Citation Impact
Citing Papers
Structural basis for the docking of mTORC1 on the lysosomal surface
2019 Science
Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi–lysosome contact site
2017
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses
2020
Nutrient sensing and TOR signaling in yeast and mammals
2017
Loss of C9 ORF 72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
2016
Dedicated SNARE s and specialized TRIM cargo receptors mediate secretory autophagy
2016
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization
2018
The Implications of Autophagy in Alzheimer’s Disease
2018
DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity
2018 StandoutNobel
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence
2019
A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway
2014
Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis
2015
Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease
2013
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans
2013
Fasting-induced hormonal regulation of lysosomal function
2017
Head and neck squamous cell carcinoma
2020 Standout
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
2013 Standout
Making new contacts: the mTOR network in metabolism and signalling crosstalk
2014
Autophagy in infection, inflammation and immunity
2013 Standout
Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism
2015 Nature
A C9orf72 ALS/FTD Ortholog Acts in Endolysosomal Degradation and Lysosomal Homeostasis
2018 Nobel
mTOR and autophagy: A dynamic relationship governed by nutrients and energy
2014
Controversies around epithelial–mesenchymal plasticity in cancer metastasis
2019
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
2013
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
2020 Standout
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
2017
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue
2016
Mechanism and medical implications of mammalian autophagy
2018 Standout
Molecular mechanisms of epithelial–mesenchymal transition
2014 Standout
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
2017 Nature
The role of autophagy in neurodegenerative disease
2013 Standout
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
2017
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
2016
An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis
2019
Wnt signaling in cancer
2016 Standout
Targeting Ferroptosis to Iron Out Cancer
2019 Standout
Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
2018 Nature
Sphingolipids and their metabolism in physiology and disease
2017 Standout
Nutrient-sensing mechanisms and pathways
2015 Nature
Hallmarks of aging: An expanding universe
2023 Standout
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
2018 Standout
The Enigmatic Role of C9ORF72 in Autophagy
2017
mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy
2017
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Recent insights into the function of autophagy in cancer
2016
Decoding ALS: from genes to mechanism
2016 StandoutNature
TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis
2016
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
2020 Standout
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy
2013
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival
2012 Nature
Extracellular matrix structure
2015 Standout
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
2017
Drug repurposing: progress, challenges and recommendations
2018 Standout
Dynamics and functions of lipid droplets
2018 Standout
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
2017 Nature
Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism
2015
A RANKL–PKCβ–TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts
2013
Breaking fat: The regulation and mechanisms of lipophagy
2017
Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism
2017 StandoutNobel
Oxidative Stress in Cancer
2020 Standout
The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
2014
Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism
2015
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
2022 Standout
Insights into the key roles of proteoglycans in breast cancer biology and translational medicine
2015
Pleiotropic Effects of mTOR and Autophagy During Development and Aging
2019
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
Regulation of proteasome assembly and activity in health and disease
2018
Targeting autophagy in cancer
2017 Standout
AKT/PKB Signaling: Navigating the Network
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
2016
p120 Catenin
2013
Mitochondrial TCA cycle metabolites control physiology and disease
2020 Standout
The PI3K Pathway in Human Disease
2017 Standout
Regulation of mTORC1 and its impact on gene expression at a glance
2013
Regulation of mTORC1 by amino acids
2014
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy
2017
Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy
2017
Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
2017
Molecular logic of mTORC1 signalling as a metabolic rheostat
2019
Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells
2013
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Innate Host Defense Requires TFEB-Mediated Transcription of Cytoprotective and Antimicrobial Genes
2014
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
Autophagy in the liver: functions in health and disease
2017
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
The pros, cons, and many unknowns of probiotics
2019 Standout
Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier
2019 StandoutNobel
TFEB at a glance
2016
mTOR coordinates protein synthesis, mitochondrial activity and proliferation
2015
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Intestinal permeability – a new target for disease prevention and therapy
2014 Standout
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence
2016
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
2015
MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells
2015
Metabolic reprogramming and cancer progression
2020 StandoutScience
MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5
2015
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
2013 StandoutNobel
Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
2013
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
2013
mTOR: a pharmacologic target for autophagy regulation
2015 Standout
Hepatocyte Nuclear Factor 4α, a Key Factor for Homeostasis, Cell Architecture, and Barrier Function of the Adult Intestinal Epithelium
2009
Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
2018
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes
2013
The position of lysosomes within the cell determines their luminal pH
2016
NUFIP1 is a ribosome receptor for starvation-induced ribophagy
2018 Science
Works of Constance Petit being referenced
Requirement of Cellular Prion Protein for Intestinal Barrier Function and Mislocalization in Patients With Inflammatory Bowel Disease
2012
The Cellular Prion Protein PrPc Is Involved in the Proliferation of Epithelial Cells and in the Distribution of Junction-Associated Proteins
2008
Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions
2008
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
2012
Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
2013
Correction: The Cellular Prion Protein PrPc Is Involved in the Proliferation of Epithelial Cells and in the Distribution of Junction-Associated Proteins
2008