Standout Papers
Citation Impact
Citing Papers
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
2010 StandoutScience
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.
1990
Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers.
1991
Abnormalities of B-cell activation and immunoregulation in patients with Crohn's disease.
1984
Activation of peripheral blood and intestinal lamina propria lymphocytes in Crohn's disease. In vivo state of activation and in vitro response to stimulation as defined by the expression of early activation antigens.
1987
Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques.
1984
Soluble interleukin-2 receptor in Crohn's disease: relation of serum concentrations to disease activity.
1990
Differential expression of CD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis.
1990
Ulcerative colitis--a disease characterised by the abnormal colonic epithelial cell?
1988
Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent
1995
Prostanoid synthesis by cultured intestinal epithelial and mononuclear cells in inflammatory bowel disease.
1983
A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.
1995
The alarmin IL-33 promotes regulatory T-cell function in the intestine
2014 Nature
Cytokines in inflammatory bowel disease
2014 Standout
Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine
2010
Expression of adhesion molecules and HLA-DR by macrophages and dendritic cells in aphthoid lesions of Crohn's disease: An immunocytochemical study
1994
Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species
2007
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
2000 StandoutNature
Hypoxia and gastrointestinal disease
2007
Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis
2013 Standout
Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review
2011 Standout
The anatomical basis of intestinal immunity
1997
Tumor necrosis factor-?, interleukin-1?, and interleukin-6 expression in inflammatory bowel disease
1992
A Novel Mouse Model of Inflammatory Bowel Disease Links Mammalian Target of Rapamycin-Dependent Hyperproliferation of Colonic Epithelium to Inflammation-Associated Tumorigenesis
2009
Colitis-associated cancer: the role of T cells in tumor development
2009
Protection of Epithelial Barrier Function by the Crohn's Disease Associated Gene Protein Tyrosine Phosphatase N2
2009
Neutrophil autoantibodies in ulcerative colitis: Familial aggregation and genetic heterogeneity
1992
Regulated expression and binding of three VLA (β1) integrin receptors on T cells
1990 Nature
Mucosal subclass distribution of immunoglobulin G-producing cells is different in ulcerative colitis and Crohn's disease of the colon
1987
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
The Influence of Cigarette Smoking on Cytokine Levels in Patients with Inflammatory Bowel Disease
1999
Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease.
1990
Cell-Cell Contacts Prevent Anoikis in Primary Human Colonic Epithelial Cells
2006
Continuing low incidence of Crohn’s disease in Northwest Greece
2003
The Where, When, How, and Why of Hyaluronan Binding by Immune Cells
2015
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
2002
Circulating soluble intercellular adhesion molecule-1 (sICAM-1) in active inflammatory bowel disease
1994
Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis
2008
Epidemiology of Crohnʼs Disease in QuéBec, Canada
2008
Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease
2005
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
2001 StandoutNature
The transcription factor IFN regulatory factor–4 controls experimental colitis in mice via T cell–derived IL-6
2008
A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease
1997 Standout
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
2009 StandoutNature
Inflammatory bowel disease: cause and immunobiology
2007 Standout
Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease
1997
Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis
1995
Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
2004
Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease
2010
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Crohn's disease
1987
Prevalence of inflammatory bowel disease in two districts of Sri Lanka: a hospital based survey
2010
Transforming growth factor-β induces development of the TH17 lineage
2006 StandoutNature
Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis
1992
Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers
2008 StandoutNobel
Intestinal macrophages: unique effector cells of the innate immune system
2005
Antibodies to cytoskeletal proteins in patients with Crohn's disease
1990
Lymphocyte interactions with endothelial cells
1992
Inflammatory Bowel Disease
1991 Standout
Nucleotide Binding Oligomerization Domain 2 Deficiency Leads to Dysregulated TLR2 Signaling and Induction of Antigen-Specific Colitis
2006
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
2001 StandoutNature
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
1993 Nobel
Selective expansion of specific T cell receptors in the inflamed colon of Crohn's disease.
