Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation
2004 StandoutNobel
Reduced VEGF Production, Angiogenesis, and Vascular Regrowth Contribute to the Antitumor Properties of Dual mTORC1/mTORC2 Inhibitors
2011
The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations
2007 Science
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
2004 StandoutScience
TOR Signaling in Growth and Metabolism
2006 Standout
Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition
2006 StandoutNobel
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
2003
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen
2003
Phosphoinositides and signal transduction
2002
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
2005 StandoutNobel
Genetic Alterations of Phosphoinositide 3‐kinase Subunit Genes in Human Glioblastomas
2004
mTOR Signaling in Growth Control and Disease
2012 Standout
PIK3CA is implicated as an oncogene in ovarian cancer
1999
Oncogenic kinase signalling
2001 StandoutNature
Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents
2003
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
2017 StandoutNobel
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Regulation of translation initiation by FRAP/mTOR
2001
The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function
1999
An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways
2005
Phosphatidylinositol 3-Kinase Signaling Inhibits DAF-16 DNA Binding and Function via 14-3-3-dependent and 14-3-3-independent Pathways
2001 StandoutNobel
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
Hepatocyte growth factor exerts a proliferative effect on oval cells through the PI3K/AKT signaling pathway
2003
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes
2007
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells
2002 StandoutNobel
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
Analysis of the Catalytic Domain of Phosphatidylinositol 4-Kinase Type II
2002 StandoutNobel
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
The microenvironment of the tumour–host interface
2001 StandoutNature
Modulation of cellular apoptotic potential: contributions to oncogenesis
1999
Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30/Autophagy-related Protein 6 and Its Specific Role in Autophagy
2012 StandoutNobel
Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxia
2010
β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis
2003 StandoutNobel
The emerging mechanisms of isoform-specific PI3K signalling
2010
Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes
2004 StandoutNobel
Portrait of PTEN: Messages from mutant mice
2008 StandoutNobel
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Expression of a mutated form of the p85α regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO)
2002
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
AKT/PKB Signaling: Navigating the Network
2017 Standout
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
2019 StandoutNature
Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development
2006 StandoutNobel
mTOR-targeted therapy of cancer with rapamycin derivatives
2005
Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
2000
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Oncogenic PI3K deregulates transcription and translation
2005
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
2001 StandoutNobel
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
2012 StandoutNobel
The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.
2001
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.
2002
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Responding to Hypoxia: Lessons From a Model Cell Line
2002
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation
2000
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling
1998
Therapeutic potential of phosphoinositide 3-kinase inhibitors
2004
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines
2004
Physiological Functions of Pten in Mouse Tissues.
2003 StandoutNobel
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
Responding to Hypoxia: Lessons From a Model Cell Line
2002
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway
1998
O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling
2011
The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling
2003
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
The Phosphoinositide 3-Kinase Pathway
2002 StandoutScience
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
1999
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Concepción Jiménez being referenced
A New Role for the p85-Phosphatidylinositol 3-Kinase Regulatory Subunit Linking FRAP to p70 S6 Kinase Activation
2002
Increased phosphoinositide 3‐kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
2000
Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase
1998
The p85 Regulatory Subunit Controls Sequential Activation of Phosphoinositide 3-Kinase by Tyr Kinases and Ras
2002
Hypoxia Induces the Activation of the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway in PC12 Cells
2001
Role of the Pi3k Regulatory Subunit in the Control of Actin Organization and Cell Migration
2000