Citation Impact
Citing Papers
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
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Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
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Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Infectious enveloped RNA virus antigenic chimeras.
1992 StandoutNobel
Single-crystal x-ray diffraction structures of covalent organic frameworks
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Paclitaxel-containing high-dose chemotherapy for relapsed or refractory testicular germ cell tumours
2004
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Molecular imaging in drug development
2008 Standout
Enzyme-Catalyzed Activation of Anticancer Prodrugs
2004
Ribosome-inactivating proteins from plants
1993
Quantitative Emergence of Hetero[4]rotaxanes by Template‐Directed Click Chemistry
2012 StandoutNobel
Dynamic imine chemistry
2012 StandoutNobel
Computational Enzyme Design
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Prodrug Strategies in Anticancer Chemotherapy
2007
Cancer Statistics, 2006
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Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
2007 StandoutNature
Gestational trophoblastic disease
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Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives
2005
Vascular targeting—a new approach to the therapy of solid tumors
1994
Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
1996 Standout
Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates
2001
Targeting nanoparticles to cancer
2010
Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway
2002
Antibody targeted drugs as cancer therapeutics
2006
The bone marrow niche for haematopoietic stem cells
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Temsirolimus, Interferon Alfa, or Both for Advanced Renal-Cell Carcinoma
2007 Standout
Physical properties and in vitro transfection efficiency of gene delivery vectors based on complexes of DNA with synthetic polycations
2002
Catalytic antibodies
1998
Receptor-Mediated Gene Transfer Vectors: Progress Towards Genetic Pharmaceuticals
2003
Identification and expansion of human colon-cancer-initiating cells
2006 StandoutNature
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
2010 StandoutNature
Template‐Directed Syntheses of Rigid Oligorotaxanes under Thermodynamic Control
2010 StandoutNobel
Adjuvant Chemotherapy With Gemcitabine vs Observation in Patients Undergoing Curative-Intent Resection of Pancreatic Cancer
2007 Standout
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
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Tumor-activated Prodrugs—A New Approach to Cancer Therapy
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Trigger release liposome systems: local and remote controlled delivery?
2011
Liposomal drug delivery systems: From concept to clinical applications
2012 Standout
Understanding biophysicochemical interactions at the nano–bio interface
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Modifying an immunogenic epitope on a therapeutic protein: a step towards an improved system for antibody-directed enzyme prodrug therapy (ADEPT)
2004
Synthesis of Heterobifunctional Protein Fusions Using Copper‐Free Click Chemistry and the Aldehyde Tag
2012 StandoutNobel
Arming antibodies: prospects and challenges for immunoconjugates
2005
Dynamic donor–acceptor [2]catenanes
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Kinetic and Thermodynamic Approaches for the Efficient Formation of Mechanical Bonds
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Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
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Generation of an Intensely Potent Anthracycline by a Monoclonal Antibody−β-Galactosidase Conjugate
2005
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
2005
Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin
2005 Standout
Vascular Targeting Agents as Cancer Therapeutics
2004
A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy
1993
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
2009 Standout
Nonviral Vectors for Gene Delivery
2008 Standout
Positive Cooperativity in the Template-Directed Synthesis of Monodisperse Macromolecules
2012 StandoutNobel
Dynamic Transformation between Covalent Organic Frameworks and Discrete Organic Cages
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Dynamic Combinatorial Chemistry
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Nanoparticles in Photodynamic Therapy
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Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells
2002
Prodrugs of Anthracyclines for Use in Antibody-Directed Enzyme Prodrug Therapy
1998
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
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In vivo activity in a catalytic antibody-prodrug system: Antibody catalyzed etoposide prodrug activation for selective chemotherapy
2001
Antibody Design by Man and Nature
2002 Science
Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model
1998 StandoutScience
A phase I study of bolus versus continuous infusion of the anti-CD19 immunotoxin, IgG-HD37-dgA, in patients with B-cell lymphoma
1996
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Synthesis of an organoinsulin molecule that can be activated by antibody catalysis
2001 StandoutNobel
Enzyme-Responsive Snap-Top Covered Silica Nanocontainers
2008 StandoutNobel
Sustained Tumor Regression of Human Colorectal Cancer Xenografts Using a Multifunctional Mannosylated Fusion Protein in Antibody-Directed Enzyme Prodrug Therapy
2005
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
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Antibody–Enzyme Fusion Proteins for Cancer Therapy
2011
pH-Operated Nanopistons on the Surfaces of Mesoporous Silica Nanoparticles
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Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab
2004
Antibody-directed enzyme prodrug therapy (ADEPT): a review
1997
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
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Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Multiple event activation of a generic prodrug trigger by antibody catalysis
1999 StandoutNobel
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
2010 StandoutScience
Transferrin-Containing, Cyclodextrin Polymer-Based Particles for Tumor-Targeted Gene Delivery
2003
Redesigning Nature's Poisons to Create Anti-Tumor Reagents
1987 Science
Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis
1997 StandoutScienceNobel
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
Works of D C Blakey being referenced
A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours
2002
Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue
2001
Cellular glutathione as a determinant of the sensitivity of colorectal tumour cell-lines to ZD2767 antibody-directed enzyme prodrug therapy (ADEPT)
2000
Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging
2003
Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma
2008
Antitumor effects of an antibody-carboxypeptidase g2 conjugate in combination with a benzoic acid mustard prodrug
1993
Anti-tumour effects of an antibody-carboxypeptidase G2 conjugate in combination with phenol mustard prodrugs
1995
A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression
2000
Isolex 300i CD34-selected cells to support multiple cycles of high-dose therapy
2002
Repetitive high-dose therapy with cyclophosphamide, thiotepa and docetaxel with peripheral blood progenitor cell and filgrastim support for metastatic and locally advanced breast cancer: results of a phase I study
2000
Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody-Directed Enzyme Prodrug Therapy
1995
ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumour regressions in colorectal tumour xenografts
1997
Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages.
1988
Comparison of Two Anti-Thy 1.1-Abrin A-Chain Immunotoxins Prepared With Different Cross-Linking Agents: Antitumor Effects, In Vivo Fate, and Tumor Cell Mutants
1987
A new clinical candidate for antibody-directed enzyme prodrug therapy (ADEPT): ZD2767
1995
Tumour regressions with novel prodrugs in antibody-directed enzyme prodrug therapy (ADEPT)
1994
ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts.
1996
Purification of ricin A1, A2, and B chains and characterization of their toxicity.
1986
Antibody-directed enzyme prodrug therapy (ADEPT) for treatment of major solid tumour disease
1995
ChemInform Abstract: Optimization of Alkylating Agent Prodrugs Derived from Phenol and Aniline Mustards: A New Clinical Candidate Prodrug (ZD2767) for Antibody‐Directed Enzyme Prodrug Therapy (ADEPT).
1996
Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing.
1996
Comparison of the pharmacokinetics and hepatotoxic effects of saporin and ricin A-chain immunotoxins on murine liver parenchymal cells.
1988