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Citing Papers
Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginine.
1992
1990
Arginine, arginine analogs and nitric oxide production in chronic kidney disease
2006
1990
A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle.
1991
The generation of L-arginine in endothelial cells is linked to the release of endothelium-derived relaxing factor
1990 Nobel
NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy
2005
NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the l-arginine-nitric oxide pathway
1991
Endothelial cells metabolize NG -monomethyl-L-arginine to L-citrulline and subsequently to L-arginine
1990
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
1992 Standout
Biosynthesis of nitric oxide from l-arginine
1989
The 1991 Ulf von Euler Lecture:Thel ‐arginine: nitric oxide pathway
1992
A specific inhibitor of nitric oxide formation from l ‐arginine attenuates endothelium‐dependent relaxation
1989
The involvement of endothelium‐derived relaxing factor in the regulation of renal cortical blood flow in the rat
1991 Nobel
Chemical oxidation of N-hydroxyguanidine compounds
1992
NO•, CO and •OH Endogenous soluble guanylyl cyclase‐activating factors
1992
Hyperdynamic circulation in cirrhosis: a role for nitric oxide?
1991
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats.
1991
Nitric oxide, a novel neuronal messenger
1992 Standout
NG-Amino-L-arginine: A new potent antagonist of L-arginine-mediated endothelium-dependent relaxation
1990
Widespread tissue distribution, species distribution and changes in activity of Ca2+‐dependent and Ca2+‐independent nitric oxide synthases
1991
Stimulus-Secretion Coupling in Vascular Endothelial Cells
1990
Cultured endothelial cells maintain their L-arginine level despite the continuous release of EDRF
1990 Nobel
A synaptic model of memory: long-term potentiation in the hippocampus
1993 StandoutNature
Nitric oxide synthase is a cytochrome P-450 type hemoprotein
1992
The crucial role of physiological Ca2+concentrations in the production of endothelial nitric oxide and the control of vascular tone
1990
Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide
1990
Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation
1989
Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.
1990
Endothelial cells have a particulate enzyme system responsible for EDRF formation: Measurement by vascular relaxation
1991 StandoutNobel
Signal transduction mechanisms involving nitric oxide
1991 StandoutNobel
Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxidedelivery
2001
A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells
1989
Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: Requirement for inducible and constitutive components
1989
Klotho Protein Protects against Endothelial Dysfunction
1998
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans.
1992
Nitric oxide can modify amino acid residues in proteins
1992
L-arginine availability determines the duration of acetylcholine-induced systemic vasodilatation in vivo
1989
The 1989 Ulf von Euler Lecture Studies on endothelium‐dependent vasodilation and the endothelium‐derived relaxing factor
1990 StandoutNobel
Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands
1989
The L-Arginine-Nitric Oxide Pathway
1993 Standout
EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN
1989 Standout
Hemodynamic Shear Stress and Its Role in Atherosclerosis
1999 Standout
An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro
1989
Sickle-cell disease
2010 Standout
FAD and GSH participate in macrophage synthesis of nitric oxide
1990
Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation
1989
Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.
1992
Nitric oxide: A cytotoxic activated macrophage effector molecule
1988 Standout
Regulatory Functions of the Vascular Endothelium
1990 StandoutNobel
Nitric Oxide Acts Directly in the Presynaptic Neuron to Produce Long-Term Potentiationin Cultured Hippocampal Neurons
1996 StandoutNobel
Atherosclerosis — An Inflammatory Disease
1999 Standout
The role of nitric oxide in hippocampal long-term potentiation
1992
Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.
1990
Inhaled Nitric Oxide for the Adult Respiratory Distress Syndrome
1993
Mammalian Nitric Oxide Synthases
1992
Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages
1990
Effects of NG-monomethyl-L-arginine on field stimulation-induced decreases in cytosolic Ca2+ levels and relaxation in the rat anococcygeus muscle
1989
NG-methylarginine, and inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?
1989
Endothelial Regulation of Vascular Tone and Growth
1993
Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission
1992 StandoutNobel
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
1988 StandoutNature
Impact energy measurement in time-of-flight mass spectrometry with cryogenic microcalorimeters
1998 StandoutNatureNobel
Formation and release of nitric oxide from human neutrophils and HL‐60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4
1989
L-Arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation
1989
Does carbon monoxide have a physiological function?
1991
The Nitric Oxide Synthase II InhibitorNG-Nitro-L-Arginine Stimulates Pancreatic Islet Insulin Releasein Vitro, but not in the Perfused Pancreas*
1991
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate
1988
Impairment of Endothelium-Dependent Pulmonary-Artery Relaxation in Chronic Obstructive Lung Disease
1991
Modulation of acute inflammation by endogenous nitric oxide
1992
Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase
1996 StandoutNobel
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.
1989 Standout
The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes
1992 Standout
Endothelial nitric oxide synthase is myristylated
1992 StandoutNobel
Nitric oxide, a biological effector
1991
Pulmonary Complications of Sickle Cell Disease
2008
Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.