1996
CD4 Antibody Treatment in Crohn's Disease
1992
Remission of Crohn's Disease After Human Immunodeficiency Virus Infection
1988
Oxazolone Colitis, a Th2 Colitis Model Resembling Ulcerative Colitis, Is Mediated by IL-13-Producing NK-T Cells
2002
Inflammatory Bowel Disease
2002 Standout
Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes
1989
Immunohistological studies of surface antigen on colonic lymphoid cells in normal and inflamed mucosa
1990
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
1999 StandoutNature
Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease
1995
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
1993
Immunity, Inflammation, and Cancer
2010 Standout
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
2003
Activation-independent binding of human memory T cells to adhesion molecule ELAM-1
1991 Nature
Distribution and Manifestations of Inflammatory Bowel Disease in Asians, Hispanics and African Americans: A Systematic Review
2009
Intestinal immune reactivity to interleukin 2 differs among Crohn's disease, ulcerative colitis, and controls
1989
Adhesion receptors of the immune system
1990 StandoutNature
Inflammatory bowel disease: Incidence, prevalence, and disease characteristics in Barbados, West Indies
2008
Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement
2018 StandoutNobel
Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist
1994
Differential expression of mucosal addressin cell adhesion molecule‐1 (MAdCAM‐1) in ulcerative colitis and Crohn's disease
2002
Hypoxia and Metabolic Factors That Influence Inflammatory Bowel Disease Pathogenesis
2011
Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis
2006
Inflammatory Bowel Disease in Japan: Studies of Epidemiology and Etiopathogenesis
1990
Ulcerative colitis
2016 Standout
High incidence of inflammatory bowel disease in Australia: A prospective population-based Australian incidence study
2010
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
Phenotypic characterization of isolated intraepithelial lymphocytes in patients with ulcerative colitis and normal controls
1992
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
1992 StandoutNature
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
A randomized placebo-controlled trial of a humanized monoclonal antibody to α4 integrin in active crohn's disease
2001
Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease
1991
Points of control in inflammation
2002 StandoutNature
Inflammation, Atherosclerosis, and Coronary Artery Disease
2005 Standout
Inflammatory bowel disease: Etiology and pathogenesis
1998 Standout
Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis
2008
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Increased intestinal permeability in obese mice: new evidence in the pathogenesis of nonalcoholic steatohepatitis
2006
Diversity, stability and resilience of the human gut microbiota
2012 StandoutNature
Epidemiology and clinical characteristics of ulcerative colitis in Chinese population: Experience from a single center in Hong Kong
2007
Chronic T Cell-Mediated Enteropathy in Rural West African Children: Relationship with Nutritional Status and Small Bowel Function
2003
Cancer-related inflammation
2008 StandoutNature
Antimicrobial peptides of multicellular organisms
2002 StandoutNature
Analysis of single-nucleotide polymorphisms in the interleukin-4 receptor gene for association with inflammatory bowel disease
2000
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Autophagy in immunity and inflammation
2011 StandoutNature
Passive Smoking and Inflammatory Bowel Disease: A Meta-Analysis
2008
The immunopathogenesis of sepsis
2002 StandoutNature
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006 StandoutScience
The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity
2009
Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation.
1994
Reduced suppressor cell activity in intestinal lymphocytes from patients with Crohn's disease.
1982
Environmental risk factors for inflammatory bowel disease.
2010
Alterations of IgM, IgG, and IgA Synthesis and Secretion by Peripheral Blood and Intestinal Mononuclear Cells from Patients with Ulcerative Colitis and Crohn's Disease
1981
T Helper 1 and T Helper 2 Cells Are Pathogenic in an Antigen-specific Model of Colitis
2002
Plasma and tissue interleukin-2 receptor levels in inflammatory bowel disease
1990
Lymphocyte Homing and Homeostasis
1996 StandoutScience
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease
1993
Spontaneous and Continuous Cyclooxygenase-2-Dependent Prostaglandin E2 Production by Stromal Cells in the Murine Small Intestine Lamina Propria: Directing the Tone of the Intestinal Immune Response
2001
Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes
2003
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
2003
Intestinal Inflammation and the Gut Microflora
1999
A family of beta 7 integrins on human mucosal lymphocytes.
