Citation Impact
Citing Papers
Argonaute2 Is the Catalytic Engine of Mammalian RNAi
2004 StandoutScience
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
Regulation of neddylation and deneddylation of cullin1 in SCF Skp2 ubiquitin ligase by F-box protein and substrate
2006 Nobel
A Bacterial Inhibitor of Host Programmed Cell Death Defenses Is an E3 Ubiquitin Ligase
2005 Science
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Arabidopsis ETA2 , an Apparent Ortholog of the Human Cullin-Interacting Protein CAND1, Is Required for Auxin Responses Mediated by the SCF TIR1 Ubiquitin Ligase
2004
Hallucinating symmetric protein assemblies
2022 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Mechanism of auxin perception by the TIR1 ubiquitin ligase
2007 Nature
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein–ubiquitin ligase SCFSkp2
2002
p53 and p21 Form an Inducible Barrier that Protects Cells against Cyclin E-cdk2 Deregulation
2002
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
2003 Nature
Drosophila Roc1a Encodes a RING-H2 Protein with a Unique Function in Processing the Hh Signal Transducer Ci by the SCF E3 Ubiquitin Ligase
2002
Structure of the Cand1-Cul1-Roc1 Complex Reveals Regulatory Mechanisms for the Assembly of the Multisubunit Cullin-Dependent Ubiquitin Ligases
2004
The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC
2008
Crystal structure of the human COP9 signalosome
2014 Nature
Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression
2007
Tandem repeats in proteins: From sequence to structure
2011
DNA Damage Response-mediated Degradation of Ho Endonuclease via the Ubiquitin System Involves Its Nuclear Export
2003
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
LIN-23-Mediated Degradation of β-Catenin Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Nerve Cord of C. elegans
2005
Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways
2007
Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime
2002 Nature
Cell cycle proteins as promising targets in cancer therapy
2017 Standout
Role of the SCFSkp2 Ubiquitin Ligase in the Degradation of p21Cip1 in S Phase
2003 StandoutNobel
Release of Ubiquitin-Charged Cdc34-S∼Ub from the RING Domain Is Essential for Ubiquitination of the SCFCdc4-Bound Substrate Sic1
2003
Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
2008
Stability of Homologue of Slimb F-box Protein Is Regulated by Availability of Its Substrate
2004
Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases
2003
Function and regulation of cullin–RING ubiquitin ligases
2005 Standout
Dual mode of degradation of Cdc25 A phosphatase
2002
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
A mouse model for cyclin E-dependent genetic instability and tumorigenesis
2005
A conserved catalytic residue in the ubiquitin-conjugating enzyme family
2003
Neddylation and Deneddylation of CUL-3 Is Required to Target MEI-1/Katanin for Degradation at the Meiosis-to-Mitosis Transition in C. elegans
2003
Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination
2007
Three Different Binding Sites of Cks1 Are Required for p27-Ubiquitin Ligation
2002 StandoutNobel
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
The JAZ family of repressors is the missing link in jasmonate signalling
2007 StandoutNature
JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling
2007 StandoutNature
Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis
2005
SCFβ-TRCP Controls Clock-dependent Transcription via Casein Kinase 1-dependent Degradation of the Mammalian Period-1 (Per1) Proteinm
2005
The COP9 Signalosome Promotes Degradation of Cyclin E during Early Drosophila Oogenesis
2003
The Mdm2 RING domain C‐terminus is required for supramolecular assembly and ubiquitin ligase activity
2006
The Ubiquitin Ligase Activity in the DDB2 and CSA Complexes Is Differentially Regulated by the COP9 Signalosome in Response to DNA Damage
2003
TIP120A Associates with Cullins and Modulates Ubiquitin Ligase Activity
2003
Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases
2007
The cullin protein family
2011
Diversity of degradation signals in the ubiquitin–proteasome system
2008
CRL4s: the CUL4-RING E3 ubiquitin ligases
2009
Structural basis of ubiquitylation
2002
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity
2007
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Fbw7/hCDC4 dimerization regulates its substrate interactions.
