Citation Impact
Citing Papers
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
2012 StandoutNobel
Integrin αvβ3-Targeted Radioimmunotherapy of Glioblastoma Multiforme
2008
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
Mechanisms of Integrin–Vascular Endothelial Growth Factor Receptor Cross-Activation in Angiogenesis
2007
Tumor-Selective Response to Antibody-Mediated Targeting of αvβ3 Integrin in Ovarian Cancer
2008
The DNA-damage response in human biology and disease
2009 StandoutNature
Angiogenesis in Wound Healing
2000
Structure and Function of Leukocyte Integrins
1990
Quantitative studies of endothelial cell adhesion. Directional remodeling of focal adhesion sites in response to flow forces.
1994
The Retinal Pigment Epithelium in Visual Function
2005 Standout
Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
1988 Standout
Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins
2002
An integrin αvβ3–c-Src oncogenic unit promotes anchorage-independence and tumor progression
2009
Integrins in cancer: biological implications and therapeutic opportunities
2009 Standout
Clinical translation of angiogenesis inhibitors
2002 Standout
Volociximab, a chimeric integrin alpha5beta1 antibody, inhibits the growth of VX2 tumors in rabbits
2007
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
1990 Nature
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Fibronectin and integrins in invasion and metastasis
1995
Targeting by affinity–matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform
1997 StandoutNobel
Elastin‐like polypeptides: Biomedical applications of tunable biopolymers
2010
Phase I and pharmacokinetic study of etaracizumab (Abegrin™), a humanized monoclonal antibody against αvβ3 integrin receptor, in patients with advanced solid tumors
2007
Src Kinase Activity Is Required for Integrin αVβ3-Mediated Activation of Nuclear Factor-κB
2005
Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor-2
1999
Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2), a beta integrin antagonist, in patients with solid tumours
2006
The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters
1998 StandoutNobel
Selective regulation of integrin–cytoskeleton interactions by the tyrosine kinase Src
1999
Interactions between cancer cells and the microvasculature: a rate-regulator for metastasis
1989
Integrins in angiogenesis and lymphangiogenesis
2008
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
2015 Standout
Structure, function and biological properties of integrin ?v?3on human melanoma cells
1991
Identity between the novel integrin β7 subunit and an antigen found highly expressed on intraepithelial lymphocytes in the small intestine
1991
The Hallmarks of Cancer
2000 Standout
Integrins and cancer
1996
Platelet Membrane Glycoproteins: Functions in Cellular Interactions
1990
Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies
2003
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Effects of Vitaxin®, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro
2007
alpha vbeta 3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF
1997
Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
1994 Standout
Noninvasive Visualization of the Activated αvβ3 Integrin in Cancer Patients by Positron Emission Tomography and [18F]Galacto-RGD
2005
Roles of Adhesion Molecules in T‐Cell Recognition: Fundamental Similarities between Four Integrins on Resting Human T Cells (LFA‐1, VLA‐4, VLA‐5, VLA‐6) in Expression, Binding, and Costimulation
1990
Expression of Integrin αVβ3 in Pancreatic Carcinoma: Relation to MMP-2 Activation and Lymph Node Metastasis
2002
Rho GTPases in cell biology
2002 StandoutNature
Retinal and choroidal neovascularization
2000
The microenvironment of the tumour–host interface
2001 StandoutNature
Review: The Integrin αvβ3: Angiogenesis and Apoptosis
1995
Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling
1993
Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.
1995
Adhesion receptors of the immune system
1990 StandoutNature
αvβ3 integrin and angiogenesis: a moody integrin in a changing environment
2008
Classification of anticancer drugs—a new system based on therapeutic targets
2003
The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression
1996
Atherosclerosis — An Inflammatory Disease
1999 Standout
Integrin signalling during tumour progression
2004
Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition
2003
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
A novel vitronectin receptor integrin (αvβx) is responsible for distinct adhesive properties of carcinoma cells
1989
Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.
