Citation Impact
Citing Papers
Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors
2004
Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors
2008
Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination
2009
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
2005
Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis.
2003
Antitumoral actions of the anti-obesity drug orlistat (Xenical™) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene
2005
Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor
1998
Molecular-cytogenetic analysis of HER-2/neu gene in BRCA1-associated breast cancers.
2002
American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer
2007 Standout
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Gene amplification in cancer
2006
Selective activation of the fatty acid synthesis pathway in human prostate cancer
2000
mTOR Signaling in Growth Control and Disease
2012 Standout
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
2005
NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps
2001
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Inhibition of Tumor-associated Fatty Acid Synthase Hyperactivity Induces Synergistic Chemosensitization of HER-2/neu-Overexpressing Human Breast Cancer Cells to Docetaxel (taxotere)
2004
"Spot 14" Protein: A Metabolic Integrator in Normal and Neoplastic Cells
1998
Intraperitoneal Chemohyperthermia Using a Closed Abdominal Procedure and Cytoreductive Surgery for the Treatment of Peritoneal Carcinomatosis: Morbidity and Mortality Analysis of 216 Consecutive Procedures
2003
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
2007 Standout
Molecular mechanisms of drug resistance
2005
Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model
2003
A Fatty Acid Synthase Blockade Induces Tumor Cell-cycle Arrest by Down-regulating Skp2
2004
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
Clinical applications of TNF-α in cancer
1998
Cancer Cell Metabolism: Warburg and Beyond
2008 Standout
The contribution of the study of neurodegenerative disorders to the understanding of human memory
2004
Adhesion molecules in cancer: the role of integrins
1993
Tumor Metastasis: Molecular Insights and Evolving Paradigms
2011 Standout
Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer
2013 Standout
Impact of germline BRCA1 mutations and overexpression of p53 on prognosis and response to treatment following breast carcinoma
2003
Dynamic control over cell adhesive properties using molecular-based surface engineering strategies
2009 StandoutNobel
Expression of “Spot 14” (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker
2006
Tumor cells caught in the act of invading: their strategy for enhanced cell motility
2005
Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer
2001
Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer
2004
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival
1997
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI
2019 StandoutNobel
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice
2004
Incidence and patterns of recurrence following curative resection for colorectal carcinoma
1997
Extended Lymph-Node Dissection for Gastric Cancer
1999 Standout
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Oxaliplatin, Fluorouracil, and Leucovorin as Adjuvant Treatment for Colon Cancer
2004 Standout
The microenvironment of the tumour–host interface
2001 StandoutNature
Increased expression of fatty acid synthase and progesterone receptor in early steps of human mammary carcinogenesis
2006
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology
2000
Activation of Fatty Acid Synthesis during Neoplastic Transformation: Role of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase
2002
Inhibition of tumor-associated fatty acid synthase activity antagonizes estradiol- and tamoxifen-induced agonist transactivation of estrogen receptor (ER) in human endometrial adenocarcinoma cells
2004
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c
2003
Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway
2000
Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer
2007
Inflammation and cancer: back to Virchow?
