Citation Impact
Citing Papers
Small molecule enhancers of autophagy for neurodegenerative diseases
2008
Apg13p and Vac8p Are Part of a Complex of Phosphoproteins That Are Required for Cytoplasm to Vacuole Targeting
2000 StandoutNobel
Roles of tau protein in health and disease
2017
Interaction of Hydroxylated Collagen IV with the von Hippel-Lindau Tumor Suppressor
2007 StandoutNobel
Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9
2008 StandoutNobel
Increased autophagy blocks HER2-mediated breast tumorigenesis
2018
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
Targeting autophagy in obesity: from pathophysiology to management
2018
HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death
2003
The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
2001
Autophagy as a promoter of longevity: insights from model organisms
2018
The Role of Autophagy in Parkinson's Disease
2012
Role of JNK1-dependent Bcl-2 Phosphorylation in Ceramide-induced Macroautophagy
2008
Erk1/2-dependent Phosphorylation of Gα-interacting Protein Stimulates Its GTPase Accelerating Activity and Autophagy in Human Colon Cancer Cells
2000
mTOR Signaling in Growth Control and Disease
2012 Standout
β-Arrestin Scaffolding of the ERK Cascade Enhances Cytosolic ERK Activity but Inhibits ERK-mediated Transcription following Angiotensin AT1a Receptor Stimulation
2002 StandoutNobel
Autophagy in the liver
2008
Signal Transduction Pathways in Macroautophagy
1997
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
2003 StandoutNobel
4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells
2008
4-Hydroxynonenal–protein adducts: A reliable biomarker of lipid oxidation in liver diseases
2007
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Intracellular trafficking and degradation of unassociated proα2 chains of collagen type I
2004
The role of autophagy in neurodegenerative disease
2013 Standout
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo
2012
Regulation and role of autophagy in mammalian cells
2004
Regulation of apoptosis-associated lysosomal membrane permeabilization
2010
Delivery of proteins and organelles to the vacuole from the cytoplasm
1998
Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice
2009
Mannose 6-Phosphate Receptor Targeting and its Applications in Human Diseases
2007
Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance
2013
Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
2005 Standout
Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4
2006
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3
2009
Autophagy as a cell death and tumor suppressor mechanism
2004 Standout
Hallmarks of aging: An expanding universe
2023 Standout
Analyses of Gα-Interacting Protein and Activator of G-Protein-Signaling-3 Functions in Macroautophagy
2004
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
The G-protein Regulator AGS3 Controls an Early Event during Macroautophagy in Human Intestinal HT-29 Cells
2003
Lysosomal membrane permeabilization in cell death
2008
4‐Hydroxynonenal: A membrane lipid oxidation product of medicinal interest
2007
LC3 conjugation system in mammalian autophagy
2004 Standout
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
2009
Amyotrophic lateral sclerosis
2011 Standout
The Lipid Peroxidation Product 4‐Hydroxy‐2,3‐Nonenal Increases AP‐1‐Binding Activity Through Caspase Activation in Neurons
2000
Huntington’s disease: degradation of mutant huntingtin by autophagy
2008
Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function
2011
Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model
2008
Proteomic maps of breast cancer subtypes
2016
Autophagy-Independent Functions of the Autophagy Machinery
2019
Apg2p Functions in Autophagosome Formation on the Perivacuolar Structure
2001 StandoutNobel
Autophagy: Renovation of Cells and Tissues
2011 Standout
In Vitro Reconstitution of Plant Atg8 and Atg12 Conjugation Systems Essential for Autophagy
2007 StandoutNobel
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Recent insights into the function of autophagy in cancer
2016
Amyotrophic lateral sclerosis: A 40-year personal perspective
2009
Autophagy: a barrier or an adaptive response to cancer
2003
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Activation of metallothionein transcription by 4‐hydroxynonenal
2010
Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann–Sträussler–Scheinker Disease
2012
Autophagy
1996
The development of allergic inflammation
2008 StandoutNature
Induction of autophagy and inhibition of tumorigenesis by beclin 1
1999 StandoutNature
Autophagy in the Pathogenesis of Disease
2008 Standout
Enzymes of UDP‐GlcNAc biosynthesis in yeast
2006
The Atg18-Atg2 Complex Is Recruited to Autophagic Membranes via Phosphatidylinositol 3-Phosphate and Exerts an Essential Function
2008 StandoutNobel
Predicting Drug‐Resistant Mutations of HIV Protease
2007 StandoutNobel
Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death
2008
Mast Cell Proteases
2007
Signaling properties of 4-hydroxyalkenals formed by lipid peroxidation in diabetes
2013
On the Dependency of Cellular Protein Levels on mRNA Abundance
2016 Standout
Oxidative Stress Induces Increase in Intracellular Amyloid β-Protein Production and Selective Activation of βI and βII PKCs in NT2 Cells
2000
Autophagy in Human Health and Disease
2013 Standout
Guanine Nucleotide Exchange on Heterotrimeric Gi3 Protein Controls Autophagic Sequestration in HT-29 Cells
1996
Does Lithium Prevent Alzheimerʼs Disease?
