Citation Impact
Citing Papers
Prospective identification of tumorigenic breast cancer cells
2003 Standout
Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation
2001
Disruption of Transforming Growth Factor-β Signaling in ELF β-Spectrin-Deficient Mice
2003 Science
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
The BRCT Domain Is a Phospho-Protein Binding Domain
2003 Science
TGF-β Signaling in Myeloid Cells Is Required for Tumor Metastasis
2013
The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity
2002
The Abnormal Spindle-like, Microcephaly-associated (ASPM) Gene Encodes a Centrosomal Protein
2005
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
High serum interleukin‐6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B
2009
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
The many substrates and functions of ATM
2000
Gene expression profiling predicts clinical outcome of breast cancer
2002 StandoutNature
The DNA-damage response in human biology and disease
2009 StandoutNature
Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice
2001
Probing p53 biological functions through the use of genetically engineered mouse models
2005
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Macrophage-derived IL-1β stimulates Wnt signaling and growth of colon cancer cells: a crosstalk interrupted by vitamin D3
2009
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
2005 StandoutNature
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
2008
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
2012
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Cell-cycle checkpoints and cancer
2004 StandoutNature
SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling
2017
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019 Standout
TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment
2017
Insights into the functions of BRCA1 and BRCA2
2000
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
Molecular Mechanism of Liver Development and Regeneration
2007
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
2000
The Breast Cancer Susceptibility Gene BRCA1 Is Required for Subnuclear Assembly of Rad51 and Survival following Treatment with the DNA Cross-linking Agent Cisplatin
2000
Cancer Risk and the ATM Gene: a Continuing Debate
2000
Frequent chromosomal translocations induced by DNA double-strand breaks
2000 Nature
The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling
2009
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
2000
Cancer Modeling in the Modern Era
2002
DNA repair deficiency as a therapeutic target in cancer
2008
NFBD1, a Novel Nuclear Protein with Signature Motifs of FHA and BRCT, and an Internal 41-Amino Acid Repeat Sequence, Is an Early Participant in DNA Damage Response
2003
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
2000 Nature
BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression
2000
Regulatory phases of early liver development: paradigms of organogenesis
2002
TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
2010
Inflammation and Colon Cancer
2010 Standout
TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota
2017
Induction of GADD45 and JNK/SAPK-Dependent Apoptosis following Inducible Expression of BRCA1
1999
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
2001
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
2003
Immunity, Inflammation, and Cancer
2010 Standout
Immunoregulation by members of the TGFβ superfamily
2016
Combined immune checkpoint blockade as a therapeutic strategy for BRCA1 -mutated breast cancer
2017
Identification and expansion of human colon-cancer-initiating cells
2006 StandoutNature
Sensing and responding to DNA damage
2000
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
2009
Comparative biology of mouse versus human cells: modelling human cancer in mice
2003
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
2000 Nature
The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation
2001
DNA double-strand breaks: signaling, repair and the cancer connection
2001 Standout
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences
2001
LKB1; linking cell structure and tumor suppression
2008
The genetics of hereditary colon cancer
2007
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
TGFβ in Cancer
2008 Standout
Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation
2000
Transforming growth factor beta (TGF-β) and inflammation in cancer
2009
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Regulation of chromatin structure by site-specific histone H3 methyltransferases
2000 StandoutNature
MicroRNA expression profiles classify human cancers
2005 StandoutNatureNobel
Collaboration of Brca1 and Chk2 in tumorigenesis
2004
The Hallmarks of Aging
2013 Standout
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Inflammation-Mediated Genetic and Epigenetic Alterations Drive Cancer Development in the Neighboring Epithelium upon Stromal Abrogation of TGF-β Signaling
2013
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
2002
BRCA1 Is Associated with a Human SWI/SNF-Related Complex
2000
Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice
2011
Identification of human brain tumour initiating cells
2004 StandoutNature
Recent advances in breast cancer biology
1999
VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing
2012 Standout
Co-evolution of tumor cells and their microenvironment
2008
TGF-β signaling alterations and susceptibility to colorectal cancer
2007
Activin receptor‐like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes
2014
Activin receptor‐like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes
2013
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
Brca2 (XRCC11) Deficiency Results in Radioresistant DNA Synthesis and a Higher Frequency of Spontaneous Deletions
2002
TGF-β Activation and Function in Immunity
2013
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
2000
Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells
2008
The G2-phase DNA-damage checkpoint
2000
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
2006 StandoutNature
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development
2010
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response
1999 Science
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor
2001
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
2012 StandoutNobel
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
2006 StandoutNobel
Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
1999 Science
The genesis and evolution of high-grade serous ovarian cancer
2010
Cancer Genome Landscapes
2013 StandoutScience
Translating the Histone Code
2001 StandoutScience
Targeting the TGFβ pathway for cancer therapy
2014
A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53‐null mammary epithelial cell mode .
2000
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
2000 Nobel
Brca1 Controls Homology-Directed DNA Repair
1999
Human DNA Repair Genes
2001 StandoutScienceNobel
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Works of Cuiling Li being referenced
Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling
2008
Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce Genetic Instability in BRCA1 Exon 11 Isoform–Deficient Cells
1999
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
2006 Nature
The Inhibition and Treatment of Breast Cancer with Poly (ADP-ribose) Polymerase (PARP-1) Inhibitors
2006
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation
1999
Smad Proteins and Hepatocyte Growth Factor Control Parallel Regulatory Pathways That Converge on β1-Integrin To Promote Normal Liver Development
2001