1992
The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis
2008
Reduced suppressor cell activity in intestinal lymphocytes from patients with Crohn's disease
1982
Activation and differentiation requirements of primary T cells in vitro.
1993 StandoutNobel
Network of dendritic cells within the muscular layer of the mouse intestine
2005 StandoutNobel
Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa.
1993
Inflammatory Bowel Disease
2010 Standout
Circulating antiinflammatory cytokine IL-10 in patients with inflammatory bowel disease (IBD)
1995
The effects of migration on ulcerative colitis: a three-year prospective study among Europeans and first- and second-generation South Asians in Leicester (1991–1994)
1999
Autoantibodies to colonic cells and subcellular fractions in inflammatory bowel disease: Do they exist?
1990
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
T-cell activation in Crohn's disease
1990
Oxazolone Colitis: A Murine Model of T Helper Cell Type 2 Colitis Treatable with Antibodies to Interleukin 4
1998
Importance of intestinal mucosal immunity and luminal bacterial cell wall polymers in the aetiology of inflammatory joint diseases
1989
Molecular Mechanisms RegulatinG Th1 Immune Responses
2003
T-cell activation in Crohn's disease. Increased levels of soluble interleukin-2 receptor in serum and in supernatants of stimulated peripheral blood mononuclear cells.
1990
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Human naive and memory T cells
1988
Myofibroblasts. II. Intestinal subepithelial myofibroblasts
1999
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Opposing functions of IKKβ during acute and chronic intestinal inflammation
2008
Enteric β-Defensin: Molecular Cloning and Characterization of a Gene with Inducible Intestinal Epithelial Cell Expression Associated with Cryptosporidium parvum Infection
1998
Low prevalence of p-ANCA in unaffected relatives of patients with ulcerative colitis from a mediterranean area
1996
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response
2009 StandoutNobel
Flagellin, a Novel Mediator of Salmonella-Induced Epithelial Activation and Systemic Inflammation: IκBα Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction
2001
Alterations of the Immune System in Ulcerative Colitis and Crohn's Disease
1988
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
2010 StandoutNobel
LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens
2010
IL-23 and Autoimmunity: New Insights into the Pathogenesis of Inflammatory Bowel Disease
2008
Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine
1990
Recent Developments in Nonspecific Inflammatory Bowel Disease
1982
Expression of HLA-DR antigens in inflammatory bowel disease mucosa: Role of intestinal lamina propria mononuclear cell-derived interferon ?
1988
Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis
1982
Persistent clonal expansions of peripheral blood CD4+ lymphocytes in chronic inflammatory bowel disease.
1996
An Inherited Disorder of Lymphocyte Apoptosis: The Autoimmune Lymphoproliferative Syndrome
1999
Immunohistological characterization of intraepithelial and lamina propria lymphocytes in control ileum and colon and in inflammatory bowel disease
1986
Biologic therapy for inflammatory bowel disease
1997
T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice.
1995
Antibodies to cytoskeletal proteins in patients with Crohn's disease
1990
Inflammatory bowel disease mucosal biopsies have specialized lymphokine mRNA profiles
1996
Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions.
1991
Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1
1994 StandoutNobel
Crohn's disease and the mycobacterioses: a review and comparison of two disease entities
1989
Works of Claudio Fiocchi being referenced
Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease
1988
Cytokines and intestinal inflammation.
1996
Immunoregulatory function of human intestinal mucosa lymphoid cells: evidence for enhanced suppressor cell activity in inflammatory bowel disease.
