Standout Papers
Citation Impact
Citing Papers
The CREB-Binding Protein Inhibitor ICG-001 Suppresses Pancreatic Cancer Growth
2014
The Immunology of Fibrosis
2013
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Klotho/FGF23 and Wnt Signaling as Important Players in the Comorbidities Associated with Chronic Kidney Disease
2020
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
2022 Standout
Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study
2021 Standout
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
2016
Loss of β-catenin in resident cardiac fibroblasts attenuates fibrosis induced by pressure overload in mice
2017
Interleukin-6 (IL-6) Trans Signaling Drives a STAT3-dependent Pathway That Leads to Hyperactive Transforming Growth Factor-β (TGF-β) Signaling Promoting SMAD3 Activation and Fibrosis via Gremlin Protein
2014
Scleroderma pathogenesis: a pivotal role for fibroblasts as effector cells
2013
Inference and analysis of cell-cell communication using CellChat
2021 Standout
B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis
2016
Shared and distinct mechanisms of fibrosis
2019
Immunogenetics of systemic sclerosis: Defining heritability, functional variants and shared-autoimmunity pathways
2015
Systemic sclerosis-associated interstitial lung disease
2020
Fibrosing connective tissue disorders of the skin: Molecular similarities and distinctions
2013
Dasatinib
2009
Hepatic stellate cells as key target in liver fibrosis
2017
The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases
2016
Can we safely target the WNT pathway?
2014
Mechanotransduction and fibrosis
2014
Mechanism and medical implications of mammalian autophagy
2018 Standout
Mechanisms of hepatic stellate cell activation
2017 Standout
Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes
2014 Standout
Epigenetics and systemic sclerosis
2015
Wnt signaling in cancer
2016 Standout
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Transforming Growth Factor-β Signaling in Immunity and Cancer
2019 Standout
Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis
2016
Mechanotransduction and extracellular matrix homeostasis
2014 Standout
TGF-β: the master regulator of fibrosis
2016 Standout
Emerging role of extracellular vesicles in inflammatory diseases
2014
Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis
2015
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
2015 Standout
The biology and function of fibroblasts in cancer
2016 Standout
Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-β signalling to prevent fibrosis
2013
Genetic factors and systemic sclerosis
2016
Systemic sclerosis
2017 Standout
Hepatocellular carcinoma
2021 Standout
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
2018 Standout
Cancer stem cells revisited
2017 Standout
WNT Signaling in Cardiac and Vascular Disease
2017
Scleroderma
2009 Standout
Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
2011
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
IL-6 as a keystone cytokine in health and disease
2015 Standout
Dissecting fibrosis: therapeutic insights from the small-molecule toolbox
2015
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
15-Lipoxygenases in cancer: A double-edged sword?
2013
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
2011 Standout
Pathogenetic mechanisms in radiation fibrosis
2010
Tyrosine kinase signaling in fibrotic disorders
2012
Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82
2017
Development, maintenance and disruption of the blood-brain barrier
2013 Standout
Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC–MS/MS
2012
Genetics of systemic sclerosis
2015
Therapeutic targets in the Wnt signaling pathway: Feasibility of targeting TNIK in colorectal cancer
2015
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
2019 Standout
Emerging Biological Principles of Metastasis
2017 Standout
Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model
2015
The immunology of fibrosis: innate and adaptive responses
2010
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
2017 Standout
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
2023 Standout
EMT: 2016
2016 Standout
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
2012 Standout
Oxidative Stress in Cancer
2020 Standout
Tyrosine kinase inhibitors for the treatment of fibrotic diseases such as systemic sclerosis: towards molecular targeted therapies
2009
Riociguat for the treatment of pulmonary arterial hypertension associated with connective tissue disease: results from PATENT-1 and PATENT-2
2016
Scarless wound healing: finding the right cells and signals
2016
Scarless Wound Healing
2015
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer
2017 Standout
PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity
2015
The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia
2018
Classification, Functions, and Clinical Relevance of Extracellular Vesicles
2012 Standout
TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology
2016 Standout
Mitochondria as multifaceted regulators of cell death
2019 Standout
MicroRNA‐29, a key regulator of collagen expression in systemic sclerosis
2010
A Unifying Hypothesis for Scleroderma: Identifying a Target Cell for Scleroderma
2010
Autophagy: controlling cell fate in rheumatic diseases
2016
LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer
2014
Emerging cellular and molecular targets in fibrosis
2014
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
2015
Systemic sclerosis
2015
Integrins and cadherins as therapeutic targets in fibrosis
2014
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice
2013
Multipoint targeting of TGF-β/Wnt transactivation circuit with microRNA 384-5p for cardiac fibrosis
2018
Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis
2021
Wound repair and regeneration: Mechanisms, signaling, and translation
2014 Standout
Review: Frontiers of Antifibrotic Therapy in Systemic Sclerosis
2016
Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease
2019 Standout
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
2016 Standout
Potential Therapeutic Targets for Cardiac Fibrosis
2010
Interleukin‐6: a new therapeutic target in systemic sclerosis?
