Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma
2005
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Multipotent CD15+ Cancer Stem Cells in Patched-1 –Deficient Mouse Medulloblastoma
2009
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
2001 Standout
Unbalanced overexpression of the mutant allele in murine Patched mutants
2002
Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
2014 Standout
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
Caught up in a Wnt storm: Wnt signaling in cancer
2003
The NEDD8 Pathway Is Essential for SCFβ-TrCP-mediated Ubiquitination and Processing of the NF-κB Precursor p105
2002 StandoutNobel
Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449
2009 Standout
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
1999 StandoutNature
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
2003 StandoutNature
Structural basis of the Axin–adenomatous polyposis coli interaction
2000
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
2002 Standout
Frequent Nuclear/Cytoplasmic Localization of β-Catenin without Exon 3 Mutations in Malignant Melanoma
1999
Applying the principles of stem-cell biology to cancer
2003
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
2002 Standout
The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cell
1999
Cancer Metastasis: Building a Framework
2006 Standout
Beta‐catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics
2009
WNT signalling pathways as therapeutic targets in cancer
2012 Standout
A common human skin tumour is caused by activating mutations in β-catenin
1999
Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer
1998
The minimum LOH region defined on chromosome 17p13.3 in human hepatocellular carcinoma with gene content analysis
2003
Wnt proteins are lipid-modified and can act as stem cell growth factors
2003 StandoutNature
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Stem cells find their niche
2001 StandoutNature
Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade
2002 StandoutScience
The links between axin and carcinogenesis
2005
Evolution of a designed protein assembly encapsulating its own RNA genome
2017 StandoutNatureNobel
Missing Pieces in the NF-κB Puzzle
2002 Standout
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function
2004 StandoutNobel
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Processing of p105 Is Inhibited by Docking of p50 Active Subunits to the Ankyrin Repeat Domain, and Inhibition Is Alleviated by Signaling via the Carboxyl-terminal Phosphorylation/ Ubiquitin-Ligase Binding Domain
2001 StandoutNobel
Wnt/β-Catenin Signaling and Disease
2012 Standout
Medulloblastoma in childhood: new biological advances
2007
AXIN1 mutations but not deletions in cerebellar medulloblastomas
2003
Cancer stem cells and brain tumors: uprooting the bad seeds
2007
Engineering targeted viral vectors for gene therapy
2007
Analysis of <i>β-Catenin</i> Gene Mutations in Pancreatic Tumors
1999
Identification and expansion of human colon-cancer-initiating cells
2006 StandoutNature
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
Malignant Gliomas in Adults
2008 Standout
Inhibition of NF-κB Activation by Arsenite through Reaction with a Critical Cysteine in the Activation Loop of IκB Kinase
2000 StandoutNobel
The oncogenic activation of β-catenin
1999
Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways
1999
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
β-Catenin Expression Pattern in Stage I and II Ovarian Carcinomas
1999
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Antigen‐presenting cell exosomes are protected from complement‐mediated lysis by expression of CD55 and CD59
2003
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
β-Catenin Mutations Are Frequent in Human Hepatocellular Carcinomas Associated with Hepatitis C Virus Infection
1999
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 Standout
Identification of human brain tumour initiating cells
2004 StandoutNature
Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor)
1999
Wnt signalling in stem cells and cancer
2005 StandoutNature
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice
2004
Crypt stem cells as the cells-of-origin of intestinal cancer
2008 StandoutNature
Mutations in SUFU predispose to medulloblastoma
2002 Standout
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
2000
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin gene
1999
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
β-Trcp couples β-catenin phosphorylation-degradation and regulates Xenopus axis formation
1999
Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene.
1999
Genomics Identifies Medulloblastoma Subgroups That Are Enriched for Specific Genetic Alterations
2006
Wnt signaling and cancer
2000 Standout
A molecular fingerprint for medulloblastoma.
2003
The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression.
2000
Inhibition of Adipogenesis by Wnt Signaling
2000 StandoutScience
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched.
2000
Integrin Signaling
1999 StandoutScience
The Origins of Medulloblastoma Subtypes
2008
γ-Catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of β-catenin
2000
Neoplastic Transformation of RK3E by Mutant β-Catenin Requires Deregulation of Tcf/Lef Transcription but Not Activation of c-myc Expression
1999
The Developmental Biology of Brain Tumors
2001
Medulloblastoma Stem Cells
2008
Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas.
2001
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
2004 Standout
Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched.
2001
Works of Cory Allen being referenced
Retargeted Oncolytic Measles Strains Entering via the EGFRvIII Receptor Maintain Significant Antitumor Activity against Gliomas with Increased Tumor Specificity
2006
Analysis ofPTCH/SMO/SHH pathway genes in medulloblastoma
2000
Cloning of a Human Ortholog (RPH3AL) of (RNO)Rph3al from a Candidate 17p13.3 Medulloblastoma Tumor Suppressor Locus
1999
Membrane cofactor protein (CD46) protects cells from complement-mediated attack by an intrinsic mechanism.
1992
Evidence that haploinsufficiency ofPtch leads to medulloblastoma in mice
2000
Sporadic medulloblastomas contain oncogenic beta-catenin mutations.
1998