1997
Revealing the world of RNA interference
2004 StandoutNatureNobel
Novel Targets Against Retinal Angiogenesis in Diabetic Retinopathy
2012
CNTO 95, a fully human monoclonal antibody that inhibits αv integrins, has antitumor and antiangiogenic activity in vivo
2004
Mechanisms of Bone Metastasis
2004 Standout
αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells
2000
Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.
1996
Atherosclerosis
2000 StandoutNature
Controlling protein assembly on inorganic crystals through designed protein interfaces
2019 StandoutNatureNobel
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)
1991
Basic FGF and TGF-β differentially modulate integrin expression of human microvascular endothelial cells
1992
Integrins as mechanochemical transducers
1991
Prolonged exercise induces angiogenesis and increases cerebral blood volume in primary motor cortex of the rat
2003 StandoutNobel
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
Absence of Adverse Effects in Cynomolgus Macaques Treated with CNTO 95, a Fully Human Anti-αv Integrin Monoclonal Antibody, Despite Widespread Tissue Binding
2005
Cation-dependent changes in the binding specificity of the platelet receptor GPIIb/IIIa.
1990
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
1997 StandoutScience
Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface.
1991
Proliferation and the Monoclonal Origins of Atherosclerotic Lesions
1998
Dysregulation of Apoptosis in Cancer
1999
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
2015 StandoutNobel
The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site.
1991
A systems approach to cancer therapy
1996
Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.
1994
Specific Targeting of Tumor Angiogenesis by RGD-Conjugated Ultrasmall Superparamagnetic Iron Oxide Particles Using a Clinical 1.5-T Magnetic Resonance Scanner
2007
Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites.
1990
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
2001 Standout
Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.
1996
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
Preferential Susceptibility of Brain Tumors to the Antiangiogenic Effects of an αv Integrin Antagonist
2001
Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death.
1999
Modulation of vitronectin receptor binding by membrane lipid composition.
1990
Progress in the Delivery of Therapeutic Oligonucleotides: Organ/Cellular Distribution and Targeted Delivery of OligonucleotidesIn Vivo
2003
Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking αvβ5 integrin
2003
Direct targeting of αvβ3 integrin on tumor cells with a monoclonal antibody, Abegrin™
2006
Integrin αv-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen
2004
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
Cloning and expression of a divergent integrin subunit beta 8.
1991
Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.
1987
Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis
2003
Substratum-induced stress fiber assembly in vascular endothelial cells during spreading in vitro
1990
Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.
1994
In vitro and In vivo Characterization of 64Cu-Labeled AbegrinTM, a Humanized Monoclonal Antibody against Integrin αvβ3
2006
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3
2003
Wound Healing--Aiming for Perfect Skin Regeneration
1997 StandoutScience
Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo.
1998
Integrin Signaling
1999 StandoutScience
Integrin αvβ3 Requirement for Sustained Mitogen-activated Protein Kinase Activity during Angiogenesis
1998
Function and Regulation of the β3 Integrins in Hemostasis and Vascular Biology
1995
pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
1998 StandoutNobel
Adhesion of Activated Platelets to Endothelial Cells: Evidence for a GPIIbIIIa-dependent Bridging Mechanism and Novel Roles for Endothelial Intercellular Adhesion Molecule 1 (ICAM-1), αvβ3 Integrin, and GPIbα
1998
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Phase I Trial of a Monoclonal Antibody Specific for αvβ3 Integrin (MEDI-522) in Patients with Advanced Malignancies, Including an Assessment of Effect on Tumor Perfusion
2005
Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice.
2003
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Noninvasive Assessment of Angiogenesis by Ultrasound and Microbubbles Targeted to α v -Integrins
2003
Elevated Flk1 (Vascular Endothelial Growth Factor Receptor 2) Signaling Mediates Enhanced Angiogenesis in β3-Integrin–Deficient Mice
2004
A novel integrin beta subunit is associated with the vitronectin receptor alpha subunit (alpha v) in a human osteosarcoma cell line and is a substrate for protein kinase C.