2001 Standout
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
EMT: 2016
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A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer
2004 Standout
Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
2004
Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer
2001 Standout
Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma
2004
Pharmacological inhibition of fatty acid synthase (FAS): A novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her‐2/neu (erbB‐2) oncogene‐induced malignant transformation
2004
Airway Mucus Function and Dysfunction
2010 Standout
Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
2004
Pharmacological and small interference RNA‐mediated inhibition of breast cancer‐associated fatty acid synthase (oncogenic antigen‐519) synergistically enhances Taxol (paclitaxel)‐induced cytotoxicity
2005
The basics of epithelial-mesenchymal transition
2009 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
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IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
2001 StandoutNature
Factors Predicting Survival After Intraperitoneal Hyperthermic Chemotherapy With Mitomycin C After Cytoreductive Surgery for Patients With Peritoneal Carcinomatosis
2003
MHC antigens and tumor escape from immune surveillance
2001
MUC1 and the MUCs: A Family of Human Mucins with Impact in Cancer Biology
2004
Acetyl-CoA carboxylase gene and breast cancer susceptibility
2004
Defects of basement membrane and hemidesmosome structure correlate with malignant phenotype and stromal interactions in HaCaT-Ras xenografts
1999
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Frailty in elderly people
2013 Standout
Tumor Markers in Breast Cancer – European Group on Tumor Markers Recommendations
2005
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis
2006 Standout
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
2008 Standout
Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer
2016 Standout
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Glycolysis in cancer: A potential target for therapy
2007
Airway Epithelium and Mucus
2001
Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance
1999
Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells
2003
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006 StandoutScience
Clues from cell metabolism
2010 StandoutNatureNobel
Biologic Correlates of 18Fluorodeoxyglucose Uptake in Human Breast Cancer Measured by Positron Emission Tomography
2002 StandoutNobel
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
2001
FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis
2005
Positron Emission Tomography Using [18F]-Fluorodeoxy-d -Glucose to Predict the Pathologic Response of Breast Cancer to Primary Chemotherapy
2000
Repeated observation of breast tumor subtypes in independent gene expression data sets
2003 Standout
Mechanism of Apoptosis Induced by the Inhibition of Fatty Acid Synthase in Breast Cancer Cells
2006
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
The “Spot 14” gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: Implications for control of tumor metabolism
1998
Structural and Functional Aspects of RGD-Containing Cyclic Pentapeptides as Highly Potent and Selective Integrin αVβ3Antagonists
1996
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
Fatty Acid Synthase Is Expressed Mainly in Adult Hormone-sensitive Cells or Cells with High Lipid Metabolism and in Proliferating Fetal Cells1
2000
Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model
1988 StandoutScience
2000 Update of Recommendations for the Use of Tumor Markers in Breast and Colorectal Cancer: Clinical Practice Guidelines of the American Society of Clinical Oncology*
2001
Integrins and Signal Transduction Pathways: the Road Taken
1995 StandoutScience
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
2003 Standout
Blood flow and metabolism in locally advanced breast cancer: relationship to response to therapy.
2002
Targeting Fatty Acid Synthase in Breast and Endometrial Cancer: An Alternative to Selective Estrogen Receptor Modulators?
2006
Androgens Stimulate Lipogenic Gene Expression in Prostate Cancer Cells by Activation of the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein/Sterol Regulatory Element-Binding Protein Pathway
2001
Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells.
2003
Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma.
1997
Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer
2018 Standout
Randomized Trial of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy and Palliative Surgery in Patients With Peritoneal Carcinomatosis of Colorectal Cancer
2003 Standout
Chemically tunable mucin chimeras assembled on living cells
2015 StandoutNobel
Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity
2004
THE GREAT ESCAPE: When Cancer Cells Hijack the Genes for Chemotaxis and Motility
2005
Tissue architecture: the ultimate regulator of epithelial function?
1998
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
2009 StandoutScience
Considerations in the Design of Possible Cell Cycle Effective Drugs
1986
Prognostic Value of CA 15.3 Kinetics for Metastatic Breast Cancer
2002
Bone Marrow as a Potential Source of Hepatic Oval Cells
1999 StandoutScience
Acetyl-CoA Carboxylase α Is Essential to Breast Cancer Cell Survival
2006
Fatty Acid Synthase and Cancer: New Application of an Old Pathway
2006
Local recurrence of rectal adenocarcinoma after ‘curative’ surgery with and without preoperative radiotherapy
1994
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Role of Splenectomy in Gastric Cancer Surgery: Adverse Effect of Elective Splenectomy on Longterm Survival
1997
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Cytoreductive Surgery Combined With Perioperative Intraperitoneal Chemotherapy for the Management of Peritoneal Carcinomatosis From Colorectal Cancer: A Multi-Institutional Study
2004 Standout
Inhibition of fatty acid synthase (FAS) suppressesHER2/neu(erbB-2) oncogene overexpression in cancer cells
2004
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts.
