Citation Impact
Citing Papers
Regulation and Role of Raf-1/B-Raf Heterodimerization
2006
Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer
2005 StandoutNobel
High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells
2005 StandoutScience
Raf-1 regulates Rho signaling and cell migration
2005
In Melanoma, RAS Mutations Are Accompanied by Switching Signaling from BRAF to CRAF and Disrupted Cyclic AMP Signaling
2006
Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
2010
Conferring specificity on the ubiquitous Raf/MEK signalling pathway
2004
β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor
2005 StandoutNobel
Signal perception and transduction: the role of protein kinases
1999
RAF/RAS oncogenes and mismatch-repair status
2002 Nature
Metastasis is driven by sequential elevation of H-ras and Smad2 levels
2002
T‐box genes in early embryogenesis
2003
Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades
1999
A view on drug resistance in cancer
2019 StandoutNature
β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation
2002 StandoutNobel
Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily
1996
Differential Kinetic and Spatial Patterns of β-Arrestin and G Protein-mediated ERK Activation by the Angiotensin II Receptor
2004 StandoutNobel
Tumor adaptation and resistance to RAF inhibitors
2013
Guilty as charged
2004
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Phosphorylation of 338SSYY341 Regulates Specific Interaction between Raf-1 and MEK1
2002
Oncogenic kinase signalling
2001 StandoutNature
The exocyst is a Ral effector complex
2001
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Cells’ Perception of Position in a Concentration Gradient
1998 StandoutNobel
Eomesodermin, a Key Early Gene in Xenopus Mesoderm Differentiation
1996 StandoutNobel
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Ras proteins: different signals from different locations
2003
A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics
2016 StandoutNobel
Raf-1 is the predominant Raf isoform that mediates growth factor-stimulated growth in ovarian cancer cells
2005
Dynamin Is Required for the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase
1999
Epidermal growth factor receptor: mechanisms of activation and signalling
2003
Signal Transduction by the Receptor Tyrosine Kinase Ret
1998
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
2010 StandoutNature
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
2004 Standout
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
1998
Serum- and Glucocorticoid-inducible Kinase SGK Phosphorylates and Negatively Regulates B-Raf
2001
MAP kinase signalling pathways in cancer
2007 Standout
The RAF proteins take centre stage
2004
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
1998 StandoutNature
Rho GTPases in cell biology
2002 StandoutNature
Epidermal Growth Factor (EGF) Receptor-dependent ERK Activation by G Protein-coupled Receptors
2001 StandoutNobel
Developmental regulation of the growth plate
2003 StandoutNature
Untying the regulation of the Raf-1 kinase
2002
PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway
2002
Dephosphorylation of Ser-259 Regulates Raf-1 Membrane Association
2002
MKP-3, a Novel Cytosolic Protein-tyrosine Phosphatase That Exemplifies a New Class of Mitogen-activated Protein Kinase Phosphatase
1996
ERK and PDE4 cooperate to induce RAF isoform switching in melanoma
2011
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
1996 StandoutNature
Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells
1999
Dissection of Amyloid-β Precursor Protein-dependent Transcriptional Transactivation
2004 StandoutNobel
Drug repurposing: progress, challenges and recommendations
2018 Standout
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
2000
Identification of direct transcriptional targets of V600EBRAF/MEK signalling in melanoma
2009
RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling
2011
Mesoderm Induction Assays
2003
GDNF signalling through the Ret receptor tyrosine kinase
1996 StandoutNature
Polycomb complexes repress developmental regulators in murine embryonic stem cells
2006 StandoutNature
Plant recognition of symbiotic bacteria requires two LysM receptor-like kinases
2003 StandoutNature
Mammalian MAP kinase signalling cascades
2001 StandoutNature
Wild-Type and Mutant B-RAF Activate C-RAF through Distinct Mechanisms Involving Heterodimerization
2005
Regulation of RAF protein kinases in ERK signalling
2015
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
New Insights into the Control of MAP Kinase Pathways
1999
Fibroblast Growth Factors as Multifunctional Signaling Factors
1998
β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf
2000
Mechanisms of regulating the Raf kinase family
2003
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 Cells
2001
T-box genes: what they do and how they do it
1999
BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition
2015
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
2004 Standout
Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling
2014
A Novel Regulatory Mechanism in the Mitogen-activated Protein (MAP) Kinase Cascade
1997
Positive and negative regulation of Raf kinase activity and function by phosphorylation
2001
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice
1996
Gatekeeper Mutations Mediate Resistance to BRAF-Targeted Therapies
2010
Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors.
2003
Signaling in Myocardial Hypertrophy
1999
The Fission Yeast pmk1+ Gene Encodes a Novel Mitogen-Activated Protein Kinase Homolog Which Regulates Cell Integrity and Functions Coordinately with the Protein Kinase C Pathway
1996
Biology of the p21-Activated Kinases
2003
Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt
1999 Science
Cyanogen Bromide Cleavage Generates Fragments Suitable for Expressed Protein and Glycoprotein Ligation
2004 StandoutNobel
Orphan Nuclear Receptors: From Gene to Function*
1999
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
2000
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
MAP Kinase Is Required for the Spindle Assembly Checkpoint but Is Dispensable for the Normal M Phase Entry and Exit in Xenopus Egg Cell Cycle Extracts
1997
Gene Regulatory Networks and the Evolution of Animal Body Plans
2006 StandoutScience
MAP Kinases
2001
Essential role of B-Raf in ERK activation during extraembryonic development
2006
A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation
1999 StandoutNobel
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
1997
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Neural Science
2000 StandoutNobel
Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction
1998
Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm
1996
Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression
1998 StandoutNobel
A comprehensive pathway map of epidermal growth factor receptor signaling
2005
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.
1996
Semisynthesis and Folding of the Potassium Channel KcsA
2002 StandoutNobel
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
2002 StandoutScience
Two Transforming C-RAF Germ-Line Mutations Identified in Patients with Therapy-Related Acute Myeloid Leukemia
2006
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
2011 StandoutScience
Up-regulation of the chondrogenicSox9gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway
2000
Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.
1994
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
1999 Standout
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors
2000
Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate
2004
Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor
1996
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
2000
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
2001 Standout
Signal Transduction through MAP Kinase Cascades
1998 Standout
Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259
2002
Morphogen gradient interpretation
2001 StandoutNatureNobel
Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell Data
2005 Science
Works of Clive Mason being referenced
Mutations of C-RAF Are Rare in Human Cancer because C-RAF Has a Low Basal Kinase Activity Compared with B-RAF
2005
Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases
1997
Mesoderm induction in Xenopus caused by activation of MAP kinase
1995 Nature
A novel nuclear receptor superfamily member inXenopusthat associates with RXR, and shares extensive sequence similarity to the mammalian vitamin D3 receptor
1994
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
1999
Isolation of a novel RXR from Xenopus that most closely resembles mammalian RXRβ and is expressed throughout early development
1994
Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237
2010
S338 Phosphorylation of Raf-1 Is Independent of Phosphatidylinositol 3-Kinase and Pak3
2001
Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C
1998 Science