2013
Microparticles and their roles in inflammatory arthritides
2010
Therapy for Fibrotic Diseases: Nearing the Starting Line
2013
Sustained β‐catenin activity in dermal fibroblasts promotes fibrosis by up‐regulating expression of extracellular matrix protein‐coding genes
2014
Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease
2018
5‐HT 2A receptor antagonists inhibit hepatic stellate cell activation and facilitate apoptosis
2013
Nintedanib in Progressive Fibrosing Interstitial Lung Diseases
2019 Standout
Wound Healing: A Cellular Perspective
2018 Standout
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
2011 StandoutScience
Molecular stratification and precision medicine in systemic sclerosis from genomic and proteomic data
2015
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
2014 Standout
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
2017
Specificity, versatility, and control of TGF-β family signaling
2019
The R740S mutation in the V‐ATP ase a3 subunit results in osteoclast apoptosis and defective early‐stage autophagy
2013
Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing
2016
Inflammation and metabolism in tissue repair and regeneration
2017 StandoutScience
Rationale for the evaluation of nintedanib as a treatment for systemic sclerosis–associated interstitial lung disease
2019
Inhibition of T Cell Apoptosis in the Aqueous Humor of Patients with Uveitis by IL-6/Soluble IL-6 Receptor trans-Signaling
2004
Macrophage plasticity, polarization, and function in health and disease
2018 Standout
Works of Clara Dees being referenced
Platelet-derived serotonin links vascular disease and tissue fibrosis
2011
Fas-Fas ligand-mediated apoptosis within aqueous during idiopathic acute anterior uveitis.
1999
Type 2 innate lymphoid cell counts are increased in patients with systemic sclerosis and correlate with the extent of fibrosis
2015
Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling
2012
Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis
2012
Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis
2011
Activation of pregnane X receptor inhibits experimental dermal fibrosis
2013
The cannabinoid receptor CB2 exerts antifibrotic effects in experimental dermal fibrosis
2009
The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis
2013
Inhibition of H3K27 histone trimethylation activates fibroblasts and induces fibrosis
2012
Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis
2011
Morphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis
2012
Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis
2012
β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
2012
Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators
2018
Autophagy regulates TNFα-mediated joint destruction in experimental arthritis
2012
Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages
2014
Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis
2013
Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies
2015
The transcription factor GLI2 as a downstream mediator of transforming growth factor-β-induced fibroblast activation in SSc
2016
The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis
2012
The transcription factor JunD mediates transforming growth factor β-induced fibroblast activation and fibrosis in systemic sclerosis
2011
Vitamin D receptor regulates TGF-β signalling in systemic sclerosis
2014
Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling
2014
Microparticles stimulate angiogenesis by inducing ELR+ CXC-chemokines in synovial fibroblasts
2010
Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis
2010
Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis
2014
Combined Inhibition of c-Abl and PDGF Receptors for Prevention and Treatment of Murine Sclerodermatous Chronic Graft-versus-Host Disease
2012
Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis
2008
S100A4 amplifies TGF-β-induced fibroblast activation in systemic sclerosis
2014
JAK‐2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis
2012
Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis
2012
Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis
2010
Src kinases in systemic sclerosis: Central roles in fibroblast activation and in skin fibrosis
2008
Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis
2012
Inhibition of glycogen synthase kinase 3β induces dermal fibrosis by activation of the canonical Wnt pathway
2011
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
2012 Standout
Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis
2017
Inhibition of activator protein 1 signaling abrogates transforming growth factor β–mediated activation of fibroblasts and prevents experimental fibrosis
2011
Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors
2013
Poly(ADP-ribose) polymerase-1 regulates fibroblast activation in systemic sclerosis
2018
Pomalidomide is effective for prevention and treatment of experimental skin fibrosis
2012
Canonical Wnt signalling as a key regulator of fibrogenesis – implications for targeted therapies?
2013
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis
2015
OP0228 Protective Effect of LPA1 and 3 Receptor Antagonism in Experimental Skin Fibrosis is Linked to LPA Activity in Dermal Fibroblasts of SSC Patients
2013
The Nuclear Receptor Constitutive Androstane Receptor/NR1I3 Enhances the Profibrotic Effects of Transforming Growth Factor β and Contributes to the Development of Experimental Dermal Fibrosis
2014
Rho‐associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts
2008
Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease
2012
Dual inhibition of c‐abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis
2008