Strategies of the Single Stranded RNA Viruses of Eukaryotes
1983
The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E.
1996
The 3′-untranslated region of CaMKIIα is a cis-acting signal for the localization and translation of mRNA in dendrites
1996 StandoutNobel
The effect of poliovirus proteinase 2Apro expression on cellular metabolism. Inhibition of DNA replication, RNA polymerase II transcription, and translation
1991
RNA polymerase transcription factor IIH holoenzyme from yeast.
1994 StandoutNobel
Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus.
1996
Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation.
1992
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.
1990
Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits.
1993
Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end.
1991 StandoutNobel
Poly(A)-binding protein binds to the non-polyadenylated 3′ untranslated region of dengue virus and modulates translation efficiency
2009
Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.
1994
Identification of the Major Phosphorylation Site of the Hepatitis C Virus H Strain NS5A Protein as Serine 2321
1999 StandoutNobel
Poliovirus mutant that does not selectively inhibit host cell protein synthesis.
1985 Nobel
Interactions of the eIF-4F subunits in the yeast Saccharomyces cerevisiae.
1992
Functional Dissection of Eukaryotic Initiation Factor 4F: the 4A Subunit and the Central Domain of the 4G Subunit Are Sufficient To Mediate Internal Entry of 43S Preinitiation Complexes
1996
Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes
1998
Capped mRNAs with Reduced Secondary Structure Can Function in Extracts from Poliovirus-Infected Cells
1982
5'-Conformation of capped alfalfa mosaic virus ribonucleic acid may reflect its independence of the cap structure or of cap-binding protein for efficient translation
1983
RNA-protein interactions in regulation of picornavirus RNA translation
1996
Yeast RAD3 protein binds directly to both SSL2 and SSL1 proteins: implications for the structure and function of transcription/repair factor b.
1994 StandoutNobel
A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation
1988
Angiotensin II induces phosphorylation of eukaryotic protein synthesis initiation factor 4E in vascular smooth muscle cells.
1994
Phorbol esters stimulate phosphorylation of eukaryotic initiation factors 3, 4B, and 4F
1989
Shutoff of host translation by encephalomyocarditis virus infection does not involve cleavage of the eucaryotic initiation factor 4F polypeptide that accompanies poliovirus infection
1985
Identification and quantitation of levels of protein synthesis initiation factors in crude HeLa cell lysates by two-dimensional polyacrylamide gel electrophoresis.
1983
eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the α, β and δ subunits of eIF2B from mammals and yeast
1996
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.
1993
SIMIAN VIRUS 40 AS A EUKARYOTIC CLONING VEHICLE
1981
The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase
1996
TIF4631 and TIF4632: two yeast genes encoding the high-molecular-weight subunits of the cap-binding protein complex (eukaryotic initiation factor 4F) contain an RNA recognition motif-like sequence and carry out an essential function.
1993
Monensin and nigericin prevent the inhibition of host translation by poliovirus, without affecting p220 cleavage
1995
eIF4G--A Multipurpose Ribosome Adapter?
1997 Science
The adenovirus tripartite leader may eliminate the requirement for cap-binding protein complex during translation initiation
1988
Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation.
1989
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
The target of rapamycin (TOR) proteins
2001
Cap-Independent Translation Is Required for Starvation-Induced Differentiation in Yeast
2007 StandoutScienceNobel
Cap-Binding Protein (Eukaryotic Initiation Factor 4E) and 4E-Inactivating Protein BP-1 Independently Regulate Cap-Dependent Translation
1996
Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA
2004 StandoutNobel
Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.
1990
Primary structure, gene organization and polypeptide expression of poliovirus RNA
1981 Nature
In vitro synthesis of human protein synthesis initiation factor 4 gamma and its localization on 43 and 48 S initiation complexes.
1994
Nucleotide sequences from the adenovirus-2 genome.
1982 StandoutNobel
Works of D Etchison being referenced
Separation of protein synthesis initiation factor eIF4A from a p220-associated cap binding complex activity
1987
Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro
1985
Cap-binding complex protein p220 is not cleaved during echovirus 22 replication in HeLa cells
1991
Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex.
1985
Localization of Cap-Binding Protein in Subcellular Fractions of HeLa Cells
1982
Cleavage of the cap binding protein complex polypeptide p220 is not effected by the second poliovirus protease 2A
1986
Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma
1992
Phosphorylation of eIF-4F by protein kinase C or multipotential S6 kinase stimulates protein synthesis at initiation.
1991
Variations in cap-binding complexes from uninfected and poliovirus-infected HeLa cells.
1990
Viral polypeptides associated with the RNA replication complex in poliovirus-infected cells
1980
Subunit interactions in polyoma virus structure
1977
Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220
1987
Localization of Cap-Binding Protein in Subcellular Fractions of HeLa Cells
1982
Protein synthesis eukaryotic initiation factors 4A and 4B are not altered by poliovirus infection of HeLa cells.
1983
Association of cap-binding protein with eucaryotic initiation factor 3 in initiation factor preparations from uninfected and poliovirus-infected HeLa cells
1982
Demonstration in vitro that eucaryotic initiation factor 3 is active but that a cap-binding protein complex is inactive in poliovirus-infected HeLa cells
1984
Monoclonal antibody-aided characterization of cellular p220 in uninfected and poliovirus-infected HeLa cells: subcellular distribution and identification of conformers
1987
Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.
1982