Citation Impact
Citing Papers
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
Transforming Growth Factor (TGF)-β1 Internalization
2001
Beta-adrenoceptors in cardiac disease
1993
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Phosphorylation of Cell Surface Receptors: A Mechanism for Regulating Signal Transduction Pathways
1988 StandoutNobel
Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M 3 receptor
2006
Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor
1995 StandoutNatureNobel
β3 and Atypical β‐Adrenoceptors
1993
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins
2002
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
1992 StandoutNatureNobel
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins
1996
Endocytosis and recycling of G protein-coupled receptors
1997
Phosphorylation of the β-adrenergic receptor in intact cells: Relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization
1987 StandoutNobel
Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization
1988 StandoutNatureNobel
Binding of the β2 Adrenergic Receptor toN-Ethylmaleimide-sensitive Factor Regulates Receptor Recycling
2001 StandoutNobel
The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
1998 StandoutNatureNobel
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
Type-specific Sorting of G Protein-coupled Receptors after Endocytosis
2000
The C-terminus of the S. cerevisiae α-pheromone receptor mediates an adaptive response to pheromone
1988 StandoutNobel
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
Expression and purification of truncated, non-glycosylated turkey beta-adrenergic receptors for crystallization
2003
A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.
1994 StandoutNobel
THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
1998
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.
1986 StandoutNobel
Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.
1990 StandoutNobel
Two isoforms of prostaglandin E receptor EP3 subtype. Different COOH-terminal domains determine sensitivity to agonist-induced desensitization
1993
Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.
1992 StandoutNobel
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia
1992 StandoutScienceNobel
Stage-specific assays for coated pit formation and coated vesicle budding in vitro.
1991
Antagonist-dependent and -independent steps in the mechanism of adrenergic receptor internalization
1994 StandoutNobel
Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.
1990 StandoutNobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration
1987
Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor
1994 StandoutScienceNobel
Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.
1986 StandoutNobel
Localization of β-adrenergic receptors in A431 cells in situ. Effect of chronic exposure to agonist
1989
Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.
1987 StandoutNobel
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation.
1991
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.
1983
Carbachol induces desensitization of cardiac β-adrenergic receptors through muscarinic M1 receptors
1985
A dileucine motif in the C terminus of the β 2 -adrenergic receptor is involved in receptor internalization
1997
Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c
1996 StandoutScienceNobel
A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for .beta.-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase
1986 StandoutNobel
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins
1996
Bromoacetylalprenololmenthane binding to β‐receptors modulates the rate of hormone‐induced internalization but not desensitization in S49 cells
1987
Overlapping multi-site domains of the muscarinic cholinergic Hm1 receptor involved in signal transduction and sequestration.
1994
Agonist-Induced Redistribution of 0-Adrenergic Receptors on Intact Human Mononuclear Leukocyte Redistributed Receptors Are Nonfunctional*
1985
Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization
1989 StandoutNobel
Synergistic Regulation of β2-Adrenergic Receptor Sequestration: Intracellular Complement of β-Adrenergic Receptor Kinase and β-Arrestin Determine Kinetics of Internalization
1997 StandoutNobel
Do agonists promote rapid internalization of beta-adrenergic receptors?
1985
Functional alteration of the beta-adrenergic receptor during desensitization of mammalian adenylate cyclase by beta-agonists.
1984
Genetic analysis of beta-adrenergic receptor internalization and down-regulation.
1985
Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization.
1984
Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.
1993
Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase
1986 StandoutNatureNobel
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
Desensitization of the beta-adrenergic receptor-coupled adenylate cyclase in cultured mammalian cells. Receptor sequestration versus receptor function.
1986
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
1987 StandoutScienceNobel
Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment.
1985 StandoutNobel
Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2.
1992
Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model
1985 StandoutNatureNobel
Endocytosis and recycling of G protein-coupled receptors
1997
Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors
1992 StandoutScienceNobel
Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.
1988
Conformational thermostabilization of the β1-adrenergic receptor in a detergent-resistant form
2008
β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
1990 StandoutScienceNobel
ATP is required for receptor-mediated endocytosis in intact cells.
1990
Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.
1985 StandoutNobel
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
β‐Adrenergic receptor desensitization of wild‐type but not cyc lymphoma cells unmasked by submillimolar Mg 2+
1987
Works of Cornelia Hertel being referenced
A truncation mutation in the avian beta-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors.
1990
Determination of the desensitization of β-adrenergic receptors by [3H]CGP-12177
1983
Some Unique Properties of CGP-12177
1984
A comparison of catecholamine-induced internalization of beta-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. Inhibition by phenylarsine oxide.
1985
Receptor-specific mechanisms of desensitization of β-adrenergic receptor function
1984
(-)-S-[3H]CGP-12177 and its use to determine the rate constants of unlabeled beta-adrenergic antagonists.
1985
Reappearance of beta-adrenergic receptors after isoproterenol treatment in intact C6-cells.
1983
Cellular redistribution of β‐adrenergic receptors in a human astrocytoma cell line: A comparison with the epidermal growth factor receptor in murine fibroblasts
1985
Evidence for intravesicular beta-adrenergic receptors in membrane fractions from desensitized cells: binding of the hydrophilic ligand CGP-12177 only in the presence of alamethicin.
1983
The involvement of cellular ATP in receptor-mediated internalization of epidermal growth factor and hormone-induced internalization of beta-adrenergic receptors.
1986
[3H]CGP-12177, A β-Adrenergic Ligand Suitable for Measuring Cell Surface Receptors
1983