2012
Autophagic proteolysis: control and specificity
1997
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
2010
Mutant Fibrinogen Cleared from the Endoplasmic Reticulum via Endoplasmic Reticulum-Associated Protein Degradation and Autophagy
2006
Glycogen autophagy
2004
Active autophagy in the tumor microenvironment: A novel mechanism for cancer metastasis
2012
Autophagy and Cell Death
2007
4-hydroxynonenal and regulation of cell cycle: effects on the pRb/E2F pathway
2004
Cathepsin D—Many functions of one aspartic protease
2008
Lipophagy and liver disease: New perspectives to better understanding and therapy
2017
Activation of PKC-β isoforms mediates HNE-induced MCP-1 release by macrophages
2002
Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism
2015
The cell biology of lysosomal storage disorders
2004
Presenilin Mutations in Familial Alzheimer Disease and Transgenic Mouse Models Accelerate Neuronal Lysosomal Pathology
2004
Molecular dissection of autophagy: two ubiquitin-like systems
2001 StandoutNobel
4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells
2002
Regulation of protein degradation in normal and transformed human bronchial epithelial cells in culture
1992
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
2010
Inhibition of the Lipopolysaccharide-Induced Stimulation of the Members of the MAPK Family in Human Monocytes/Macrophages by 4-Hydroxynonenal, a Product of Oxidized Omega-6 Fatty Acids
2008
Control of the Expression and Activity of the Gα-interacting Protein (GAIP) in Human Intestinal Cells
1997
Expanding perspectives on the significance of mitophagy in cancer
2017
HNE––signaling pathways leading to its elimination
2003
AKT/PKB Signaling: Navigating the Network
2017 Standout
Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis
2011
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
The autophagic network and cancer
2018
Dynamics and diversity in autophagy mechanisms: lessons from yeast
2009 StandoutNobel
Unraveling Inter‐ and Intrachain Electronics in Polythiophene Assemblies Mediated by Coordination Nanospaces
2015 StandoutNobel
Autophagy and Neuronal Cell Death in Neurological Disorders
2012
Distinct Classes of Phosphatidylinositol 3′-Kinases Are Involved in Signaling Pathways That Control Macroautophagy in HT-29 Cells
2000
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
2008
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
2000 StandoutNature
Role of PKC-dependent pathways in HNE-induced cell protein transport and secretion
2003
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Basic aspects of the biochemical reactivity of 4-hydroxynonenal
2003
Autophagy and human diseases
2013
Autophagy Delays Sulindac Sulfide-Induced Apoptosis in the Human Intestinal Colon Cancer Cell Line HT-29
2001
The Stability of the G Protein-coupled Receptor-β-Arrestin Interaction Determines the Mechanism and Functional Consequence of ERK Activation
2003 StandoutNobel
Pathogenic Lysosomal Depletion in Parkinson's Disease
2010
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis
2019
Protein clearing pathways in ALS.
2011
Autophagy wins the 2016 Nobel Prize in Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research
2016
Confinement of Single Polysilane Chains in Coordination Nanospaces
2015 StandoutNobel
Amino Acids Interfere with the ERK1/2-dependent Control of Macroautophagy by Controlling the Activation of Raf-1 in Human Colon Cancer HT-29 Cells
2003
Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology
2015
An obligatory requirement for the heterotrimeric G protein G i3 in the antiautophagic action of insulin in the liver
2007
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells
1997
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling
2010
Targeted metabolic labeling of yeast N-glycans with unnatural sugars
2010 StandoutNobel
Incorporation of a Semiconductive Polymer into Mesoporous SBA-15 Platelets: Toward New Luminescent Hybrid Materials
2011
Cytolysin-dependent evasion of lysosomal killing
2005
Autophagy in stem cells: repair, remodelling and metabolic reprogramming
2018
The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation
2015
Regulation of protein turnover versus growth state
1988
Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy
2017
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
Purification and characterization of autophagosomes from rat hepatocytes
1998
Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
2013
Signaling and cytotoxic functions of 4-hydroxyalkenals
2010
PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells
1999
4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis
2005
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
2014 Standout
Diversity of Signaling Controls of Macroautophagy in Mammalian Cells.
