Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Mechanism of met oncogene activation
1986
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast
1995 StandoutNobel
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Oncogenes and Cancer
2008
Chronic myelogenous leukemia
2001
Cytogenetics in acute leukemia
2003
Chronic myeloid leukaemia as a model of disease evolution in human cancer
2007
Multilineage hematopoietic disorders induced by transplantation of bone marrow cells expressing the v-fms oncogene
1987
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias
1988
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
the Viral and Cellular Forms of the Abelson (Dbl) Oncogene
1988
Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas
2010 StandoutNobel
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma
1993
Causes and consequences of microRNA dysregulation in cancer
2009 Standout
Chromosomal translocations in human cancer
1994 Nature
Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia
2001
HIV infection does not require endocytosis of its receptor, CD4
1988 StandoutNobel
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting
1989 StandoutNatureNobel
Molecular portraits of human breast tumours
2000 StandoutNature
Molecular genetics, natural history and the demise of childhood leukaemia
1999
Role of the newer p53 family proteins in malignancy
2001 StandoutNobel
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Regulation by HIV Rev depends upon recognition of splice sites
1989 StandoutNobel
Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations
1991
Platelet-activating factor enhances the expression of vascular endothelial growth factor in normal human astrocytes
2002
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
Activation of C. elegans cell death protein CED-9 by an ammo-acid substitution in a domain conserved in Bcl-2
1994 StandoutNatureNobel
p73: Friend or foe in tumorigenesis
2002
Retroviruses
1988 Science
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
The Chronic Myelocytic Cell Line K562 Contains a Breakpoint in bcr and Produces a Chimeric bcr/c-abl Transcript
1986
Sustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence.
1988 StandoutNobel
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
1999 StandoutScience
Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.
1985
Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
2013 StandoutNobel
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/neuOncogene
1987 StandoutScience
An appraisal of the application of recombinant DNA techniques to chromosome defects
1985
Activation Of Cellular Oncogenes in Hemopoietic Cells by Chromosome Translocation
1986
A cluster of chromosome 11p13 translocations found via distinct D-D and D-D-J rearrangements of the human T cell receptor delta chain gene.
1988
DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer
1997
Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene.
1986 StandoutNobel
Molecular analysis of mbcl-2: Structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma
1987
THE MOLECULAR GENETICS OF CELLULAR ONCOGENES
1984
Induction of Chronic Myelogenous Leukemia in Mice by the P210 bcr/abl Gene of the Philadelphia Chromosome
1990 StandoutScienceNobel
Isolation of the proto-oncogene c-myb from D. melanogaster
1985 StandoutNobel
Structural organization and nucleotide sequence of mouse c-myboncogene: activation in ABPL tumors is due to viral integration in an intron which results in the deletion of the 5′ coding sequences
1986
Variable Philadelphia breakpoints and potential lineage restriction of bcr rearrangement in acute lymphoblastic leukemia
1988
v-ras genes from harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis
1986
An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity
1984
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate
2000
The First Intron in the Human c-abl Gene Is at Least 200 Kilobases Long and Is a Target for Translocations in Chronic Myelogenous Leukemia
1987 Nobel
Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
1995 StandoutScience
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Evidence for the Involvement of GM-CSF and FMS in the Deletion (5q) in Myeloid Disorders
1986 Science
Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.
1986
Fused transcript of abl and bcr genes in chronic myelogenous leukaemia
1985 StandoutNature
Evolution of tumours and the impact of molecular oncology
1985 Nature
The CML-Specific P210 bcr / abl Protein, Unlike v- abl , Does Not Transform NIH/3T3 Fibroblasts
1987 ScienceNobel
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
2000 StandoutNobel
Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.
1999
Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
1985 StandoutScienceNobel
Variable expression of the translocated c-abl oncogene in Philadelphia-chromosome-positive B-lymphoid cell lines from chronic myelogenous leukemia patients.
1986
DNA sequences that mediate attenuation of transcription from the mouse protooncogene myc.
1989 StandoutNobel
Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma.
1989 StandoutNobel
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
1985 StandoutNobel
Cellular transforming genes and oncogenesis
1984
TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia
1996
The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion
2000
Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.
1988 Nobel
In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.
1987
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
1987 StandoutNobel
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.
1986
Evidence of a New Chimericbcr/c-ablmRNA in Patients with Chronic Myelocytic Leukemia and the Philadelphia Chromosome
1985
Autoproteolysis in nucleoporin biogenesis
1999 StandoutNobel
A cellular gene encodes scrapie PrP 27-30 protein
1985 StandoutNobel
Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice
2011 StandoutNobel
Current status of cytogenetic research in childhood acute lymphoblastic leukemia
1993
Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.
1988
Oncogene Amplification in Tumor Cells
1986
Oncogene v-src transforms and establishes embryonic rodent fibroblasts but not diploid human fibroblasts.
1988 StandoutNobel
Structural organization of the bcr gene and its role in the Ph′ translocation
1985 Nature
Large-scale analysis of the human and mouse transcriptomes
2002 StandoutNobel
Two closely linked but separable promoters for human neuronal nitric oxide synthase gene transcription.
1995 StandoutNobel
Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae.
1987 StandoutNobel
The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia.
1987 Nobel
Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties.
1985
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture
1985 StandoutNatureNobel
Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene.
1992
Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.
1985
Works of CR Bartram being referenced
Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92.
1996
Acute leukemia with chromosome translocation (4; 11): 7 new patients and analysis of 71 cases
1987
Activation of proto-oncogenes in human leukemias
1985
Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
1984 Standout
bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia
1986
T lymphocytes lack rearrangement of the bcr gene in Philadelphia chromosome-positive chronic myelocytic leukemia
1987
Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia.
1996
TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia
1996
Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation.
1999
Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KIP1
1996
Clonal remissions in acute nonlymphocytic leukemia: evidence for a multistep pathogenesis of the malignancy
1991
Dek-can rearrangement in translocation (6;9)(p23;q34).
1992
Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood
1993
Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood
1995
Rapid and reliable quantification of minimal residual disease in acute lymphoblastic leukemia using rearranged immunoglobulin and T-cell receptor loci by LightCycler technology.
2000