2000
Synthesis and antitumor activity of an inhibitor of fatty acid synthase
2000
Works of Claudio Botti being referenced
Non‐small‐cell lung carcinoma: Tumor characterization on the basis of flow cytometrically determined cellular heterogeneity
1983
Role of P53 and BCL-2 in high-risk breast cancer patients treated with adjuvant anthracycline-based chemotherapy
2000
Low Frequency of ErbB-2 Proto-oncogene Overexpression in Human Leukocyte Antigen-A2-Positive Breast Cancer Patients
1997
The Cytoskeleton Regulatory Protein hMena (ENAH) Is Overexpressed in Human Benign Breast Lesions with High Risk of Transformation and Human Epidermal Growth Factor Receptor-2–Positive/Hormonal Receptor–Negative Tumors
2006
Peritonectomy and hyperthermic antiblastic perfusion in the treatment of peritoneal carcinomatosis
2000
Treatment of peritoneal carcinomatosis with intent to cure
2000
Breast cancer is associated with loss of the c‐kit oncogene product
1992
Phenotypic changes of p53, HER2, and FAS system in multiple normal tissues surrounding breast cancer
2004
Human mena protein, a serex‐defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T‐cell immune response
2004
Serum tissue polypeptide specific antigen (TPS): a complementary tumor marker to CA 15-3 in the management of breast cancer
2001
Local recurrence after curative resection for colorectal cancer: Frequency, risk factors and treatment
1991
Incidence of chromosomes 1 and 17 aneusomy in breast cancer and adjacent tissue: an interphase cytogenetic study1
2000
Immunohistochemical Expression of Human Erythrocyte Glucose Transporter and Fatty Acid Synthase in Infiltrating Breast Carcinomas and Adjacent Typical/Atypical Hyperplastic or Normal Breast Tissue
2001
Changes in expression of α6/β 4 integrin heterodimer in primary and metastatic breast cancer
1992
Immunohistochemical study of fatty acid synthase, Ki67, proliferating cell nuclear antigen, and p53 expression in hyperplastic parathyroids
1999
Learning and forgetting processes in Parkinson's disease:
1997
Prognostic relevance of altered Fas (CD95)-system in human breast cancer
2000
Hyperthermic Antiblastic Perfusion with Alpha Tumor Necrosis Factor and Doxorubicin for the Treatment of Soft Tissue Limb Sarcoma in Candidates for Amputation
1999
Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients
1996
Fatty Acid Synthase (Fas) Predictive Strength in Poorly Differentiated Early Breast Carcinomas
1999
Immunohistochemical expression and prognostic significance of FAS and GLUT1 in bladder carcinoma.
2003
Effects of steroid-free fetal serum and steroid supplementation on MUC1 gene expression in human breast cancer cell line MCF7.
1997
Addition of Either Lonidamine or Granulocyte Colony-Stimulating Factor Does Not Improve Survival in Early Breast Cancer Patients Treated With High-Dose Epirubicin and Cyclophosphamide
2003
Hormonal Regulation of MUC1 Expression
1999
Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa.
1999
EGF-R expression in ductal breast cancer: proliferation and prognostic implications.
1997
The role of multiploidy as unfavorable prognostic variable in colorectal cancer.
1998
Two Novel Monoclonal Antibodies against the MUC4 Tandem Repeat Reacting with an Antigen Overexpressed by Lung Cancer
2000
Fatty acid synthase (FAS) is a marker of increased risk of recurrence in lung carcinoma.
2005
The influence of tumor lymphocytic infiltration on long term survival of surgically treated colorectal cancer patients.
1993
Immunohistochemical study of fatty acid synthase in ovarian neoplasms.
2000
A re-evaluation of carcinoembryonic antigen (CEA) as a serum marker for breast cancer: a prospective longitudinal study.
2001
Results of curative gastrectomy for carcinoma.
1994
Immunosuppressive Factors: Role in Cancer Development and Progression
1998
Altered Expression of FAS System Is Related to Adverse Clinical Outcome in Stage I-II Breast Cancer Patients Treated with Adjuvant Anthracycline-Based Chemotherapy
2004
Prognostic value of lymph node metastases after neoadjuvant chemotherapy for large-sized operable carcinoma of the breast.
1995
Technetium-99m-MIBI scintigraphy in the assessment of neoadjuvant chemotherapy in breast carcinoma.
1997