1996
Possible role of nitric oxide in transmitting information from vasodilator nerve to cerebroarterial muscle
1990
Isoforms of nitric oxide synthase Characterization and purification from different cell types
1991 StandoutNobel
On the stimulation of soluble and particulate guanylate cyclase in the rat brain and the involvement of nitric oxide as studied by cGMP immunocytochemistry
1992
L-Arginine is a precursor for nitrate biosynthesis in humans
1989
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Transgenic Mice Overexpressing Glycogen Synthase Kinase 3β: A Putative Model of Hyperactivity and Mania
2006
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation
1994 StandoutNatureNobel
NITRERGIC TRANSMISSION: NITRIC OXIDE AS A MEDIATOR OF NON‐ADRENERGIC, NON‐CHOLINERGIC NEURO‐EFFECTOR TRANSMISSION
1992
Synthesis of nitric oxide from l -arginine by neutrophils. Release and interaction with superoxide anion
1989
Biochemistry of Nitric Oxide and Its Redox-Activated Forms
1992 StandoutScience
Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages
1991
Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis.
1992 StandoutNobel
Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.
1991
Peroxynitrite oxidation of sulfhydryls.
1991 Standout
Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.
1992
Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus
1993 StandoutScienceNobel
Effects of amino acid infusion on renal hemodynamics. Role of endothelium-derived relaxing factor.
1991
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.
1993
Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.
1990
Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions.
1992
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
Nitric oxide: biosynthesis and biological significance
1989
Ion channels and regulation of intracellular calcium in vascular endothelial cells
1989
Nitric oxide therapy in sickle cell disease
2001
Production of an EDRF‐like activity in the cytosol of N1E‐115 neuroblastoma cells
1990 StandoutNobel
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
The emergence of mass spectrometry in biochemical research.
1994
L-arginine-induced hypotension
1991
Nitric oxide decreases cytosolic free calcium in Balb/c 3T3 fibroblasts by a cyclic GMP-independent mechanism.
1991
Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.
1994
Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.
1991 StandoutNobel
Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.
1989 StandoutNobel
Identification of arginine as a precursor of endothelium-derived relaxing factor.
1988
Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages
1989
Basic polyamino acids rich in arginine, lysine, or ornithine cause both enhancement of and refractoriness to formation of endothelium-derived nitric oxide in pulmonary artery and vein.
1989 StandoutNobel
Shear stress-induced release of nitric oxide from endothelial cells grown on beads.
1991 StandoutNobel
The possible role of hydrogen sulfide as an endogenous neuromodulator
1996 Standout
Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries. A new mechanism of vasospasm?
1990
Role of endothelium-derived relaxing factor in regulation of vascular tone and remodeling. Update on humoral regulation of vascular tone.
1991
Role of endothelium-derived nitric oxide in the regulation of blood pressure.
1989 Standout
Endothelium-derived relaxing factor and coronary vasospasm.
1989
Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide.
1989
Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.
1992
Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides
1992 Science
Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.
1991
EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.
1990
Are Adult Learning Mechanisms Also Used for Development?
1992 StandoutScienceNobel
Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate
1989
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.
1991
Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.
1989
Endothelial NOS and the Blockade of LTP by NOS Inhibitors in Mice Lacking Neuronal NOS
1994 StandoutScienceNobel
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
1991 StandoutNobel
Endothelium‐derived nitric oxide: actions and properties
1989 StandoutNobel
Effect of NG-monomethyl L-arginine on endothelium-dependent relaxation in arterioles of one-kidney, one clip hypertensive rats.
1991
Endothelium and control of vascular function. State of the Art lecture.
1989
Early loss of the tyrosyl radical in ribonucleotide reductase of adenocarcinoma cells producing nitric oxide
1992
Neuronal NADPH diaphorase is a nitric oxide synthase.
1991 Standout
Nitric oxide. A novel signal transduction mechanism for transcellular communication.
1990 StandoutNobel
Induction of calcium-dependent nitric oxide synthases by sex hormones.
1994
Nitric oxide as a secretory product of mammalian cells
1992 Standout
The discovery of nitric oxide as the endogenous nitrovasodilator.
1988
Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology.
1994
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.
1990 Standout
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
1996 StandoutNobel
Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.
1992
Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide.
1990 Nobel
An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.
1990
Flow-mediated endothelial mechanotransduction
1995 Standout
Atherosclerosis or lipoprotein-induced endothelial dysfunction. Potential mechanisms underlying reduction in EDRF/nitric oxide activity.
1992
Increased serum nitrite and nitrate levels in patients with cirrhosis: Relationship to endotoxemia
1993
Macrophages can convert citrulline into arginine
1992
Response : Nitric Oxide and Arginine-Evoked Insulin Secretion
1992 StandoutScienceNobel
Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells
1997
Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.
1989 Nobel
Nitric oxide synthases in mammals
1994 Standout
NG-methyl-L-arginine causes endothelium-dependent contraction and inhibition of cyclic GMP formation in artery and vein.
1990 StandoutNobel
Works of D. Ashton being referenced
Rapid validation of molecular structures of biological samples by electrospray‐mass spectrometry
1994
Neonatal neuronal overexpression of glycogen synthase kinase-3β reduces brain size in transgenic mice
2002
Vascular endothelial cells synthesize nitric oxide from L-arginine
1988 StandoutNature
Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline.
1991