1983
Soluble interleukin 2 and CD8 and CD4 receptors in inflammatory bowel disease
1992
Management consensus of inflammatory bowel disease for the Asia–Pacific region
2006
Adequacy of mucosal biopsies for evaluation of intestinal cytokine-specific mRNA
1995
Production of inflammatory cytokines in the intestinal lamina propria
1991
Modulation of intestinal immune reactivity by interleukin 2
1988
Loss of interleukin-2—Producing intestinal CD4+ T cells in inflammatory bowel disease
1991
Ulcerative Colitis
2011 Standout
A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-κB
2003
Interferon ? production by human intestinal mucosal mononuclear cells
1988
Immune Events Associated with Inflammatory Bowel Disease
1990
Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity
1996
Inflammatory bowel disease: the role of environmental factors
2004
Immune activation genes in inflammatory bowel disease
1993
Pathogenesis of inflammatory bowel disease
1999
Hierarchical cleavage of focal adhesion kinase by caspases alters signal transduction during apoptosis of intestinal epithelial cells
2001
VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis
2008
Polyclonal nature of the intestinal mucosal lymphocyte populations in inflammatory bowel disease
1988
High Prevalence of Antibodies to Intestinal Epithelial Antigens in Patients with Inflammatory Bowel Disease and Their Relatives
1989
New Isolation Technique to Study Apoptosis in Human Intestinal Epithelial Cells
1998
Lymphokine-activated killer (LAK) cells from human intestinal mucosa: Cytotoxic activity against tumor cell lines and modified self but not autologous and allogeneic colon cancer cells
1988
Signal Transducers and Activators of Transcription 3 Signaling Pathway
2005
Hyaluronan (HA) Deposition Precedes and Promotes Leukocyte Recruitment in Intestinal Inflammation
2008
Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease
1998
Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells
1993
Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease
1997
Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease
2007
Inflammatory bowel disease: dogmas and heresies
2002
“Immune/Non-Immune Cell Interactions in Intestinal Inflammation” Workshop
1997
“Immune/non-immune cell interactions in intestinal inflammation” workshop
1997
Immunology of the Gastrointestinal Tract
1980
Resistance of Crohn’s Disease T Cells to Multiple Apoptotic Signals Is Associated with a Bcl-2/Bax Mucosal Imbalance
1999
Redox Equilibrium in Mucosal T Cells Tunes the Intestinal TCR Signaling Threshold
2005
Gut mucosal lymphocytes in inflammatory bowel disease
1979
Sequential and rapid activation of select caspases during apoptosis of normal intestinal epithelial cells
1998
CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria.
1988
Immunoregulatory Function of Lamina Propria T Cells in Crohn's Disease
1985
The emergence of inflammatory bowel disease in the Asian Pacific region.
2005
Sensitization to epithelial antigens in chronic mucosal inflammatory disease. Characterization of human intestinal mucosa-derived mononuclear cells reactive with purified epithelial cell-associated components in vitro.
1985
Cytokines and animal models: A combined path to inflammatory bowel disease pathogenesis
1993
Immune Regulation by Microvascular Endothelial Cells: Directing Innate and Adaptive Immunity, Coagulation, and Inflammation
2007
Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis
2010
Studies on isolated gut mucosal lymphocytes in inflammatory bowel disease
1981
Phenotypic analysis of lamina propria lymphocytes. Predominance of helper-inducer and cytolytic T-cell phenotypes and deficiency of suppressor-inducer phenotypes in Crohn's disease and control patients.
1986
Interleukin 2 Activity of Human Intestinal Mucosa Mononuclear Cells
1984
Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.
1996
Intestinal immunity and inflammation: Recent progress
1986
Human intestinal mucosal mononuclear cells exhibit lymphokine-activated killer cell activity
1985
Intestinal inflammation: a complex interplay of immune and nonimmune cell interactions
1997
Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation.
1995
T cell receptor Vβ gene expression in inflammatory bowel disease lamina propria lymphocytes: Evidence for altered Vβ gene usage
1995
Phenotypic analysis of lamina propria lymphocytes
1986