Citation Impact
Citing Papers
In Vitro Selection of Highly Modified Cyclic Peptides That Act as Tight Binding Inhibitors
2012 Nobel
Parenteral Anticoagulants
2012 Standout
Impact of protein-protein contacts on the conformation of thrombin-bound hirudin studied by comparison with the nuclear magnetic resonance solution structure of hirudin(1–51)
1992 StandoutNobel
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Kinetic and Crystallographic Studies of Thrombin with Ac-(D)Phe-Pro-boroArg-OH and Its Lysine, Amidine, Homolysine, and Ornithine Analogs
1995
Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen
1997 Standout
Functionality map analysis of the active site cleft of human thrombin
1996 StandoutNobel
Population frequencies of inherited neuromuscular diseases—A world survey
1991 Standout
Heparin and Low-Molecular-Weight Heparin Mechanisms of Action, Pharmacokinetics, Dosing, Monitoring, Efficacy, and Safety
2001 Standout
Discovery of potent, selective 4-fluoroproline-based thrombin inhibitors with improved metabolic stability
2006
Synthetic low-molecular weight thrombin inhibitors: molecular design and pharmacological profile
1993
Peptide-derived transition state analogue inhibitors of thrombin; Synthesis, activity and selectivity
1995
Enzymatic Synthesis of Enantiopure α‐ and β‐Amino Acids by Phenylalanine Aminomutase‐Catalysed Amination of Cinnamic Acid Derivatives
2009 StandoutNobel
A Fast Flexible Docking Method using an Incremental Construction Algorithm
1996 Standout
NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata
1994 StandoutNobel
Azetidin-2-one derivatives as inhibitors of thrombin
1995
Cysteine Promoted C‐Terminal Hydrazinolysis of Native Peptides and Proteins
2013 StandoutNobel
Recombinant expression of selectively sulfated proteins in Escherichia coli
2006
Encoded libraries of chemically modified peptides
2015 StandoutNobel
Why are ?natively unfolded? proteins unstructured under physiologic conditions?
2000 Standout
Treatment and Prevention of Heparin-Induced Thrombocytopenia
2008 Standout
Dynamic control over cell adhesive properties using molecular-based surface engineering strategies
2009 StandoutNobel
Changes in interactions in complexes of hirudin derivatives and human α‐thrombin due to different crystal forms
1993
Novel amidine-containing peptidyl phosphonates as irreversible inhibitors for blood coagulation and related serine proteases
1994
The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships
1992
Electrostatic complementarity in molecular associations
1989
The coagulation cascade: initiation, maintenance, and regulation
1991 Standout
Identification of cellular proteins binding to the scrapie prion protein
1990 StandoutNobel
Inhibitors of proteases and amide hydrolases that employ an α-ketoheterocycle as a key enabling functionality
2007
Geometry of binding of the benzamidine‐ and arginine‐based inhibitors Nα‐(2‐naphthyl‐sulphonyl‐glycyl)‐dl ‐p‐amidinophenylalanyl‐piperidine (NAPAP) and (2R,4R)‐4‐methyl‐1‐[Nα‐(3‐methyl‐1,2,3,4‐tetrahydro‐8‐quinolinesulphonyl)‐l ‐arginyl]‐2‐piperidine carboxylic acid (MQPA) to human α‐thrombin
1990
Geometry of binding of the Nα‐tosylated piperidides of m‐amidino‐, p‐amidino‐ and p‐guanidino phenylalanine to thrombin and trypsin
1991
Nuclear magnetic resonance solution structure of hirudin(1–51) and comparison with corresponding three-dimensional structures determined using the complete 65-residue hirudin polypeptide chain
1992 StandoutNobel
Heparin-induced thrombocytopenia and cardiac surgery
2003 Standout
Novel biosynthetic approaches to the production of unnatural amino acids using transaminases
1998
Cysteinyl Proteinases and Their Selective Inactivation
1990
Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin
1990
The conformations of hirudin in solution: a study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics
1987
Use of fragments of hirudin to investigate thrombin‐hirudin interaction
1990
On the mechanisms of biocompatibility
2008 Standout
Selection of single-stranded DNA molecules that bind and inhibit human thrombin
1992 StandoutNature
Characterization, stability and refolding of recombinant hirudin
1991
Defective arachidonate release and PGE2 production in Giα2-deficient intestinal and colonic subepithelial myofibroblasts
2006 StandoutNobel
Higher Level Relationships of Leeches (Annelida: Clitellata: Euhirudinea) Based on Morphology and Gene Sequences
1999 Standout
Comparison of the structures of the cyclotheonamide a complexes of human α‐thrombin and bovine β‐trypsin
1996
A player of many parts: The spotlight falls on thrombin's structure
1993
Inter-strand crosslinking of DNA by nitrogen mustard
1966 StandoutNobel
CSAR Benchmark Exercise 2013: Evaluation of Results from a Combined Computational Protein Design, Docking, and Scoring/Ranking Challenge
2015 StandoutNobel
Design and Synthesis of Thrombin Inhibitors: Analogues of MD-805 with Reduced Stereogenicity and Improved Potency
1999
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Bioorganometallic Chemistry of Ferrocene
2004 Standout
Serpin Structure, Mechanism, and Function
2002 Standout
Peptidomimetics—Tailored Enzyme Inhibitors
1994
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.