2007
The SCF ubiquitin ligase: insights into a molecular machine
2004
Ubiquitin: structures, functions, mechanisms
2004
Enhancement of BRCA1 E3 Ubiquitin Ligase Activity through Direct Interaction with the BARD1 Protein
2003
Context of Multiubiquitin Chain Attachment Influences the Rate of Sic1 Degradation
2003
The SCF Ubiquitin Ligase
2002
Mutations in Fbx4 Inhibit Dimerization of the SCFFbx4 Ligase and Contribute to Cyclin D1 Overexpression in Human Cancer
2008
BTB/POZ Domain Proteins Are Putative Substrate Adaptors for Cullin 3 Ubiquitin Ligases
2003
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan
2011
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Structural Basis of the Cks1-Dependent Recognition of p27Kip1 by the SCFSkp2 Ubiquitin Ligase
2005
Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma
2009
Phase transitions in the assembly of multivalent signalling proteins
2012 StandoutNature
Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation
2008
Cullin‐based ubiquitin ligases: Cul3–BTB complexes join the family
2004
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APCCdh1
2002
An Altered-specificity Ubiquitin-conjugating Enzyme/Ubiquitin–Protein Ligase Pair
2004
S-Phase Kinase-Associated Protein 2 Expression in Non-Hodgkin's Lymphoma Inversely Correlates with p27 Expression and Defines Cells in S Phase
2002
Skp2 Regulates Myc Protein Stability and Activity
2003
X-Linked Mental Retardation Gene CUL4B Targets Ubiquitylation of H3K4 Methyltransferase Component WDR5 and Regulates Neuronal Gene Expression
2011
Protein–protein interaction through β-strand addition
2006
Mechanism of Lysine 48-Linked Ubiquitin-Chain Synthesis by the Cullin-RING Ubiquitin-Ligase Complex SCF-Cdc34
2005
Multisite Phosphorylation and the Countdown to S Phase
2001
Structural Insights into the COP9 Signalosome and Its Common Architecture with the 26S Proteasome Lid and eIF3
2010
Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development
2002
The anaphase-promoting complex: it's not just for mitosis any more
2002
Oncogenic aberrations of cullin-dependent ubiquitin ligases
2004
The Anaphase-Promoting Complex
2002
Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity
2003
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Structure of a β-TrCP1-Skp1-β-Catenin Complex
2003
Human Origin Recognition Complex Large Subunit Is Degraded by Ubiquitin-Mediated Proteolysis after Initiation of DNA Replication
2002
To cycle or not to cycle: a critical decision in cancer
2001
The Hallmarks of Aging
2013 Standout
Inactivation of hCDC4 can cause chromosomal instability
2004 Nature
Evaluation of a Diffusion-Driven Mechanism for Substrate Ubiquitination by the SCF-Cdc34 Ubiquitin Ligase Complex
2006
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Back to the Future with Ubiquitin
2004
Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover
2003
Global quantification of mammalian gene expression control
2011 StandoutNature
Multisite Phosphorylation by Cdk2 and GSK3 Controls Cyclin E Degradation
2003
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase
2003 Nature
The plant immune system
2006 StandoutNature
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
APC/C and SCF: Controlling Each Other and the Cell Cycle
2004
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
TIP120A associates with unneddylated cullin 1 and regulates its neddylation
2003
Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase
2003
Prolyl 4-hydroxylase-1 mediates O2 signaling during development ofDictyostelium
2007
Paramyxoviruses SV5 and HPIV2 Assemble STAT Protein Ubiquitin Ligase Complexes from Cellular Components
2002
BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase
2004
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
Getting into position: the catalytic mechanisms of protein ubiquitylation
2004
Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma
2012
Identification of SCF Ubiquitin Ligase Substrates by Global Protein Stability Profiling
2008 Science
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity
2024 StandoutNobel
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases
2005 Nobel
Global Protein Stability Profiling in Mammalian Cells
2008 Science
Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
2005
hCDC4 gene mutations in endometrial cancer.
2002
Building and remodelling Cullin–RING E3 ubiquitin ligases
2013
CDC4 Mutations Occur in a Subset of Colorectal Cancers but Are Not Predicted to Cause Loss of Function and Are Not Associated with Chromosomal Instability
2005
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
RING Domain E3 Ubiquitin Ligases
2009 Standout
Assembly of Cell Regulatory Systems Through Protein Interaction Domains
2003 Science
Autoubiquitylation of the V(D)J recombinase protein RAG1
2003
COI1 links jasmonate signalling and fertility to the SCF ubiquitin–ligase complex in Arabidopsis
2002
Overproduction of Polypeptides Corresponding to the Amino Terminus of the F-Box Proteins Cdc4p and Met30p Inhibits Ubiquitin Ligase Activities of Their SCF Complexes
2003
Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2
2004 Standout
Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis duringDrosophilaoogenesis
2003
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas
2007
Structural and Functional Analysis of Essential pre-mRNA Splicing Factor Prp19p
2004
Cancer Genome Landscapes
2013 StandoutScience
The Ubiquitin-Proteasome Pathway and Plant Development
2004
The Ubiquitin-Proteasome Pathway and Its Role in Cancer
2005
Mutation of hCDC4 Leads to Cell Cycle Deregulation of Cyclin E in Cancer
2004
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
F-Box Protein XREP-4 Is a New Regulator of the Oxidative Stress Response in Caenorhabditis elegans
2017
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α
2011
CUL7: A DOC domain-containing cullin selectively binds Skp1⋅Fbx29 to form an SCF-like complex
2002
The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling
2004 Science
Structural Mechanisms Underlying Posttranslational Modification by Ubiquitin-Like Proteins
2007
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex
2003
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
Arabidopsis CAND1, an Unmodified CUL1-Interacting Protein, Is Involved in Multiple Developmental Pathways Controlled by Ubiquitin/Proteasome-Mediated Protein Degradation
2004
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Works of Claire Chu being referenced
Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex
2002 Nature
Phosphorylation-Dependent Ubiquitination of Cyclin E by the SCF Fbw7 Ubiquitin Ligase
2001 Science