2002
Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein
2001 StandoutNobel
Autophagy, Cytoplasm-to-Vacuole Targeting Pathway, and Pexophagy in Yeast and Mammalian Cells
2000
The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
2018
Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
2001 StandoutNobel
Stapled β-Hairpins Featuring 4-Mercaptoproline
2021 StandoutNobel
Structure and Mechanism of the Pepsin-Like Family of Aspartic Peptidases
2002
Autophagy as a Regulated Pathway of Cellular Degradation
2000 StandoutScience
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies
2016
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Ciro Isidoro being referenced
Lithium delays progression of amyotrophic lateral sclerosis
2008
Protein turnover states of tumour cells and host tissues in an experimental model.
1986
The fine tuning of metabolism, autophagy and differentiation during in vitro myogenesis
2016
Exposed Thiols Confer Localization in the Endoplasmic Reticulum by Retention Rather than Retrieval
1996
Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D
2006
Destination ‘Lysosome’: a target organelle for tumour cell killing?
2003
Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas
2001
Differentiation-induced changes in the content, secretion, and subcellular distribution of lysosomal cathepsins in the human colon cancer HT-29 cell line
1997
Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas
2010
Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome
2015
Autophagy, lithium, and amyotrophic lateral sclerosis
2009
Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium
2008
Cathepsin D–Bax death pathway in oxidative stressed neuroblastoma cells
2007
Chemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D‐Bax activation loop
2008
Induced autophagy reduces virus output in dengue infected monocytic cells
2011
Regulation of Rat Hepatocyte Protein Kinase C β Isoenzymes by the Lipid Peroxidation Product 4–Hydroxy–2,3–Nonenal: A Signaling Pathway to Modulate Vesicular Transport of Glycoproteins
1999
Suppression of autophagy precipitates neuronal cell death following low doses of methamphetamine
2008
Autophagic‐lysosomal perturbation enhances tau aggregation in transfectants with induced wild‐type tau expression
2008
A fast and simple method for simultaneous mixed site‐specific mutagenesis of a wide coding sequence
2008
Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts
1997
A Heterotrimeric G i3-protein Controls Autophagic Sequestration in the Human Colon Cancer Cell Line HT-29
1995
Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis
2015
Increase in Ceramide Level Alters the Lysosomal Targeting of Cathepsin D prior to Onset of Apoptosis in HT-29 Colon Cancer Cells
2002
Autophagy‐dependent cell survival and cell death in an autosomal dominant familial neurohypophyseal diabetes insipidus in vitro model
2005
Photoactive Hybrid Nanomaterials: Indocyanine Immobilized in Mesoporous MCM-41 for “In-Cell” Bioimaging
2009
Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection
2015
Expression and posttranslational fate of cathepsin D in HT-29 tumor cells depend on their enterocytic differentiation state.
1997
Regulation of lysosomal cysteine-proteinase activities in 3T3 and SV-3T3 cells*
1986
PTEN deficiency and mutant p53 confer glucose-addiction to thyroid cancer cells: impact of glucose depletion on cell proliferation, cell survival, autophagy and cell migration
2014
Cathepsin D released by lactating rat mammary epithelial cells is involved in prolactin cleavage under physiological conditions
2004
Differential segregation of human and hamster cathepsin D in transfected baby-hàmster kidney cells
1991
Expression and Clinical Significance of the Autophagy Proteins BECLIN 1 and LC3 in Ovarian Cancer
2014
The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders
2016
The lysosomal protease cathepsin D is efficiently sorted to and secreted from regulated secretory compartments in the rat basophilic/mast cell line RBL
2000
Differentiation-dependent autophagy controls the fate of newly synthesized N-linked glycoproteins in the colon adenocarcinoma HT-29 cell line
1995
Autophagy is a prosurvival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene
2005