1989 Nobel
Phenylalanine Aminomutase-Catalyzed Addition of Ammonia to Substituted Cinnamic Acids: a Route to Enantiopure α- and β-Amino Acids
2009 StandoutNobel
The Nature and Significance of Platelet Products in Human Plasma
1967 Standout
Serine protease selectivity of the thrombin inhibitor D-Phe-Pro-Agmatine and its homologs
1995
Exploiting the current paradigm of blood–material interactions for the rational design of blood-compatible materials
2000
Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.
1993
The selective inhibition of thrombin by peptides of boroarginine.
1990
Peptido-organic Diels–Alder reactions on hydrophilic resin: scope for combinatorial chemistry
2001 StandoutNobel
Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.
1994 StandoutNobel
Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
2010 Standout
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy
2004 Standout
In-Depth Study of Tripeptide-Based α-Ketoheterocycles as Inhibitors of Thrombin. Effective Utilization of the S1‘ Subsite and Its Implications to Structure-Based Drug Design
2004
Etude des antigènes plaquettaires et, en particulier, du fibrinogène
1958
Derivatives of 5-amidine indole as inhibitors of thrombin catalytic activity
1996
Receptor and G protein-mediated responses to thrombin in HEL cells.
1991
Structure-Based Understanding of Ligand Affinity Using Human Thrombin as a Model System
1996
Structure of the hirugen and hirulog 1 complexes of α-thrombin
1991
Inhibition of Trypsin and Thrombin by Amino(4-amidinophenyl)methanephosphonate Diphenyl Ester Derivatives: X-ray Structures and Molecular Models,
1996
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Tripeptidyl pyridinium methyl ketones as potent active site inhibitors of thrombin
1996
Crystal structures of thrombin and thrombin complexes as a framework for antithrombotic drug design
1994
Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma.
1982
Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.
1990
A Field Guide to Foldamers
2001 Standout
Biochemical Properties and Crystal Structure of a β-Phenylalanine Aminotransferase from Variovorax paradoxus
2012 StandoutNobel
Small-molecule inhibitors of thrombin
1994
Active and Inactive Forms of the Transition-state Analog Protease Inhibitor Leupeptin: Explanation of the Observed Slow Binding of Leupeptin to Cathepsin B and Papain
1989
Cloning and expression of a cDNA coding for the anticoagulant hirudin from the bloodsucking leech, Hirudo medicinalis.
1986
Synthesis of peptide C-terminal derivatives using the transfer active ester condensation technique
1998
Molecular Docking: Challenges, Advances and its Use in Drug Discovery Perspective
2018 Standout
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
New Anticoagulants for the Cardiovascular Patient
1995
Specific Electrostatic Molecular Recognition in Water
2016 StandoutNobel
Transglutaminases: multifunctional cross‐linking enzymes that stabilize tissues
1991 Standout
Activation of the fibrin stabilizing factor of plasma by thrombin
1964
The use of sequence-specific antibodies to identify a secondary binding site in thrombin.
1988
Cyclic amides of Nα-arylsulfonylaminoacylated 4-amidinophenylalanine - tight binding inhibitors of thrombin
1983
Inhibitors of Serine Proteases as Potential Therapeutic Agents: The Road from Thrombin to Tryptase to Cathepsin G
2004
Refined 2·3ÅX-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA
1992
Sedimentation studies of the size and shape of DNA
1965 Standout
PAR1-dependent and independent increases in COX-2 and PGE2 in human colonic myofibroblasts stimulated by thrombin
2003
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening
2004 Standout
Biological importance of the indole nucleus in recent years: A comprehensive review
2010 Standout
On the isolation of the thrombin inhibitor hirudin
1985
The Alkaline Denaturation of Deoxyribose Nucleic Acid
1958
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Dissociation of fibrinogen and fibronectin binding from transglutaminase-mediated cross-linking at the hepatocyte surface.
1988
Arginine mimetics
2001
Epidemiology of amyotrophic lateral sclerosis.
1982
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Modulation of Procarboxypeptidase R (ProCPR) Activation by Complementary Peptides to Thrombomodulin
2003 StandoutNobel
Bioorthogonale Chemie – oder: in einem Meer aus Funktionalität nach Selektivität fischen
2009 StandoutNobel
Works of D Bagdy being referenced
Highly active and selective anticoagulants: D-Phe-Pro-Arg-H, a free tripeptide aldehyde prone to spontaneous inactivation, and its stable N-methyl derivative, D-MePhe-Pro-Arg-H
1990
[54] Hirudin
1976
On the NH2-terminal residue of hirudin
1973
Mammalian specificity of fibrinogen
1953
On the polysaccharide of fibrinogen and fibrin
1953
Inhibition by D-MePhe-Pro-Arg-H (GYKI-14766) of Thrombus Growth in Experimental Models of Thrombosis
1992
In Vitro Inhibition of Blood Coagulation by Tripeptide Aldehydes - A Retrospective Screening Study Focused on the Stable D-MePhe-Pro-Arg-H · H2SO4
1992
In Vivo Anticoagulant and Antiplatelet Effect of D-Phe-Pro-Arg-H and D-MePhe-Pro-Arg-H
1992
INHIBITION OF THROMBIN AND TRYPSIN BY TRIPEPTIDE ALDEHYDES
1978
Large scale preparation of hirudin
1973