Standout Papers
Citation Impact
Citing Papers
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Expansion and Function of CD8+ T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules
2004 StandoutNobel
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
2005 StandoutNatureNobel
The CD95 (APO-1/Fas) and the TRAIL (APO-2L) Apoptosis Systems
2000
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
The level of CD8 expression can determine the outcome of thymic selection
1992 StandoutNobel
Multiplex messenger assay: simultaneous, quantitative measurement of expression of many genes in the context of T cell activation
1996
Regulated portals of entry into the cell
2003 StandoutNature
Molecular Events Mediating T Cell Activation
1990
Mammalian GPI proteins: sorting, membrane residence and functions
1997
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
CD4: Collaborator in immune recognition and HIV infection
1990 StandoutNobel
Molecular Biology and Function of CD4 and CD8
1989
T-cell antigen receptor genes and T-cell recognition
1988 StandoutNature
Adhesion receptors of the immune system
1990 StandoutNature
The Impact of Duration versus Extent of TCR Occupancy on T Cell Activation
2001
The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations
2000
Practical design criteria for a dynamic ratio imaging system
1990 StandoutNobel
Fluorescence ratio imaging of cyclic AMP in single cells
1991 StandoutNatureNobel
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
1991 StandoutNobel
The Fas Death Factor
1995 StandoutScience
p53 is required for radiation-induced apoptosis in mouse thymocytes
1993 StandoutNature
The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble
1988
Negative Regulation of T Cell Receptor Signaling by Siglec-7 (p70/AIRM) and Siglec-9
2004
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
Autoreactivity by design: innate B and T lymphocytes
2001
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
Inhibition of death receptor signals by cellular FLIP
1997 StandoutNature
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution
1992 StandoutNobel
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
1998 StandoutNature
A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
2006 StandoutNobel
Molecular Mechanism of the Activation-Induced Cell Death Inhibition Mediated by a p70 Inhibitory Killer Cell Ig-Like Receptor in Jurkat T Cells
2002
Positive and Negative Selection of T Cells
2003
In vivoblockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
1999 StandoutNobel
Hierarchical Assembly of Model Cell Surfaces: Synthesis of Mucin Mimetic Polymers and Their Display on Supported Bilayers
2007 StandoutNobel
T Cell Activation Induces Rapid Tyrosine Phosphorylation of a Limited Number of Cellular Substrates
1989
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.
1992 Nobel
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
1999 StandoutScience
CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.
1988 StandoutNobel
Control of the Molecular Orientation of Membrane-Anchored Biomimetic Glycopolymers
2009 StandoutNobel
T cell receptor tyrosine phosphorylation. Variable coupling for different activating ligands.
1987
Supported planar membranes in studies of cell-cell recognition in the immune system
1986
Proteasome regulation of activation-induced T cell death
1997 StandoutNobel
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Expression of CD4 in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex.
1991 StandoutNobel
A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity
2009
Tolerance induction by thymic medullary epithelium.
1992 StandoutNobel
Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen beta and gamma chains.
1987 StandoutNobel
Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes
1987
Contingent Genetic Regulatory Events in T Lymphocyte Activation
1989 Science
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Synthetic Analogues of Glycosylphosphatidylinositol-Anchored Proteins and Their Behavior in Supported Lipid Bilayers
2007 StandoutNobel
Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis
2004 StandoutNobel
Non‐Deletional Mechanisms of Peripheral and Central Tolerance: Studies with Transgenic Mice with Tissue‐Specific Expression of a Foreign MHC Class I Antigen
1991
The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14
1986 Nature
Allogeneic stimulation of cytotoxic T cells by supported planar membranes.
1984
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
A role in transmembrane signaling for the cytoplasmic domain of the CD2 T lymphocyte surface antigen
1988
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
1990 StandoutScienceNobel
MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function
1997
The Danger Model: A Renewed Sense of Self
2002 StandoutScience
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets.
1987 StandoutNobel
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor
2007 StandoutNobel
Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.
1992 Nobel
Relationships Among TCR Ligand Potency, Thresholds for Effector Function Elicitation, and the Quality of Early Signaling Events in Human T Cells
1998
Supported phospholipid bilayers
1985
Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells.
1996
Nanoscale Complexity of Phospholipid Monolayers Investigated by Near-Field Scanning Optical Microscopy
1995 StandoutScienceNobel
Biological Basket Weaving: Formation and Function of Clathrin-Coated Vesicles
2001
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Synthesis of Lipidated Green Fluorescent Protein and Its Incorporation in Supported Lipid Bilayers
2005 StandoutNobel
Direct evidence for chromosomal inversion during T-cell receptor β-gene rearrangements
1986 Nature
Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice
1992 Science
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
1999 StandoutNobel
Works of Claude Boyer being referenced
Biochemical and functional association between CD8 and H-2 at the surface of a T cell clone
1991
Role of Ti/CD3, Thy‐1, and Ly‐6 in Cytolytic T‐Cell Activation Analyzed with Ti Loss Variantsa
1988 Nobel
Two signaling pathways can lead to Fas ligand expression in CD8+ cytotoxic T lymphocyte clones
1995
TCR-Associated ζ-FcϵRlγ heterodimers on CD4−CD8− NK1.1+ t cells selected by specific class I MHC antigen
1995
Selection of phenotypically distinct NK1.1+ T cells upon antigen expression in the thymus or in the liver
1999
Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling
1999
T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: Evidence for a protein kinase C‐independent staurosporine‐sensitive step
1991
T cell receptor‐induced Fas ligand expression in cytotoxic T lymphocyte clones is blocked by protein tyrosine kinase inhibitors and cyclosporin A
1994
T Cell Development and T Cell Responses in Mice with Mutations Affecting Tyrosines 292 or 315 of the Zap-70 Protein Tyrosine Kinase
2001
Pleiotropic loss of activation pathways in a T-cell receptor α-chain deletion variant of a cytolytic T-cell clone
1987 StandoutNatureNobel
Interactions between MHC-encoded products and cloned T-cells. I. Fine specificity of induction of proliferation and lysis
1982
Immunopurification and insertion into liposomes of native and mutant H-2Kb: quantification by solid phase radioimmunoassay
1983