1989
Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.
1990
Cooperation between VEGF and β3 integrin during cardiac vascular development
2006
Wound Healing: A Cellular Perspective
2018 Standout
Surfing the p53 network
2000 StandoutNature
Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes
1998
Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits.
1990
Regulation of the fibronectin receptor affinity by divalent cations.
1988
Modulation of vitronectin receptor-mediated osteoclast adhesion by Arg-Gly-Asp peptide analogs: A structure-function analysis
1993
A phage display approach for rapid antibody humanization: Designed combinatorial V gene libraries
1998
Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.
1992
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
1997 StandoutScience
Endothelial cells use alpha 2 beta 1 integrin as a laminin receptor.
1989
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
2005 StandoutScience
A distinct integrin-mediated phagocytic pathway for extracellular matrix remodeling by RPE cells.
1999
Role of the alpha v beta 3 integrin in human melanoma cell invasion.
1992
Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8.
1990
Enhanced Expression of Osteopontin by High Glucose in Cultured Rat Aortic Smooth Muscle Cells
1999
Phase I and Correlative Biology Study of Cilengitide in Patients With Recurrent Malignant Glioma
2007
Integrin (alpha v beta 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor.
1990
Definition of Two Angiogenic Pathways by Distinct α v Integrins
1995 Science
Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the β-subunits of the integrin family
1991
Synergistic effect of HIF-1α gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
2009 StandoutNobel
Osteopontin
2000 Standout
The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross-linking implicates amino acid residues 61-203 of the beta subunit.
1988
Endothelial cells in physiology and in the pathophysiology of vascular disorders.
1998 Standout
Requirement of Vascular Integrin α v β 3 for Angiogenesis
1994 StandoutScience
An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization
1995
A β 3 Integrin Mutation Abolishes Ligand Binding and Alters Divalent Cation-Dependent Conformation
1990 Science
Requirement of the integrin beta 3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen
1992
Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task
2000 StandoutNobel
The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.
1990
Cloning of an integrin beta subunit exhibiting high homology with integrin beta 3 subunit.
1990
Minute dosages of α ν β 3 ‐targeted fumagillin nanoparticles impair Vx‐2 tumor angiogenesis and development in rabbits
2008
Geometric Control of Cell Life and Death
1997 StandoutScience
NF-κB Mediates αvβ3 Integrin-induced Endothelial Cell Survival
1998
Lipopeptide with a RGDK Tetrapeptide Sequence Can Selectively Target Genes to Proangiogenic α5β1 Integrin Receptor and Mouse Tumor Vasculature
2008
Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry
2014 StandoutNobel
Flow-mediated endothelial mechanotransduction
1995 Standout
Integrin heterodimer and receptor complexity in avian and mammalian cells.
1989
Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells.
1991
Integrin αvβ3‐targeted therapy for Kaposi's sarcoma with an in vitro‐evolved antibody
2002
The membrane glycoprotein Ia-IIa (VLA-2) complex mediates the Mg++-dependent adhesion of platelets to collagen.
1989
Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.
1992
Works of D A Cheresh being referenced
The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.
1995
Role of V Integrins and Vitronectin in Human Melanoma Cell Growth
1992
Integrins, angiogenesis and vascular cell survival
1996
Design, synthesis and biological evaluation of nonpeptide integrin antagonists
1998
Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells
1989
Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin.
1992
Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells.
1991
Transient functional expression of alphaVbeta 3 on vascular cells during wound repair.
1996
Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin alphavbeta3.
2000
Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor.
1987
The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin.
1990
Integrin alphavbeta3 is expressed in selected microvessels after focal cerebral ischemia.
1996
cDNA sequence of the human integrin beta 5 subunit.
1990
Role of alpha v integrins during angiogenesis.
2000
Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases.
1996
Tumor angiogenesis and the role of vascular cell integrin alphavbeta3.
1996