Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
2006
A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
2001 StandoutScience
Mutations in the VHL tumor suppressor gene and associated lesions in families with von Hippel-Lindau disease from central Europe
1996
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer
2015 Standout
Interaction of Hydroxylated Collagen IV with the von Hippel-Lindau Tumor Suppressor
2007 StandoutNobel
Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy
2010 StandoutNobel
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
2001 StandoutNobel
Suppression of tumor growth through disruption of hypoxia-inducible transcription
2000 StandoutNobel
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid1
1998
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Combination therapy for Cushing’s disease: effectiveness of two schedules of treatment. Should we start with cabergoline or ketoconazole?
2013
pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2
2007 StandoutNobel
Cushing’s Syndrome: Adrenalectomy and Long-Term Results
2004
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
2001 StandoutNobel
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
2008 StandoutNobel
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Pheochromocytomas in von Hippel-Lindau Syndrome and Multiple Endocrine Neoplasia Type 2 Display Distinct Biochemical and Clinical Phenotypes
2001
Increased oxidative stress in obesity and its impact on metabolic syndrome
2004 Standout
Clinical and molecular aspects of adrenocortical tumourigenesis
2003
Efficient Short-Term Control of Hypercortisolaemia by Low-Dose Etomidate in Severe Paediatric Cushing’s Disease
2005
Molecular basis of the VHL hereditary cancer syndrome
2002 StandoutNobel
Cushing's syndrome
2015 Standout
Phaeochromocytoma
2005 Standout
Hypoxia and Inflammation
2011 Standout
Medical Treatment of Cushing's Disease
2013
Hereditary paraganglioma targets diverse paraganglia: Table 1
2002
Epidemiologie, Pathophysiologie, leitliniengerechte Diagnostik und Therapie des Schilddrüsenknotens
2010
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
2003 Standout
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
2002 StandoutNobel
von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF
2001
Nonhypnotic low-dose etomidate for rapid correction of hypercortisolaemia in cushing's syndrome
1988
von Hippel-Lindau disease
2003 Standout
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
2003 Standout
Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo
2006 StandoutNobel
CLINICAL EXPERIENCE WITH KETOCONAZOLE AS A THERAPY FOR PATIENTS WITH CUSHING'S SYNDROME
1987
Medical Therapy of Cushing's Disease
2002
Emergency and Prolonged Use of Intravenous Etomidate to Control Hypercortisolemia in a Patient with Cushing’s Syndrome and Peritonitis
1998
Origin and physiological roles of inflammation
2008 StandoutNature
Cushing's syndrome in pregnancy treated by ketoconazole: Case report and review of the literature
1999
Use of a Parenteral Propylene Glycol-Containing Etomidate Preparation for the Long-Term Management of Ectopic Cushing’s Syndrome
2001
Selection of Mutant CHO Cells with Constitutive Activation of the HIF System and Inactivation of the von Hippel-Lindau Tumor Suppressor
2001 StandoutNobel
Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors
1997
Sporadic Pheochromocytomas Are Rarely Associated with Germline Mutations in thevhlTumor Suppressor Gene or theretProtooncogene1
1997
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
2001 StandoutNobel
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
2001 StandoutNobel
Infusion of Low Dose Etomidate: Correction of Hypercortisolemia in Patients with Cushing's Syndrome and Dose-Response Relationship in Normal Subjects
1990
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein
2000 StandoutNobel
Early Morning Cortisol Levels as a Predictor of Remission After Transsphenoidal Surgery for Cushing’s Disease
2006
Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF
2001
Use of ketoconazole in the treatment of Cushing's disease and ectopic ACTH syndrome
1991
New developments in the medical treatment of Cushing's syndrome
2012
Central nervous system hemangioblastomas, endolymphatic sac tumors, and von Hippel-Lindau disease
2000
Hypoxia Inducible Factor Activates the Transforming Growth Factor-α/Epidermal Growth Factor Receptor Growth Stimulatory Pathway in VHL-/- Renal Cell Carcinoma Cells
2003
Approach to the Cushing's Disease Patient With Persistent/Recurrent Hypercortisolism After Pituitary Surgery
2013
A reappraisal of the medical therapy with steroidogenesis inhibitors in C ushing's syndrome
2012
The Use of Ketoconazole as an Inhibitor of Steroid Production
1987
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Effects of etomidate on Cortisol biosynthesis in isolated guinea-pig adrenal cells: comparison with metyrapone
1985
Ketoconazole and Other Imidazole Derivatives as Inhibitors of Steroidogenesis
1986
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
2007 StandoutScience
von Hippel-Lindau Disease
2006 StandoutNobel
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
PROLINE HYDROXYLATION AND GENE EXPRESSION
2005 StandoutNobel
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Ectopic ACTH Syndrome and CRH-Mediated Cushing’s Syndrome
1994
Kinase requirements in human cells: III. Altered kinase requirements inVHL−/− cancer cells detected in a pilot synthetic lethal screen
2008 StandoutNobel
The von Hippel-Lindau Tumor Suppressor Gene
2020
pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
1998 StandoutNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Retinal hemangioblastoma in von Hippel-Lindau disease: a clinical and molecular study.
2002
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Adrenal Rest Tumor of the Liver Causing Cushing's Syndrome: Treatment withKetoconazole preceding an Apparent Surgical Cure*
1985
Cushing’s Syndrome: Therapy Directed at the Adrenal Glands
1994
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
2001 Standout
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Role ofVHLGene Mutation in Human Cancer
2004 StandoutNobel
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
1999
The Molecular Basis of Von Hippel-Lindau Disease
1997 StandoutNobel
Works of D. Engelhardt being referenced
Ketoconazole inhibits cortisol secretion of an adrenal adenoma in vivo and in vitro
1983
Therapy of Cushing's syndrome with steroid biosynthesis inhibitors
1994
Different inhibitory effect of etomidate and ketoconazole on the human adrenal steroid biosynthesis
1993
Effect of ketoconazole on human ovarian C17,20-desmolase and aromatase
1991
Different therapeutic efficacy of ketoconazole in patients with Cushing's syndrome
1989
Steroid biosynthesis inhibitors in Cushing's syndrome
1994
The influence of ketoconazole on human adrenal steroidogenesis: incubation studies with tissue slices
1991
Inhibition of human adrenal androgen secretion by ketoconazole
1989
Ketoconazole blocks cortisol secretion in man by inhibition of adrenal 11β-hydroxylase
1985
Interleukin-3 and Interleukin-6 Stimulate Cortisol Secretion from Adult Human Adrenocortical Cells
1997
[Results of radioiodine treatment of patients with immunogenic and non-immunogenic hyperthyroidism using different focal doses].
1988
Isolated familial pheochromocytoma as a variant of von Hippel-Lindau disease.
1996
Influence of low-dose etomidate on adrenal and gonadal steroid hormone secretion in normal men
1986
Overexpression of insulin-like growth factor-binding protein-2 results in increased tumorigenic potential in Y-1 adrenocortical tumor cells.
2000
Longterm treatment of Cushing's disease by ketoconazole
1987
EFFECT OF A SINGLE BOLUS OF ETOMIDATE UPON EIGHT MAJOR CORTICOSTEROID HORMONES AND PLASMA ACTH
1985